PROGRAMME AND ABSTRACT BOOK

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INTERNATIONAL CON FERENCE ON
NATURAL PRODUCTS 2015

PROGRAMME AND ABSTRACT BOOK

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Propelling Science and Technology

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24-25 March 2015
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Johor Bahru

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Propellitrg kience and Technology through Notural Prodrcts

FOREWORD BY
DR HASNAH MOHD SIRAT
CHAIRPERSON OF ICNP 2015

PROFESSOR

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It is indeed my great pleasure
participants and delegates

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and honour

to welcome all

to the International

Conference on
(ICNP
Natural Products 2015
2015). As the organizer for this year's
ICNP, Universiti Teknologi Malaysia is honoured

to host this annual
Products Society (MNPS) that
encourages the involvement of various organizations, especially
those related to research, teaching and learning. My deepest
appreciation goes to all our guest, plenary and invited speakers for
their commitment to participate in this cont-erence and sharing the

experiences and expertise in their respective fields with all the
participants, especially the young researchers. I hope that everyone
will take this opportunity to interact, change of ideas and initiate the
fruitful collaboration, linkages and networking in varieties of issues related to the development
of natural products research areas. In this year conference, we manage to attract scientists from
seventeen countries, with guest speakers [2), plenary and invited speakers (L5), oral presenters
(77), and poster presenters [160). This is a great achievement for these two days conference.

event

of the Malaysian Natural

This conference will act as a platform for academicians, scientists, researchers and students in
the field of natural products to showcase recent research findings involving natural products
research, to exchange ideas and knowledge on the latest development and advancement of
instrumentation employed in natural productslesearch, and to encourage the development of
professional an,/ar.,
First and foremost I would like to take the opportunity to extend
my warm welcome to all the speakers and participants attending
the International Conference on Natural Products 2015 flCNP

2015), organized by the Faculty of Science, UTM with the
cooperation of the Malaysian Natural Products Society (MNPSJ. I
strongly feel that this conference provides the right avenue for
researchers, academic community and students in the region to
share insights and exchange views on the findings of their work and
new discoveries in various aspects of science and technologr of the
Natural Products developmenl This is especially important for
Malaysia as research and development is essential to highlight and
uphold the status of a developed country with naturally existing
biodiversity rich ness.
Intensifoing research development and commercialization is now the focus of Malaysia as it
strives towards becoming a developed nation. The rapidly growing Malaysian industry requires
a community with sound understanding of science and technology to provide the necessary
human capital with the right intellectual capacity, innovative skills and entrepreneurial mindset

that can adapt and embrace the ongoing rapid technological change in a versatile and
resourceful manner. However, for Malaysia to.remain relevant and competitive in this global

it has become more challenging and essential for an institution of higher learning to
provide support for scientific research. Malaysia has copious amount of natural products with

high potentiality of being develop into active ingredients which can be implemented for diverse
applications such as in the pharmaceutical, agriculrural, medicinal and other high-end fields.

arena,

With the cooperation of both the Malaysian Natural Products Society, which offers a unique
plafform, and UTM's research strength and innovation, the conference will act as an impetuJ in
the efforts to establish the links between recent advancernents in the science knowleJge field

and the business industries. Such outcome could create value and oppornrnities for researchers
and their products in benefitting Malaysia's agenda of Bioeconomy. I have always believed that
a technologically literate scientific community with high awareness towards the importance of
the advancement of knowledge and skills related to natural products, is essential foi high value
added enterprises critical to ensure the sustainability in the quality of life with safer, cleaner
and healthier environment.

On that note, I wish all of you a fruitful conference which should not be limited only to
intellectual presentations, but should also be the platform to promote networking and
collaboration amongst researchers and institutions in diverse disciplines. Finally, my heirdelt
appreciation goes to the organizers for their dedication and commitment in ensuring the

success of this symposium, and my best wishes to all participants for an intellectually
stim ulating and memorable conference.

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ORGANIZING COMMITTEE

Prof. Datuk [r. Dr. Wahid Omar

Vice-Chancellor
Univcrsiti Tcknologi Malaysia

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Prof. Dr. Norsarahaida Saidina Amin
Dean, Faculty of Scicnce

Universiti Teknologi Malaysia

Cfiabrytwt

Prof. Dr. Hasnah Mohd Sirat

Coafrairyrwt

Assoc. Prof, Dr. Farcdiah Ahmad

Se{r?tfft

Dr. Shajarahtunnur Jamit

Assista*Seu*ay

Dr. Joazaizulfazli Jamalis

Tnas,mr

Assoc. Prof. Dr. Zainoha Zakaria

Assistanttreastr

Mrs. Syaheera Seliman

Scieilific Comdtte

Assoc. Prof. Dr. Farediah bt Ahmad lHead)
Dr. Mohd. Baki Bakar (Secrctary)
Prof. Dr. lVan Azlina Ahmad
Dr. Shajarahtunnur Jamil

