The Role of p53 Protein Expression in Retinoblastoma Repository - UNAIR REPOSITORY
European Journal of Biomcdical
, and Pharmaceutical Sciences
ISSN 2349-8870
ICV - 6.96
.ln International Peer Fer,iew Journal for Plralna. Xledical .t Biolo$cal
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Editorial Board
Dr. Petkova V.,
(Ph D., fi4 Sc.Frharm. M.SC.P.H.)
BULGARIA
Associate Editor
Dr. Dimitrov M.
(PhD, MScPhann, MPH-HMP)
BULGARIA
Editorial Board Member
1. Dr Shazia Jamshed, Malaysia
2. Dr. Rasha Moustafa Youssef, Egypt
3. Dr. Khaled Nabih Rashed, Egypt
4. Dr. Maryam Ahmed, Pakistan
5. Dr, Jutti Levita, lndonesia
6, Associate Professor, Ravindra Reddy Yaramala, lndia
7. Dr. Saber Mohamed Abd-Allah, Egypt
8. Dr Nitesh Kumar, lndia
9. Dr. Vinod Singh, lndia
10. Dr. Fareedi Mukram Ali, lndia
11. Prof, Dr
PJ
Hisalkar, lndia
12. Dr. Abebe G, Demissie, Ethiopia
13. Dr. Subha Ganguly, lndia
t,
14, Dr. lmran Ahmad Khan, Pakistan
15. Prof. Dr. Prakash. M.M.S. Kinthada, lndia
16, Dr. Tej Pratap Mall, lndia
17. Dr, D. Nagasamy Venkatesh, lndia
18. Dr. Amit Kumar
Dixi! India
19. Dr. Ajit Singh, lndia
20. Dr. K.V. Madhusudhan, tndia
21. Dr, Anju Verma, USA
22. Dr. Supriya Sen, USA
23. Dr. Severo VAizquez Prieto, Spain
24, Dr, Ramakrishna D,S, lndia
25. Dr. N.S. Neki, lndia
26. Prof, Dr. Patricia Severino, Brazil
27, Dr. Rafik Karaman, lsrael
28. Dr, Roshan V. Tiwari, US
29. Prof, Dr. Osmar A, Centulion, paraguay
30. Dr. Heba Abdel Hady Abdel Raouf, Egypt
31. Dr. Ahmed Kadry lbrahim lbrahim Hassan, Egypt
32, Dr. Ravi Kumar Chittoria, lndia
33, Dr. Sara Ganaha M.D., USA
34. Dr. V. Harshini, lndia
35, Dr, P. Manivannan, lndia
35. Dr. Mayank Kakkar, USA
37. Dr, Mohammed Turki Khathi, lraq
38. Dr. Vasantha Mittapelli, tndia
39. Dr. Sandeep Kumar Kar, India
40, Dr. Patient D. Dhliwayo-Chiunzi, Zimbabwe
41. Dr. Nirmala Jaget Lakkawar, lndia
42. Dr. Raymond R. Tjandrawinata, lndonesia
1. Dr. E, Stanley Lee, Taiwan
2. Prof. Herida Regina Nunes Salgado, BRAZIL
3. Dr. Mohammed Rageeb Mohammed Usman, lndia
4. Dr. Pramod Singh Khatri, lndia
5. Dr. Kedar G. Mehta, lndia
6, Dr. Mohammad Safiqul lslam, Japan
7. Dr. Jagdish Kakadiya, India
8. Dr.(Mrs) Padmini H.Sharma, lndia
9, Asnake Gudisa Ede, Ethiopia
10. Dr, Zainab Mahmood Aljamali, lraq
11. Dr. Nagarajan Kayalvizhi, lndia
12. Dr. Subhabrata Ghosh, tndia
13. Dr. Mrs. Alpana. J, Asnani, lndia
14, Dr. Datta Asaram Dhale, tndia
15. Obeagu Emmanuel lfeanyi, Nigeria
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16. Dr. Balasubramanian Sathyamurthy, lndia
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17. Dr. Sidharth Mehan, tndia
18, Dr. C. Agnes Mariya Dorthy, tndia
19, Dr. Subhadeep Ganguly, lndia
20. Dr. Pawankumar Dnyandeo Tekale, lndia
2L. Dr, Manoj Kumar Goyal, lndia
22,Dr.C. Agnes Mariya Dorthy, lndia
23, Dr. Arumugam Manickam, lndia
24. Dr. Himadri Sekhar Samanta, lndia
25. Dr. Sumanta Dey, USA
25. Dr. Rajiv Saini, India
27, Dr, Shende Krushnadev Laxman, India
28, Dr. Avinash Warundeo Lakkawar, lndia
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29. Dr. Subrata Sabui, USA
30. Dr. T. Vijaya Bhaskara Reddy, India
31. Dr. Debjit Ray, USA
32. Dr. Suman Bala, lndia
33. Dr. Payala Vijayalakshmi, tndia
34. Dr. Shaik,Md.Zakir Hussain, tndia
35. Dr, Pradeep Kumar Soni, lndia
36. Dr. Gandla Kumara Swamy, lndia
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2015 Volume 3, July lssue
7
-------
THE RoLE oF p53 PR6TEIN
Exp,RESSION IN RETINOBTASTOMA
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Bensegueni Abderrahmane,
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TNDU.EDDTABETCRAT'
*Ajiboso
S. O,, yakubu T. M
and Oladiii A. T
THE EFFECT OF
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Amna o. M. Etzein and
Nassr Etdin M. A. shrifr
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co,rruru*J,,rir;;ilil,, o*, oF srApHyrococc* ou*i
RESEARCH OF
onir*u"*;r;;;ilil;
Khadija Akter Eva, Nasma
zerin, Md. shahidur ,.abir+
pRorErN rN
suDANEs
3T:iiT"_01*:":*y*"med,
octirti*r
,";il;ililjJiTJ"llT:*'lHkani,
Abobakr (hared A,ha&
zakaria Ahmed sae
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PROTECTIVE EFFECT OF FOSFOMYCIN ON DEO)ffNIVALENOL- TREATED CEtL CULTURES
Denisa soledad P6rez Gaudio*, Guadalupe Martinez, Maria Bel6n Fern6ndez paggi,, Maria Bel6n Ricc
io1, Julieta Maria Decundo, Susana Dieguez, Maria Ofelia Tapial, Alejandro Luis Soracil,
ACUTE AND CHRONIC ATOE BARBADENSIS MILTER GEI- MEDIATES ANTIULCEROGENIC AND GASTRIC
ANTI.SECRETORY EFFECTS VIA HISTAMINERGIC HZ RECEPTORS
lnyang M. and +Ofem O. E.
