Quality Assurance Division of Glaxo Smith Kline, Jakarta, Indonesia

CURRICULUM VITAE PERSONAL INFORMATION

  Name Aditya Fitriasari, M.Sc., Pharmacist Home address Kweni Rt 03 No 172, Panggung Harjo, Sewon, Bantul, Yogyakarta 55188,

  Indonesia Telephone +62 274 372787 Mobile: +62 81808665141

  E-mail adityafitriasari@yahoo.com Nationality Indonesian

  Date of birth

  20 November 1984 Gender Female

  Marital status Married

WORK EXPERIENCES

  Dates July 2010 – May 2011 Occupation or position held Research assistant

  Main activities and Working in a research project : Identification of Anti-Hepatitis C Virus (HCV) responsibilities Substances and Development of HCV and Dengue Vaccine Name and address of JICA Project, University of Indonesia, Faculty of Medicine, IASTH Building,

  th

  employer

7 Floor, Jl Salemba Raya No 4, Jakarta Pusat 10430

  Dates January – July 2010 Occupation or position held Lecturer

  Main activities and Preparing material (module) for Moleculer Biology teaching and tutorials responsibilities Name and address of Pharmacy Division, Faculty of Medicine, Yogyakarta Muhammadiyah employer University, Yogyakarta, Indonesia

  Dates September 2008 – December 2009 Occupation or position held Lecturer assistant in Molecular Biology

  Main activities and Moleculer Biology teacher in the practical work responsibilities Name and address of Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia employer

  Dates August 2008 - December 2009 Occupation or position held Research staff

  Main activities and Working in a research team carrying out cancer chemoprevention researches responsibilities Name and address of Cancer Chemoprevention Research Center, Faculty of Pharmacy, Gadjah employer Mada University, Yogyakarta, Indonesia

  Dates March – April 2008 Occupation or position held Apprentice student

  Main activities and Performance Qualification and Gap Analysis responsibilities Name and address of Quality Assurance Division of Glaxo Smith Kline, Jakarta, Indonesia employer

  Dates September 2004 - July 2006 Occupation or position held Practical work assistant

  Main activities and Assisting the students at practical work of Basic Chemical Pharmacy, Organic responsibilities Chemistry, Microbiology Pharmacy, and Technology and Formulation of Solid Dosage Forms

  Name and address of Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia employer

EDUCATION AND TRAINING

  Dates September 2008 - January 2010 Title of qualification awarded Magister of Science in Pharmacy

  GPA : 3.90 (Max 4.00) Principal Drug Discovery and Development subjects/occupational skills Thesis Title : “Induction of Apoptosis and Cell Cycle Modulation by Naringenin to covered Increase The Cytotoxic Activity of Doxorubicin on MCF-7 Breast Cancer Cell Lines”

  Name and type of Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia organisation providing education and training

  Dates September 2007 – July 2008 Title of qualification awarded Pharmacist

  GPA : 3.86 (Max 4.00) Principal Pharmacy Science and Industry subjects/occupational skills covered

  Name and type of organisation Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia providing education and training

  Dates September 2003 - August 2007 Title of qualification awarded Bachelor of Pharmacy

  GPA : 3.86 (Max 4.00) Principal Pharmacy Science and Industry subjects/occupational skills Thesis Title : “Proliferative Effect of Ethanolic Extract of Long Bean on Breast Cell” covered

  Name and type of Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia organisation providing education and training

  Dates 11-12 September 2006 Title of qualification awarded Presenting Author

  Principal The International Symposium on Recent Progress in Curcumin Research subjects/occupational skills Presentation title : “The Potency Study of Curcumin and Its Analogues as covered Selective Estrogen Receptor Modulators (SERMs): Docking to Estrogen

  Receptors β”

  Name and type of Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia organisation providing education and training

  Dates

  3 September 2007 Title of qualification awarded Participant

  Principal National Seminar : Diversifikasi Program Studi atau Peminatan dalam Pendidikan subjects/occupational skills Tinggi Farmasi covered