Dr. Norazah Basar
Dr. Naji Arafat Mahat
Dr. Siti Paulicna Mohd Bohari
Dr. Azman Abdulsamad

Dr" Mohd. Razauden Mohd Zulkifli

Sp.n*fu4

Dr. Norazah Basar

Dr. Hcndrik Oktendy Linrang
Assoc. Profl Dr. Jafariah Jaafar
Dr. Hasmcrya Maarof

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Mrs. Zarina Junct

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Dr. Khairil Juhanni Abd. Karim

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lcNP2015

Prof. Dr. Sugcng Trirvahyono

Dr. Roswanira Abd. Wahab
Dr. Nursyafrcena Attan
Dr. Siti Aminah Setu(a)Sabru
Assoc" Prof. Dr. Nor Aziah Buang

24'25 March

2015

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Johor, MALAy5IA

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Mr- Azani Ishak
Mr. Fuaad Omar
Mrs. Ramlah Hussein
Mrs. Zahnatul 'Ain Abd Jalil

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ICNP2015

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24-25 March

Assoc. Prof. Dr. Rusmidah
Dr. Naji Arafat Mahat

2015

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Advanced Mass

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Industrial

Block T03, Llniversiti Teknologi Malaysia

Preparadve HPLC for Fracdonaton and

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* 21;00

08:00 - 08:45

ofNatural Products

ICNP20I5 Registration (Venue: 116 Floor, DoubleTree by Hilton )

lCNPZ0ls Registration (Venue: 1lrt Floor, DoubleTree by H ilton)
GRAND BALTROOM 1

08:45 .. 09:0O

Prof, Dato'Dr
Guest

09r15 - 09r4S
09:45

-

10:15

10:45

- 11:30

11:30

* l2:15

12:15 * 13$0

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SESSION

09:00 - 09r15

1:

.

rCh
Guest Speaker 2: Prof, Dr.

Title: ln

of Natural Product in

Chairperson 2: Prof. Dr. Hasnah Mohd Slrat
Plenary $peaker 1: Prof. Dr. Stephen G. pyne
of lflollongong Australia)
Boronic

Reaction in Alkaloi

Plenary Speaker ?: Prof. Dr. lkuro
red

Plenary Speaker 3 Assoc

fUnlverslty of Tolryo, fapan]
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Dr. Huang Deflrn

Methods Guided

Natural

University of Singapore, Singapore)
of Bioactive Natural

Mukrarn Mohamed

Prof. Dr, I0reliiah Aweng

fUnlverrtd Malaya)

Novel & Bioactive Compounds: Treasure From the

I Plants

GRANDBAI"LROOM 2

1:
14:25

{Universiti Putra Malaysla}

Towards

Hadiani

-

H Laiis

of Dr,

GRAND BATTROOIII 1

14:00

(Andalas

Dayar

R. CANNON

'ACK

Invited Speaker Z:
llssoc Prof. Dr. Tewln Tencomnao
(

Chulalongkorn Univemiry)

Research Advances on Herbal Medicine Ag-ainst Age-

Skin

GRAND BALTROOM 3

Chairperson:
Prof. Dr

Ahmad
Invited Speaker 3:
Prof, Dr. ttran Azlina Ahmad
[Unlversld Teknologi llalaysia]

Natural Pigmenu from Bacteria- Laboratory Scale to
Scale Production

OA1:

14:25

*

14:40

EeUgaILIu llel

Fong t{6 Kazuhldc Shrun

Okude, Vyomesh Petel
Targeted Natural Product Drug Discovery By
Zebrafish Phenotypic Assay

PqtriJ{ur Hldavah AI"Zlktl. Mubammad
Taher, Deny Susantl, Mohamad Iazlln Rezali,
Roger W Read, FaredLah Ahmad

OA2:
14:4O

-

14:55

- l5:10

14:55

Bioguided lsolation of Cytotoxic Triterpenoids From
The Stem of Luvunga scandens
OA3:

llufenUlli,

Mohd Haflz Ahmld, Nor

Hadlanl lemall

Phytochemical Studies af SyErgium filiforme var

Ftllforme

oA,h&LulIhutl

Alwanl Hamad, M. Gl$h Panft

ilahardlke, lstlfah
15110

-

15:25

Comparative Chemicd and Antimicrobial Study of
Essential Oils from Two Syagrum Species

