Catharanthus roseus Leaf Extract Accelerates Healing of Wound Wistar Rat.
rndonezta'Jaurn qJ af tsioned:cal Scaue,
Publication Information
lndonesian Joumal of Biomedical Sciences (IJBS) is an intemational .joumal published twice per y€ar in
print and onlinc by lndonesian of Biomedical Association Alumtae ill collaboration to }ostgmduate School
ot' Biomedicine Udayana Univenily, Bali-lndonesia, locat'ed at Postgraduaie School Udayana University, Jl
P.B. So€dirman, f)enpasar Bali Indonesia.
Editor in Chief
Prof. Dr. dr. I N Adipura, M.OH., Faculty ofMedicine Udayana University, Bali-Indonesia.
Vice Editor
Prof. Dr. h. I. B. Putra Manuaba, M.Phil., Postgaduatc School ofBiomedicine Udayana University Bali
Indoncsia.
Edilorial Board \{ember\:
Prol Dr. dr. i Made Bakta, Sp.PD(KEOM) (Bali-Indonesia); Prof. Dr. C. Bauer (Visiting Professor Udayana
UniveNitl,; Giessen Germany); Prcf. Dr. David J Young CNational Universitl' Brunai Darussalam, Brunai);
Prof Dr- A. Moritz (Giesen Gemany); Prof. Dr. R. Edward Tiekink (Malaya Unive6ity, Malaysia); Prol
Dr. dr. Pdhatini, Sp.PK(K) (Surabaya-Indonesia); Prol Dr. dr. A. A. Raka Sudewi, Sp.S(K) (BaliIndonesia); Prof. Dr. Made Budiarsa,
MA (Bali-Indonesia); Prol Dr. &. I Ketut Suastika, Sp.PD(KE) (Bali-
lndonesia); Prcf'. Soo Khee Chee (Singaporc); Prcf. Harald Hoekstra (Netherland); Prof. Shukla (India); Dr.
Junichi Mizuno, Ph.D (Japan); Prof. Ketut Suwiyoga, SpOG (Bali Indonesia); Prof Andi Asadul Islam
(Makasar Indonesia); Prof Dr. dr. Abdul Hafid Bajanml, Sp.BS (Surabaya-Tndonesia)i Prof. I Ketur Siki
Kawiyana SpBO (Bali-lndonesia); Dr. dr. Arlati, MS.,Sp.PK(K) (Suabaya-Indonesia); Prol Dr. Ir. Odi
Pinontoan, M.Si (Manado-Indonesia); Dr. dr. F.
W. Wagey,Sp.OC(K) (Manado-Indonesia); Prcf. drh. I N
Mantik Astawa, PhD (Ba1i-Indonesia); Prof. Dr. drh. I Made Damriyasa, M.Si (Ba1i-lndonesia); Prol Dr. dr.
Soemamo, Sp.MK(K.) (Malang-Indonesia); Prol Dr. fu. I Putu Astawa, M.Kes-,FlC (Ba1i-Indonesia); Prof.
drh. I Gusti Ngurah Kd Mahardika, PhD (Ba1i-lndonesia); Prof Dr. dr. cede Raka Widiana, Sp.PD(KGH)
(Bali Indonesia). Prol Ir. I Putu Wirawan, M.Sc., PhD (Bali-Tndonesia); Prof. Dr. dr. Wimpie Pangkahila,
Sp.And (Bali-IndoDesia); Prol K. Tuti Parwati Memti, Sp.PD-KPTI (Bali-Indonesia).
Manuscdpts ard correspondelce arc invited for pub]ication. You can submit your' papers via Wcb
submission, or E rnail to putramanuabtS@yahoo.com. Submission guidelines and Web Submission system
are availablg at http://ojs.unud.ac.id
Editorial OIfice
Postgraduate School Udayana University, BaliTndonesia
Mobile: 0823147?7050
E mail: putramnnuaba28(lyahoo.com
TN,DONSSTAN
JOURNAL OT
tsIOMEDICAL SCIEN CES ( W S)
Volume 7 Number
1
January-June 2013
CONTENTS
1. HEADACHE. A SINONASAL SYMPTOM AND MORE.''
A RFVIFW
L'6
ARTICLE..,,,..
Kout, A., and Singh, A.
2. INTERLEUKIN 1P, INTERLEUKIN-6, AND ANTAGONIST INTERLEUKIN 1
RECEPTOR AS MEMORY IMPAIRMENT RISK FACTOR 1N COMPLEX
PARTIAL
F
710
PI1EPsY........
Purwa-sdmotru, D, P. G., sudewa-Dielantilt A. A. G., dnd suostika, K
3. A NOVEL APPROACH OF VLROTHERAPY BASED HSF-1 shRNA
L1 22
rN cANCER rRADICAllON..................................
Supddmonobo, t G, P., and Wibowd'Mdnuobd,l B. T'
4, ORAL ADMINISTRATION OF PEPPERMINT IN WISTAR ALBINO RATSI
Memory Boosting and Regaining ....... . .... -.