FASTING VS. NON FASTING TIPID PROFILE AMONG SUDANESE IN KHARTOUM STATE
l-ena Mohamed Ahmed Rizig+ and Dr. Tarig Mohamed Fadl-Elmola
NOVET SYNTHESIS OF SUBSTITUTED-1-{7-NITRO.IOH.PHENOTHtAZINE.3.YL)-3- (4.NITROPHENYt)
PROP.2-EN-1.ONE
Meghasham N. Narule*
EFFECTS
OF MANGROVE PTANT EXTRACTS AGAINST THE PINK MEATY BUG (MACONETTICOCCUS
HlRsurus GREEN) oN AMINo AclDs AND ENZYME AcTlvlTY lN sltKWoRM, BoMBYx MoRt
Samba Naik A.*, Srinivas Naik 8., B. Ravi Babu and M. Jagadish
Naik
L.
.
MONITORING AND REPORTED THE ADVERSE DRUG REACTIONS OF DIFFERENT DRUGS IN RURAT
GOVERNAMENT HOSPITAT IN NAI-GONDA SPONTANEOUS REPORTING METHOD
N. shiva Krishna*, K. Nava Jyothi, H. Ramana, M. Rajeshwarit, B. Rajini, y. Ashwini, K. Lakshmi surek
ha, G. Venkateshwarlu and B. Shankar, M. Sai
A RESEARCH STUDY OF CHOLECYSTECTOMIES AND REASONS OF CONVERSION OF I.APAROSCOPIC TO
OPEN CHOIECYSTECTOMIES IN A TERTIARY CARE HOSPITAL
Dr. P. vinay+, Dr. K. Gowtham Reddy, Dr. T. Mahendra, Dr, p. Gowtham Reddy and M. venkata subb
aiah
I
I
I
I
ANTI ACNE SPOT CREAM tN CONTROIUNG FACTAL ACNE : A PROSPECTIVE OPEN LABEL
MUTTICENTER SAFEW AND EFFICACY TRIAL.
Dr. Muhammed Majeed, Dr. Raru M. Rhee and prachi S. Lad*
APPRAISAT OF DIRECT COST OF TREATING EPILEPSY PER MONTH IN GUNTUR, ANDHRA PMDESH.
K.
Siporat, D. Vidhyadhari, Tabrik Fathima, R. Venkateswara Rao and Nadendla Rama Rao
ENANTIOMERIC SEPAMTION AND QUANTITATIVE DETERMINATION OF RITONAVIR ENANTIOMER IN
RITONAVIR DRUG SUBSTANCE BY CHIRAL TIQUID CHROMATOGRAPHY
M, Subbarao+, M. Ramakrishna, D. Mogilireddy, M. yanadhirao and y. pavani
EVATUATION OF SERUM CREATININE, EGFR AND INSUI-IN.LIKE GROWTH FACTOR 1 IN HYPOIHYROID
SUBJECTS EEFORE AND AFTER t-THYROXINE REPTACEMENT
Trinanian Sanyal, Sujoy chosh and Subhankar Chowdhury
A SURVEY ON RETEVANT EDGE DETECTION TECHNIQUE FOR MEDICAT IMAGE PROCESSING
Ranita Banerjee, Dr. lndra Kanta Maitra and *prof. Samir Kumar Bandyopadhyay
GENETIC DIVERSITY ANATYSIS OF SELAGINETTA BRYOPTERIS (1.)BAK. GENOTYPES IN TETANGANA,
INDIA.
*P, Rupa and N. lakshmibhavani
FORMUTATION, OEVETOPMENT AND EVATUATION OF FTOATING DRUG DETIVERY SYSTEM OF
CEFPODOXIME PROXETIL
Manish Kumar Bhatt, Bhupendra Nath Dwivedy and Viney Chawla*
SYNTHESI' SPECTRAL PROPERTIES DNA STUDIES OF TANTHANIDE (ItI} COMPTEXES OF 2ACETYLPYRIDINE BENZOYTHYDRAZONE
Karreddula Raja, Akkili Suseelamma and (atreddi Hussain Reddy*
SYNTHESII CHARACTERIZATION, DNA BINDING AND NUCtEASE AcTlvlTY OF tRoN(tt) coMptExES
OF ISONICOTINOYL HYDRAZONES
A. Suseelammai, K. Raja and K. Hussain Reddy
PROTECTIVE ROLE OF RUTIN ON PACTITAXEL-INDUCED I.IPID PEROXIDATIO
Supratim Rayt
CTINICAL STUDY ON PANDU ROGA WITH SPECIAL REFERENCE TO IRON DEFICIENCY ANEMTA AND ITS
MANAGEMENT WITH LOHBHASM AND BALACHITRAK MOOI
Dr. D. G. Dipankar*, Dr. Mamta Nakade, Dr. Jibi varghese, Dr. Hridaynath Lad, Dr. Rajesh Tayade, Dr.
Shilpa Jungare
PHARMACEUTICAT EVALUATION OF MUSTA-TRIPHATADI AVAI.EHA, AN AYURVEDIC POLYHERBAT
FORMUTATION
O,T.M.R.K,S.B, Kalawana*, patel K.S., Rajagopala S., Kori V.K. and Shukla V.J.
A STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT FOR ANATYSIS OF ERTAPENEM IN BULK
DRU6 AND PHARMACEUTICAT DOSAGE FORM
Nilesh Jain, Ruchi Jain, Deepak Kumar Jain*, Avineesh singh, vijay Kumar patel and surendra Kumar
Jain
COMPARISON OF OPHTHALMOTOGICAT
COMPLICATIONS OF ANTIVIRAT DRUGS FOR HCV INFECTION
Prempal Kaur*, Baljinderpal Singh and Bhavkaran Singh Bal
COMPARISON OF VISUAT OUTCOME AND COMPTICATIONS IN TWO DIFFERENT TECHNIQUES OF
SCTERAL FIXATED INTRAOCUTAR tENS IMPTANTATION
Dr Mohana Majumdar*
I
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I
VENOUS GTUCOSE ESTIMATION. THE UNTOTD STORY''
Dr. Arun Kumar Harith (MD Biochemlstrylt, Garima Boradia (M.sc Biochemistry), varun Kumar singh
(lll year MBBS student), Dr. Kanchan Kulhari (MD Biochemistry), Maansi Gangwal {il year MBBS
ROTE OF CHANDRAPR/IBHA VATI IN UTI
*Dr. Sanjeev
R. Yadav, Dr. Dnyaneshwar Chavan and Dr. pankaja
Choudhari
EVALUATION O F ANTI-PARKINSONS ACTIVITY OF CARICA PAPAYA USING AIBINO RATS
Rajya taxmi Gudepu*,Sunil (andru and Dr. N. Srinivasan
APPTICATION OF THE BETHESDA SYSTEM FOR REPORTING THYROID FINE NEEDTE ASPIRATES
Dr. Neelam sreemani Kumarit, Dr. shyamala srujana, Dr. K. Rama Krishna Reddy, Dr. o. shravan Ku
mar
SYNTHESIS OF NEW FTUORINATED PYRROLE DERIVATIVES USING PAALKNORR CONDENSATION
Murtaza A. Patharia*, pankaj K. Godhaviya, Bharat K. Dhotre, pathan Mohd Arif
SIMUTTANEOUS QUANTITATIVE ESTIMATION OF NETUPITANT AND PATONOSETBON HCI BY HPTTC
METHOD: DEVETOPMENT AND VALIDATIoN.
