“Studies of depressive symptoms in schizophrenia”

Brit.J.
Psychiat.
(1981),
139,89—101

Studies of Depressive Symptoms in Schizophrenia
The Prevalence of Depression and its Possible Causes
D. A. W. JOHNSON
Summary: Depression assessedby clinical examination and Hamilton rating
scale was found in half of 37 untreated new acute schizophrenics,and in about a
third of chronic schizophrenics who relapsed whether treated with depot
injections (89) or not (79). A significant part of depressive illness in schizo
phrenics is thus not drug-related. However, depression was commoner in those
on higher doses of depot neuroleptic (P 2515—1920—25>25(a)First

Sample
NDepressionpresentBDI

ratingsHRS15—19

illness schizophrenia. No previous

drugs
Depression present on admission

History of depression in previous

-(b)Chronic

two months
Total depression37

30

377

11
184

-

-

-1

-0

-4

-2

-1

schizophrenia: Relapse, not on
drugs79242211482(c)Chronic

schizophrenia: Relapse, on

depotmedication8934149416144(d)Patients
in remission on depot
medication
2 month prospective study of

random sample
15month surveyof prescribed
antidepressants
Nurses' surveyof random sample41

140

10010

mean age of patients with a first illness (21.7 years)
was younger than the mean ages of the other groups
(27—31years). In all groups there were an excess of
female patients (51—64per cent) except the chronic
schizophrenic patients relapsing on drugs where there
was anexcess of males (56 per cent).
Only two depot preparations were used for the
patients on regular medication (fiuphenazine de
canoate N = 176; fiupenthixol decanoate N = 112).
No other form of neuroleptic drug was used, except

occasionally in acutely relapsed patients. There was no
difference in the frequency or severity of depression
between patient groups on the two drugs.
An analysis of dose schedules and the presence of
depression showed less depression with lower dose in
all groups but this only reached a level of significance
(P 20mg2716Fluphenazine
flupenthixol

= 12.5mg or
20mg4916Fluphenazine
fiupenthixol =