Alif Adlan G2A009134 Bab 8

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49

In: Joel G.Hardman, Lee E.Limbird (eds.)Dasar Farmakologi terapi. 10th ed. Jakarta: EGC; 2003. p666 - 711

2. Bertram G.Katzung. Farmakologi dasar dan klinik. 10th ed. Jakarta. EGC; 2010.p479 - 489

3. Wilmana PF, Sulistia Gan. Analgesik-antipiretik analgesik anti inflamasi non steroid dan obat gangguan sendi lainnya. In: Ganishwara SG,

Setiabudy R, Suyatna FD, Purwantyatuti, Nafrialdi (eds.)Farmakologi dan terapi. 5th ed. Jakarta: Balai penerbit FK UI; 2007. p230 - 246

4. Bedah Info. Parasetamol mampukah mengatasi nyeri pasca operasi . http://bedah.info/2011/03/parasetamol-mampukah-mengatasi-nyeri-pasca-operasi/ (accessed 20 januari 2013).

5. L Toms, HJ McQuay , S Derry , RA Moore. Single dose oral paracetamol (acetaminophen) for postoperative pain in adults (Review). The Cochrane Library [internet]. 2012 (6). Available from: http://www.thecochranelibrary.com

6. Medika Jurnal Kedokteran Indonesia. Tablet kombinasi tramadol/ parasetamol untuk nyeri pasca bedah operasi tangan rawat jalan: uji klinis tersamar ganda, model ganda, acak, paralel. http://www.jurnalmedika.com/edisi-tahun-2012/edisi-no-05-vol-xxxvii- 2012/444-saripati/913-tablet-kombinasi-tramadolparasetamol-untuk- nyeri-pascabedah-operasi-tangan-rawat-jalan-uji-klinis-tersamar-ganda-model-ganda-acak-paralel (accessed 9 february 2013).

7. Abu omar AA, Al issa KA. Intravenous Paracetamol (Perfalgan) for analgesia after cesarean section: A double-blind randomized controlled study. An official publication of Pakistan Medical Association Rawalpindi Islamabad branch. 2011: 36: 4.


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8. Larson AM, Polson J, Fontana RJ, et al. "Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study". Hepatology 42 (6): 1364–72.doi:10.1002/hep.20948

9. Corey R, Leonard M, Eghtesad B. Acetaminophen: old drug, new warnings [internet]. 2010 [cited 2012 dec 20]: 77 1 19-27. Available from: Cleveland clinic journal of medicine.

10.Sheen CL, Dillon JF, bateman DN, Simpson KJ, Macdonald TM. Paracetamol toxicity: epidemiology, prevention and cots to the health-care system [internet]. 2002 [cited 2012 dec 20]: 95 (9): 609-619. Available from: Oxford journals medicine.

11.Heirmayani. Toksikopatologi Hati Mencit Pada Pemberian Parasetamol.Bogor: IPB; 2007.

12.Paramita P. Kadar Serum Aspartat Aminotransferase dan Alanin Aminotransferase Pada Tikus Wistar Setelah Pemberian Asetaaminofen Per Oral Dalam Berbagai Dosis. Semarang: Undip; 2007.

13.Sulaiman H.A, Akbar HN, Lesmana LA, Noer HMS. Buku ajar ilmu penyakit hati edisi pertama. Jakarta: Jayabadi; 2007. P17-24, 265-274 14.G.Edward Morgan,Jr, Maged S.M,Michael JM. Clinical Anesthesiology.

4th ed. United States of America. McGraw-Hill; 2006.p 361 - 363

15.Soenarjo, Jatmiko HD. Anestesiologi. Semarang: Ikatan dokter spesialis anestesi dan reanimasi; 2010.p309 - 315

16.Encyclopedia Britannica [internet]. [cited 2013 februari 10]. Available from: http://www.britannica.com/

17.Price SA, Wilson LM. Patofisiologi konsep klinis proses-proses penyakit edisi 6. Jakarta: EGC; 2006.p 472-515

18.Sudoyo AW, Setiyohadi B, Alwi I, Simadibrata M, Setiati S. Buku ajar ilmu penyakit dalam jilid 1 edisi V. Jakarta: Interna publishing; 2009. p627-634, 708-712.

19.Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL. Editor Harrison prinsip-prinsip ilmu penyakit dalam volume 4. Jakarta: EGC; 2000.p 677-689


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20.Soemohardjo S, Bennie HS, Antonius W, Muljanto. Tes faal hati. Bandung: Penerbit Alumni; 1983. p89-98

21.Berkow R, Andrew JF. The merck manual. Ed 16 volume 2. Jakarta: Binarupa aksara; 1999.p 78-90

22.Sherlock, Sheila. Penyakit Hati dan Sistem Saluran Empedu. Jakarta: Widya Medika. 1995.p 145-167

23.Mandal A. News medical. Causes of liver disease [internet]. [cited 2013 feb 4]. Available from: http://www.news-medical.net/health/Causes-of-liver-disease.aspx

24.Treinen M, Moslen. Toxic responses of the liver. In: Klussen phD. Editor. Toxicology the basic science poisons 6th edition. New york-chicago: Mc graw-H.Medical PU; 2003.

