Hubungan Proporsi Drug Load Terhadap Disolusi Kurkumin

Daftar Pustaka Anonim, 1995, Farmakope Indonesia, Edisi IV, Departemen Kesehatan Republik Indonesia, Jakarta, pp 1036. Anonim, 2009, Guidance for the Validation of Analythical Methodology and Calibration of Equipment used for Testing of Illicit Drugs in Seized Materials and Biological Specimens , United Nations Office on Drugs and Crime UNODC, New York. Anonim, 2012, www.keison.co.uk, diakses tanggal 16 Maret 2013. Babu, P.S., Srinivasan, K., 1997, Hypolipidemic Action of Curcumin, The Active Principle of Tumeric Curcuma longa in Streptozotocin Induced Diabetic Rats., Mol. Cell. Biochem. 166, 169-175. Beringer, P., 2005, Remington: The Science and Practice of Pharmacy, Lippincott Williams Wilkins, Philadelphia, pp. 672-687. Bermawie, N., Rahardjo, M., Wahyuno, D., dan Ma‟mun, 2007, Status Teknologi Budidaya dan Pasca Panen Tanaman Kunyit dan Temulawak Sebagai Penghasil Kurkumin , Balai Penelitian Tanaman Rempah dan Obat, Jakarta. Budavari, S., O‟Neill, M,J,, Smith, A,, Heckelman, P.E., Kinneary, J.F., 1996, The Merck Index , 12th edition, Merck Co, Rahway, New Jersey, USA. Chiou, W.L., dan Riegelman, S. ,1971, Pharmaceuticl Applications of Solid of Solid Dispersion System. J. Pharm. Sci. 609: 1281-1302. Fischer, F., dan Bauer, S., 2009, Polyvinylpyrrolidon.Ein Tausendsassa in der Chemie. Chemie in unserer Zeit 43 6: 376 –383. Fudholi, A., 2013, Disolusi Pelepasan Obat in Vitro, Pustaka Pelajar, Yogyakarta, pp. 5-31, 59-81, 142-145. Gandjar, I.G., dan Rohman, A., 2007, Kimia Farmasi Analisis, Pustaka Pelajar, Yogyakarta, pp. 353-376, 456-480. Goldberg, A.H., Gibaldi, M., dan Kanig, J.L.,1965, Increasing Dissolution Rates and Gastrointestinal Absorption of Drugs via Solid Solutions and Eutectic Mixtures III – Experimental Evaluation of Griseofulvin- Succinic Aid Solid Solution., J. Pharm. Sci. 559: 487-492. Gordon H. and Tristan F., 1999, SI Chemical Data, 4 th edition , J. Wiley and Sons. Haaf, F., A. Sanner and F. Straub, 1985, Polymers of N-Vinylpyrrolidone: Synthesis, Characterization and Uses. Polymer Journal 17 1: 143 – 152. Kuttan, R., Bhanumathy, P., Nirmala, K., George, M.C., 1985. Potential Anticancer Activity of Turmeric Curcuma longa., Cancer Lett. 29, 197-202. Laurence, M.H., and Christopher, J.M., 1989, Experimental organic chemistry: Principles and Practice Illustrated ed.. pp. 47 –51. Leuner, C., Dressman, J., 2000. Improving drug solubility for oral delivery using solid dispersions., Eur. J. Pharm. 50, 47-60. Martono, S., 1996, Penentuan kadar kurkumin secara kromatografi lapis tipis- densitometri, Buletin ISFI Yogyakarta, Vol. 2, No. 4, April 1996, Yogyakarta. Peter, K.V., 2001, Handbook of Herbs and Spices, Volume 1, Woodhead Publishing, Cambridge,pp. 300-306. Santhi, M.D., 2003, Embolized Crospovidone poly[N-vinyl-2-pyrrolidone] in the Lungs of Intravenous Drug Users, Mod Pathol;164:286 –292. Seo, S., Hyo-Kyung Han, Myung-Kwan Chun, Hoo-Kyun Choi, 2012, “Preparation and Phamacokinetic Evaluation of Curcumin Solid Dispersion using Solutol ® HS15 as C arrier”., International Journal of Pharmaceutics 424: 18-25. Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., Srinivas, P.S., 1998.Influence of Piperine on The Pharmacokinetics of Curcumin in Animals and Human Volunteer. Planta Med. 64, 353-356. Srinarong P. 2009, Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants, European Journal of Pharmaceutics and Biopharma 731:8 2009 PMID 19465121 Tonnesen, H.H., Karlsen, J., 1985. Studies on Curcumin and Curcuminoids VI.Kinetics of Curcumin Degradation in Aqueous Solution . Z. Lebensm. Unters.Forsch. 180, 402-404. van Ketel, W.G., dan van den Berg, W.H., 1990, Sensitization to povidone- iodine. Dermatologic Clinics 8 1: 107 –119. Vasconcelos, T., Sarmento, B., Costa, P., 2007, Solid Dispersions as Strategy to Improve Oral Bioavailability of Poor Water Soluble Drugs, Elsevier Ltd., 12, 1068-1075. Wang, Y.J., Pan, M.H., Cheng, A.L., Lin, L.I., Ho, Y.S., Hsieh, C.Y., Lin, J.K., 1997, Stability of curcumin in buffer solutions and characterization of its degradation products. Pharm. Biomed. Anal. 15, 1867-1876. Wang, W., 2009, Formation and Characterization of Solid Dispersions of Piroxicam and Polyvinylpyrrolidone Using Spray Drying and Precipitation with Compressed Antisolvent, Wiley InterScience www.interscience.wiley.com. DOI 10.1002jps.21598 Journal Of Pharmaceutical Sciences , VOL. 98, NO. 7, JULY 2009 Lampiran Lampiran 1. Data Penimbangan Baku dan Ekstrak Temulawak Baku Kurkumin Kurkumin g Replikasi I Replikasi II Replikasi III Berat kertas 3.966 2.001 4.785 Berat kertas + zat 4.015 2.051 4.835 Berat kertas + sisa 3.966 2.001 4.785 Berat zat 49 50 50 Penimbangan Ekstrak Temulawak Ekstrak Temu Lawak g Replikasi I Replikasi II Replikasi III Replikasi IV Replikasi V Berat kertas 3.482 3.564 4.012 3.612 3.654 Berat kertas + zat 3.531 3.614 4.012 3.663 3.704 Berat kertas + sisa 3.482 3.564 4.012 3.612 3.654 Berat zat 49 50 51 51 50 Validasi Baku Kurkumin Kurkumin g Replikasi I Replikasi II Replikasi III Replikasi IV Replikasi V Berat kertas 3.445 3.566 3.412 3.233 3.564 Berat kertas + zat 3.494 3.616 3.462 3.283 3.614 Berat kertas + sisa 3.445 3.566 3.412 3.233 3.564 Berat zat 49 50 50 50 50