Agustriyanto Simulation Abstract 2015
Proceedings of The 5 t h Annual I nt ernat ional Conference Syiah Kuala Universit y ( AI C Unsyiah) 2015
I n conj unct ion wit h The 8 t h I nt ernat ional Conference of Chem ical Engineering on Science and Applicat ions ( ChESA) 2015
Sept em ber 9 - 11, 2015, Banda Aceh, I ndonesia
Sim u la t ion of Con t in u ou s Bio- Re a ct or
Rudy Agust riyant o
Depart m ent of Chem ical Engineering, Facult y of Engineering, Universit y of Surabaya,
Surabaya, I ndonesia;
* Corresponding Aut hor : rudy.agust riyant o@st aff.ubaya.ac.id
Abst r a ct
Dynam ic st udy of bioprocess syst em plays a cent ral role in bioprocess
cont rol. I t is in fact on t he basis of t he t im e required for t he dev elopm ent of
t he knowledge process t hat t he t ot al design, analysis and im plem ent at ion of
m onit oring and cont rol m et hods are carried out . Wit hin t he fram ew ork of
bioprocesses, t he m ost nat ural way t o det erm ine t he m odels t hat will enable
t he charact erizat ion of t he process dynam ics is t o consider t he m at erial
balance of m aj or com ponent s of t he process. This art icle will present
sim ulat ion result s of cont inuous bio- react or. The m at hem at ical m odels for
t he bio- react or based on t he m at erial balance had been derived ( Riggs and
Karim , 2006) and would be adopt ed in t his st udy. Those m odel were solved
and sim ulat ed using Mat lab. I t is found t hat t he dynam ic responses of t he
bio- react or due t o a st ep change in feedrat e are first order.
Ke y w or ds: Sim ulat ion, bio- react or, biochem ical, ferm ent at ion
I nt r odu ct ion
Microbial ferm ent at ion is a process in which a populat ion of m icro - organism s are grown
using cert ain nut rient s under fav orable surrounding condit ions ( t em perat ure, pH, agit at ion,
aerat ion, et c) . I t schem at ically corresponds t o t he t ransform at ion of subst ances ( generally
carbonaceous subst rat es) int o product s, result ing from m et abolic act ivit ies of cells.
The m ain com ponent s of t he react ion are as follows ( Dochain, 2008) :
• Subst rat es, denot ed as Si , which are necessary for t he growt h of m icro- organism s, or
ev en which are precursors of a com pound t o be produced. These subst rat es generally
cont ain a source of carbon ( glucose, et hanol, et c) and som et im es nit rogen ( NO 3 , NH 4 ,
et c.) and phosphorus ( PO4 , et c) .
• Microbial biom asses, denot ed as x i .
• End product s, denot ed as Pi , for agri- foods ( oils, cheese, beer, wines, et c) , chem ist ry
( solvent s, enzym es, am ino acids, et c) , t he pharm aceut ical indust ry ( ant ibiot ics,
horm ones, vit am ins, et c) or for t he product ion of energy ( bio- et hanol, biogas, et c.) .
Bio- et hanol, as a clean and renewable fuel, is gaining increasing at t ent ion, m ost ly t hrough
it s m aj or environm ent al benefit s. I t can be produced from different kinds of renewable
feedst ock such as e.g. sugar cane, corn, w heat , cassava ( first generat ion) , cellulose
biom ass ( second generat ion) and algal biom ass ( t hird generat ion) . Sanchez and Cardona
( 2008) described t he biot echnological product ion of bio- et hanol from different feedst ocks.
The agro- indust rial wast es had been explored for t heir feasibilit y as cult ure m edia for t he
product ion of bioet hanol ( Bocanegra et al, 2015 ; Balat , 2011) .