OBI: Sltl Zalton Mat So'ad,ftn&-0alg!<htb
Wan Mohd Azizi Wan $ulalman, NorAzian Hassan
Skin Sensitization Study of Crude Methanol Extract of
Acalypha indico Linn Leaves Onto Guinea Pigs
OB2: Ifan-AtlrnlJlrcmlD Mohammed Al.(aeslm
Hassan,AMul ManafAll, Xhamsah Suryatl f,lohd
lnduction ofApoptosisand GZ/M Phase Cell Cycle
Arrest by Antimicrobial Peptide HepTHl-5
OB3: $amuel lhavamrnl B
Cissampelos poruiro: Molecular Docking To

lndentity

Suitable Tar3ets For Hepatocellular Carcinoma [HCC]
By ln-Silico Technique
OB4: [3g1g[9L ifohd Shazwau l{ohd Zatn,
Faarlah Zakarla, Wan Boell l,tlan lrhah Wan
Amtr Nlzam WenAhmad

0C 1 : Xuhrda"!flrnshogr"

Antonlo Azzolllnl

Development and Validarion Of An High Throughput
Metabolomic Strategy To Reveal Fungal lnterspecies
Communication
OCZ: lcS.tLL, Medlanl, A. Abas, F'
NMR-Based Metabolomics for Understanding The
Effect of Drying Methods on The Phytochemical
ConstituenB of Dlfferent Parts of Neptunio olerocea
and The Correlation With Antioxidant and uGlucosidase Inhibitory Activities
OC 3 r-lflahrauOl['l., ilSu ffi an M.A, f,orzulaani K
Production of Zeru mbone From Adventiti ous Root
Culture of Medicinal Ginger Zingiber aerumbef Smith

IluuLDlnnEZ, lbrahtun N
Extraction Hlbiscus esculentus f0kra) Gum and
Characterization OfThe Extracted Okra Powder

OC4:

The Ability ol Ple urotu s - Saj or-CaJu Extract I n
Lowering Glycemic Response ln Normal and Diabetic
Rats

Shaiarahtunnur f amil, Norazah Baser,
Horzaiftreza tlohd Arifr n
OA5:

15:25

-

15:40

- l6:00

16:00

15:40

- 16:15

Flavonoids

F

rom Artocarprs scorfechinii King

Chalrperson:

Chalrperson:

Prof, Dr. Hasnah Osman

Assoc. Prof. Dr lamia Azdina famal

OA6: lalthh ledp. Nur lndah AMul Shukor, lluln
Abdul Azml, Lee Wee Xlan, Chan l0n Lulo, Deyang
Frcdalina Basrl

Attenuating The Methicillin-Resistant Srs phylococcus
aureus by Plants Stilbenoids

lrdemh.ll&|lltddi& Ats]ah Adem. Alunad

$aza[ Hemeah

- l6:30

Pruteomic Analysis of Anti-Cancer Effects of Pereskio
Dleo Ethyl Acetate Extract On HT-29 Human
Colorecta I Adenocarcinoma Cell Line

OCS:

Roshadara Shamsuddin, Rerno Atrdayanl

Eudtldrtllono
Chromatographic Method For The Detection Of
Undeclared Synt}etic Drugs ln famu

Tee break and Poster Sesslon

OA7:

16:15

OB5: ALlhencll|n, Norhaniza Aminudin. Puterl
Shafinaz Abdul-Rahman

Placement of Quo$$ra rorneenst's Noot
(Simaroubaceae) As lndicated By lsolation Of lts
Quassinoids

O86: Muhammad l{edeem Akhar. Norsharlna
lsmail, Seeme Zareen, Nordin Hi taiis , it. Iqbal
Choudhary
Neumprotective and Acetylcholi nesterase inh ibitory

Chairperson:
Prof, Dr. Fartdah
OC6: G. M. Liew. H. Y. Hhong A. K' Sayok.and

C,

l.

Nutol
Phytodremical Screening and Anrioxidant Activities
ofselected Fun$ From Mount Singai, Sarawak

Activities of the Stem Stem Bar'ks of Knema lourina
Shah. Sadia Sultaru Sharlfah

DiaLUff8m[gnruf l{ur Permgtasari,
I[ohrmmad $aifurRohman
Physalis mtnims Indues Re-Endotheliallzation in

6t7: gyed Adnan AII

Deoxycorticosterone Acetate-Salt-lnduced Hypertensive Rats

Steroids derived From Microbial-Catalyzed
Reactions: An Experimental and Theoretical

OB7:

Nurirzllah, El Hassane Anouar
NMR Structure Elucidation of Triterpenoids and

Muha4ma4Abubakar Ldo. Farldah Abas,
lntan Safinar lsmaii Hasanah M, Ghazali, and
Klrozlrah Shaari
Chemical Profite and Biological Evaluation of
OAB:

16:30

- l6:45

Callicorpo

Leaves

oA9 Andrlani. Y-. Herina Yuni Utami, Dody Dorl
Putra, Desy Fltrya Samsumir, Murri lstamiah
16145

