Effect of Al(OH)2 and Mg (OH)2 Suspension Dosage Form on the Absorption of Oral Ciprofloxacin Repository - UNAIR REPOSITORY
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MAJALAH
FARMASI AIRLANGGA
(Airlangga Journal of Pharmacy)
ISSN 0852-1050
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PENERBIT
FAKULTAS FARMASI UNIVERSITAS AIRLANGGA
MAJALAH FARMASI AIRLANGGA
Penanggung jawab:
Dewan Redaksi
Ketua:
Wakil Ketua:
Anggota:
Redaksi Pelaksana:
Ketua
Sekretaris:
Anggota
Alamat Redaksi:
Prof. Dr. H. Achmad Syahrani, Apt., MS
Dekan Fakultas Farmasi Universitas Airlangga
Prof. Dr.Tutuk Budiati, Apt., MS
Prof Dr. rer.nat. H. Moh. Yuwono, Apt., MS
Prof Dr. H. Achmad Syahrani, Apt., MS.
Prof Dr. Amirudin Prawita, Apt.
Prof Dr. Purwanto, Apt.
Prof Dr. Hj. Widji Soeratri, Apt. DEA
Prof Dr. Siswandono, Apt., MS.
Prof Dr. Wahono Sumaryono, Apt., APU
Prof. Dr. Sukardiman, Apt., MS.
Dr. rer.nat. Mulja Hadi Santosa, Apt.
Dr. Hj. Umi Ahtujah, Apt. MS.
Dr. Hj. Isnaeni, Apt., MS
Dr. Suhaijono, Apt., MS.
Dr. Djoko Agus Purwanto, Apt., MS.
Dr. Bambang Prayogo, Apt., MS.
Dra. Esti Henradi, MS., Ph.D.
Dra. Liza Pristianty, MSi., MM
Dr. Budi Suprapti, Apt., MS.
Drs. Abdul Rahman, Apt., MSi
Drs.Achmad Toto Poemomo, Apt., MS
Bambang Subakti Zulkamain, Apt., MSi.
Azza Faturrohmah, S.Si, Apt, MSi.
Muh. Agus Syamsur Rijal, S.Si., Apt, MSi.
Rr. Retno Widyowati, S.Si., Apr., MSc.
Fakultas Farmasi Universitas Airlangga
Jl. Dharmawangsa Dalam, Telp. (031)5033710 Fax. (031)5020514
Surabaya-60286
e-mail: achmad.toto.p@gmail.com. farmasi@unair.ac.id
Majalali Farmasi Airlangga, Vbl.6 Mo. I, April 2008
ii
DAFTAR ISI
hal
Editorial
Daftar Isi Majalah Farmasi Airlangga Vol.6 No.1 April 2008
ii
Efecl ofAl(OH)sandMg(OH),Suspesion Dosage Form on the Absorption of Oral Ciprofloxacin
Aniek Setiya Budiatin, Nunlk Wahyuni, Suharyono, Toetik Aryani ...
.
I
Mitogen-Activated Protein Kinase Menghambat Perkembangan Toleransi Analgesik Morfina pada Mencit
Toetik Aryani', Tri Kaloko, Junaidi Khotib
..
5
Hubungan Persepsi Terhadap Iklan Di Televisi Dengan Perilaku Swamedikasi Pelajar SMU Negeri Di Surabaya
Oelva Dianawati, Fasich, Umi Athijah
.
.
9
Knowledge and Attitudes of Doctors toward Adverse Drug Reaction Reporting and Monitoring in the Hospital :
A Pilot Study
Yunita Nita, Bamhnng Subakti Zulkarnain, Elida Zairina
.