Jdsiro, M., sdi-sdilesh, K., ond Mukkdddn, J, K.
5, THE RISK OF SQUAMOUS CELL CARCINOMA ON HUMAN
PAPILLOMAVIRUS TYPE 16 INFECTION IN BALI"
Mdhendtd'Dewi I G. A. s, dnd suwiyoga,
23-26
""
I K.
6. COMBlNATION OF TEMPEH AND CARROT PREVENT ATHEROSCLEROSIS
WISTAR RAT: lndicated by lncrease of HDL and Total Antioxidant,
Decrease LDL, F2_lsoprostan, and
27'29
lL-6..-. ..
30'36
Ati-Agung,l G. A-, Suryadhi, N. T.,3Mdntik, N. A., suteL I K', and
Portdmo,l. B, G.
7. CANTHARANTHUS ROSEUS LEAF EXTRACT ACCELERATES HEALING OF
WOUND WISTAR RAT.,,,.....
Anom-Dadd, t K., Beruta, I K., Putto-Monudbs, l. 8.,
and Dom ydsa,l M.
1
I
31 40
I^dnAeti.aa+^io1ut"t.)' 4tsi2fl2.d.LlzLsa:etu)et
ldw
7
,
N t1h17,2.r,
1,
Js uata'Jui@ 2073: 37'+c
t ISSN : 2 3O2 -2906.
Pri,af'ISSAli 2085 47 7 3,
CANTILA.RA.NTHUS ROSEUS LEAT' EXTRACT ACCELERA.TES IIEALING
OF WOIJND WISTAR RAT
'Anom-Dddd,l K.,tBeruto, t K.,2Putrd-Monudbo, I. 8., ondlDamtiosa,I M.
Focutty ol veterindry Medicine, Udayana lJniversity
'Faculty ol Mathemothic and Natural Science lJdoyano University
1
ABSTRACT
Conthonntus roseus (C. roseus) is a medical plantth.t has been used to treat various diseases. This
study was carried to deiermine C rosels leaf extract able to acclerate wound healing in wGtar rat. FuLl
skin tickness round wounds were created on the back of the rats. Wound healing was evaluated after
treated with 15% of a mixture of leaf extraci of C roseus and vaseline. The rats were divided into two
groups? each group consist of 16 rats. Wound healing was assesed in five and fifteen days after treatment
by measuring wound area, wound closure, and counting the new capillary vessel number (angiogenesis)
The result of the study indicated that extract of C roseus leaf accelerates the wound healing in wistar rat
Coverage rate of wound is faster on treated group than control group (p
Publication Information
lndonesian Joumal of Biomedical Sciences (IJBS) is an intemational .joumal published twice per y€ar in
print and onlinc by lndonesian of Biomedical Association Alumtae ill collaboration to }ostgmduate School
ot' Biomedicine Udayana Univenily, Bali-lndonesia, locat'ed at Postgraduaie School Udayana University, Jl
P.B. So€dirman, f)enpasar Bali Indonesia.
Editor in Chief
Prof. Dr. dr. I N Adipura, M.OH., Faculty ofMedicine Udayana University, Bali-Indonesia.
Vice Editor
Prof. Dr. h. I. B. Putra Manuaba, M.Phil., Postgaduatc School ofBiomedicine Udayana University Bali
Indoncsia.
Edilorial Board \{ember\:
Prol Dr. dr. i Made Bakta, Sp.PD(KEOM) (Bali-Indonesia); Prof. Dr. C. Bauer (Visiting Professor Udayana
UniveNitl,; Giessen Germany); Prcf. Dr. David J Young CNational Universitl' Brunai Darussalam, Brunai);
Prof Dr- A. Moritz (Giesen Gemany); Prof. Dr. R. Edward Tiekink (Malaya Unive6ity, Malaysia); Prol
Dr. dr. Pdhatini, Sp.PK(K) (Surabaya-Indonesia); Prol Dr. dr. A. A. Raka Sudewi, Sp.S(K) (BaliIndonesia); Prof. Dr. Made Budiarsa,
MA (Bali-Indonesia); Prol Dr. &. I Ketut Suastika, Sp.PD(KE) (Bali-
lndonesia); Prcf'. Soo Khee Chee (Singaporc); Prcf. Harald Hoekstra (Netherland); Prof. Shukla (India); Dr.
Junichi Mizuno, Ph.D (Japan); Prof. Ketut Suwiyoga, SpOG (Bali Indonesia); Prof Andi Asadul Islam
(Makasar Indonesia); Prof Dr. dr. Abdul Hafid Bajanml, Sp.BS (Surabaya-Tndonesia)i Prof. I Ketur Siki
Kawiyana SpBO (Bali-lndonesia); Dr. dr. Arlati, MS.,Sp.PK(K) (Suabaya-Indonesia); Prol Dr. Ir. Odi
Pinontoan, M.Si (Manado-Indonesia); Dr. dr. F.