Vasava Shilpa N. and Raiashree C. Mashru*
CHANGE IN SERUM MAGNESIUM LEVET IN PRE AND POST HEALTHY PTATELETPHERESIS DONORS.
V. B, Mane*, P. E. Jagtap, N. S, Nagane, G. J. Belwalkar, S. p. Dhonde and
y.
R.
Gotekar
ACHYLA: FlRsr REPoRT FRoM WATER BoDtEs oF pAcHMARHt DtsrRtcr HoSHANGABAD
(M.p.l
INDIA.
Ajaz Ahmad*, Ranjana Singh, Suman Trivedi* and Sheikh Sayir
PREVATENCE OF THYROID DYSFUNCTION AMONG THE ADUI-T POPUI-ATION OF KANCHIPUBAM
DISTRICT, TAMILNADU
P. Modagan*, Dr. A,
ienuka, Dr. A. Manamali and Dr. Santhi Silambanan
SYNTHESIS OF 2-HYDROXY-3-METHOXYBENZALDEHYDE.P.HYDROXY
BENZOICTIYDRAZONE
(HMBAHBH) AND ITS APPLICATION FOR DIRECT SPECIROPHOTOMERIC DETERMINATION
OF HEAVY
METAL CADMIUM (II) IN ENVIRONMENTAL SAMPIES
M, Swetha+, G. Govind, V. Krishna Reddy and p. Raveendra Reddy
ANATYSIS OF PRETIMINARY PHYTOCHEMICAT CONSTITUENTS OF WHOTE PTANT EXTRACTS OF
CROTATARIA HEBECARPA (DC.) RUDD.
R. Srinivas, P.
Jyothi Chaitanya*, N. Lakshmi Bhavani and Umme Tameem
DEVELOPMENT AND EVATUATION OF MATRIX TYPE TRANSDERMAT PATCHES OF ZALEPLON
Hemendra Pratap Singh, Kapil Kumar* and Sai Krushna padhy
I
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DEVELOPMENT AND VATIDATION OF RP-HPIC METHOD FOR ASSAY OF AMLODIPINE IN
FORMUTATIONS
*B, Balaswami and P, Venkataramana
EVALUATION OF ANALGESIC ACTIVITY OF A POTYHERBAI FORMULATION IN ALBINO RATS
K. Hari Kamesh Kiran*, Dr. A. Lakshman Rao and A. Tirupathi Rao
SYNTHESI' CHARACTERIZATION AND BIOTOGICAT EVAIUATION OF NOVEI HETEROCYCLIC
SUBSTITUTED 1,2,3.TRIAZOTES DERIVATIVES
S.
Syed Shafi and S. Senthilkumar*
INFTUENCE OF SI[K SERICIN FROM THE COCOONS OF SII-KWORM, ANTHERAEA MYLIITA (LI AND
BOMBYX MORI (L) ON HYDROGEN PEROXIDE INDUCED OXIDATIVE STRESS IN FETINE FIBROBTASTS.
Vitthalrao B. Khyade*
THE BETHESDA sYsrEM FoR REPoRT|NG THyRotD
cyropATHolocy: trs pRos AND coNs.
Archana Ticku* and Prem Singh
HONEY: A SWEET WAY TO CURE pSyCHOStS
Milind Parle+ and Arzoo
DEVELOPMENT, OPTIMIZATION AND EVATUATION OF GUAR GUM AND SCMC BASED IPN HYDROGET
BEADS FOR CONTROTTED DRUG DETIVERY OF CAPTOPRII
Himanshi Joshi*, Ganesh Kumar Bhatt, Alka Lohani and preeti Kothiyal
STUDY ON THE INFLUENCE OF COSOLVENT AND SURFACTANT ON SOTUBILIZATION OF EFAVIRENZ
Mbah Chika, Omeje Edwin* and Ugodi Gerald.
CYTOTOXIC ACTIVITY OF ANNONA MURICATA L. IEAF EXTRACT
*Sudha Karayil
SERUM TIPID LEVETS IN WOMEN WITH GESTATIONAL DIABETES IN PORT HARCOURT, NIGERIA
Fred K,
Uwikort, Davies Tamuno Emine and Kemzi N. Elechi-/Cmadi
MEDICO TEGAL EVALUATION OF ACUTE POISONING CASES IN HAPUR REGION. U.P., INDIA
Devendra Singh*, Jayanti Singh, R.K. Sharma, J.L. Agarwal, Hemant Kumar Singh, Daya Chand
STUDY OF SERUM TEVEI- OF VITAMIN C IN OSTEOARTHRITIC PATIENTS
*Lobna Dheyaa Jaafar
METALTOTHIONEIN
SYNTHESIS, MICRO-ARCHITECTURAL ATTERATIONS AND APOPTOSIS IN
CADMIUM EXPOSED LIVER TISSUE OF MARINE CATFISH, ARIUS ARIUS
Ramalingam Mani, Boominathan Meena*, Sumit Rose and Ayothi Suresh
PROFITE AND ANTIMICROBIAL SUSCEPTIBITITY PATTERN OF URINARY BACTERIAT ISOTATES
AT A
TERTIARY CARE HOSPITAT IN CENTRAL INDIA
Chaudhari Vijaya Laxman* and paril Asmita Ashok
SYNTHESIS AND BIOTOGICAT ACTIVIry OF
INDOTES
A
NOVET SERIES OF 2- PHENYT SUI-PHA/SUBSTITUTED
*Anil Kumar
ANALYTICAT AND PHYTOCHEMICAL STUDIES ON ZIZYPHUS TOTUS
Zaid NaJah and Khaled EIsherifE
AMELIORATION OF CISPTATIN-INDUCED TOXICITY IN BTOOD DOMESTIC RABBIT'S
BY SODIUM
THIOSUTFATE OR GINGER EXTRACT
Ayoub R. Aldalou*
SYNTHESIS AND IN VITRO ANTITUMOR ACTIVITY OF
QUINAZOTINE{(3H}.ONE
DITHIOCARBAMATE SIDE CHAINS
DERIVATIVES WITH
Saritha J. Tangeda*, Anuradha Sandala and Achaiah Garlapati
FORENSIC STUDY ON CHITD SEXUAT ABUSE UNDER POCSO ACT
U, K. Kulkarni*, Dr. K, V. Kulkarni, R. N. Kokre and B. B. Daundkar
A RARE cAsE oF MU[TttocutAR uNtcysTlc AMELoBLASToMA: A pRoGRESstvE
RADtoGRApHtc
PRESENTATION.
