3282–7. J. Reynolds Tobacco Company 1988. New cigarette prototypes that heat instead of burn tobacco.

Boffetta, P., Mashberg, A., Winkelmann, R., and Garfinkel, L. 1992. Carcinogenic effect of tobacco smoking and alcohol drinking on anatomic sites of the oral cavity and oropharynx. Int J Cancer 52, 530–33. Boyle, P., Macfarlane, R., McGinn, R., Zheng, T., La Vecchia, C., Maisonneuve, P., and Scully, C. 1990a. International epidemiology of head and neck cancer. In: Multiple Primary Tumors in the Head and Neck ed. N. de Vries, and J.L. Gluckman, pp. 80–138. Thieme Medical Publishers, Inc. Boyle, P., Macfarlane, G. J., Maisonneuve, P., Zheng, T., Scully, C., and Tedesco, B. 1990b. Epidemiology of mouth cancer in 1989. J Royal Soc Med 83, 724–729. Boyle, P., La Vecchia, C., Maisonneuve, P., Zheng, T., and Macfarlane, G. J. 1995. Cancer epidemiology and prevention. In: Oxford Textbook of Oncology ed. U. Veronesi, M.J. Peckham, and R. Pinedo, Oxford University Press, Oxford. Brenna, J. A., Boyle, J. O., Koch, W. M. 1995. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. N Engl J Med 332, 712–7. Brunnemann, K. D. and Hoffmann, D. 1993. Chemical composition of smokeless tobacco products. Monograph 2. Smokeless tobacco or health: An international perspective. NIH publication No, 93-3461:96-1.5. Brunnemann, K. D., Prokopczyk, B., Djordjevic, M. V., and Hoffmann, D. 1996. Formation and analysis of tobacco-specific N-nitrosamines. Crit Rev Toxicol 26, 121–37. Bundgaard, T., Wildt, J., Frydenberg, M., Elbrond, O., and Nielsen, J. E. 1995. Case-control study of squamous cell cancer of the oral cavity in Denmark. Cancer Causes Control 6, 57–67. Chyou, P. H., Momura, A. M. Y., and Stemmermann, G. N. 1995. Diet, alcohol, smoking and cancer of the upper aerodigestive tract: A prospective study among Hawaii Japanese men. Int J Cancer 60, 616–21. Day, G. L., Blot, W. J., Shore, R. E., McLaughlin, J. K., Austin, D. F., and Greenberg, R. S. 1994. Second cancers following oral and pharyngeal cancers: Role of tobacco and alcohol. JNCI 86, 131–7. Day, G. L., Blot, W. J., Austin, D. F., Bernstein, L., Greenberg, R. S., Preston-Martin, S., et al. 1993. Racial differences in risk of oral and pharyngeal cancer: Alcohol, tobacco, and other determinants. JNCI 85, 465–73. Elwood, J. M., Pearson, J. C. G., Skippen, D. H., and Jackson, S. M. 1984. Alcohol, smoking, social and occupational factors. The aetiology of cancer of the oral cavity, pharynx and larynx. Int J Cancer 34, 603–12. De Stefani, E., Boffetta, P., Oreggia, F., Fierro, L., and Mendilaharsu, M. 1998. Hard liquor drinking is associated with higher risk of cancer of the oral cavity and pharynx than wine drinking. A case-control study in Uruguay. Oral Oncol 34, 99–104. Franco, E. L., Kowalski, L. P., Oliveira, B. V., Curado, M. P., and Pereira, R. N. 1989. Risk factors for oral cancer in Brazil: A case-control study. Int J Cancer 43, 992–1000. Franceschi, S., Levi, F., La Vecchia, C., Conti, E., Maso, L. D., Barzan, L., et al. 1999 Comparison of the effect of smoking and alcohol drinking between oral and pharyngeal cancer. Int J Cancer 83, 1–4. Franceschi, S., Barra, S., La Vecchia, C., Bidoli, E., Negri, E., and Talamini, R. 1992. Risk factors for cancer of the tongue and the mouth. Cancer 70, 2227–33. Franceschi, S., Talamini, R., Barra, S., Baron, A. E., Negri, E., Bidoli, E., et al. 1990. Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in Northern Italy. Cancer Res 50, 6502–7. Franceschi, S., Bidoli, E., Herrero, R., and Munoz, N. 2000. Comparison of cancers of the oral cavity and pharynx worldwide: Etiological clues. Oral Oncol 36, 106–15. Garrote, L. F., Herrero, R., Reyes, R. O., Vaccarella, S., Anta, J. L., Ferbeye, L., et al. 2001. Risk factors for cancer of the oral cavity and oro-pharynx in Cuba. Br J Cancer 85, 46–54. Geisler, S. A. and Olshan, A. F. 2001. GSTM1, GSTT1, and the risk of squamous cell carcinoma of the head and neck: A Mini-HuGE review. Am J Epidemiol 154, 95–105. Grasso, P. and Mann, A. H. 1998. Smokeless tobacco and oral cancer: An assessment of evidence derived from laboratory animals. Food Chem Toxicol 36, 1015–29. Gupta, P. C., Murti, P. R., and Bhonsle, R. B. 1996. Epidemiology of cancer by tobacco products and the significance of TSNA. Crit Review Toxicol 26, 183–8. Gupta, P. C., Mehta, F. S., Daftary, D. K., Pindborg, J. J., Bhonsle, R. B., Jalnawalla, P. N., et al. 1980. Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10-year follow-up study of India villagers. Community Dent Oral Epidemiol 8, 287–93. Hammond, E. C. and Seidman, H. 1980. Smoking and cancer in the United States. Prevent Med 9, 169–73. Hayes, R. B., Bravo-Otero, E., Kleinman, D. V., Brown, L. M., Fraumeni, J. F., Jr., Harty L. C., et al. 1999. Tobacco and alcohol use and oral cancer in Puerto Rico. Cancer Causes Control 10, 27–33. Hirayama, T. 1966. An epidemiological study of oral and pharyngeal cancer in Central and South- East Asia. Bull WHO 34, 41–69. Hoffman, D., Brunnemann, K. D., Prokopczyk, B., and Djordjevic, M. V. 1994. Tobacco-specific N-nitrosamines and areca-derived N-nitrosamines: Chemistry, biochemistry, carcinogenicity, and relevance to humans. J Toxicol Environ Hlth 41, 1–52. Hoffman, D. and Djordjevic, M. V. 1997. Chemical composition and carcinogenicity of smokeless tobacco. Adv Dent Res 11, 322–9. Hsieh, L. L., Wang, P. F., Chen, I. H., Liao, C. T., Wang, H. M., Chen, M. C., et al. 2001. Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese. Carcinogenesis 22, 1497–503. Hung, H. C., Chuang, J., Chien, Y. C., Chern, H. D., Chiang, C. P., Kuo, Y. S., et al. 1997. Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1, environmental factors and risk of oral cancer. Cancer Epidemiol Biomark Prevent 6, 901–5. Idris, A. M., Ahmed, H. M., and Malik, M. O. A. 1995. Toomak dipping and cancer of the oral cavity in the Sudan: A case-control study. Int J Cancer 63, 477–80. International Agency for Research on Cancer 1986. Monograph 38, Tobacco Smoking. International Agency for Research on Cancer, Lyon, France. International Agency for Research on Cancer 1985. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: Tobacco habits other than smoking: betel-quid and areca-nut chewing; and some related nitrosamines. Vol. 37, p. 116. International Agency for Research on Cancer, Lyon, France. Jayant, K. and Deo, M. G. 1986. Oral cancer and cultural practices in relation to betel quid and tobacco chewing and smoking. Cancer Detect Prevent 9, 207–13. Jayant, K., Balakrishnan, V., and Sanghvi, L. D. 1971. A note on the distribution of cancer in some endogamous groups in Western India. Br J Cancer 25, 611–9. Johnson, N. 2001. Tobacco use and oral cancer: A global perspective. J Dent Educat 65, 328–39. Jones, A. 1998. A general review of the p53 gene and oral squamous cell carcinoma. Ann Roy Australas Coll Dent Surg 14, 66–9. Jones, N. J., McGregor, A. D., and Waters, R. 1993. Detection of DNA adducts in human oral tissue: Correlation of adduct levels with tobacco smoking and differential enhancement of adducts using the butanol extraction and nuclease P1 versions of 32p postlabeling. Cancer