25.Friedmen LS, Keeffe EB. Handbook of liver disease second edition. Philadelphia (USA): Churchill livingstone; 2004.

26.Mariono, di Fiore. Atlas histologi manusia edisi 4. Jakarta: EGC; 1996. 27.Davis M, William P. Hepatic disorders in: Davies DM. Editor. Textbook

of adverse drug Reactions 4th Edition volume 1 of 2. Oxford New York- Tokyo: Oxford Medical publications; 1991.

28.Jackson P. Hepatotoxicity, Nephrotoxicity [internet]. Available from: http//www.public-health.uiowa.edu/fuortes/text/hepnep.html

29.World Health Organization (WHO). General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine [Internet]. [cited 2012 Dec 11]. Geneva : WHO; 2001.

30.Yuniastuti A dan Purwaningsih E. Pengaruh pemberian susu fermentasi lactobacillus casei galur shirota terhadap kadar fraksi lipid serum dan jumlah coliform serta lactobacilli pada feses tikus hiperkolesterolemi. M Med Indones [Internet]. 2004 [cited 2012 Dec 27]; 39(4).

31.Price M. Sign and Symptoms of Aceraminophen-Related Liver Damage. Tylenol Liver Damaged Info [internet]. Available from:


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32.William P. Aspartat Aminotransferase [internet]. Available from:

http://www.clinlabnavigator.com/aspartate-aminotransferase-ast.html

33.Jack A. Hinson, Dean W. Roberts, and Laura P. James. Mechanisms of Acetaminophen-Induced Liver Necrosis [internet]. 2010 [cited 2013 jul 25]: (196):369-405. Available from: handbook of experimental


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Lampiran 1 Ethical Clearance


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Lampiran 2


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Lampiran 3

Dokumentasi Penelitian

1.Penimbangan sampel tikus wistar jantan

2.Sistem pengandangan tiap kelompok

3.Pakan dan minum standart


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4.Pemberian parasetamol lewat sonde lambung

5.Pengambilan darah melalui vena periorbita


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Lampiran 4

Hasil Uji Laboratorium

Kelompok Kadar SGOT (U/l)

Kontrol Kontrol Kontrol Kontrol Kontrol P1 P1 P1 P1 P1 P2 P2 P2 P2 P2 8,1 14,7 13,1 15,1 10,9 27,1 51,0 48,8 60,7 16,6 67,7 38,1 55,1 43,5 31,0 Keterangan

Kontrol : Tidak diberi perlakuan

P1 : Diberi parasetamol 18mg 4x sehari selama 2 hari P2 : Diberi parasetamol 18mg 4x sehari selama 4 hari


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Lampiran 5

Output Uji Statistik

1.Uji normalitas data

Case Processing Summary Cases

Valid Missing Total

N Percent N Percent N Percent

Kadar SGOT 15 100.0% 0 .0% 15 100.0%

Descriptives

Statistic Std. Error

Kadar SGOT Mean 33.433 5.1798

95% Confidence Interval for Mean

Lower Bound 22.324

Upper Bound 44.543

5% Trimmed Mean 32.937

Median 31.000

Variance 402.455

Std. Deviation 20.0613

Minimum 8.1

Maximum 67.7

Range 59.6

Interquartile Range 36.3

Skewness .275 .580

Kurtosis -1.413 1.121

Tests of Normality

Kolmogorov-Smirnova Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

Kadar SGOT .199 15 .112 .917 15 .171


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2. Uji independent t-test (kelompok kontrol dan kelompok perlakuan 1)

Group Statistics

Pemberian Parasetamol N Mean Std. Deviation Std. Error Mean

Kadar SGOT kontrol 5 12.380 2.9072 1.3002

18mg 4x sehari selama 2

hari 5 40.840 18.2850 8.1773

Independent Samples Test Levene's Test

for Equality of

Variances t-test for Equality of Means

F Sig. t df Sig. (2-tailed) Mean Difference Std. Error Difference 95% Confidence Interval of the

Difference

Lower Upper

Kadar SGOT

Equal variances assumed

17.424 .003

-3.437 8 .009 -28.4600 8.2800 -47.5538 -9.3662

Equal variances not assumed

-3.437 4.202 .024 -28.4600 8.2800 -51.0195 -5.9005

3. Uji independent t-test (kelompok kontrol dan kelompok perlakuan 2)

Group Statistics

Pemberian Parasetamol N Mean Std. Deviation Std. Error Mean

Kadar SGOT kontrol 5 12.380 2.9072 1.3002

18mg 4x sehari selama 4


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Independent Samples Test Levene's