Dr. Padmashree S., *Dr. Sayyad zohabhasan, Dr. Shilpa p. S,, MDs and 4Dr,
Rema J.
SYNTHESIS AND CHARACTERIZATION OF SITVER NANOPARTICTE OF
GINGER RHIZOME (ZINCIBER
oFFlclNALE) EXTRACT: syNTHEsls, cHARAcrERtzATtoN AND ANTt DtABETtc AcTlvtry
tN
STREPTOZOTOCIN INDUCED DIABETIC RATS
Ashish Garg*, Prakash pandey, prabhakar Sharma and Ajay Shukla
STUDY OF THE ACTIVITY OF SAI.IVARY ATKATINE PHOSPHATASE, CONCENTRATION
OF SATIVARY
CATCIUM AND PHOSPHOROUS IN DENTAL CARIES
Dr. Arshiya Jadhav*, Dr. s. p. Dhonde, Dr. p.
Nagane
E.
Jagtap, Dr. Anand shigri, Dr. G. J. Berwarkar, Dr. N. s.
NANOEMUTSION FOR COSMETIC APPLICATION
Padmadevi chellapa, Farah Diana Ariffin, Ahmad M. Eid, Asaad A. Almahgoubi,
Aref T. Mohamed, yo
usef S. lssa and Nagib A. ElmarzugL*
REGUTATORY ROTES OF POTYAMINES AND
ORNITHINE DECARBOXYLASE IN THE GROWTH OF
CANCER CETTS
Raymond R. Tjandrawinatat
NEUROLOGICAL COMPTICATION OF ANDERSON-FABRY
DISEASE AND IMPACT OF ENZYME
REPTACEMENT
Antonino Tuttoromondoi, rrene simonetta, Rosaria pecoraro,
sarvatore Miceri, varentina zappufia,
alerio Vassallo and Antonio pinto
MICROSPONGE A NOVET NEW DRUG DEuvERy
SYSTEM: A REvtEW
Swapnil Lembhe+ and Asish Dev
WOoDe€'.s LAMP EXAMINATIoN: A SIMPLE AND
QUICK
PORPHYRIA CUTANEA TAROA.
BED;*
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Premanshu Bhushan M.B,B.S, M.D, (onchok
Dorjay M.B.B.S, D.V.D. and Tasleem
Arif*
ELWA (ATOE BARBADENSISI: A REVIEW
Mohd Aslam, Anwar Husain Khan+ and Shabana
Rehman
NON.CTASSICAT ESTROGEN/XENOESTROGEN
RECEPTOR SIGNATI.ING IN MODULATION
OF
NEURONAT FUNCTION
Abhay (umar pandey*
NoN-ctAsslcAt BloAcrlvtrY oF ENVTRoNMENTAI
NEUROPHYSIOTOGY
EsTRoGEN BrspHENot A,
wrrH A Focus oN
Abhay Kumar pandey*
A WILD EDIBTE FRUIT- FICUS PALMATA
Priyanka Bhandari+
OCUI.,AR DRUG DELIVERY SYSTEM: A REVIEW
ON rrS NiCrr,N
Swapnil tembhet and Asish Dev.
AOiNirffi;;
LIPOSOMES: FROM CONCEPT TO COMMERCTAUZATTON
Ramandeep Singh*, M. K. Kale and Atul Bodkhe
a€@ENVIR'NMENTAT AND
occupA,oNAr HAzAnos or rvlrncunv
PRACTICAL GUIDETINES TO MINTMIZE
THEMA€
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Mrinar shetea, Anagha shete, Mahesh chavan,
Nikhil Diwan, paravi channe, Rashmi sapkar
CHROMIUM IN HEAI.TH AND DISEASES
Swaminathan Selvanayagamr, Revathy Kuppusamy
and Rajeswari Shanmugam
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INTERESTTNG TESIONS
OF SKIN IN PAEDIATRIC
AGE GROUP
T : "i ::i'TT ::':': a,;;,,-o","*, r..,.sri and Dr. o. shravan Kumar
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Nidhi Chaudhary*
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A PHYTOPHARMOCO.OC'.O..I
K.
M.6161*
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Dr. Priti Gupta+
HERBS AND
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DNA TECHNOTOGY
PHYTO'"U',.O,.i wtTHANTtpAR*"uso,u,orfrriri
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Rar.a.hr
Rakesh l(. Goyal* and
Janardhan Singh
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TAKAYASU AORTOOO',OU
*Dr.
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Mathakar and Nilesh
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umar M.D.s,
M.D.S, or.
Dr' G. s.
Dr. santtram
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Anshika r.ekhi and Nidht
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016, l/olune 3, lssue 7, 0l -07.
Research
Article
S,IIF Impact Factor 3.881
EUROPEAN JOURNAL OF BIOMEDIqAI.
ISSN 23il9-8870
Volume:
AND PIIASMACEUTICAI, SCIENCES
http://uuv.cibns.com
i
,*
l9L,
Year:2016
or p$ PRSTEII rr".*,!.!19*rN RErrNoBLAsroMA
i
Hendrian Dwikotoso Soebagior *, susy Fsrnrsfiysnti!, De[itri Lutti], A;;r;;*.
rr.,r.".
, r;;;..rr,.nrr*
I'1rl)epaltrnentofOphrhahnology,Faoultyofluedicins
AirlanggaUniversity,Dr-soctomoHospitalsurabaya,
East Java, Indonesia.
aBiochemistry
Laboratory, Dcpartnent ofchemistry, MathEmatics and Naoral sciences Faculty
ofBrawijaya
UDiversity, MaJarg. East Java, Ilrdoneia.
sDepartnrent
ol'Biology, Mathctratic and Natural Scicnces Faculty ol BrawUaya university, Malang, East
Java,
Ildoocsia_
" Corresponditrg Autlor: Hendrian Dwikolos Soelragio
Dq1ffir6t olOphrhalmolo$r, Fsculty ot Medicinc Airtmgge Univmity, Dr. Soctmo Hospikl Smbayt
E$t Ja!& IDd@6is
Atricte Rcrcivcd on
23ltx/2016
Arricte Rcvi.cd on
t3/05/20t6
Afiicte Accated on 02/06/20t6
ABSTRACT
'lhis study was underllkcrl to denlonstrate the
expressiorl ofp53 i[ rttinoblastoma, Thirty three retiuoblastoma
tissuc saruples
of
intratumoral rctinoblas[olra wcrc tcsrcd
wiilr
SDS-PAGE
to flnd the
of
retiioblastonra prctein, followed by Westcnr blotting and intnrutrohistocherristty
to confinn p-s3 "xprc.sionTh"
cleclrophorosis examination identified l0 orajor prctein flactiors l,itb molecula.weight
rior. "rpr"r.io,,.
td: - ta tou.
