DEVELOPMENT OF MELOXICAM TRANSDERMAL MATRIX TYPE PATCH USING POLYVINYLPYRROLIDONE, HYDROXYPROPYL METHYCELLULOSE, AND ETHYL CELLULOSE COMBINATION
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Drug Deiivery Systems:
From Drug-Discovery, Pre-formulaticn, Formulation and Technological Approaches for
Poorly Soluble Drugs and Protein
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The l"t lnternational conference on Pharmaceutics
& Pharmaceutical Sciences Proceedings
ISBN : 97 8-5A2-72333-0-0
Date 18 March 2015)
(Letter of National ISBN Agency No' 4L27lE'slp/03'2015
1st edition Proceeding
Published bY:
Faculty of Pharmacy Universitas Airlangga
Surabaya, lndonesia
Address:
Kampus B Jl. Dharmawangsa Dalam
Surabaya 60286
Phone +62315033710
Fax +62 31 5020514
Website : www.icpps2014.com or wwwff'u na i r'ac'id
Email: icppinfo@gmail.com
rsBN 1?A-t0e-?e333-0-tl
.IIil!Jil[UruUuuililil
PREFACE
From Chairman
It is our pleasure to
present you the proceedings of The Lst lnternational Conference on
Pharmaceutics and Pharmaceutical Sciences (ICPPS) organized by The Faculty of Pharmacy
Universitas Airlangga Surabaya lndonesia.
The proceeding was produced based on papers and posters presented at The
1st
lnternational
Conference on Pharmaceutics and Pharmaceutical Sciences (ICPPS), held in Surabaya, lndonesia, 14-
15November2014.
The proceeding clearly reflects broad interest, from the participants that coming from all around the
world.
The papeJ$presented were pharmaceutics and biopharmaceutics; requirements on howto evaluate
molecufp! in discovery and their appropriateness for selection as potential candidate; their
development in context of challenges and benefits, together with associated time and cost
implications and also requirements to progress through pre-clinical and clinical.
ln this an opportunity, lwould like to express my appreciation to the editorialteam of the proceeding
who have been working hard to review manuscripts, and making the first edition of this proceeding
be possible.
I would like also to thanks to all invited speakers and presenters who participated in The 1st
lnternational Conference on Pharmaceutics and Pharmaceutical Sciences (ICPPS) and your
contribution to this proceeding.
Finally, I hope this proceeding will give contribution
Sciences research.
Chairman,
Dra. Esti Hendradi, MSl., Ph.D., Apt
to the Pharmaceutics and Pharmaceutical
COMMITTEE
Advisor
Chairman
Editor
Universitas
: Dean of Faculty of Pharmacy
Ph'D' APt'
: Dra. Esti Hendradi, M'Si"
Airlangga
(Netherlands)
: Dr. Wouter U. Hinrichs
(JaPan)
Prof. Kozo TakaYama
Mutalik (lndia)
or. ttuttakorn Baisaeng {Thailand)
(lndonesia)
Prof. Dr. WidiiSoeratri' DEA
Dr. Srinivas
n
,rtn
Committee:
APt'
Prof. Dr. Widji Soeratri, DEA'
APt'
Prof. Dr. Siswandono, MS''
APt'
Prof .Dr. Tutuk Budiati' MS''
Yuwono' MS'' Apt'
Prof. Dr. rer'nat' Muhammad
APt'
Drs. Hadi Poerwono, MSc''Ph'D'
MSi'' Ph'D' Apt'
Drs. Marcellino Rudyanto'
APt'
Drs. Bambang Widjaja, M'Si'
Drs. SugiYartono, MS, APt'
APt'
Dra.Tutiek Purwanti, MSi'
APt'
Dra.Tristiana Erawati, MSi'
Dra.Retno Sari, MSc, APt'
Dra.Dewi lsadiartuti, MSi' APt'
Dra.Noorma Rosita, MSi' APt'
APt'
Dr. DwiSetyawan, SSi, MSi"
Primaharinastiti' SSi' MSi' Apt'
M'Phil'' Ph'D' Apt'
Dewi MelaniHariyadi' SSi'
APt'
HelmY Yusuf, SSi, MSc'' Ph'D'
AptDwi Lestari' SS|'MPharmSci''
Rrdhani
Dr. rer. nat. wtaria l-ucia
M'Sc' Apt'
tvt"lanny lka Sulistyowati' SFarm'
Apt' - '
Febri Annuryanti, SFarm'M'Sc'
M. Faris Adrianto, MFarm' APt'
Dini Retnowati, SFarm,APt'
Abhimata P, SFarm, APt'
Or.
ni"tt.