Res 53, 1522–8. Jussawalla, D. J. and Deshpande, V. A. 1971. Evaluation of cancer risk in tobacco chewers and smokers: An epidemiologic assessment. Cancer 28, 244–52. Kabat, G. C., Chang, C. J., and Wynder, E. L. 1994. The role of tobacco, alcohol use, and body mass index in oral and pharyngeal cancer. Int J Epidemiol 23, 1137–44. Kabat, G. C., Hebert, J. R., and Wynder, E. L. 1989. Risk factors for oral cancer in women. Cancer Res 49, 2803–6. La Vecchia, C., Franceschi, S., Bosetti, C., Levi, F., Talamini, R., and Negri, E. 1999. Time since stopping smoking and the risk of oral and pharyngeal cancers. JNCI 91, 726–7. La Vecchia, C., Bosetti, C., Negri, E., Levi, F., and Franceschi, S. 1998. Cigar smoking and cancers of the upper digestive tract. JNCI 90, 1670. La Vecchia, C., Bidoli, E., Barra, S., D’Avanzo, B., Negri, E., Talamini, R., et al. 1990. Type of cigarette and cancers of the upper digestive and respiratory tract. Cancer Causes Control 1, 69–74. La Vecchia, C., Tavani, A., Franceschi, S., Levi, F., Corrao, G., and Negri, E. 1997. Epidemiology and prevention of oral cancer. Oral Oncol 33, 302–12. Lewin, F., Norell, S. E., Johansson, H., Gustavsson, P., Wennerberg, J., Biorklund, A., Rutqvist, L. E. 1997. Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck. Cancer 82, 1367–75. London, S. J., Daly, A. K., Cooper, J., Navidi, W. C., Capenter, C., Idle, J. R., et al. 1995. Polymorphism of gluathione S-transferase M1 and lung cancer risk among African Americans and Caucasians in Los Angeles County, California. JNCI 87, 1246–53. Macfarlane, G. J., Boyle, P., Evstifeeva, T. V., Robertson, C., and Scully, C. 1994. Rising trends of oral cancer mortality among males worldwide: The return of an old public health problem. Cancer Causes Control 5, 259–65. Macfarlane, G. J., Zheng, T., Marshall, J. R., Boffetta, P., Niu, S., Brasure, J., et al. 1995. Alcohol, tobacco, diet and risk of oral cancer: A pooled analysis of three case-control studies. Oral Oncol, Eur J Cancer 31B, 181–7. Marshall, J. R., Graham, S., Haughey, B. P., Shedd, D., O’Shea, R., Brasure, J., et al. 1992. Smoking, alcohol, dentition and diet in the epidemiology of oral cancer. Oral Oncol, Eur J Cancer 28B, 9–15. Mashberg, A., Boffetta, P., Winkelman, R., and Garfinkel, L. 1993. Tobacco smoking, alcohol drinking, and cancer of the oral cavity and oropharynx among U.S. veterans. Cancer 72, 1360–75. Merletti, F., Boffetta, P., Cicone, G., Msshberg, A., and Terracini, B. 1989. Role of tobacco and alcoholic beverages in the etiology of cancer of the oral cavityoropharynx in Torino, Italy. Cancer Res 49, 4919–24. Moreno-Lopez, L. A., Esparza-Gomez, G. C., Gonzalez-Navarro, A., Cerero-Lapiedra, R., Gonzalez- Henandez, M. J., and Dominguez-Rojas, V. 2000. Risk of oral cancer associated with tobacco smoking, alcohol consumption and oral hygiene: A case-control study in Madrid, Spain. Oral Oncol 36, 170–4. Muscat, J. E., Richie, J. P., Thompson, S., and Wynder, E. L. 1996. Gender differences in smoking and risk for oral cancer. Cancer Res 56, 5192–7. Nandakumar, A., Thimmasetty, K. T., Sreeramareddy, N. M., Venugopal, T. C., Rajanna, Vinutha, A. T., et al. 1990. A population-based case-control investigation on cancers of the oral cavity in Bangalore, India. Br J Cancer 62, 847–51. Negri, E., La Vecchia, C., Franceschi, S., and Tavani, A. 1993. Attributable risk for oral cancer in Northern Italy. Cancer Epidemiol Biomark Prevent 2, 189093. Nordgren, P. and Ramstrom, L. 1990. Moist snuff in Sweden: Tradition and evolution. Br J Addict

85, 1107–12.