*

17:00

OB8: l(hanhe Hasllza Abdul Kheltl. Norhanlza
Amluudin, Onn Hafl Hashim

Enhancement of Uterus Conratility Potential
Following Administration af Ficus deltoideo
OB9: Tang Suk Peng. IC{S

Siraiudeen, Has[an

Iaafar, Slew Hua Gan, Uuzaiml Mustapha, $ld

l(assim

Amrah Sulaiman

Hydnophytum formicarum Tuber Fractions As
Antioxi dant, Antitracterial and Anticanccr potential
Agents

Protective E$ects OfTualang Honey On Repeated
Exposure OfParaquat In The Rats' Lung and
Midbmin Region: Comparison with Ubiquinol

OC8:

l{oer lhsanah. Trlyanto, Altm lsnansctyo

Antibacterial Compounds From lndonesian Red Alga
Against Fish Pathogen

OC9: Abdul Hekeem llemon. Fouad Saleih Resq
Al-$uede, Abdalrahlm F. A. Aisha, Mohammad
$hahrul Ridzuao llamil, ilohammed Ali Ahmed
$aeed, Madeeha lagharl, Zhari lsmail, Amin Melik

ShahAbdul Maiid
lsolation, Characlerization, Crystal Structure
Elucidadon, Anticancer Activity of New flavanone
and Simultaneous HPLC DeterminaHon of Four Major
Compounds f rom Syzygium cam ponu loru m Korth.

oAl0:
17:00

*

Abd Rashld l"i, Pzaralnl

l(amaruu. ilohd f,edd ithnad
17:15

lsolation and Characterization of Galactomannan
Fmm leucoena leucocephola

In

oAl 1: lntan Saflnar Ismail. Azizul Isha, Nur

17130

- 17:30

lR- and NMB-Metabolomic Approach ln Detecdng
The Changes Of Andmgraphis pniculota Metabolites
Due To Different Harvesting Ages and Times

- 1B:30

OCt0: Chan Chun Foong
ldeal Me$od Transfer from TLC to Column
Chromatography * True Theory of Chromatography

Plants

oB11
Khamsah Suryati
tf ohd, Seranenan Dharmaraf, Sharif llahsuff

AtkifahYusof
t7:15

oB10:
Khan, Norasyldah Hart& Azharl Hamld Nour
Abduelrahman, Mashltah Mohd Yusoff
Isolation and Chemical Characterization ol

Mansor

0C1 1: Ilanlel.Anthony Dlas
The Past and Present Endeavors ofThe Biodiscovery
Natural Products Research Croup

Apoptosis Effects of rt{elostoma molobsthricum L.
Extracts on HepG2 Cells
MNPSAI{NUAL IIEE-TING
1.h

20:00

-

CONFEEENCE

23:00

DINNER & OPET{II{G CERET{ONY

1lth
GRAND AALLROOM

T

lbrehim
O8:30

Plenary Speaker 4: Prof. Dr, Sltesh Chandra

- 09:t.5

09:15

-

10:00

10:00

-

10:45

Chemometric

Plenary

(Unlverslty ofDhaka,

for Sclective
5: Prof. Emeritus Dr. Geoftey A. Cordell (President of Natural products lac,
of Natural
Speaker 6:
Dr. DHC Yoshinorl Asakawa (Tokushlma Bunri University,
Tide Chemical Constituents of
and
()

{,

10:45- 11:15

Tea Breek and Poster Session
GRAND BALLROOM

11r15

- I l:40

GRAND BALTROOM 2

1

ChalrTerson:

Chalrperson:

Chalrpersonl

Prof. Dr. Stephen G. Pyne
Invlted Speaker 4:
Prof, Dr. Ahmad Sazall Hamzah
(Univprdd Teknologl UARA)
Chemlstry of Five Membered Nltrogen Heterocycles:

Prof. Dr, Sttesh C. Bachar
lnvlted Speaker 5:
Dr. Merc. Utaudon
(lnsdtut de Chlmle des Substences Nahrraelleq
France)
Prospection of Malaysian Biodiversity: a Productive
Route to Druc Discovery
OB12: Nlda N, Farshort, Ebtesam 5. Al-Sheddl, Mai
M. Al-Oqail, QualserSaqulb, Maesood A. Slddiqul,

Prof. Dr. Wan Azlina Ahmad
lnvlted Speaker 6:
Assoc Prof. Dr. Davld Churchlll

Desiga and Synthesis of Novel Fused Lactam-Lactone

Ring System As Potential Bio-Actlve Compounds

!9fl3a,[[g1g l{lk Hhalrunlssa Nlk
Abdullah Zawawl, iluhammad Teha, Nor Hadlanl
OA12:

I l:40

- l1:55

lsmall
Synthesis and Evah,ration of Biscoumarin Analogues
Bearlng Thiourea Derivatives as o-Clucosidase

lnhibitor
OA13: Tna lG )Oru Subashanl Manlam, Hendrlk

dkrendy Llntary, Steven tangford, Mohd

l1:55 -

12;10

Brtrt

Bakar
Synthetic Strategies of Nature-lnspired Porphyrin
Models for Arti ficial Photosystems
OA14: SZgIfgLIeon& Sld Munlrah Mohd Faudzi,
Farldah Abas, Mohd Fadhltzll Faelhl Mohd Aluwl,

l2:lo -

12:25

GRAND BALTROOM 3

l(amal Rullah, Lam Xok Wai, Mohd Nazri Abdul
Baharl, Syahlda Ahmad, Chau LlngTham,
lftozirah Shaari, Nordin H. Iails
Design, Synthesis and Anti-inflammatory Activity
Evaluation of Novel Diarylpentanoid Derivatives

faved Musarrrt Abdulazlz A. Al'Khedhairy
Cytotoxicity, Cell Cycle Arresg and lnduction of
Apoptnsis by ATRA Hybrid Drugs in Hurnan Breast
and Liver Cancer Cell Lines
0 B I 3; Md.MELmld4.UlgO Sltl Zalton Mat Soad,
Tg M Fark Spfiq, Md.Taher, falifah LaHp,
Faredlah Ahma4 Qamar Uddln Ahmed
lsolation. Charaherization anrl A Comparative
Cytotoxicity Study of Flavones lsolated hom
Tetraceru indico Merr.
OB14: M.lghEilbill, S.H. Gan, H, Faszahtul, M.F.
Wan Ezuml, W.M. Wan Maidiah andA.A. Nurul
lnhibitory Effeas of lrgnosus rhinocerus fTiger Milk
M ushroom) ExtracLs on Ovalbumin-lnduced Airway
lnflammadon

IKArsf,)
Heavier Group 15-based Organic Molecular Probes
for Neurodegeneradve Disease Research

Atrnad,fElaL Danny Geelen
Reguladon of p-Amyrin Synthase ln Triterpene
Saponin Production of Medicinal Plant Moeso
lanceoloto

OC 12:

OCf 3:

fufiL[cliltl,

Nlk Sorlrnl Yaacob Choon-

Sbeen l,al
Chemical Constituents of A Fraction of Strobtlanthes
cnqpus That lnhlblts Breast Cancer Cell Growth /n

Vitm
OCl4: Sarllru$dErt, Sharlfah Nurfazllah lYan
Yusop, M. Zalml Mohd Noor, Syed AdnanAli
Shah, El Hassane Anouar, lean-Fr6d6rlc F. Weber
Screening of New Microbial Strains for Bioconversion

of Physiologically Active Steroids: Experimental and
Theoretical Approaches

0A 1 5:

t{lk lotelrrntg3r' iltk AMullnh ?-wawl.

Muhammad Tahe, l{orlzan Ahmat Nor Hadlenl

lemall
12:25

-

l2:4O

12:40

-

12155

I 5:

ilorlah"Eerlr
J.

Olaylnka Ayotunde

Rtchle, Lutfun ilahar,

Nashwa ilostafa M. Osnan, Augela Stefford,

Hablblon Kushle% Asuman lGn
and Satyaflt D. Sarker

Synthesis and Evaluation of Benzlmidazole
Analogues Bearing Thiourea Derivarives As qGlucosidase lnhibitor

OAl6r

O B

Orldupa, Kenneth

low ttuk Wah

Next Generatlon NMR Spectrometers, Other New
Producs and Appllcations

Comparative Cytotoxicity Of Glycyrrhiza Glabra
Roots From Different Geographlcal Origins Against
lmmortal Human Keratinocyte {HaCaT), Lung
Adenocarcinoma (A549) And Liver Carcinoma
(Hepc2) Cells
OB16: Suleiman M AlnalJnat. ltllton Walnwrfht,
Salah labcr, Reda Amasha
Mechanism of the Antibacterial Action of
{Leptospermum scoparium) Manuka Oil on
Methicillin-resisunt Scoplrylo coccus o ureus (MRSA)
and E coli Determlned by Disc Dlffusion Assay. MlCs
and MBCs values. Time-Kill and Electron Microscopy

l3:0.1-:ll'90

t4;00 * 14:25

Chairperson:

Chairperson:

Prof. Ilr. Yoshlnorl Asakawa
lnvltcd Speaker 7:
Prof. Dr. Charles S. Valrappan
(Unlversi{ Melapla Sabah}
Marine Ecological Chemicals as Lead Pharmaceuticals