  Name and type of Asosiasi Pendidikan Tinggi Farmasi Indonesia (APTFI) organisation providing education and training

  Dates 11-12 August 2008 Title of qualification awarded Presenting Author

  Principal Scientific Congress XVI of Association of Indonesian Pharmacist (IAI) subjects/occupational skills Presentation title : “Proliferative Effect of Ethanolic Extract of Long Bean on T47D covered Cell”

  Name and type of Association of Indonesian Pharmacist (IAI), Yogyakarta, Indonesia organisation providing education and training

  Dates 24-25 November 2008 Title of qualification awarded Presenting Author

  Principal International Joint Symposium Frontier In Biomedical Sciences : From Genes to subjects/occupational skills Applications covered Presentation title : “Modulation of Cell Cycle and Apoptotic Induction by

  Pentagamavunon-0 and Doxorubicin Combination Toward MCF-7 Breast Cancer Cell”

  Name and type of Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia organisation providing education and training

  Dates 16-17 July 2009 Title of qualification awarded Committee and Co-trainer

  Principal Workshop Molecular Biology on Cancer : Western Blot subjects/occupational skills covered

  Name and type of Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia organisation providing education and training

  Dates 11-12 August 2009 Title of qualification awarded Presenting Author Principal Symposium of Natural Drugs Research (PERHIPBA) XIV subjects/occupational skills Presentation title : “The Increase Cytotoxic Activity of Doxorubicin by Citrus covered Flavonoid, Tangeretin on Breast Cancer Cells MCF-7”

  Name and type of Badan Pengkajian dan Penerapan Teknologi, Jakarta, Indonesia organisation providing education and training

  Dates 18-20 August 2009 Title of qualification awarded Finalist

  Principal Ristek-Novartis Indonesia Biotechnology Leadership Camp subjects/occupational skills covered

  Name and type of Novartis Indonesia and Ministry of Research and Technology, Jakarta, organisation providing Indonesia education and training

  Dates 5-6 October 2009 Title of qualification awarded Presenting Author

  Principal The International Conference on Pharmacy and Advanced Pharmaceutical subjects/occupational skills Sciences covered Presentation title : “Induction of Apoptosis and Cell Cycle Arrest by Naringenin to

  Increase The Cytotoxic Activity of Doxorubicin on Breast Cancer Cell Lines” Name and type of Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia organisation providing education and training

  Dates 28-29 September 2010 Title of qualification awarded Participant

  Principal International Seminar on Viral Diseases : Control and Management 2010 subjects/occupational skills covered

  Name and type of Faculty of Medicine, University of Indonesia organisation providing Graduate School of Medicine, Kobe University education and training

  Dates 26-30 July 2010 Title of qualification awarded Trainee

  Principal Biosafety Training subjects/occupational skills - Recognizing and Assesing Biological Hazard in The Laboratory covered - Biosafety Practices, Equipment, and Facility Safeguard

• Emergency Responses and Transport of Infectious Substances - Animal Biosafety Name and type of

  Institute of Human Virology and Cancer Biology, Faculty of Medicine,

  organisation providing

  University of Indonesia

  education and training Dates

  30 March 2011

• DNA Sequencing Data Analysis - Best Practice in Sample Preparation Name and type of organisation providing education and training

  Other language

  During my working experinces as a research assistant in Cancer Chemoprevention Research Center, I’ve conducted a lot of cancer researches in developing a chemopreventive agent from natural compounds. These researches including in silico and in vitro research. In silico researches including molecular docking of natural compounds to receptor using HyperChem and ArgusLab programs, and also DNA, RNA, and protein analysis using BLAST program. In vitro researches including cell culture techniques, cytotoxicity assay of plant extracts, and their combination with chemotherapy agent (co-chemotherapy) in several cancer cell lines, especially breast cancer cell lines (MCF-7 and T47D) using MTT method. In CCRC, I’ve also investigated the antiproliferative and apoptotic effect of plant extracts and natural compounds using double staining method, protein analyisis by immunocyotchemistry and Western Blotting, and cell cycle analysis using flowcytometry assay.