TABLE ofCONTENT
Preface from Chairman
Committee
Table of Contents
Author
...... ii
....--..--..--.
................. iii
lndex
.................... iii
AUTHQR INDEX
COMPARISON OF SODIUM STARCH GLYCOLATE AND CROSSCARMELLOSE SODIUM AS
SUPERDISINTEGRANT IN MEFENAMIC ACID FAST DISINTEGRATING TABLET
Adeltrudis Adelsa D, Oktavia Eka Puspita, Amalia Ayuningtyas, Marulita lsadora ,..........,........ 1
STUDY EXPRESSION OF HUMAN ERYTHROPOIETIN EXPRESSSION IN MAMMALIAN CELL
Adi Santoso, Popi Hadiwisnuwardhani, Yana Rubiana, Yulaika Romadhani, Endah Puji
Septisetyani, Dyaningtyas D.P. Putri
ANTIOXIDANT STABILITY ASSAY OF ALPHA TOCOPHERYL ACETATE IN SOL]D LIPlD NANOPARTICLE
SYSTEM (LlPlD BASE BEESWAX AND MONOSTEARIC GLISERYL
50:50)
Anggie Widhi, Noorma Rosita, Widji Soeratri ......................
A BIOACTIVE BOVINE HYDROXYAPATITE4ELATIN IMPLANT FOR IN VITRO GENTAMIC]N RELEASE
..... 13
Aniek Setiya Budiatin, M. Zainuddin, Junaidi Khotib, Diah Himawati
EFFECT OF COMPARISON SURFACTANTAND COSURFACTANT IN WATER/OIL MICROEMULSION IN
OVALBUMIN Microemulsion Water/Oilwith Surfactant (Span 8O-Tween 80) :
C-osurfactant (Ethanol) =5:L,6:!, and 7:1)
................. 18
Anisa Rizki Amalia, Riesta Primaharinastiti, Esti Hendradi ........,......,
RELEASE OF
ANALYSIS OF MYCOLIC ACIDS CLEAVAGE PRODUCT OF
Mycobacterium tuberculosis
CHROMATOGRAPHY-FLAM E IONIZATION DETECTOR
Asri Darmawati, Deby Kusumaningrum, lsnaeni, Muhamad
Zainuddin
PERIPLASMIC EXPRESSION OF GENE ENCODING ANTI-EGFRvIIISINGLE-CHAIN
ANTIBODY USING PelB LEADER SEQUENCE lN ESCHER/CHIA COLI
BY GAS
.............. 21
VARIABLE FRAGMENT
lGrtika Sari Dewi, Debbie Sofie Retnoningrum, Catur Riani, Asrul Muhamad Fuad ................24
IN VIVO ANTIMALARIAL ACTIVIry OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION OF
Alectryon serrotus LEAVES ON Plasmodium bergheilNFECTED MICE
Aty Widyawaruyanti, Uswatun Khasanah, Lidya Tumewu, Hilkatul llmi, Achmad Fuad Hafid,
Indah S Tantular ...............
..................... 30
PROFILE OF COMMUNIry PHARMACISTS KNOWLEDGE IN PATIENT ASSESSMENT WITH INFLUENZA
SYMPTOMS AND ITS PRODUCTS
Azza Faturrohmah, Arie Sulistyarini, Ana Yuda
...........
..........,........ 33
MoDlFlcArtoNPRocEssoFNATURALCASSAVAsTARcH:THESTUDYoFCHARACIERISTICSAND
M'A'C
Yulianingsih' I M'A'(''
PHYSICAL
r---.: a
A D As'tuti'
a
K#pffiffi rRffis@
s"€s
Drug Deiivery Systems:
From Drug-Discovery, Pre-formulaticn, Formulation and Technological Approaches for
Poorly Soluble Drugs and Protein
..',...-.-.,
'.t
I
.4. :lt-
D
::
-.....