Poorly dillcrcntiatcd tctiroblas(oma samplcs rivcajed 10
uorein fiacrions (nrolccula.u:eight 103 - 14 kDa) ard
wBll di(Itrcutialcd rc(inoblastomtr rcvcalod 9 protcin fractions (molccular
rvcight liour 97 --14 kDa). wcster.J trtor
arrd irnrnunohistochcnristry assay using rrronoclonal antiborly p53
showed tlit saurplcs arc positively ;";;;;
p5j No sigtrificillt coilelation was found bctwccn p53 expusion tnd dilfcrctrtisrion
of rctinoblastoma (p
, and Pharmaceutical Sciences
ISSN 2349-8870
ICV - 6.96
.ln International Peer Fer,iew Journal for Plralna. Xledical .t Biolo$cal
,q,i
}i!,u:CicC
$sl+l-CIen
s$$
Editorial Board
Dr. Petkova V.,
(Ph D., fi4 Sc.Frharm. M.SC.P.H.)
BULGARIA
Associate Editor
Dr. Dimitrov M.
(PhD, MScPhann, MPH-HMP)
BULGARIA
Editorial Board Member
1. Dr Shazia Jamshed, Malaysia
2. Dr. Rasha Moustafa Youssef, Egypt
3. Dr. Khaled Nabih Rashed, Egypt
4. Dr. Maryam Ahmed, Pakistan
5. Dr, Jutti Levita, lndonesia
6, Associate Professor, Ravindra Reddy Yaramala, lndia
7. Dr. Saber Mohamed Abd-Allah, Egypt
8. Dr Nitesh Kumar, lndia
9. Dr. Vinod Singh, lndia
10. Dr. Fareedi Mukram Ali, lndia
11. Prof, Dr
PJ
Hisalkar, lndia
12. Dr. Abebe G, Demissie, Ethiopia
13. Dr. Subha Ganguly, lndia
t,
14, Dr. lmran Ahmad Khan, Pakistan
15. Prof. Dr. Prakash. M.M.S. Kinthada, lndia
16, Dr. Tej Pratap Mall, lndia
17. Dr, D. Nagasamy Venkatesh, lndia
18. Dr. Amit Kumar
Dixi! India
19. Dr. Ajit Singh, lndia
20. Dr. K.V. Madhusudhan, tndia
21. Dr, Anju Verma, USA
22. Dr. Supriya Sen, USA
23. Dr. Severo VAizquez Prieto, Spain
24, Dr, Ramakrishna D,S, lndia
25. Dr. N.S. Neki, lndia
26. Prof, Dr. Patricia Severino, Brazil
27, Dr. Rafik Karaman, lsrael
28. Dr, Roshan V. Tiwari, US
29. Prof, Dr. Osmar A, Centulion, paraguay
30. Dr. Heba Abdel Hady Abdel Raouf, Egypt
31. Dr. Ahmed Kadry lbrahim lbrahim Hassan, Egypt
32, Dr. Ravi Kumar Chittoria, lndia
33, Dr. Sara Ganaha M.D., USA
34. Dr. V. Harshini, lndia
35, Dr, P. Manivannan, lndia
35. Dr. Mayank Kakkar, USA
37. Dr, Mohammed Turki Khathi, lraq
38. Dr. Vasantha Mittapelli, tndia
39. Dr. Sandeep Kumar Kar, India
40, Dr. Patient D. Dhliwayo-Chiunzi, Zimbabwe
41. Dr. Nirmala Jaget Lakkawar, lndia
42. Dr. Raymond R. Tjandrawinata, lndonesia
1. Dr. E, Stanley Lee, Taiwan
2. Prof. Herida Regina Nunes Salgado, BRAZIL
3. Dr. Mohammed Rageeb Mohammed Usman, lndia
4. Dr. Pramod Singh Khatri, lndia
5. Dr. Kedar G. Mehta, lndia
6, Dr. Mohammad Safiqul lslam, Japan
7. Dr. Jagdish Kakadiya, India
8. Dr.(Mrs) Padmini H.Sharma, lndia
9, Asnake Gudisa Ede, Ethiopia
10. Dr, Zainab Mahmood Aljamali, lraq
11. Dr. Nagarajan Kayalvizhi, lndia
12. Dr. Subhabrata Ghosh, tndia
13. Dr. Mrs. Alpana. J, Asnani, lndia
14, Dr. Datta Asaram Dhale, tndia
15. Obeagu Emmanuel lfeanyi, Nigeria
I
lr
16. Dr. Balasubramanian Sathyamurthy, lndia
i
I
17. Dr. Sidharth Mehan, tndia
18, Dr. C. Agnes Mariya Dorthy, tndia
19, Dr. Subhadeep Ganguly, lndia
20. Dr. Pawankumar Dnyandeo Tekale, lndia
2L. Dr, Manoj Kumar Goyal, lndia
22,Dr.C. Agnes Mariya Dorthy, lndia
23, Dr. Arumugam Manickam, lndia
24. Dr. Himadri Sekhar Samanta, lndia
25. Dr. Sumanta Dey, USA
25. Dr. Rajiv Saini, India
27, Dr, Shende Krushnadev Laxman, India
28, Dr. Avinash Warundeo Lakkawar, lndia
I
I
29. Dr. Subrata Sabui, USA
30. Dr. T. Vijaya Bhaskara Reddy, India
31. Dr. Debjit Ray, USA
32. Dr. Suman Bala, lndia
33. Dr. Payala Vijayalakshmi, tndia
34. Dr. Shaik,Md.Zakir Hussain, tndia
35. Dr, Pradeep Kumar Soni, lndia
36. Dr. Gandla Kumara Swamy, lndia
I
I
2015 Volume 3, July lssue
7
-------
THE RoLE oF p53 PR6TEIN
Exp,RESSION IN RETINOBTASTOMA
l::11'r1": '::Y'j':'l
:',"1'y'1',3"n*,
,,*. o,o",.",,
sutiman Bambans sum,tro
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potyMoRpHtsM
(HTERT)
ffi:gfl
^EvEtr)E HANSCRIPTASEu *i.
lli"#S X,Hll
:::-dlS. o.,i*rr,*,r.*io,
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FTNDINGS
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pAnENrs
I
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PATIENTS
_
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Omnia Noreldeen Gamaletdee
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rN I nL vlu,ERN Tt
Mohamed Anwar osama,
Muhammad
ammad Abbas*, Suzan
Adel
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and Dr.
ur. Huixla Lv
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tv
EFFECTS
EFFEcrs
OF
oF
CHt-o"oronM
cHr-ono..ro.
oN FoRMAuN-rNor..o
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paw oEDEMA
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O. E. Famobuwa+, B.