16
Penggunaan Dimetii Sulfoksida (DMSO) Sebagai Pclarut Untuk Analisis Uji Batas “Cemaran Organik Mudah
Menguap” Mcnggunakan Kromatografi Gas
Asri Darmawati, Ahmad Syafi'i Afandi, Achmad lnoni
21
The Comparison of Densitometry andUPLC Method for Determination of Codein Phosphate
and Paracetamol Simultaneously in Analgesic Tablet
Juniar Moechtar, Asri Darmawati
24
Kandungan Logam Berat Timbal (Pb), Kadmium (Cd) dan Tembaga (Cu) dalam air Sungai Kali Wonokromo
Amirudin Prawita, Dewi Murnitasari, Asri Darmawati
27
Ganibarsampul:
Skema amobilisasi molekul enzim didalam pendukung nanoporous. Credit: Eric Ackerman, PNNL. Gambar
didownload dari : http://nanotechweb.org/
Effect of Al(OH), and Mg(OH),
Majalah Farmasi Airlangga, Vol.6 No. I, April 2
Efect of AI(OH)3 and Mg(OH)2 Suspesion Dosage Form on the Absorption of Oral Ciproflo
Aniek Setiya Budiatin, Nunik Wahyuni, Suharyono, Toetik Aryani
Departement of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya.
Potential interaction of fluroquinolone with other drugs have been established in the several repo
absorption of fluroquinolones were almost entirety inhibited by concomitant administration ofdi and t
cations such magnesium and aluminium in the antacids were significantly decreased the absorp
ciprofloxacin through formation of a complex. The effect of antacid (Antasida DOEN) 1.4 ml/kg body weig
which containing polyvalent cation Mg(OH). and Al(OH) on the absorption of ciprofloxacin, were ex
healthy rabbit. Twelve subjects were given 23 mg/ml BW ciprofloxacin alone as control. On day 8 the six
were given antacid and ciprofloxacin concomitant and the other were given antacid two hours after ciprof
The absorption parameters of ciprofloxacin were determined by spectrofluommetric method. Those par
were Cmax, tmax and A L/C, the administration of ciprofloxacin and antacids concomitantly result Cmax, tm
AUC were I.27±0.45g/ml; 110ÿ.48.99 minutes and 248.63±94.77g.minutes/ml respectively in a sig
decrease in ciprofloxacin absorption (p
MAJALAH
FARMASI AIRLANGGA
(Airlangga Journal of Pharmacy)
ISSN 0852-1050
.
. -mg
■ &'
if f$s
• *jf
in
,
■
4
■
VOL.6 No. 1-APR-2008
...
■
ml
*****__fc£ vw
®?!-Har sc.-i
-'Pflt-C
-f
caV--
*
•
L
cj
-
P7f
I
r
PENERBIT
FAKULTAS FARMASI UNIVERSITAS AIRLANGGA
MAJALAH FARMASI AIRLANGGA
Penanggung jawab:
Dewan Redaksi
Ketua:
Wakil Ketua:
Anggota:
Redaksi Pelaksana:
Ketua
Sekretaris:
Anggota
Alamat Redaksi:
Prof. Dr. H. Achmad Syahrani, Apt., MS
Dekan Fakultas Farmasi Universitas Airlangga
Prof. Dr.Tutuk Budiati, Apt., MS
Prof Dr. rer.nat. H. Moh. Yuwono, Apt., MS
Prof Dr. H. Achmad Syahrani, Apt., MS.
Prof Dr. Amirudin Prawita, Apt.
Prof Dr. Purwanto, Apt.
Prof Dr. Hj. Widji Soeratri, Apt. DEA
Prof Dr. Siswandono, Apt., MS.
Prof Dr. Wahono Sumaryono, Apt., APU
Prof. Dr. Sukardiman, Apt., MS.
Dr. rer.nat. Mulja Hadi Santosa, Apt.
Dr. Hj. Umi Ahtujah, Apt. MS.
Dr. Hj. Isnaeni, Apt., MS
Dr. Suhaijono, Apt., MS.
Dr. Djoko Agus Purwanto, Apt., MS.
Dr. Bambang Prayogo, Apt., MS.
Dra. Esti Henradi, MS., Ph.D.
Dra. Liza Pristianty, MSi., MM
Dr. Budi Suprapti, Apt., MS.
Drs. Abdul Rahman, Apt., MSi
Drs.Achmad Toto Poemomo, Apt., MS
Bambang Subakti Zulkamain, Apt., MSi.
