Cordyline terminalis Kunth Leave's saponin lowered plasma cholesterol and bile acids levels by increased the excretion of fecal total bile acids and cholesterol in male wistar rats.

ejbps, 2015, Volume 2, Issue 5, 122-134.

Bogoriani et al.

Research Article

SJIF Impact Factor 2.062

European
Journal of Biomedical
and Pharmaceutical Sciences
ISSN 2349-8870
European
Journal
of Biomedical
Volume: 2
AND
Issue: 5
122-134
Pharmaceutical sciences
Year: 2015

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CORDYLINE TERMINALIS KUNTH LEAVES’S SAPONIN LOWERED

PLASMA CHOLESTEROL AND BILE ACIDS LEVELS BY
INCREASED THE EXCRETION OF FECAL TOTAL BILE ACIDS AND
CHOLESTEROL IN MALE WISTAR RATS
Ni Wayan Bogoriani1*, Ida Bagus Putra-Manuaba1, Ketut Suastika2,
I Wayan Wita3
*Chemistry Department, Faculty of Mathemathic and Natural Science, University of
Udayana.
1

Chemistry Departement, Faculty of Mathemathic and Natural Science, University of
Udayana, Denpasar, Bali, Indonesia.

2

Professor of Medicine, Head, Division of Endocrinology and Metabolism, Department of

Internal Medicine, Faculty of Medicine, Rector Udayana University;
3

Departement of Cordiology and Vascular Medicine, Faculty of Medicine; Udayana
University, Denpasar, Bali, Indonesia.

Article Received on 05/08/2015

Article Revised on 30/08/2015

Article Accepted on 21/09/2015

ABSTRACT
*Correspondence for
Author

Saponins in the suspect can inhibit cholesterol absorption directly and

Ni Wayan Bogoriani

indirectly in the gut so it can reduce plasma total cholesterol and bile

Chemistry Department,

acids, the various mechanisms that are still unclear. The purpose of this

Faculty of Mathemathic and

study is to prove that saponin intake of Cordyline terminalis kunth

Natural Science,
University of Udayana.

leaf, can inhibit cholesterol absorption directly and indirectly, thus
lowering plasma cholesterol and total bile acids, by increasing the
excretion total cholesterol and bile acids of feces. The study design

was a randomized post-test only control group design, conducted in Wistar rats. Twenty-five
rats were divided into four groups; Control, treatment 1, treatment 2, and treatment 3, each of
6 rats. The control group was given only the standard diet, treatment 1 was given highcholesterol foods, treatment 2 was given high-cholesterol foods and Cordyline teminalis

Kunth leaf saponin 30 mg / day, and treatment 3 was given high-cholesterol foods and
gemfibrozil 30 mg / day. After treatment 30 days and the rats were fasted 18 hours, blood
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Bogoriani et al.

European Journal of Biomedical and Pharmaceutical Sciences

samples were taken and plasma separated for examination of cholesterol, and bile acids.
Three days last treatment the rats feces were collected for examination of total cholesterol
and total bile acids. The results showed an increase in total cholesterol, LDL cholesterol,
triglycerides, ratio of total cholesterol / HDL and a decrease in HDL cholesterol, and
excretion fecal total cholesterol, total bile acids were significantly (p