The Relationship Between Molecular Mechanism of Maternal Iron De

Relationship Between Molecular Mechanism Of Maternal
Iron Deficiency And Central Nervous System Function Of
Neonatal
Yusrawati MD, Dr, Sp.OG, Defrin MD, Sp.OG, Karmia fIR MD, Sp.OG

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecologt Faculty
of iu[ed icine, Andalas Univers ity, P adang, Indones ia

Abstract Matemal iron deficiency in pregnancy, labor, and postpartum will provide
indirect effect which decrease neonatal growth, neonatal neurotrophine, ferritin, and
zinc. This study was conducted to determine the relationship between molecular
mechanism of maternal iron deficiency and central nervous system function of neonatal.
This is an observational study with cross sectional design to 80 at term pregnant women
in Yarsi and BMC Hospital in Padang that examined in August-November 2016. The
haemoglobin concentration, leukocytes, and ferritin will be taken from maternal blood.
After giving birth, neonatal ferritin, neonatal neurotrophine, and neonatal zinc will be
taken from umbilical cord of neonatal by using ELISA method. Statistical analysis was
conducted by using independent-t test. The maternal ferritin level then divided into two
groups, maternal ferritin 15 pglL. The results showed
that neonatal ferritin was lower in subjects with matemal fenitin lip/L (58.59 + 2.33 vs 134.68 + 7.44 yglL, P0.05). Study by Dalal et al in 2009 also found that
mean value of head cicumference were lower in the anemic group mother than head

circumference in non-anemic group mother (31.08 vs 32.27 cm).8