  ƒ Good knowledge of Microsoft Word, Excel, and Powerpoint. ƒ Good knowledge of Graphic Design Program (CorelDraw, Adobe Photoshop) ƒ Excellent ability in navigation through the Internet.

  COMPUTER SKILLS AND COMPETENCES ƒ Good knowledge of Microsoft Windows and Machintosh.

  During my job at the Cancer Chemoprevention Research Center, Faculty of Pharmacy, Gadjah Mada University and JICA Project, I used to coordinate team of researcher and students thus developing a good experience in the administration of people.

  Kline Indonesia motivate me to learn fast and quickly adapt to new environment, which is very different with academic situation that I used to be experienced before. ƒ Since I was a student, I am highly motivated to be the best, which is proved from my GPA that are above the average level.

  ƒ Excellent ability of communication and teamwork especially developed during my job at the Cancer Chemoprevention Research Center, Faculty of Pharmacy, Gadjah Mada University and JICA Project where I often worked with other people. ƒ Became an apprentice student at Quality Assurance Division of Glaxo Smith

  English

  INDONESIAN

  Mother tongue

  1 st BASE and PT. Genetika Science PERSONAL SKILLS AND COMPETENCES

  BASE DNA Sequencing Data Analysis Seminar

  st

  1

  Title of qualification awarded Participant Principal subjects/occupational skills covered

• Writing Skills Excellent • Reading Skills Excellent • Verbal Skills Excellent

SOCIAL SKILLS AND COMPETENCES

ORGANISATIONAL SKILLS AND COMPETENCES

RESEARCH SKILLS AND COMPETENCES

  While during my working experinces as a research assistant in JICA project on Identification of Anti-Hepatitis C Virus (HCV) Substances and Development of HCV and Dengue Vaccine, my research skills has been improved rapidly. I’ve conducted anti-HCV activity of plant extracts by virus titration experiment and immunostaining method. In this project, I propagated HCV virus in hepatocarcinoma cells (Huh7 it-1). I also cloned virus gene into bacteria, purified DNA/plasmid, transcripted DNA into RNA (RNA in vitro transcription), and transfected RNA into mammalian cells. I amplified virus gene with PCR method and did sequence DNA analysis to know that I’ve already get the correct DNA sequences.

  

DRIVING LICENCE I am a holder of an Indonesian drivers licence. Category A and C vehicle.

ADDITIONAL INFORMATION RESEARCH EXPERIENCES

  ƒ Proliferative Effect of Ethanolic Extract of Long Bean on Breast Cell (2006) ƒ The Potency Study of Curcumin and Its Analogues as Selective Estrogen

  Receptor Modulators (SERMs): Docking to Estrogen Receptors β (2006)

  ƒ Ethanolic Extract and Ethyl Acetate Fraction Effect of Long Bean (Vigna

  cylindrica (L.) Skeels) on The Increase of Estrogen Receptor Expression in

  Breast Epithelial Cell (2007) ƒ The Use of Local Mandarin Orange (Citrus reticulata) Peel Extracts to Increase

  Sensitization of Breast Cancer Cells MCF-7 against Chemotherapeutic Agent Doxorubicin (2007)

  ƒ Modulation of Cell Cycle and Apoptotic Induction by Pentagamavunon-0 and Doxorubicin Combination Toward MCF-7 Breast Cancer Cell (2008)

  ƒ The Increase of Doxorubicin Cytotoxic Activity by Citrus Flavonoid, Tangeretin on Breast Cancer Cells MCF-7 (2009) ƒ Tangeretin Increase Doxorubicin Cytotoxic Activity on Breast Cancer Cells

  T47D (2009) ƒ Cytotoxic Effect of Awar-Awar (Ficus Septica Burm F.) Leaves Ethanolic

  Extract on Colon Cancer WiDr and Servix Cancer HeLa (2009) ƒ Induction of Apoptosis and Cell Cycle Arrest by Naringenin to Increase The

