The Effectiveness Test of Oil Phase Ointment Containing Snakehead Fish (Channa striata) Extract on Open Stage II Acute Wounded Wistar Strain Male Rats | Daisa | Majalah Obat Tradisional (Traditional Medicine Journal) 27920 61650 1 PB
Submitted : 10-11-2016
Revised : 21-02-2017
Accepted : 21-07-2017
Trad. Med. J., May - August 2017
Vol. 22(2), p 97-102
ISSN-p : 1410-5918 ISSN-e : 2406-9086
The Effectiveness Test of Oil Phase Ointment Containing Snakehead
Fish (Channa striata) Extract on Open Stage II Acute Wounded Wistar
Strain Male Rats
Uji Efektivitas Salep Fase Minyak Ekstrak Ikan Gabus (Channa striata)
pada Tikus Jantan Galur Wistar Yang Diberi Luka Akut
Stadium II Terbuka
Fransisca Daisa*, Mohamad Andrie, Wintari Taurina
Program Studi Farmasi, Fakultas Kedokteran Universitas Tanjungpura Pontianak
ABSTRACT
The snakehead (Channa striata) contained fatty acids omega-3 and omega-6 are useful as nutrients in
accelerating the wound healing process. This study aims to determine the effectiveness of the oil phase
extract ointment snakehead in the healing of acute wounds open stage II. Testing the effectiveness of wound
healing using 6 groups: normal, gel bioplacenton (positive control), ointment base (negative control),
ointments snakehead extract oil phase concentration of 10; 20 and 40% of the 4 rats with acute wounds open
stage II and observation until day 16 injury. The area of the wound was measured with the image J program
Macbiophotonic, calculated% healing power, and AUC values. A statistical test to the total AUC values per rat
with SPSS for Windows 22.0 program using One Way ANOVA and Post-hoc LSD test. The results showed a
significant difference in the negative group with ointment concentration of 20% (p
Revised : 21-02-2017
Accepted : 21-07-2017
Trad. Med. J., May - August 2017
Vol. 22(2), p 97-102
ISSN-p : 1410-5918 ISSN-e : 2406-9086
The Effectiveness Test of Oil Phase Ointment Containing Snakehead
Fish (Channa striata) Extract on Open Stage II Acute Wounded Wistar
Strain Male Rats
Uji Efektivitas Salep Fase Minyak Ekstrak Ikan Gabus (Channa striata)
pada Tikus Jantan Galur Wistar Yang Diberi Luka Akut
Stadium II Terbuka
Fransisca Daisa*, Mohamad Andrie, Wintari Taurina
Program Studi Farmasi, Fakultas Kedokteran Universitas Tanjungpura Pontianak
ABSTRACT
The snakehead (Channa striata) contained fatty acids omega-3 and omega-6 are useful as nutrients in
accelerating the wound healing process. This study aims to determine the effectiveness of the oil phase
extract ointment snakehead in the healing of acute wounds open stage II. Testing the effectiveness of wound
healing using 6 groups: normal, gel bioplacenton (positive control), ointment base (negative control),
ointments snakehead extract oil phase concentration of 10; 20 and 40% of the 4 rats with acute wounds open
stage II and observation until day 16 injury. The area of the wound was measured with the image J program
Macbiophotonic, calculated% healing power, and AUC values. A statistical test to the total AUC values per rat
with SPSS for Windows 22.0 program using One Way ANOVA and Post-hoc LSD test. The results showed a
significant difference in the negative group with ointment concentration of 20% (p