.;
.:
..'l}.:'1;:r'x.]q{':
:l-
!
.'{:9'
i::r'r,:tr*
',t:
The l"t lnternational conference on Pharmaceutics
& Pharmaceutical Sciences Proceedings
ISBN : 97 8-5A2-72333-0-0
Date 18 March 2015)
(Letter of National ISBN Agency No' 4L27lE'slp/03'2015
1st edition Proceeding
Published bY:
Faculty of Pharmacy Universitas Airlangga
Surabaya, lndonesia
Address:
Kampus B Jl. Dharmawangsa Dalam
Surabaya 60286
Phone +62315033710
Fax +62 31 5020514
Website : www.icpps2014.com or wwwff'u na i r'ac'id
Email: icppinfo@gmail.com
rsBN 1?A-t0e-?e333-0-tl
.IIil!Jil[UruUuuililil
PREFACE
From Chairman
It is our pleasure to
present you the proceedings of The Lst lnternational Conference on
Pharmaceutics and Pharmaceutical Sciences (ICPPS) organized by The Faculty of Pharmacy
Universitas Airlangga Surabaya lndonesia.
The proceeding was produced based on papers and posters presented at The
1st
lnternational
Conference on Pharmaceutics and Pharmaceutical Sciences (ICPPS), held in Surabaya, lndonesia, 14-
15November2014.
The proceeding clearly reflects broad interest, from the participants that coming from all around the
world.
The papeJ$presented were pharmaceutics and biopharmaceutics; requirements on howto evaluate
molecufp! in discovery and their appropriateness for selection as potential candidate; their
development in context of challenges and benefits, together with associated time and cost
implications and also requirements to progress through pre-clinical and clinical.
ln this an opportunity, lwould like to express my appreciation to the editorialteam of the proceeding
who have been working hard to review manuscripts, and making the first edition of this proceeding
be possible.
I would like also to thanks to all invited speakers and presenters who participated in The 1st
lnternational Conference on Pharmaceutics and Pharmaceutical Sciences (ICPPS) and your
contribution to this proceeding.
Finally, I hope this proceeding will give contribution
Sciences research.
Chairman,
Dra. Esti Hendradi, MSl., Ph.D., Apt
to the Pharmaceutics and Pharmaceutical
COMMITTEE
Advisor
Chairman
Editor
Universitas
: Dean of Faculty of Pharmacy
Ph'D' APt'
: Dra. Esti Hendradi, M'Si"
Airlangga
(Netherlands)
: Dr. Wouter U. Hinrichs
(JaPan)
Prof. Kozo TakaYama
Mutalik (lndia)
or. ttuttakorn Baisaeng {Thailand)
(lndonesia)
Prof. Dr. WidiiSoeratri' DEA
Dr. Srinivas
n
,rtn
Committee:
APt'
Prof. Dr. Widji Soeratri, DEA'
APt'
Prof. Dr. Siswandono, MS''
APt'
Prof .Dr. Tutuk Budiati' MS''
Yuwono' MS'' Apt'
Prof. Dr. rer'nat' Muhammad
APt'
Drs. Hadi Poerwono, MSc''Ph'D'
MSi'' Ph'D' Apt'
Drs. Marcellino Rudyanto'
APt'
Drs. Bambang Widjaja, M'Si'
Drs. SugiYartono, MS, APt'
APt'
Dra.Tutiek Purwanti, MSi'
APt'
Dra.Tristiana Erawati, MSi'
Dra.Retno Sari, MSc, APt'
Dra.Dewi lsadiartuti, MSi' APt'
Dra.Noorma Rosita, MSi' APt'
APt'
Dr. DwiSetyawan, SSi, MSi"
Primaharinastiti' SSi' MSi' Apt'
M'Phil'' Ph'D' Apt'
Dewi MelaniHariyadi' SSi'
APt'
HelmY Yusuf, SSi, MSc'' Ph'D'
AptDwi Lestari' SS|'MPharmSci''
Rrdhani
Dr. rer. nat. wtaria l-ucia
M'Sc' Apt'
tvt"lanny lka Sulistyowati' SFarm'
Apt' - '
Febri Annuryanti, SFarm'M'Sc'
M. Faris Adrianto, MFarm' APt'
Dini Retnowati, SFarm,APt'
Abhimata P, SFarm, APt'
Or.
ni"tt.
