ISSN:2252-8806
IJPHS Vol. x, No. x, Month201x : xx – xx 34
effect to people’s living quality[7]. This research used Brief Pain Inventory questioner, in which questioner was able to represent: general activities, mood situation, walking capability, usual chores, relationship with other people, and
the way to enjoy life.This questioner has lowest score which means to have the best living quality. The processing data of the questioner result score used t-test with trust rate 95 by comparing the mean rate of patients’ living
quality.
Measurment of living quality value used score with 0-10 scales in which score 0 meaning that it did not disturb, and score 10 was very disturbing, so the less the score, the better living quality the patients have.The result
of this research also shows that both gabapentin group and amitriptilin group show living quality decrease if it was compared before and after the theraphy. The result of the analysis is presented in Table 2.
Table2. Mean Score of Living Quality of Patients with PostNyeriPain in the Initial Condition
Description Gabapentin Group
mean±SD Amitriptilin Group
mean±SD Week O
Week 4 p-value
Week O Week 4
p-value
Daily Activities 4.83±2.19 3.00±1.76 0.00 4.50±1.98 2.94±1.69 0.00
Mood Situation 3.91±1.99
2.35±1.27 0.00 4.22±2.24 2.44±1.19 0.00 Walking Ability
5.22±2.09 3.17±1.59 0.00 3.11±2.35 2.00±1.41
0.00 Daily Chores
4.78±2.11 3.13±1.71
0.00 4.22±1.96 2.89±1.75 0.00 Relationship with
Others 4.43±2.15 2.91±1.62
0.00 3.06±1.79 1.89±0.83 0.00 Sleeping Quality
3.30±2.64 1.83±1.80 0.00 3.33±2.47 2.06±1.66
0.00 Enjoying Life
4.13±1.91 2.52±1.41 0.00 3.50±2.04 2.17±1.25 0.00 Whole Living
Quality 26.49±11.08 16.39±8.14 0.00 22.44±9.85 14.22±6.98
0.00 Mean Value of
Living Quality 4.37±1.82 2.70±1.34
0.00 3.71±1.64 2.34±1.14 0.00
independent test result of t-test Based on the table 2, it can be known that the mean score of initial whole living quality in gabapentin group
got 4.37±1.82. After getting 1 month theraphy, they were re-measured,and the result was 2.70±1.34. Systematically there was decrease 1.67 strengthening by paired sample t-test which got p-value 0.00p0.05 meaning that it was
statistically different significant, while amitriptilin group got 3.71±1.64.After getting the theraphy for 1, the patients were re-examined, and the result got was 2.34±1.14. Systematically, there was decrease 1.37 strengthening
by paired sample t-test normal data distributed getting p-value 0.00p0.05. It means that it was statistically different significant.
The explanation above shows that the use of gabapentin andamitriptilin can increase the patients’ living quality shown by the decrease of BPI score.There is also the examination of pain intencity, and there was decrease of pain
scale by using VAS scale 2.87±1.33 for gabapentin group, and 2.44±0.78 for amitriptilin group in 1 month. Pain intencity could also affect the patients’ living quality because the patients do not experience long term pain
disturbance, so the patients would feel more comfortable to the disease they had. The idea is similar to Smith 2012 mentioning that patients with neurophaty pain can increase their living quality if they have good living
management[8]. Connor 2009 also mentions that the repairment of living quality is strongly correlated to the increase of living quality[9].
In addition, the comparison of using amitriptilin and gabapentin as a neurophaty pain therapy of post stroke is not included in the list of medicine leaphet, so the use still becomes off label use because there were not enough
researches that supported the effectivity of both medicines in pain management of post stroke neurophaty. So far there are two Randomized Control Trial investigating the comparison of the theraphy effect of gabapentin and
amitriptilin; those are Diabetic Peripheral Neurophaty Pain DPN Morello et. al., 1999 and Spinal Cord Injury Rintala et. al., 2007[10],[11]. The result of Morello’s research 1999 reported that 52 11 of 21 patients got
gabapentin cure daily dosage 1.565 mg and 67 14 of 21 with amitriptilin daily dosage 59 mg. The research shows that the cure of both medicines candecreasase pain intencity, but it could not reflect the comparison
effectivity between gabapentin and amitriptilin.
In this research, the investigation was seen from the difference of the initial and the end mean score of the patients’ living quality, and those two groups were compared. The objective was to see from which group that was
able to repair the patients’ living quality after stroke. Based on the table 3 it can be known that the whole living
IJPHS ISSN: 2252-8806
Title of manuscript is short and clear, implies research results First Author 35
quality of the patients got Mean result±SD. Systematically, gabapentin group was better than amitriptilin group. However, after they were tested by using independent t-test sample normal distribution, significance score was
p0,05 meaning that in this research the change of living quality of gabapentin group and amitriptilin group was not significantly different statistically not significant.The result of the analysis is presented in Table 3.
Table3.Mean Score of Living Quality Difference of Post Stroke Pain Patients
Explanation Gabapentin Group
mean±SD Amitriptilin
Group mean±SD
p-value
Daily Activities 1.83±1.23 1.56±0.98 0.53
Mood Condition 1.57±1.16 1.78±1.35 0.71
Walking Ability 2.04±1.43 1.11±1.23 0.03
Usual Chore 1.65±1.07 1.33±0.97 0.34
Relationship with Other People 1.52±1.08
1.17±1.25 0.18
Sleeping Quality 1.48±1.38 1.28±1.23 0.66
Enjoying Life 1.61±0.89 1.33±1.09 0.15
Whole Living Quality 10.87±4.90 8.22±4.81
0.22 Mean Value of Difference Living Quality