  Cytotoxic Activity of Doxorubicin on Breast Cancer Cell Lines (2009) ƒ Hesperidin Increase Cytotoxic Effect of Doxorubicin in MCF-7 and T47D Cells

  (2009) ƒ The Improvement of Doxorubicin Activity by Etanolic Extract of Citrus

  Aurantifolia Peel on MCF-7 Breast Cancer Cell through the Induction of Cell

  Cycle Arrest and Apoptosis (2009) ƒ Combination of Awar-Awar (Ficus Septica Burm F.) Leaves Ethanolic Extract and Doxorubicin Gives Synergistic Effect In T47D Cells (2009) ƒ Identification of Anti-Hepatitis C Virus (HCV) Substances and Development of

  HCV and Dengue Vaccine (2010-2011)

  PUBLICATIONS

  ƒ Fitriasari A, Wijayanti NK, Fitriyah NQ, Dewi IP, Mayasari MP, and Meiyanto

  E, Proliferative Effect of Ethanolic Extract of Long Bean on T47 D Cell, PHARMACON, Vol. 8, No. 2, Desember 2007, 44-50. ƒ Yunas SR, Latifah N, Rokhman MR, Fitriasari A, Putri DA, and Meiyanto E,

  Ethanolic Extract of Mandarin Orange (Citrus Reticutata) Peels to Incerase The Sensitivity of MCF-7 Breast Cancer Cell to Doxorubicin, PHARMACON, Vol. 8, No. 2, Desember 2007, 64-69.

  ƒ Fitriasari A, Wijayanti NK, Ismiyati N, Dewi D, Kundarto W, Sudarmanto A, and Meiyanto E, Selective Estrogen Receptor Modulators (SERMs) Potency of Curcumin and Its Analogues : Docking to Estrogen

  β Receptors, PHARMACON, Vol. 9, No. 1, June 2008, 27-32. ƒ Fitriasari A, Susidarti RA, and Meiyanto E, Peningkatan Efek Sitotoksik

  Doxorubicin oleh Naringenin Melalui Pemacuan Apoptosis Sel Kanker Payudara MCF-7, Jurnal Bahan Alam Indonesia, Vol. 7, No. 3, 2010, 165-170. ƒ Pratama RH, Ikhtiarsyah YG, Anindyajati, Fitriasari A, Ikawati M, dan

  Meiyanto E, Ekstrak Etanolik Daun Awar-Awar (Ficus septica Burm F.) secara Sinergis Meningkatkan Efektivitas Doxorubicin terhadap Sel Kanker Payudara T47D, Jurnal Ilmu Kefarmasian Indonesia, Vol. 9, No. 1, April 2011, 67-71.

  ƒ Meiyanto E, Hermawan A, Junedi S, Fitriasari A, and Susidarti RA, Nobiletin Increased Cytotoxic Activity of Doxorubicin on MCF-7 Cells But Not on T47D Cells, International Journal of Phytomedicine, Vol. 3, No. 1, 2011, 129-137.

  ƒ Meiyanto E, Fitriasari A, Hermawan A, Junedi S, and Susidarti RA, The Improvement of Doxorubicin Activity on Breast Cancer Cell Lines by Tangeretin through Cell Cycle Modulation, Oriental Pharmacy and Experimental Medicine, Vol. 11, published online 5 July 2011.

  REFERENCES

  ƒ Prof. Edy Meiyanto, PhD, Pharmacist, Head of Cancer Chemoprevention Research Center, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia. Address : Sekip Utara, Yogyakarta. E-mail : meiyan_e@ugm.ac.id .

  Tel (+62) 8122735092. ƒ Dr. Ratna Asmah Susidarti, Pharmacist, Head of Chemical Pharmacy

  Department, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia. Address : Sekip Utara, Yogyakarta. E-mail : susidarti@yahooo.com Tel (+62) 81328770163.

  I hereby agree to the handling of my personal data.

  Aditya Fitriasari