The influence of black cumin seed oil therapy with dosage of 1.5 mL/day and 3 mL/day to interleukin-21 (IL-21) expression of the patients with metabolic syndrome risk - Repository Universitas Ahmad Dahlan
IOP Conference Series: Materials Science and Engineering
Related content
PAPER • OPEN ACCESS
The influence of black cumin seed oil therapy with
dosage of 1.5 mL/day and 3 mL/day to interleukin21 (IL-21) expression of the patients with
metabolic syndrome risk
To cite this article: D R Fajar et al 2017 IOP Conf. Ser.: Mater. Sci. Eng. 259 012012
- The efficacy of black cumin seed (Nigella
sativa) oil and hypoglycemic drug
combination to reduce HbA1c level in
patients with metabolic syndrome risk
P N R Rachman, Akrom and E Darmawan
- Topical Review
Anil S Modak
- The emerging role of reactive oxygen and
nitrogen species in redox biology and
some implications for plasma applications
to medicine and biology
David B Graves
View the article online for updates and enhancements.
This content was downloaded from IP address 36.73.68.127 on 27/12/2017 at 20:00
IPCUAD2017
IOP Publishing
IOP Conf. Series: Materials Science and Engineering
259 (2017) 012012 doi:10.1088/1757-899X/259/1/012012
1234567890
The influence of black cumin seed oil therapy with dosage of
1.5 mL/day and 3 mL/day to interleukin-21 (IL-21) expression
of the patients with metabolic syndrome risk
D R Fajar1, Akrom1,2 , E Darmawan1
1
Faculty of Pharmacy , Universitas Ahmad Dahlan, Yogyakarta, Indonesia
2
Center of Drug Information and Study, Universitas Ahmad Dahlan, Yogyakarta,
Indonesia
E-mail: desi.rf1991@gmail.com
Abstrak. Metabolic syndrome (MS) is a metabolic disorder caused by obesity and insulin
resistance. In the state of obesity and insulin resistance occurs increased fat metabolism that
causes production reactive oxygen species (ROS) and oxidative stress that makes dysregulation
of adipose tissue that decreases antioxidant enzymes and immune system disorders. In diabetes
mellitus there is pancreatic β cell damage caused by pro-inflammatory cytokines i.e
interleukin-21 (IL-21). Black cumin seed oil (BCSO) contains antioxidants and
immunomodulators but has not seen how it affects to IL-21. This study used cross over design
to determine the effect of BCSO with dose of 1.5 mL/day and 3 mL/day dose of IL-21 in MS
patients. The total subjects 66 of MS patients were divided into 2 groups. Group I was
administered 1.5 mL/day and 3 mL/day of BCSO in dosage for 20 days and continued with
washing out (BCSO discontinued) for 7 days. On the day 28, group I administrated 3 mL/day
of BCSO and group II were given 1.5 mL/day of BCSO during 20 days. Statistical analysis
showed that mean value expression of IL-21 were given by BCSO at dose 1.5 mL/day was
5.06±5.48 and BCSO at dose 3 mL/day 4.66±3.63 (p
Related content
PAPER • OPEN ACCESS
The influence of black cumin seed oil therapy with
dosage of 1.5 mL/day and 3 mL/day to interleukin21 (IL-21) expression of the patients with
metabolic syndrome risk
To cite this article: D R Fajar et al 2017 IOP Conf. Ser.: Mater. Sci. Eng. 259 012012
- The efficacy of black cumin seed (Nigella
sativa) oil and hypoglycemic drug
combination to reduce HbA1c level in
patients with metabolic syndrome risk
P N R Rachman, Akrom and E Darmawan
- Topical Review
Anil S Modak
- The emerging role of reactive oxygen and
nitrogen species in redox biology and
some implications for plasma applications
to medicine and biology
David B Graves
View the article online for updates and enhancements.
This content was downloaded from IP address 36.73.68.127 on 27/12/2017 at 20:00
IPCUAD2017
IOP Publishing
IOP Conf. Series: Materials Science and Engineering
259 (2017) 012012 doi:10.1088/1757-899X/259/1/012012
1234567890
The influence of black cumin seed oil therapy with dosage of
1.5 mL/day and 3 mL/day to interleukin-21 (IL-21) expression
of the patients with metabolic syndrome risk
D R Fajar1, Akrom1,2 , E Darmawan1
1
Faculty of Pharmacy , Universitas Ahmad Dahlan, Yogyakarta, Indonesia
2
Center of Drug Information and Study, Universitas Ahmad Dahlan, Yogyakarta,
Indonesia
E-mail: desi.rf1991@gmail.com
Abstrak. Metabolic syndrome (MS) is a metabolic disorder caused by obesity and insulin
resistance. In the state of obesity and insulin resistance occurs increased fat metabolism that
causes production reactive oxygen species (ROS) and oxidative stress that makes dysregulation
of adipose tissue that decreases antioxidant enzymes and immune system disorders. In diabetes
mellitus there is pancreatic β cell damage caused by pro-inflammatory cytokines i.e
interleukin-21 (IL-21). Black cumin seed oil (BCSO) contains antioxidants and
immunomodulators but has not seen how it affects to IL-21. This study used cross over design
to determine the effect of BCSO with dose of 1.5 mL/day and 3 mL/day dose of IL-21 in MS
patients. The total subjects 66 of MS patients were divided into 2 groups. Group I was
administered 1.5 mL/day and 3 mL/day of BCSO in dosage for 20 days and continued with
washing out (BCSO discontinued) for 7 days. On the day 28, group I administrated 3 mL/day
of BCSO and group II were given 1.5 mL/day of BCSO during 20 days. Statistical analysis
showed that mean value expression of IL-21 were given by BCSO at dose 1.5 mL/day was
5.06±5.48 and BCSO at dose 3 mL/day 4.66±3.63 (p