Azza Faturrohmah, S.Si, Apt, MSi.
Muh. Agus Syamsur Rijal, S.Si., Apt, MSi.
Rr. Retno Widyowati, S.Si., Apr., MSc.
Fakultas Farmasi Universitas Airlangga
Jl. Dharmawangsa Dalam, Telp. (031)5033710 Fax. (031)5020514
Surabaya-60286
e-mail: achmad.toto.p@gmail.com. farmasi@unair.ac.id
Majalali Farmasi Airlangga, Vbl.6 Mo. I, April 2008
ii
DAFTAR ISI
hal
Editorial
Daftar Isi Majalah Farmasi Airlangga Vol.6 No.1 April 2008
ii
Efecl ofAl(OH)sandMg(OH),Suspesion Dosage Form on the Absorption of Oral Ciprofloxacin
Aniek Setiya Budiatin, Nunlk Wahyuni, Suharyono, Toetik Aryani ...
.
I
Mitogen-Activated Protein Kinase Menghambat Perkembangan Toleransi Analgesik Morfina pada Mencit
Toetik Aryani', Tri Kaloko, Junaidi Khotib
..
5
Hubungan Persepsi Terhadap Iklan Di Televisi Dengan Perilaku Swamedikasi Pelajar SMU Negeri Di Surabaya
Oelva Dianawati, Fasich, Umi Athijah
.
.
9
Knowledge and Attitudes of Doctors toward Adverse Drug Reaction Reporting and Monitoring in the Hospital :
A Pilot Study
Yunita Nita, Bamhnng Subakti Zulkarnain, Elida Zairina
.
16
Penggunaan Dimetii Sulfoksida (DMSO) Sebagai Pclarut Untuk Analisis Uji Batas “Cemaran Organik Mudah
Menguap” Mcnggunakan Kromatografi Gas
Asri Darmawati, Ahmad Syafi'i Afandi, Achmad lnoni
21
The Comparison of Densitometry andUPLC Method for Determination of Codein Phosphate
and Paracetamol Simultaneously in Analgesic Tablet
Juniar Moechtar, Asri Darmawati
24
Kandungan Logam Berat Timbal (Pb), Kadmium (Cd) dan Tembaga (Cu) dalam air Sungai Kali Wonokromo
Amirudin Prawita, Dewi Murnitasari, Asri Darmawati
27
Ganibarsampul:
Skema amobilisasi molekul enzim didalam pendukung nanoporous. Credit: Eric Ackerman, PNNL. Gambar
didownload dari : http://nanotechweb.org/
Effect of Al(OH), and Mg(OH),
Majalah Farmasi Airlangga, Vol.6 No. I, April 2
Efect of AI(OH)3 and Mg(OH)2 Suspesion Dosage Form on the Absorption of Oral Ciproflo
Aniek Setiya Budiatin, Nunik Wahyuni, Suharyono, Toetik Aryani
Departement of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya.
Potential interaction of fluroquinolone with other drugs have been established in the several repo
absorption of fluroquinolones were almost entirety inhibited by concomitant administration ofdi and t
cations such magnesium and aluminium in the antacids were significantly decreased the absorp
ciprofloxacin through formation of a complex. The effect of antacid (Antasida DOEN) 1.4 ml/kg body weig
which containing polyvalent cation Mg(OH). and Al(OH) on the absorption of ciprofloxacin, were ex
healthy rabbit. Twelve subjects were given 23 mg/ml BW ciprofloxacin alone as control. On day 8 the six
were given antacid and ciprofloxacin concomitant and the other were given antacid two hours after ciprof
The absorption parameters of ciprofloxacin were determined by spectrofluommetric method. Those par
were Cmax, tmax and A L/C, the administration of ciprofloxacin and antacids concomitantly result Cmax, tm
AUC were I.27±0.45g/ml; 110ÿ.48.99 minutes and 248.63±94.77g.minutes/ml respectively in a sig
decrease in ciprofloxacin absorption (p