M. OJo and J. S. Amoko
EVAI.UATTON OF
O*,,O'.,O*
dil
ANrrBAcn.,o,
ililil:;ll;vD
l':r: T',jT,l:.1:r:r:,:r]ran,
(ruRMERrs
,PtD PROFttE ANO
KHART',M srar.
a-*aoarr]
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w;ffi ffi;;rrooi.r*u,,
Eoucherit Hanane+,
Nouioua Amira',
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Merzoug Amina
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ANTIDTABETIC
OCH*O,O*A
BRAND
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QUAUTY ASSESSTTBI,
x::*:.,:'i.,,ui.u,.,,*
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Wafa Al-Madhagi*,
Ahmed Abr
ed, Nahrah
_
se,ar Asma, chikhi Abderouahab,
Bensegueni Abderrahmane,
AC',,,, O, O
TNDU.EDDTABETCRAT'
*Ajiboso
S. O,, yakubu T. M
and Oladiii A. T
THE EFFECT OF
_
Amna o. M. Etzein and
Nassr Etdin M. A. shrifr
NE*,,,,,,i
co,rruru*J,,rir;;ilil,, o*, oF srApHyrococc* ou*i
RESEARCH OF
onir*u"*;r;;;ilil;
Khadija Akter Eva, Nasma
zerin, Md. shahidur ,.abir+
pRorErN rN
suDANEs
3T:iiT"_01*:":*y*"med,
octirti*r
,";il;ililjJiTJ"llT:*'lHkani,
Abobakr (hared A,ha&
zakaria Ahmed sae
_
PROTECTIVE EFFECT OF FOSFOMYCIN ON DEO)ffNIVALENOL- TREATED CEtL CULTURES
Denisa soledad P6rez Gaudio*, Guadalupe Martinez, Maria Bel6n Fern6ndez paggi,, Maria Bel6n Ricc
io1, Julieta Maria Decundo, Susana Dieguez, Maria Ofelia Tapial, Alejandro Luis Soracil,
ACUTE AND CHRONIC ATOE BARBADENSIS MILTER GEI- MEDIATES ANTIULCEROGENIC AND GASTRIC
ANTI.SECRETORY EFFECTS VIA HISTAMINERGIC HZ RECEPTORS
lnyang M. and +Ofem O. E.
FASTING VS. NON FASTING TIPID PROFILE AMONG SUDANESE IN KHARTOUM STATE
l-ena Mohamed Ahmed Rizig+ and Dr. Tarig Mohamed Fadl-Elmola
NOVET SYNTHESIS OF SUBSTITUTED-1-{7-NITRO.IOH.PHENOTHtAZINE.3.YL)-3- (4.NITROPHENYt)
PROP.2-EN-1.ONE
Meghasham N. Narule*
EFFECTS
OF MANGROVE PTANT EXTRACTS AGAINST THE PINK MEATY BUG (MACONETTICOCCUS
HlRsurus GREEN) oN AMINo AclDs AND ENZYME AcTlvlTY lN sltKWoRM, BoMBYx MoRt
Samba Naik A.*, Srinivas Naik 8., B. Ravi Babu and M. Jagadish
Naik
L.
.
MONITORING AND REPORTED THE ADVERSE DRUG REACTIONS OF DIFFERENT DRUGS IN RURAT
GOVERNAMENT HOSPITAT IN NAI-GONDA SPONTANEOUS REPORTING METHOD
N. shiva Krishna*, K. Nava Jyothi, H. Ramana, M. Rajeshwarit, B. Rajini, y. Ashwini, K. Lakshmi surek
ha, G. Venkateshwarlu and B. Shankar, M. Sai
A RESEARCH STUDY OF CHOLECYSTECTOMIES AND REASONS OF CONVERSION OF I.APAROSCOPIC TO
OPEN CHOIECYSTECTOMIES IN A TERTIARY CARE HOSPITAL
Dr. P. vinay+, Dr. K. Gowtham Reddy, Dr. T. Mahendra, Dr, p. Gowtham Reddy and M. venkata subb
aiah
I
I
I
I
ANTI ACNE SPOT CREAM tN CONTROIUNG FACTAL ACNE : A PROSPECTIVE OPEN LABEL
MUTTICENTER SAFEW AND EFFICACY TRIAL.
Dr. Muhammed Majeed, Dr. Raru M. Rhee and prachi S. Lad*
APPRAISAT OF DIRECT COST OF TREATING EPILEPSY PER MONTH IN GUNTUR, ANDHRA PMDESH.
K.
Siporat, D. Vidhyadhari, Tabrik Fathima, R. Venkateswara Rao and Nadendla Rama Rao
ENANTIOMERIC SEPAMTION AND QUANTITATIVE DETERMINATION OF RITONAVIR ENANTIOMER IN
RITONAVIR DRUG SUBSTANCE BY CHIRAL TIQUID CHROMATOGRAPHY
M, Subbarao+, M. Ramakrishna, D. Mogilireddy, M. yanadhirao and y. pavani
EVATUATION OF SERUM CREATININE, EGFR AND INSUI-IN.LIKE GROWTH FACTOR 1 IN HYPOIHYROID
SUBJECTS EEFORE AND AFTER t-THYROXINE REPTACEMENT
Trinanian Sanyal, Sujoy chosh and Subhankar Chowdhury
A SURVEY ON RETEVANT EDGE DETECTION TECHNIQUE FOR MEDICAT IMAGE PROCESSING
Ranita Banerjee, Dr. lndra Kanta Maitra and *prof. Samir Kumar Bandyopadhyay
GENETIC DIVERSITY ANATYSIS OF SELAGINETTA BRYOPTERIS (1.)BAK. GENOTYPES IN TETANGANA,
INDIA.
