WHAT IS IN STORE FOR THE FUTURE?

III. WHAT IS IN STORE FOR THE FUTURE?

A multidisciplinary approach will be necessary to overcome the challenges associated with the development of ocular mucoadhesives. A nonbiodegrad- able adhesive is adequate for topical use to treat perforations and ulcera- tions. However, the use of a nontoxic biodegradable surgical adhesive is deemed necessary for long-term use in ocular drug delivery. Mucoadhesives can make an important contribution in this area. An ideal ocular mucoadhesive would be site specific, durable for the desired period of time, biodegradable, and above all nontoxic, nonimmunogenic, and nonir- ritant. It would be even better if the adhesive could serve as absorption enhancers (for therapeutic protein and peptide drugs) and/or as enzyme inhibitors.

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