fullpaper effect of ethanolic extract of morinda

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*Faculty of Medicine, University of Sumatera Utara, ** Faculty of Pharmacy
University of Sumatera Utara, ***Faculty of Mathematic and Natural Science,
University of Sumatera Utara, ****Polytechnic of Health, Ministry of Health, Indonesia

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Hyperlipidemic state requires pharmacologic therapy, the materials of nature are
considered more secure. Noni (
, L.) has long used the community as
an alternative treatment of hyperlipidemia. Objective of the study was to determine the
effect of ethanolic extract of noni with and without hypercholesterol diet on lowering
lipid profiles.
Thirty male Wistar rats divided into 6 groups: P0 = negative control group, P1 =
positive control group, P2 = received hypercholesterol diet and ethanolic extract of noni
for 4 weeks, P3 = received hypercholesterol diet and ethanolic extract of noni for 8
weeks, P4 = received standard diet and extract ethanolic of noni for 4 weeks, P5 =
received standard diet and ethanol extract of noni fruit for 8 weeks.
Groups of P2 and P3 decrease significantly levels of triglycerides, but no
significantly different in lowering total cholesterol, LDL, the ratio LDL/HDL, and raise
HDL level, whereas P4 and P5 have no significantly differences in lowering total
cholesterol, triglycerides, LDL, the ratio of LDL/HDL, and increase HDL levels.
Ethanolic extract of noni with hypercholesterol diet for 4 weeks showed significant
differences in lowering total cholesterol, triglycerides, LDL, the ratio of LDL / HDL,
but no significant differences in raising HDL. Whilst for 8 weeks showed significant
differences in lowering levels of LDL and the ratio of LDL / HDL, but no significant
differences in lowering cholesterol total, triglyceride, and raise HDL.

ethanolic extract of noni decrease total cholesterol, triglycerides, LDL, the ratio of LDL
/ HDL and raise HDL level.

-

.) $ : hypercholesterol,

, L., LDL/HDL ratio, triglycerides

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Hyperlipidemic state requires pharmacologic therapy, the materials of nature are
considered more secure. Noni (
, L.) has long used the community as
an alternative treatment of hyperlipidemia. Objective of the study was to determine the
effect of ethanolic extract of noni with and without hypercholesterol diet on lowering
lipid profiles.
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Thirty male Wistar rats divided into 6 groups: P0 = negative control group, P1 =
positive control group, P2 = received hypercholesterol diet and ethanolic extract of noni
for 4 weeks, P3 = received hypercholesterol diet and ethanolic extract of noni for 8
weeks, P4 = received standard diet and extract ethanolic of noni for 4 weeks, P5 =
received standard diet and ethanol extract of noni fruit for 8 weeks.
30 male

rats age 12 weeks, weight 180>200 g

Fed by standard diet (for 1 week) ad libitum

randomize
Week

P0

P1

P2

Hari 1
Minggu 1

P3

P4

P5

Adrenalin injection 0,006 mg/IV

2
3
4
5
6
7
8
9
10

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Standard diet
hypercholesterol diet
hypercholesterol diet + 50 mg ethanolic extract of mengkudu fruit
Standard diet + 50 mg ethanolic extract of mengkudu fruit
Dislocation of neck

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Groups of P2 and P3 decrease significantly levels of triglycerides, but no significantly
different in lowering total cholesterol, LDL, the ratio LDL/HDL, and raise HDL level,
whereas P4 and P5 have no significantly differences in lowering total cholesterol,
triglycerides, LDL, the ratio of LDL/HDL, and increase HDL levels.
Ethanolic extract of noni with hypercholesterol diet for 4 weeks showed significant
differences in lowering total cholesterol, triglycerides, LDL, the ratio of LDL / HDL,
but no significant differences in raising HDL. Whilst for 8 weeks showed significant
differences in lowering levels of LDL and the ratio of LDL / HDL, but no significant
differences in lowering cholesterol total, triglyceride, and raise HDL.
ethanolic extract of noni decrease total cholesterol, triglycerides, LDL, the ratio of LDL
/ HDL and raise HDL level.

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P0

P1

P2

P3

P4

P5

Treatments
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2 Total cholesterol level of male wistar rat
No significantly different group (p>0,05) marked by the same abjad;
significantly different group (p< 0,05) marked by different abjad; ┬ =
standar deviation (SD)

P0 = negative control (induce by standard diet for 2 weeks)
P1 = positive control (induce by hypercholesterol diet for 2 weeks)
P2 = induce by hypercholesterol diet for 2 weeks + ethanolic extract of noni 50 mg for 4
weeks with hypercholesterol diet

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P3 = induce by hypercholesterol diet for 2 weeks + ethanolic extract of noni 50 mg for 8
weeks with hypercholesterol diet
P4 = induce by hypercholesterol diet for 2 weeks + ethanolic extract of noni 50 mg for 4
weeks with standard diet
P5 = induce by hypercholesterol diet for 2 weeks + ethanolic extract of noni 50 mg for 8
weeks with standard diet

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Based on the results, we concluded that ethanolic extract of noni decrease total
cholesterol, triglycerides, LDL, the ratio of LDL/ HDL and raise HDL level on male
wistar rat induced by hypercholesterol diet.
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4. Dripa Sjabana, Ramadhani Rusli B (2002). Mengkudu.

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! , 91>120.
6.

Younos, C., Rolland, A., Fluerentin, J., Lanchers, M., Misslin, R., and Mortier,
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,
56, 430>434.

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