OA17: Belme Konuklugtl. B0lent G&zcelioflu,

P€ter Proksch
14t25

- t4:40

Some Secondary Metabolites From Endophytes
The Turkish Marine Sponges

of

Prof. Dr, Nordln Hi taiis
lnylted Speaker 8:
Prof. Dr.AmenlS Awaad
(Salman Bln Abdulazlz Unlverslty)
New Activitles for lsolated Compounds from
Convolvulus oustro-oe$rytiocus as Anti-Ulcerogenic,
Anti- Helicobader fflori and Their Mimic Synthesis
Using Bio-Guided Fracdonation
OBI 7: lavanlya $anlvannan. Nor Azeera Mohd
All, Ahmad Sukarl Hallm, Nor Hayad Othroan,
Kirnpal Kaur Banp Slnoh, Lald Boukraa, Serlngat
Bale, $ld Amrah Sulalman

Antibacterial Properties ofTualang Honey Spray and
Gel Formulations on Full Thickness Burn Wounds ln
Streptozotocin lnduced Diabetic Spragure-Dawley
Rats

OCt5: Amlrah lrVan Azmln, Nallb Yahaya S4nl.
Suleiman Danladl, l0ramsah Suryatl Mohd, Sharlf
ilahsuff Mansor, Saravanan Dharmaral
Classifi cation of Common Mela stomo ma laboth r ic u m
East Coast Malaysia using Metabolite Fingerprinting
by Means of Fourier Transformation lnfra Red (FTIR)

Spectral Analysis

OC16: Osman N-A., Elhusceln SA., Elzaln, M-4. M
Studies on Balonites aeg)lptiaca -- Formulation and In

lritro Evaluation of Balanite Kernel Oil (BKo)-based
Cream for the Treatment of Tinea copitis

Chalrperson:
Assoc. Prof. Dr. NorizanAhmat
Iwlted Speaker 9:

Dr. Marianl Abdut Hamld
(Unlverslts Teknologl ttlalaysla)
A New Discovery ofCosmeceudcal lngredients:

Alpha-Mags*

OC17r Chan Gomathl. Io€lBoustie, lftalliah Awang
C6ltne Le Qu6merer, Gr6golreAudo
Centrifugal Partition Chromatography (CPC): The
I nnovative Purification Technology

OA1 8: C[luSCcL[bn, $hcan-Ycaw tg, f un-A
Xlm, You.lln feon and Chrrles Santhanarafu

14:40

- l4:55

Vairappan
Sinugermacrane

A and B, Bioacrive Secondary

pentandro Extracts Towards Human Breast
Adenocarcinoma (MCF-7) Cells

OAl9llhOflf,lUlf,

OB19:flilrlawad. A.T: Manalu, W; Suparto, l.H;

C. S.

Matbela, Geeta Tewari,

Monoterpene lridoid and Acetylenic Compounds For
Crop Pest Management

Fauzlrh Abdullah,

ilesilrr

Mobter, Olg Boo

Kean, Vlmale Subramanlam, NorAzah Mohamrd

Ali, Maty l0roo, Nuzlah Hashln and Mohd lnnan
$hah Musafar

Metabolites From Borneon Soft Coral, Sirularla sp.

A. K. Pandey

l4:55 - 15:10

Nth Xnlnuddlut, Ugbd
OBlS: Nlk
De$rkl SUI'tln
Antiproliferative Effects of Various Dcndropthoe

Development of Plant Based Cosmetic Preseryative
I ngredient Fronr Piper Sp.

Mauboy, RS
Potential of The marine Sponge Clathria basilana
Extracts As Antioxidant and Anticancer

oc19:MWanMohd
Zahtruddin lfIan Mohamrnad, Murtafr Musa,
Mahlran liustrfa, famaruddin Mat Asan, Sltl
Amrah Sulaiman
Tualang Honey Has The Potential'fo lmprove The
Quality of Life and Viral Load In Asymptomatic
Human lmmunodeficiecy Virus (HlV) Patients

OA20:

15:10

*

15:25

OA21:
15:25

-

15:40

IlnqyJlll'llstr&

Melad Xhalruddean,

Cboon-Sheen [al
lsolation and Strurture Elucidatlon of Chlorin
cnmpounds From Strorirqnthes crispus and Their
Cytotoxic Actlvities

I$AthLf,.mrulo Talshlro lshll,

Cherles

Santlanaraf u Vairappan
Bioactive Halogenated Chamigrenes fmm Bornean
Red Algae laurencia maJuscule

lEull&dlnlJamL Eldlza Pull Rahml,
Endang Kumolosasl, Nor-Ashila Aladdin
Labisia pumilo Inhibited lnflammation lnduced By
Monosodlum Urate Crystals ln Vltra and ln Vivo

OB20:

OC20:WNorAzah

Ittoharned All, Vimah Subramanlem, Shallnl

f,larkandan, Zunollza Abdrlhh, Azrlna Azl& Mohd
Fari& Zoll Patrh
f,ffect of Different Tempemhtre and Stirring
Conditions on Toal Phenollc Content and Antioxi&nt
Acdvity in Aquihria Leaf Tea.

