41
BAB V KESIMPULAN DAN SARAN
A. Kesimpulan
Dari hasil penelitian yang dilakukan maka dapat disimpulkan bahwa ada pengaruh proporsi drugload terhadap profil disolusi dispersi padat kurkumin
ekstrak temulawak dalam HPMC. Dispersi padat dengan drug load 2,4 memberikan Efisiensi Disolusi yang lebih tinggi daripada pada drug load 4 dan
6 , dan dari uji disolusi diperoleh bahwa disolusi kurkumin meningkat seiring dengan meningkatnya jumlah HPMC E-15 dalam dispersi padat.
B. Saran
1. Perlu melihat glass transition temperature dari serbuk dispersi padat danserbuk
campuran fisik dengan menggunakan Differential ScanningCalorimetry DSC. 2.
Perlu dilakukan uji bioavailibilitas.
42
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45
LAMPIRAN
Lampiran 1. Penimbangan pembuatan dispersi padat dan campuran fisik
Dispersi Padat
a. Formula 1 1 : 1
Ekstrak temulawak Wadah kosong
= 0,210 g Wadah + isi
= 5,212 g Wadah + sisa
= 0,210 g Ekstrak temulawak
= 5,002 g HPMC
Wadah kosong = 0,310 g
Wadah + isi = 5,314 g
Wadah + sisa = 0,311 g
Ekstrak temulawak = 5,003 g
Drug load =
12 � 5,002
5,003 +5,002
= 6 b.
Formula II 1 : 2 Ekstrak temulawak
Wadah kosong = 0,231 g
Wadah + isi = 5,235 g
Wadah + sisa = 0,231 g
Ekstrak temulawak = 5,004 g
HPMC Wadah kosong
= 0,252 g Wadah + isi
= 10,253 g Wadah + sisa
= 0,252 g Ekstrak temulawak
= 10,001 g Drug load =
12 � 5,004
5,004 +10,001
= 4
c. Formula III
Ekstrak temulawak Wadah kosong
= 0,240 g Wadah + isi
= 5,245 g
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