Previous research include kinet ic st udy of bat ch et hanol product ion from sugar beet raw
j uice ( Dodic at al, 2012) . Cont inuous bio- react ors based on a CSTR are not com m only used
in biot echnology indust ry alt hough t hey are good candidat es for t he product ion of high
volum e product s, such as, bioet hanol. The design and dev elopm ent of cont inuous
50
I n conj unct ion wit h The 8 t h I nt ernat ional Conference of Chem ical Engineering on Science and Applicat ions ( ChESA) 2015
Sept em ber 9 - 11, 2015, Banda Aceh, I ndonesia
Sim u la t ion of Con t in u ou s Bio- Re a ct or
Rudy Agust riyant o
Depart m ent of Chem ical Engineering, Facult y of Engineering, Universit y of Surabaya,
Surabaya, I ndonesia;
* Corresponding Aut hor : rudy.agust riyant o@st aff.ubaya.ac.id
Abst r a ct
Dynam ic st udy of bioprocess syst em plays a cent ral role in bioprocess
cont rol. I t is in fact on t he basis of t he t im e required for t he dev elopm ent of
t he knowledge process t hat t he t ot al design, analysis and im plem ent at ion of
m onit oring and cont rol m et hods are carried out . Wit hin t he fram ew ork of
bioprocesses, t he m ost nat ural way t o det erm ine t he m odels t hat will enable
t he charact erizat ion of t he process dynam ics is t o consider t he m at erial
balance of m aj or com ponent s of t he process. This art icle will present
sim ulat ion result s of cont inuous bio- react or. The m at hem at ical m odels for
t he bio- react or based on t he m at erial balance had been derived ( Riggs and
Karim , 2006) and would be adopt ed in t his st udy. Those m odel were solved
and sim ulat ed using Mat lab. I t is found t hat t he dynam ic responses of t he
bio- react or due t o a st ep change in feedrat e are first order.
Ke y w or ds: Sim ulat ion, bio- react or, biochem ical, ferm ent at ion
I nt r odu ct ion
Microbial ferm ent at ion is a process in which a populat ion of m icro - organism s are grown
using cert ain nut rient s under fav orable surrounding condit ions ( t em perat ure, pH, agit at ion,
aerat ion, et c) . I t schem at ically corresponds t o t he t ransform at ion of subst ances ( generally
carbonaceous subst rat es) int o product s, result ing from m et abolic act ivit ies of cells.
The m ain com ponent s of t he react ion are as follows ( Dochain, 2008) :
• Subst rat es, denot ed as Si , which are necessary for t he growt h of m icro- organism s, or
ev en which are precursors of a com pound t o be produced. These subst rat es generally
cont ain a source of carbon ( glucose, et hanol, et c) and som et im es nit rogen ( NO 3 , NH 4 ,
et c.) and phosphorus ( PO4 , et c) .
• Microbial biom asses, denot ed as x i .
• End product s, denot ed as Pi , for agri- foods ( oils, cheese, beer, wines, et c) , chem ist ry
( solvent s, enzym es, am ino acids, et c) , t he pharm aceut ical indust ry ( ant ibiot ics,
horm ones, vit am ins, et c) or for t he product ion of energy ( bio- et hanol, biogas, et c.) .
Bio- et hanol, as a clean and renewable fuel, is gaining increasing at t ent ion, m ost ly t hrough
it s m aj or environm ent al benefit s. I t can be produced from different kinds of renewable
feedst ock such as e.g. sugar cane, corn, w heat , cassava ( first generat ion) , cellulose
biom ass ( second generat ion) and algal biom ass ( t hird generat ion) . Sanchez and Cardona
( 2008) described t he biot echnological product ion of bio- et hanol from different feedst ocks.
The agro- indust rial wast es had been explored for t heir feasibilit y as cult ure m edia for t he
product ion of bioet hanol ( Bocanegra et al, 2015 ; Balat , 2011) .
Previous research include kinet ic st udy of bat ch et hanol product ion from sugar beet raw
j uice ( Dodic at al, 2012) . Cont inuous bio- react ors based on a CSTR are not com m only used
in biot echnology indust ry alt hough t hey are good candidat es for t he product ion of high
volum e product s, such as, bioet hanol. The design and dev elopm ent of cont inuous
50