W. Wagey,Sp.OC(K) (Manado-Indonesia); Prcf. drh. I N
Mantik Astawa, PhD (Ba1i-Indonesia); Prof. Dr. drh. I Made Damriyasa, M.Si (Ba1i-lndonesia); Prol Dr. dr.
Soemamo, Sp.MK(K.) (Malang-Indonesia); Prol Dr. fu. I Putu Astawa, M.Kes-,FlC (Ba1i-Indonesia); Prof.
drh. I Gusti Ngurah Kd Mahardika, PhD (Ba1i-lndonesia); Prof Dr. dr. cede Raka Widiana, Sp.PD(KGH)
(Bali Indonesia). Prol Ir. I Putu Wirawan, M.Sc., PhD (Bali-Tndonesia); Prof. Dr. dr. Wimpie Pangkahila,
Sp.And (Bali-IndoDesia); Prol K. Tuti Parwati Memti, Sp.PD-KPTI (Bali-Indonesia).
Manuscdpts ard correspondelce arc invited for pub]ication. You can submit your' papers via Wcb
submission, or E rnail to putramanuabtS@yahoo.com. Submission guidelines and Web Submission system
are availablg at http://ojs.unud.ac.id
Editorial OIfice
Postgraduate School Udayana University, BaliTndonesia
Mobile: 0823147?7050
E mail: putramnnuaba28(lyahoo.com
TN,DONSSTAN
JOURNAL OT
tsIOMEDICAL SCIEN CES ( W S)
Volume 7 Number
1
January-June 2013
CONTENTS
1. HEADACHE. A SINONASAL SYMPTOM AND MORE.''
A RFVIFW
L'6
ARTICLE..,,,..
Kout, A., and Singh, A.
2. INTERLEUKIN 1P, INTERLEUKIN-6, AND ANTAGONIST INTERLEUKIN 1
RECEPTOR AS MEMORY IMPAIRMENT RISK FACTOR 1N COMPLEX
PARTIAL
F
710
PI1EPsY........
Purwa-sdmotru, D, P. G., sudewa-Dielantilt A. A. G., dnd suostika, K
3. A NOVEL APPROACH OF VLROTHERAPY BASED HSF-1 shRNA
L1 22
rN cANCER rRADICAllON..................................
Supddmonobo, t G, P., and Wibowd'Mdnuobd,l B. T'
4, ORAL ADMINISTRATION OF PEPPERMINT IN WISTAR ALBINO RATSI
Memory Boosting and Regaining ....... . .... -.
Jdsiro, M., sdi-sdilesh, K., ond Mukkdddn, J, K.
5, THE RISK OF SQUAMOUS CELL CARCINOMA ON HUMAN
PAPILLOMAVIRUS TYPE 16 INFECTION IN BALI"
Mdhendtd'Dewi I G. A. s, dnd suwiyoga,
23-26
""
I K.
6. COMBlNATION OF TEMPEH AND CARROT PREVENT ATHEROSCLEROSIS
WISTAR RAT: lndicated by lncrease of HDL and Total Antioxidant,
Decrease LDL, F2_lsoprostan, and
27'29
lL-6..-. ..
30'36
Ati-Agung,l G. A-, Suryadhi, N. T.,3Mdntik, N. A., suteL I K', and
Portdmo,l. B, G.
7. CANTHARANTHUS ROSEUS LEAF EXTRACT ACCELERATES HEALING OF
WOUND WISTAR RAT.,,,.....
Anom-Dadd, t K., Beruta, I K., Putto-Monudbs, l. 8.,
and Dom ydsa,l M.
1
I
31 40
I^dnAeti.aa+^io1ut"t.)' 4tsi2fl2.d.LlzLsa:etu)et
ldw
7
,
N t1h17,2.r,
1,
Js uata'Jui@ 2073: 37'+c
t ISSN : 2 3O2 -2906.
Pri,af'ISSAli 2085 47 7 3,
CANTILA.RA.NTHUS ROSEUS LEAT' EXTRACT ACCELERA.TES IIEALING
OF WOIJND WISTAR RAT
'Anom-Dddd,l K.,tBeruto, t K.,2Putrd-Monudbo, I. 8., ondlDamtiosa,I M.
Focutty ol veterindry Medicine, Udayana lJniversity
'Faculty ol Mathemothic and Natural Science lJdoyano University
1
ABSTRACT
Conthonntus roseus (C. roseus) is a medical plantth.t has been used to treat various diseases. This
study was carried to deiermine C rosels leaf extract able to acclerate wound healing in wGtar rat. FuLl
skin tickness round wounds were created on the back of the rats. Wound healing was evaluated after
treated with 15% of a mixture of leaf extraci of C roseus and vaseline. The rats were divided into two
groups? each group consist of 16 rats. Wound healing was assesed in five and fifteen days after treatment
by measuring wound area, wound closure, and counting the new capillary vessel number (angiogenesis)
The result of the study indicated that extract of C roseus leaf accelerates the wound healing in wistar rat
Coverage rate of wound is faster on treated group than control group (p