Notani, P.N. 1988 Role of alcohol in cancers of the upper alimentary tract: Use of models in risk assessment. J Epidemiol Commun Hlth 42, 187–92. Park, J. Y., Schantz, S. P., Stern, J. C., Kaur, T., and Lazarus, P. 1999. Association between glutathione S-transferase π genetic polymorphisms and oral cancer risk. Pharmacogenetics 9, 497–504. Parkin, D. M., Pisani, P., and Masuyer, E. 2000. Tobacco-attributable cancer burden: a global review. In: Tobacco: The Growing Epidemic, Proceedings of the Tenth World Conference on Tobacco or Health ed. R. Lu, J. Mackay, S. Niu, and R. Peto, 24–28 August 1997, Springer-Verlag London Limited, Beijing, China. pages 81–84. Ralhan, R., Nath, N., Agarwal, S., Mathur, M., Wasylyk, B., and Shukla, N. K. 1998. Circulating p53 antibodies as early markers of oral cancer: Correlation with p53 alterations. Clin Cancer Res 4, 2147–52. Rao, D. N., Ganesh, B., Rao, R. S., and Desai, P. B. 1994. Risk assessment of tobacco, alcohol and diet in oral cancer—A case-control study. Int J Cancer 58, 469–73. Rothman, K. and Keller, A. 1972. The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chron Dis 25, 711–6. Sanghvi, L. D., Rao, K. C. M., and Khanolkar, V. R. 1955. Smoking and chewing tobacco in relation to cancer of the upper alimentary tract. BMJ I, 1111–4. Saranath, D., Tandle, A. T., Teni, T. R., Dedhia, P. M., Borgens, A. M., Parikh, D., et al. 1999. p53 inactivation in chewing tobacco-induced oral cancers and leukoplakias from India. Oral Oncol 35, 242–50. Sato, M., Sato, T., Izumo, T., and Amagasa, T. 2000. Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes. Oral Oncol 36, 267–71. Sato, M., Sato, T., Izumo, T., and Amagasa, T. 1999. Genetic polymorphism of drug-metabolizing enzymes and susceptibility to oral cancer. Carcinogenesis 20, 1927–31. Schildt, E. B., Eriksson, M., Hardell, L., and Maonuson, A. 1998. Oral snuff, smoking habits and alcohol consumption in relation to oral cancer in a Swedish case-control study. Int J Cancer 77, 341–6. Schlecht, N. F., Franco, E. L., Pintos, J., and Kowalski, L. P. 1999. Effect of smoking cessation and tobacco type on the risk of cancers of the upper aero-digestive tract in Brazil. Epidemiology 10, 412–8. Schwartz, S. M., Daling, J. R., Doody, D. R., Wipf, G. C., Carter, J. J., Madeleine, M. M., et al. 1998. Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. JNCI 90, 1626–36. Shanks, T. G. and Burns, D. M. 1998. Disease consequences of cigar smoking. Smoking and Tobacco Control Monograph 9 Cigars. Health effects and trends. Bethesda MD, pp. 105–158. National Institutes of Health, Report No: DHHS Publ No. NIH 98-4302. Shapiro, J. A., Jacobs, E. J., and Thun, M. J. 2000. Cigar smoking in men and risk of death from tobacco-related cancers. JNCI 92, 333–7. Spitz, M. R., Fueger, J. J., Goepfert, H., Hong, W. K., and Newell, G. R. 1988. Squamous cell carcinoma of the upper aerodigestive tract. Cancer 61, 203–8. Sterling, T. D., Rosenbaum, W. L., and Weinkam, J. J. 1992. Analysis of the relationship between smokeless tobacco and cancer based on data from the national mortality followback survey. J Clin Epidemiol 42, 223–31. Talamini, R., Vaccarella, S., Barbone, F., Tavani, A., La Vecchia, C., et al. 2000. Oral hygiene, dentition, sexual habits and risk of oral cancer. Br J Cancer 83, 1238–42.