FORMULASI DAN STUDI IN VITRO SEDIAAN TRANSDERMAL KETOPROFEN DENGAN PENINGKAT PENETRASI ASAM OLEAT.
ABSTRAK
Dilakukan formulasi sediaan transdermal ketoprofen dengan menggunakan asam
oleat sebagai peningkat penetrasi. Dibuat tiga formula dengan variasi konsentrasi
asam oleat masing-masing 0%, 1%, 5%, dan 10%. Sediaan dibuat dalam bentuk patch
dengan metode penguapan pelarut. Eudragit RS100 dan PVP digunakan sebagai basis
polimer dan pengontrol pelepasan obat. Evaluasi sediaan dilakukan dengan uji
permeasi secara in vitro menggunakan metode sel difusi Franz dengan membran
lepasan kulit ular sanca kembang (Reticulated phyton). Uji permeasi dilakukan
selama 12 jam. Hasil penelitian menunjukan bahwa terjadi peningkatan permeasi
ketoprofen yang sebanding pada peningkatan konsentrasi peningkat penetrasi.
Formula F3 yang mengandung 10% asam oleat memberikan persen permeasi yang
paling signifikan terhadap formula lainnya. Semua formula menunjukan kinetika
pelepasan orde nol.
Kata kunci : Ketoprofen, Transdermal, Asam Oleat, in vitro
ABSTRACT
Formulation of ketoprofen transdermal have been done by using oleic acid as
penetration enhancer. Three formulas were prepared by varying concentration of
oleic acid respectively 0%, 1%, 5%, and 10%. Ketoprofen transdermals were made in
patch form with solvent evaporation method. Eudragit RS100 and PVP were used as
polymers base as well as control drug releases. Ketoprofen transdermals were
evaluated by in vitro permeation test using Franz diffusion cell method and shed
snake skin of Reticulated python as a membrane. Permeation tests were carried out
for 12 hours The results showed that an increase in permeation of ketoprofen is
comparable to the increased concentration of penetration enhancers. F3 formula
which contains 10% oleic acid gaves percent permeation of the most significant
impact on other formulas. All formulas showed zero-order release kinetics.
Keywords: Ketoprofen, Transdermal, Oleic Acid, in vitro
Dilakukan formulasi sediaan transdermal ketoprofen dengan menggunakan asam
oleat sebagai peningkat penetrasi. Dibuat tiga formula dengan variasi konsentrasi
asam oleat masing-masing 0%, 1%, 5%, dan 10%. Sediaan dibuat dalam bentuk patch
dengan metode penguapan pelarut. Eudragit RS100 dan PVP digunakan sebagai basis
polimer dan pengontrol pelepasan obat. Evaluasi sediaan dilakukan dengan uji
permeasi secara in vitro menggunakan metode sel difusi Franz dengan membran
lepasan kulit ular sanca kembang (Reticulated phyton). Uji permeasi dilakukan
selama 12 jam. Hasil penelitian menunjukan bahwa terjadi peningkatan permeasi
ketoprofen yang sebanding pada peningkatan konsentrasi peningkat penetrasi.
Formula F3 yang mengandung 10% asam oleat memberikan persen permeasi yang
paling signifikan terhadap formula lainnya. Semua formula menunjukan kinetika
pelepasan orde nol.
Kata kunci : Ketoprofen, Transdermal, Asam Oleat, in vitro
ABSTRACT
Formulation of ketoprofen transdermal have been done by using oleic acid as
penetration enhancer. Three formulas were prepared by varying concentration of
oleic acid respectively 0%, 1%, 5%, and 10%. Ketoprofen transdermals were made in
patch form with solvent evaporation method. Eudragit RS100 and PVP were used as
polymers base as well as control drug releases. Ketoprofen transdermals were
evaluated by in vitro permeation test using Franz diffusion cell method and shed
snake skin of Reticulated python as a membrane. Permeation tests were carried out
for 12 hours The results showed that an increase in permeation of ketoprofen is
comparable to the increased concentration of penetration enhancers. F3 formula
which contains 10% oleic acid gaves percent permeation of the most significant
impact on other formulas. All formulas showed zero-order release kinetics.
Keywords: Ketoprofen, Transdermal, Oleic Acid, in vitro