OB21:

Armagihp Sh&er. Abdalrehlm

F.A.

Aisha

&erllsmail
Anti-Hypertension Studies of Orthosiphon stsminew
Nano Liposomes

OC21:

Ahmed-Erdirnl Farldah Abas, Alfi Khatlb,

Tar Chlr Plng lntan Saffnar lsmail, lftoatrah

Shaarl, Amln lsmall, I{.H. lafts
Phytochemical and Biological Features of Phyllanthus
nirurt and Phyllanthus urlnaria Harvested at Different

Crowth Ages Revealed

by IH'NMR

Based

Metabolomics Analysis
15:40

- t6:00

Tea Break and Pocter Sesslon

Chairperson:
Assoc Prof. Dr.Azlan Haffah
OA22:
16:00

- l6:15

XOrEro31EIrOlL

Sul Kiong Ling, Vyomesh

Patel and Pel fean Tan
Cytotoxic Compounds Fmm Bracea javanica Root

Chalrperson:
Assoc. Prof. Dr. latlfah

Chairperson:

ladp

OB22; Mukram llohaned ltlackeen
Total Synthesis and Stnrctural Characterisation of
The Erad Glucosylated Tetraseccharidc

Glc3ManMoiety

Prof. Dr.

Mohd.Ali

Kamal l0raltfa Taha, Setrr.Ahpcd-Khalll
Corrosion lnhibition ofCarbon Steel in 1 M HCI
OC22:

Solution by Methanolic Extract of Agaruood Leaves

I
i

OA23

:

H.LEOI&

G. M.

Llw,

A.

K Sayoh C l.

Kutol
l6:15 * 16130

Phytochemical Screenlng and Blological Activities of
Selected lndlgenous Mediclnal Plants From Mount
Singai, Sarawak
OA 24:

16:30

- l6:45

Bghag1|hUr{

ItIu

rsyaza Husns

Shahamddln, Nur Haklmah Abdutlah, Nurliayana
Ibrahim. Nor Hadlani lsmall, Nurhuda Manshoor,
Fatimah Salim
Metabolite Profillng and Quantification of Flavonoids
of Malaysian Uncario Spp

l6:45 - l7:00

OB23 : Maqsood

A Slddl{ul. Nlda N. Farchorl,
Ebtesam S. Al-Sheddl, Mal M. Al-Oqall, faved

OC23:

Musarrat, AMulazlz A. Al-lftedhalry
Seed Exbact of Lepidium sativum lnhibits Hydrogen

Chlorogenic Acld, Caffeine and Toul Phenolic
Content ln Coffeo arabica aod Coffea liberico

Peroxide-lnduced Cytotoxicity and Oxidative Sress
ln Human Llver Cell Line (HepG2)
0824: $heaq-Yeew I{g Eun-A XIm, You-Iln leon,
ilonlca Suleiman, Charles Santhanaraf u

fforArccrr-llohlAll lavanlya
Manlvlnnan, Rumalzl Shearl, Nor Hayatl Othman,
oC24:

Valrappan

516

Cytotoxicity Activity From Selected Borneon
Liverworts Against HL-60 Human Promyelocytic

LongTerm Administration Of Camma lrradiated
Tualang Honey ln Specific Pathogen Free Sprague-

Leukemia

Dawley Rats

0A25: lor-Hly$LAbddhh, lftellfah Awang
Yasodha Slvasothy, Khallt ilohemad, Llrg Sul

OB25:

l(Iong

Cardamonin lnduces Apoptosis in Human
Nasopharyngal Carcinoma Cells vio Mltochondrial

lsolation of New lridoid From Prismatomeris

Ardllla Mubarak. Catherlne P. Bondonno,
Kevln D. Croft

UlctrelhllLl& Chlew-Foen
l{laft, Terry-f ln l(hoo

ChIn,

Chrtstophe

Amrah Sulalman

OC25r

Yuldchllq Narate

Utillzation of Wild Meat for Rural Sustainability: A
Case offapanese Deer

Death Pathway Mediated by Caspase-3 and CaspaseActivation, lnUependent of Caspase- 9 Signalling

temndm

B

Responses

17:00

- 17:15

OA26: ttlelson GDear leqg Yeou. Lai Choon Sheen,
Vikne*vara n Murugalyah
Antioxidant Activities and Chemical Constihrents of
Ed ible Fern, Stcn ochl o e na polustrls (Paku M i d in) At

OC26:

IlfalimJL-SeltL Naslr, Mohamad, Mohd.

