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Anticancer Effect and Cell Cycle Analysis of Ethanolic Extract of Gembili (Dioscorea esculantaa L. Burkill) on T47D Breast Cancer Cell Line

International Conference: Research and Application
on Traditional Complementary and Alternative Medicine in Health Care (TCAM)
nd
rd
June, 22 -23 2012 Surakarta Indonesia

Anticancer Effect and Cell Cycle Analysis of Ethanolic Extract of
Gembili (Dioscorea esculantaa L. Burkill) on T47D Breast Cancer
Cell Line
Dina Fatmawati Soetoko,1* Sumarno
1

Faculty of Medicine, Islamic University of Sultan Agung
*Corresponding author, email: dienafatma@gmail.com

Abstract
Gembili (Dioscorea esculantae) has been known to contain saponin showing promise as
potential candidate for anticancer therapy. Gembili extract has also shown cytotoxic activity
against T47D breast cancer cell line. The present study aims to investigate the antiproliferative effect of ethanolic extract of gembili against T47D breast cancer line. In this
study, the T47D breast cancer cell line was divided into 3 groups including the control group
and study groups (treated with the ethanolic extract of gembili at the dose of 40 g/mL and 20

g/mL). The anticancer activity was determined by cytotoxic test using MTT assay and
distribution of each phases in cycle cell was tested against T47D breast cancer cell line by
propidium iodine assay. Accumulation of cell in cycle cell were observed using flow
cytometry. The study showed ethanolic extract of gembili has moderete cytotoxicity againts
T47D breast cancer cell line and has a significant difference (p

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