TABLE ofCONTENT
Preface from Chairman
Committee
Table of Contents
Author
...... ii
....--..--..--.
................. iii
lndex
.................... iii
AUTHQR INDEX
COMPARISON OF SODIUM STARCH GLYCOLATE AND CROSSCARMELLOSE SODIUM AS
SUPERDISINTEGRANT IN MEFENAMIC ACID FAST DISINTEGRATING TABLET
Adeltrudis Adelsa D, Oktavia Eka Puspita, Amalia Ayuningtyas, Marulita lsadora ,..........,........ 1
STUDY EXPRESSION OF HUMAN ERYTHROPOIETIN EXPRESSSION IN MAMMALIAN CELL
Adi Santoso, Popi Hadiwisnuwardhani, Yana Rubiana, Yulaika Romadhani, Endah Puji
Septisetyani, Dyaningtyas D.P. Putri
ANTIOXIDANT STABILITY ASSAY OF ALPHA TOCOPHERYL ACETATE IN SOL]D LIPlD NANOPARTICLE
SYSTEM (LlPlD BASE BEESWAX AND MONOSTEARIC GLISERYL
50:50)
Anggie Widhi, Noorma Rosita, Widji Soeratri ......................
A BIOACTIVE BOVINE HYDROXYAPATITE4ELATIN IMPLANT FOR IN VITRO GENTAMIC]N RELEASE
..... 13
Aniek Setiya Budiatin, M. Zainuddin, Junaidi Khotib, Diah Himawati
EFFECT OF COMPARISON SURFACTANTAND COSURFACTANT IN WATER/OIL MICROEMULSION IN
OVALBUMIN Microemulsion Water/Oilwith Surfactant (Span 8O-Tween 80) :
C-osurfactant (Ethanol) =5:L,6:!, and 7:1)
................. 18
Anisa Rizki Amalia, Riesta Primaharinastiti, Esti Hendradi ........,......,
RELEASE OF
ANALYSIS OF MYCOLIC ACIDS CLEAVAGE PRODUCT OF
Mycobacterium tuberculosis
CHROMATOGRAPHY-FLAM E IONIZATION DETECTOR
Asri Darmawati, Deby Kusumaningrum, lsnaeni, Muhamad
Zainuddin
PERIPLASMIC EXPRESSION OF GENE ENCODING ANTI-EGFRvIIISINGLE-CHAIN
ANTIBODY USING PelB LEADER SEQUENCE lN ESCHER/CHIA COLI
BY GAS
.............. 21
VARIABLE FRAGMENT
lGrtika Sari Dewi, Debbie Sofie Retnoningrum, Catur Riani, Asrul Muhamad Fuad ................24
IN VIVO ANTIMALARIAL ACTIVIry OF ETHANOL EXTRACT AND ETHYL ACETATE FRACTION OF
Alectryon serrotus LEAVES ON Plasmodium bergheilNFECTED MICE
Aty Widyawaruyanti, Uswatun Khasanah, Lidya Tumewu, Hilkatul llmi, Achmad Fuad Hafid,
Indah S Tantular ...............
..................... 30
PROFILE OF COMMUNIry PHARMACISTS KNOWLEDGE IN PATIENT ASSESSMENT WITH INFLUENZA
SYMPTOMS AND ITS PRODUCTS
Azza Faturrohmah, Arie Sulistyarini, Ana Yuda
...........
..........,........ 33
MoDlFlcArtoNPRocEssoFNATURALCASSAVAsTARcH:THESTUDYoFCHARACIERISTICSAND
M'A'C
Yulianingsih' I M'A'(''
PHYSICAL
r---.: a
A D As'tuti'
a