Adzlm l0mllll Rohln

Antioxidant Potential of Phoenix dactylifera
Mariami Date Fruits

Two Stages of Maturity

26tr March Z0rS (THURSDAY)
POST COilTERENCE WORKSilOP

08:00

*

15:30

Centrlfugal Partition Chrometography (CPC) -The lnnoyadve Purlficadon Technlque
of

08:00

-

17100

POST CONFERENCE TOUR

L.

$****OUTM J&

Propellirg Scierce and Technolry through Natural Prodw*

P51

DETERMI NATION OF CYTOTOXICITY, NE U ROTOXICITY A N D
NEUROPROTEECTION ACTIVITIES OT' SELECTED MALAYSIAN FRUITS
Rosmawati Ahdul Aziz*rJn Norizan Ahmltr'2, Mazatulikhma Mat Zrint, Siti Haziyah Mohd

Chachulil
t

Faculry oJ'Applied Sciences, {Jniversiti'l'elcnologi MARA, 40450 Shah Alam, Selungtr Darul Ehrun.

Malaysia
:Atta-w-Rahman Institutefor Namral Product Discewery, Universiti |'tlotologi MARA, Puncuk Alarn

(amFus'42300*an*;::;:::{,i#;,:::;:tr;:,,i:::,ffi

.#;tuvsia'

'I'he peel crude exfiacts of thc six typical Malaysian fruits wcre evaluated for their
cytotoxicity, neurotoxicity and neuroprotection activities. Thc selected fruits were
mangosteen, durian, rambutan, dokong, jackfruit and sapodilla. The fmit peels were extracted
using ethanol. Six concentrations of the extracts; 100 pglml, I ng/ml, l0 ng/ml. l0Onglml.
lfrgiml and l0 pgiml were uscd to determine the activities. Cytotoxicity activities werc tested
against SII-SYSY cell line for incuhation 24 hours and 48 hours. Cell viability was asscssed
tbr this test. Mangosteen extract showed significant cytotoxic activity (108.4 % cell viabiliry'l
against S[{-SY5Y cell line for incubation 24 hours whilc iackfruit extract displayed highest
activity {121.2 o/o) for 48 hours incubation. For neurotoxicity test, dokong pccl extract gave
the highest cell viability $A2 o/o) at l0ng/ml, whilc jackfiuit and rambutan produced thc
lowest cell viability (less than 82o/o\ at l0 pg/ml. Neuropnrtection activity u,ere determined
on the peel extract which induced with hydrogen peroxide-indtrced ccll damage (ICso) and
incubated for 24 hours. The results showed durian and dokong (both I ng/ml) presented cell
viability 88 % and 85 7o respectively, which is greater than ICso (50 % cell viability), while
rambutan showed lowest cell viability t42.2o/o) at I pe/ml). The results showed that all of the
crude extracl.s were not toxic to the cells and also possessed newoprotective ell'ect towards
neuronal cells. At low concentration, the fruit peel extract presentcd good neuroprotection
etlect toward SH-SY5Y ccll line.
P52
PHYSALIS MINIMA DECREASED BLOOI} PRNSSURE AND IMPROVED
VASCULAR ENDOTITELIAL IMPAIRMENT IN OVARIECTOMIZED RATS
Nur Permatasari', Dian Nugrahenny, Setyawati Soeharto
Medical Faculty of Brawijaya Universilv. Jln Veteran, Malang, 65145, Indanesia
*Corresponding author: permatasarirazaq.fk@.ub.ac. id

Physalis minima is an important genus of thc Solanaceae family sontains natural stcroids,
withanolides. The study was to evaluate the effccts of methanolic extract of Ph_vsalis minima
(MEP) on blood pressure and vascular endothelial in ovariectomized rats. Twenty femalc
Wistar rats were subjected to bilateral ovaiiectomy. After fivc weeks, ovariectomized rats
(ovx) were randomly divided intcl five groups, tluee gpoups of ovx rats treated rvith MEP at
dose of 500, 1500, and 2500mg, mg/kgBW, respectively for four weeks, and two group as a
ovariectomized con&ol groups (ovx 5 weeks and 9 wccks). In addition, four female rats
without any treatment were provided as a nonnal group. Systolic hlood pressrue (SBP) was

ICNP2015

24-25 March

2015

I

DoubleTree by Hilton, fohor Bahru, fohor, MALAYSIA

$,,,,,,*.,

@uru

vl,

Proprlling kierce

ctd

Technology through

Naaral Produc5

cvaluated using animal blood prcssure aralyzel. Thoracic aorta rings were isolated tbr the
endothelial lunction analysis. l'he amount ofendothelial cell oflhoracic ao as were observe