Test for Equality of

Variances t-test for Equality of Means

F Sig. t df Sig. (2-tailed) Mean Difference Std. Error Difference 95% Confidence Interval of the

Difference

Lower Upper

Kadar SGOT

Equal variances assumed

8.698 .018

-5.245 8 .001 -34.7000 6.6156 -49.9557 -19.4443

Equal variances not assumed

-5.245 4.321 .005 -34.7000 6.6156 -52.5423 -16.8577

4.Uji Statistik ANOVA

ANOVA Kadar SGOT

Sum of Squares df Mean Square F Sig.

Between Groups 3421.665 2 1710.833 9.278 .004

Within Groups 2212.708 12 184.392


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Multiple Comparisons Kadar SGOT LSD (I) Pemberian Parasetamol (J) Pemberian Parasetamol Mean Difference (I-J) Std. Error Sig.

95% Confidence Interval Lower Bound Upper Bound

kontrol 18mg 4x sehari

selama 2 hari -28.4600 *

8.5882 .006 -47.172 -9.748

18mg 4x sehari

selama 4 hari -34.7000 *

8.5882 .002 -53.412 -15.988

18mg 4x sehari selama 2 hari

kontrol 28.4600* 8.5882 .006 9.748 47.172

18mg 4x sehari

selama 4 hari -6.2400 8.5882 .481 -24.952 12.472

18mg 4x sehari selama 4 hari

kontrol 34.7000* 8.5882 .002 15.988 53.412

18mg 4x sehari

selama 2 hari 6.2400 8.5882 .481 -12.472 24.952


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Lampiran 6

Daftar Riwayat Hidup

Identitas

Nama : Alif Adlan Zulizar

NIM : G2A009134

Tempat/tanggal lahir : Kebumen, 15 September 1990 Jenis kelamin : Lak-laki

Alamat : Jalan Tirto Mukti VIII/1, Semarang Nomor Telpon : (024) 6715109

Nomor HP : 08560221885

e-mail : [email protected],

Riwayat Pendidikan Formal

1. SD : SD SUPRIYADI Lulus tahun : 2003

2. SMP : SMPN 2 Semarang Lulus tahun : 2006

3. SMA : SMA SEMESTA Semarang Lulus tahun : 2009

4. FK UNDIP : Masuk tahun : 2009

Keanggotaan Organisasi

1. Staf Bidang Hubungan Luar Negri BEM KU UNDIP Tahun 2009 s/d 2010 2. Anggota Medical Creative Art FK UNDIP Tahun 2009 s/d 2011 3. Ketua Medical Creative Art FK UNDIP Tahun 2011 s/d 2012 4. Anggota Komisi Disiplin Pemilihan Raya FK UNDIP Tahun 2010

5. Ketua Komisi Disiplin Pemilihan Raya FK UNDIP Tahun 2011

6. Sie Acara PMB FK UNDIP Tahun 2010

7. Sie Publikasi Dokumentasi Sientific Fair 2011 Tahun 2011 8. Sie Acara Pekan Olahraga Seni 2011 FK UNDIP Tahun 2011 9. Sie Acara Kemah Bakti 2012 FK UNDIP Tahun 2012

Pengalaman penelitian Belum ada

Pengalaman publikasi tulisan ilmiah Belum ada

Pengalaman presentasi karya ilmiah Belum ada

Pengalaman mengikuti lomba karya ilmiah Belum ada


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Lampiran 4

Hasil Uji Laboratorium

Kelompok

Kadar SGOT (U/l)

Kontrol

Kontrol

Kontrol

Kontrol

Kontrol

P1

P1

P1

P1

P1

P2

P2

P2

P2

P2

8,1

14,7

13,1

15,1

10,9

27,1

51,0

48,8

60,7

16,6

67,7

38,1

55,1

43,5

31,0

Keterangan

Kontrol

: Tidak diberi perlakuan

P1

: Diberi parasetamol 18mg 4x sehari selama 2 hari

P2

: Diberi parasetamol 18mg 4x sehari selama 4 hari


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Lampiran 5

Output Uji Statistik

1.Uji normalitas data

Case Processing Summary

Cases

Valid Missing Total

N Percent N Percent N Percent

Kadar SGOT 15 100.0% 0 .0% 15 100.0%

Descriptives

Statistic Std. Error

Kadar SGOT Mean 33.433 5.1798

95% Confidence Interval for Mean

Lower Bound 22.324

Upper Bound 44.543

5% Trimmed Mean 32.937

Median 31.000

Variance 402.455

Std. Deviation 20.0613

Minimum 8.1

Maximum 67.7

Range 59.6

Interquartile Range 36.3

Skewness .275 .580

Kurtosis -1.413 1.121

Tests of Normality

Kolmogorov-Smirnova Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

Kadar SGOT .199 15 .112 .917 15 .171


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2. Uji independent t-test (kelompok kontrol dan kelompok perlakuan 1)