*P, Rupa and N. lakshmibhavani
FORMUTATION, OEVETOPMENT AND EVATUATION OF FTOATING DRUG DETIVERY SYSTEM OF
CEFPODOXIME PROXETIL
Manish Kumar Bhatt, Bhupendra Nath Dwivedy and Viney Chawla*
SYNTHESI' SPECTRAL PROPERTIES DNA STUDIES OF TANTHANIDE (ItI} COMPTEXES OF 2ACETYLPYRIDINE BENZOYTHYDRAZONE
Karreddula Raja, Akkili Suseelamma and (atreddi Hussain Reddy*
SYNTHESII CHARACTERIZATION, DNA BINDING AND NUCtEASE AcTlvlTY OF tRoN(tt) coMptExES
OF ISONICOTINOYL HYDRAZONES
A. Suseelammai, K. Raja and K. Hussain Reddy
PROTECTIVE ROLE OF RUTIN ON PACTITAXEL-INDUCED I.IPID PEROXIDATIO
Supratim Rayt
CTINICAL STUDY ON PANDU ROGA WITH SPECIAL REFERENCE TO IRON DEFICIENCY ANEMTA AND ITS
MANAGEMENT WITH LOHBHASM AND BALACHITRAK MOOI
Dr. D. G. Dipankar*, Dr. Mamta Nakade, Dr. Jibi varghese, Dr. Hridaynath Lad, Dr. Rajesh Tayade, Dr.
Shilpa Jungare
PHARMACEUTICAT EVALUATION OF MUSTA-TRIPHATADI AVAI.EHA, AN AYURVEDIC POLYHERBAT
FORMUTATION
O,T.M.R.K,S.B, Kalawana*, patel K.S., Rajagopala S., Kori V.K. and Shukla V.J.
A STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT FOR ANATYSIS OF ERTAPENEM IN BULK
DRU6 AND PHARMACEUTICAT DOSAGE FORM
Nilesh Jain, Ruchi Jain, Deepak Kumar Jain*, Avineesh singh, vijay Kumar patel and surendra Kumar
Jain
COMPARISON OF OPHTHALMOTOGICAT
COMPLICATIONS OF ANTIVIRAT DRUGS FOR HCV INFECTION
Prempal Kaur*, Baljinderpal Singh and Bhavkaran Singh Bal
COMPARISON OF VISUAT OUTCOME AND COMPTICATIONS IN TWO DIFFERENT TECHNIQUES OF
SCTERAL FIXATED INTRAOCUTAR tENS IMPTANTATION
Dr Mohana Majumdar*
I
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I
VENOUS GTUCOSE ESTIMATION. THE UNTOTD STORY''
Dr. Arun Kumar Harith (MD Biochemlstrylt, Garima Boradia (M.sc Biochemistry), varun Kumar singh
(lll year MBBS student), Dr. Kanchan Kulhari (MD Biochemistry), Maansi Gangwal {il year MBBS
ROTE OF CHANDRAPR/IBHA VATI IN UTI
*Dr. Sanjeev
R. Yadav, Dr. Dnyaneshwar Chavan and Dr. pankaja
Choudhari
EVALUATION O F ANTI-PARKINSONS ACTIVITY OF CARICA PAPAYA USING AIBINO RATS
Rajya taxmi Gudepu*,Sunil (andru and Dr. N. Srinivasan
APPTICATION OF THE BETHESDA SYSTEM FOR REPORTING THYROID FINE NEEDTE ASPIRATES
Dr. Neelam sreemani Kumarit, Dr. shyamala srujana, Dr. K. Rama Krishna Reddy, Dr. o. shravan Ku
mar
SYNTHESIS OF NEW FTUORINATED PYRROLE DERIVATIVES USING PAALKNORR CONDENSATION
Murtaza A. Patharia*, pankaj K. Godhaviya, Bharat K. Dhotre, pathan Mohd Arif
SIMUTTANEOUS QUANTITATIVE ESTIMATION OF NETUPITANT AND PATONOSETBON HCI BY HPTTC
METHOD: DEVETOPMENT AND VALIDATIoN.
Vasava Shilpa N. and Raiashree C. Mashru*
CHANGE IN SERUM MAGNESIUM LEVET IN PRE AND POST HEALTHY PTATELETPHERESIS DONORS.
V. B, Mane*, P. E. Jagtap, N. S, Nagane, G. J. Belwalkar, S. p. Dhonde and
y.
R.
Gotekar
ACHYLA: FlRsr REPoRT FRoM WATER BoDtEs oF pAcHMARHt DtsrRtcr HoSHANGABAD
(M.p.l
INDIA.
Ajaz Ahmad*, Ranjana Singh, Suman Trivedi* and Sheikh Sayir
PREVATENCE OF THYROID DYSFUNCTION AMONG THE ADUI-T POPUI-ATION OF KANCHIPUBAM
DISTRICT, TAMILNADU
P. Modagan*, Dr. A,
ienuka, Dr. A. Manamali and Dr. Santhi Silambanan
SYNTHESIS OF 2-HYDROXY-3-METHOXYBENZALDEHYDE.P.HYDROXY
BENZOICTIYDRAZONE
(HMBAHBH) AND ITS APPLICATION FOR DIRECT SPECIROPHOTOMERIC DETERMINATION
OF HEAVY
METAL CADMIUM (II) IN ENVIRONMENTAL SAMPIES
M, Swetha+, G. Govind, V. Krishna Reddy and p. Raveendra Reddy
ANATYSIS OF PRETIMINARY PHYTOCHEMICAT CONSTITUENTS OF WHOTE PTANT EXTRACTS OF
CROTATARIA HEBECARPA (DC.) RUDD.
R. Srinivas, P.
Jyothi Chaitanya*, N. Lakshmi Bhavani and Umme Tameem
DEVELOPMENT AND EVATUATION OF MATRIX TYPE TRANSDERMAT PATCHES OF ZALEPLON
Hemendra Pratap Singh, Kapil Kumar* and Sai Krushna padhy
I
I
DEVELOPMENT AND VATIDATION OF RP-HPIC METHOD FOR ASSAY OF AMLODIPINE IN
FORMUTATIONS
*B, Balaswami and P, Venkataramana
EVALUATION OF ANALGESIC ACTIVITY OF A POTYHERBAI FORMULATION IN ALBINO RATS
K. Hari Kamesh Kiran*, Dr. A. Lakshman Rao and A. Tirupathi Rao
SYNTHESI' CHARACTERIZATION AND BIOTOGICAT EVAIUATION OF NOVEI HETEROCYCLIC
SUBSTITUTED 1,2,3.TRIAZOTES DERIVATIVES
S.
Syed Shafi and S. Senthilkumar*
INFTUENCE OF SI[K SERICIN FROM THE COCOONS OF SII-KWORM, ANTHERAEA MYLIITA (LI AND
BOMBYX MORI (L) ON HYDROGEN PEROXIDE INDUCED OXIDATIVE STRESS IN FETINE FIBROBTASTS.
Vitthalrao B. Khyade*
THE BETHESDA sYsrEM FoR REPoRT|NG THyRotD
cyropATHolocy: trs pRos AND coNs.
