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DOI: 10.21776/ub.jpacr.2018.007.01.357
J. Pure App. Chem. Res., 2018, 7(1), XX-XX
Day month Year
X
Optimization Of Elevating Blood Uric Acid Levels With
High Purine Diet
Fitria Rahmawati,1 Putranty Widha Nugraheni,1 Chanif Mahdi,1 Arie Srihardyastutie1 and Sasangka
Prasetyawan1
1
Chemistry Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia
*
Corresponding email : [email protected]
ABSTRACT
Exploration of the use of medicinal plants to lower uric acid levels has been widely
practiced. Stages of new drug development research are preclinical test using experimental
animals, therefore the manufacture of animal model of hyperuricemia is necessary. This
study aims to determine the optimal induction of uric acid to increase blood uric acid levels
by administering high purine diets such as cow’s liver, cow’s spleen, Gnetum gnemon,
emping and fried peanuts. Eighty male white rats were used individually and divided into 4
groups, they were: (I) cow’s liver, (II) cow’s liver and cow’s spleen, (III) cow’s liver,
cow’s spleen and boiled Gnetum gnemon beans, and (IV) cow’s liver, cow’s spleen,
emping and fried peanuts. This study applied easy touch GCU to measure blood uric acid
level. The result of statistical analysis of uric acid level with 5 times repetition using One
Way ANOVA showed that there was a very significant difference between treatments (p
J. Pure App. Chem. Res., 2018, 7(1), XX-XX
Day month Year
X
Optimization Of Elevating Blood Uric Acid Levels With
High Purine Diet
Fitria Rahmawati,1 Putranty Widha Nugraheni,1 Chanif Mahdi,1 Arie Srihardyastutie1 and Sasangka
Prasetyawan1
1
Chemistry Department, Faculty of Mathematics and Natural Sciences, Brawijaya University, Indonesia
*
Corresponding email : [email protected]
ABSTRACT
Exploration of the use of medicinal plants to lower uric acid levels has been widely
practiced. Stages of new drug development research are preclinical test using experimental
animals, therefore the manufacture of animal model of hyperuricemia is necessary. This
study aims to determine the optimal induction of uric acid to increase blood uric acid levels
by administering high purine diets such as cow’s liver, cow’s spleen, Gnetum gnemon,
emping and fried peanuts. Eighty male white rats were used individually and divided into 4
groups, they were: (I) cow’s liver, (II) cow’s liver and cow’s spleen, (III) cow’s liver,
cow’s spleen and boiled Gnetum gnemon beans, and (IV) cow’s liver, cow’s spleen,
emping and fried peanuts. This study applied easy touch GCU to measure blood uric acid
level. The result of statistical analysis of uric acid level with 5 times repetition using One
Way ANOVA showed that there was a very significant difference between treatments (p