Group Statistics

Pemberian Parasetamol N Mean Std. Deviation Std. Error Mean

Kadar SGOT kontrol 5 12.380 2.9072 1.3002

18mg 4x sehari selama 2

hari 5 40.840 18.2850 8.1773

Independent Samples Test

Levene's Test for Equality of

Variances t-test for Equality of Means

F Sig. t df

Sig. (2-tailed)

Mean Difference

Std. Error Difference

95% Confidence Interval of the

Difference

Lower Upper

Kadar SGOT

Equal variances assumed

17.424 .003

-3.437 8 .009 -28.4600 8.2800 -47.5538 -9.3662

Equal variances not assumed

-3.437 4.202 .024 -28.4600 8.2800 -51.0195 -5.9005

3. Uji independent t-test (kelompok kontrol dan kelompok perlakuan 2)

Group Statistics

Pemberian Parasetamol N Mean Std. Deviation Std. Error Mean

Kadar SGOT kontrol 5 12.380 2.9072 1.3002

18mg 4x sehari selama 4


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Independent Samples Test

Levene's Test for Equality of

Variances t-test for Equality of Means

F Sig. t df

Sig. (2-tailed)

Mean Difference

Std. Error Difference

95% Confidence Interval of the

Difference

Lower Upper

Kadar SGOT

Equal variances assumed

8.698 .018

-5.245 8 .001 -34.7000 6.6156 -49.9557 -19.4443

Equal variances not assumed

-5.245 4.321 .005 -34.7000 6.6156 -52.5423 -16.8577

4.Uji Statistik ANOVA

ANOVA

Kadar SGOT

Sum of Squares df Mean Square F Sig.

Between Groups 3421.665 2 1710.833 9.278 .004

Within Groups 2212.708 12 184.392


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Multiple Comparisons

Kadar SGOT LSD

(I) Pemberian Parasetamol

(J) Pemberian Parasetamol

Mean Difference (I-J)

Std. Error Sig.

95% Confidence Interval

Lower Bound

Upper Bound

kontrol 18mg 4x sehari

selama 2 hari -28.4600

*

8.5882 .006 -47.172 -9.748

18mg 4x sehari

selama 4 hari -34.7000

*

8.5882 .002 -53.412 -15.988

18mg 4x sehari selama 2 hari

kontrol 28.4600* 8.5882 .006 9.748 47.172

18mg 4x sehari

selama 4 hari -6.2400 8.5882 .481 -24.952 12.472

18mg 4x sehari selama 4 hari

kontrol 34.7000* 8.5882 .002 15.988 53.412

18mg 4x sehari

selama 2 hari 6.2400 8.5882 .481 -12.472 24.952


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Lampiran 6

Daftar Riwayat Hidup

Identitas

Nama

: Alif Adlan Zulizar

NIM

: G2A009134

Tempat/tanggal lahir : Kebumen, 15 September 1990

Jenis kelamin

: Lak-laki

Alamat

: Jalan Tirto Mukti VIII/1, Semarang

Nomor Telpon

: (024) 6715109

Nomor HP

: 08560221885

e-mail

: [email protected],

Riwayat Pendidikan Formal

1. SD

: SD SUPRIYADI

Lulus tahun

: 2003

2. SMP

: SMPN 2 Semarang

Lulus tahun

: 2006

3. SMA

: SMA SEMESTA Semarang

Lulus tahun

: 2009

4. FK UNDIP :

Masuk tahun : 2009

Keanggotaan Organisasi

1. Staf Bidang Hubungan Luar Negri BEM KU UNDIP

Tahun 2009 s/d 2010

2. Anggota Medical Creative Art FK UNDIP

Tahun 2009 s/d 2011

3. Ketua Medical Creative Art FK UNDIP

Tahun 2011 s/d 2012

4. Anggota Komisi Disiplin Pemilihan Raya FK UNDIP

Tahun 2010

5. Ketua Komisi Disiplin Pemilihan Raya FK UNDIP

Tahun 2011

6. Sie Acara PMB FK UNDIP

Tahun 2010

7. Sie Publikasi Dokumentasi Sientific Fair 2011

Tahun 2011

8. Sie Acara Pekan Olahraga Seni 2011 FK UNDIP

Tahun 2011

9. Sie Acara Kemah Bakti 2012 FK UNDIP

Tahun 2012

Pengalaman penelitian

Belum ada

Pengalaman publikasi tulisan ilmiah

Belum ada

Pengalaman presentasi karya ilmiah

Belum ada

Pengalaman mengikuti lomba karya ilmiah

Belum ada