Archana Ticku* and Prem Singh
HONEY: A SWEET WAY TO CURE pSyCHOStS
Milind Parle+ and Arzoo
DEVELOPMENT, OPTIMIZATION AND EVATUATION OF GUAR GUM AND SCMC BASED IPN HYDROGET
BEADS FOR CONTROTTED DRUG DETIVERY OF CAPTOPRII
Himanshi Joshi*, Ganesh Kumar Bhatt, Alka Lohani and preeti Kothiyal
STUDY ON THE INFLUENCE OF COSOLVENT AND SURFACTANT ON SOTUBILIZATION OF EFAVIRENZ
Mbah Chika, Omeje Edwin* and Ugodi Gerald.
CYTOTOXIC ACTIVITY OF ANNONA MURICATA L. IEAF EXTRACT
*Sudha Karayil
SERUM TIPID LEVETS IN WOMEN WITH GESTATIONAL DIABETES IN PORT HARCOURT, NIGERIA
Fred K,
Uwikort, Davies Tamuno Emine and Kemzi N. Elechi-/Cmadi
MEDICO TEGAL EVALUATION OF ACUTE POISONING CASES IN HAPUR REGION. U.P., INDIA
Devendra Singh*, Jayanti Singh, R.K. Sharma, J.L. Agarwal, Hemant Kumar Singh, Daya Chand
STUDY OF SERUM TEVEI- OF VITAMIN C IN OSTEOARTHRITIC PATIENTS
*Lobna Dheyaa Jaafar
METALTOTHIONEIN
SYNTHESIS, MICRO-ARCHITECTURAL ATTERATIONS AND APOPTOSIS IN
CADMIUM EXPOSED LIVER TISSUE OF MARINE CATFISH, ARIUS ARIUS
Ramalingam Mani, Boominathan Meena*, Sumit Rose and Ayothi Suresh
PROFITE AND ANTIMICROBIAL SUSCEPTIBITITY PATTERN OF URINARY BACTERIAT ISOTATES
AT A
TERTIARY CARE HOSPITAT IN CENTRAL INDIA
Chaudhari Vijaya Laxman* and paril Asmita Ashok
SYNTHESIS AND BIOTOGICAT ACTIVIry OF
INDOTES
A
NOVET SERIES OF 2- PHENYT SUI-PHA/SUBSTITUTED
*Anil Kumar
ANALYTICAT AND PHYTOCHEMICAL STUDIES ON ZIZYPHUS TOTUS
Zaid NaJah and Khaled EIsherifE
AMELIORATION OF CISPTATIN-INDUCED TOXICITY IN BTOOD DOMESTIC RABBIT'S
BY SODIUM
THIOSUTFATE OR GINGER EXTRACT
Ayoub R. Aldalou*
SYNTHESIS AND IN VITRO ANTITUMOR ACTIVITY OF
QUINAZOTINE{(3H}.ONE
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FORENSIC STUDY ON CHITD SEXUAT ABUSE UNDER POCSO ACT
U, K. Kulkarni*, Dr. K, V. Kulkarni, R. N. Kokre and B. B. Daundkar
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Ashish Garg*, Prakash pandey, prabhakar Sharma and Ajay Shukla
STUDY OF THE ACTIVITY OF SAI.IVARY ATKATINE PHOSPHATASE, CONCENTRATION
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Dr. Arshiya Jadhav*, Dr. s. p. Dhonde, Dr. p.
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NANOEMUTSION FOR COSMETIC APPLICATION
Padmadevi chellapa, Farah Diana Ariffin, Ahmad M. Eid, Asaad A. Almahgoubi,
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REGUTATORY ROTES OF POTYAMINES AND
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Raymond R. Tjandrawinatat
NEUROLOGICAL COMPTICATION OF ANDERSON-FABRY
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Antonino Tuttoromondoi, rrene simonetta, Rosaria pecoraro,
sarvatore Miceri, varentina zappufia,
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ELWA (ATOE BARBADENSISI: A REVIEW
Mohd Aslam, Anwar Husain Khan+ and Shabana
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Research
Article
S,IIF Impact Factor 3.881
EUROPEAN JOURNAL OF BIOMEDIqAI.
ISSN 23il9-8870
Volume:
AND PIIASMACEUTICAI, SCIENCES
http://uuv.cibns.com
i
,*
l9L,
Year:2016
or p$ PRSTEII rr".*,!.!19*rN RErrNoBLAsroMA
i
Hendrian Dwikotoso Soebagior *, susy Fsrnrsfiysnti!, De[itri Lutti], A;;r;;*.
rr.,r.".
, r;;;..rr,.nrr*
I'1rl)epaltrnentofOphrhahnology,Faoultyofluedicins
AirlanggaUniversity,Dr-soctomoHospitalsurabaya,
East Java, Indonesia.
aBiochemistry
Laboratory, Dcpartnent ofchemistry, MathEmatics and Naoral sciences Faculty
ofBrawijaya
UDiversity, MaJarg. East Java, Ilrdoneia.
sDepartnrent
ol'Biology, Mathctratic and Natural Scicnces Faculty ol BrawUaya university, Malang, East
Java,
Ildoocsia_
" Corresponditrg Autlor: Hendrian Dwikolos Soelragio
Dq1ffir6t olOphrhalmolo$r, Fsculty ot Medicinc Airtmgge Univmity, Dr. Soctmo Hospikl Smbayt
E$t Ja!& IDd@6is
Atricte Rcrcivcd on
23ltx/2016
Arricte Rcvi.cd on
t3/05/20t6
Afiicte Accated on 02/06/20t6
ABSTRACT
'lhis study was underllkcrl to denlonstrate the
expressiorl ofp53 i[ rttinoblastoma, Thirty three retiuoblastoma
tissuc saruples
of
intratumoral rctinoblas[olra wcrc tcsrcd
wiilr
SDS-PAGE
to flnd the
of
retiioblastonra prctein, followed by Westcnr blotting and intnrutrohistocherristty
to confinn p-s3 "xprc.sionTh"
cleclrophorosis examination identified l0 orajor prctein flactiors l,itb molecula.weight
rior. "rpr"r.io,,.
td: - ta tou.
Poorly dillcrcntiatcd tctiroblas(oma samplcs rivcajed 10
uorein fiacrions (nrolccula.u:eight 103 - 14 kDa) ard
wBll di(Itrcutialcd rc(inoblastomtr rcvcalod 9 protcin fractions (molccular
rvcight liour 97 --14 kDa). wcster.J trtor
arrd irnrnunohistochcnristry assay using rrronoclonal antiborly p53
showed tlit saurplcs arc positively ;";;;;
p5j No sigtrificillt coilelation was found bctwccn p53 expusion tnd dilfcrctrtisrion
of rctinoblastoma (p