The effect of indigestible dextrin and phytosterol on serum LDL-cholesterol level on hypercholesterolemic subjects

Med J Indones

114 Then et al.

The effect of indigestible dextrin and phytosterol on serum LDL-cholesterol
level on hypercholesterolemic subjects
Anna H. Then1, Saptawati Bardosono1, Indriati P. Harahap2
1
2

Nutrition Department, Faculty of Medicine, University of Indonesia, Jakarta
Biochemistry Department, Faculty of Medicine, University of Indonesia, Jakarta

Abstrak
Tujuan Membandingkan efek pemberian indigestible dextrin 2x2.3g/hari (ID) dan itosterol 2x0.6g/hari (FS) selama
6 minggu dalam menurunkan kadar kolesterol-LDL pada pasien hiperkolesterolemia
Metode Menggunakan rancangan studi uji klinis pada dua kelompok pararel tersamar ganda dengan alokasi random
pada 16 subyek per-kelompok.
Hasil Sebelum intervensi, kadar kolesterol-LDL pada kelompok ID dan kelompok FS masing-masing adalah 158,81
± 17,74 mg/dL and 176,18 ± 25,31 mg/dL. Setelah intervensi, didapatkan penurunan kadar kolesterol-LDL yag
bermakna pada kedua kelompok, yaitu masing-masing sebesar 20,93 ± 12,65 mg/dL (13.24%) dengan nilai P 60% TCR, cholesterol intake

was >200 mg/day, while the average of iber intake was
< 30 g/day and phytosterol intake was < 2g/day.
Before the intervention, the average of calorie
intake of the ID group was suficient, while after the
intervention there were decreases in the average intake
of fat, carbohydrate, and cholesterol. On the other
hand in PS group, before the intervention, the average
calorie intake, and the average intakes of fat, protein,
carbohydrate, cholesterol and iber were deicient. After
intervention there were no difference between the two
groups (Table 2).

Vol.18, No.2, April - June 2009

Effect of indigestible dextrin and sterol 117

Table 2. Nutrient intake pattern, nutrient intake before and after intervention in percentage of total calorie requirement (TCR)
No

Nutrient

1

Calorie intake (kkal),
- Intake pattern
- Daily intake:
Before intervention
After intervention
- TCR
- % intake pattern to TCR
- % intake to TCR:
Before intervention
After intervention
Protein intake (g)
- Intake pattern
- % intake pattern to TCR
- Daily intake
Before intervention
After intervention
-% intake to TCR

Before intervention
After intervention
Fat intake (g)
- Intake pattern
- % intake pattern to TCR
- Daily intake:
Before intervention
After intervention
-% intake to TCR
Before intervention
After intervention
Carbohydrate (g)
- Intake pattern
- % intake pattern to TCR
- Daily intake
Before intervention
After intervention
-% intake to TCR:
Before intervention
After intervention

Cholesterol (mg)
- Intake pattern (g):
- Daily intake
Before intervention
After intervention

2.

3

4

5.

ID group
(n = 16)

FS group
(n = 16)

2153 ± 847

2301 ± 748

1388.14 ± 398.73
1330.17 ± 339.04
1595.07± 276.07
140.57±66.43

1188.40 ± 318.51
1157.28 ± 261.11
2258.87±2502.52
135.58±58.92

88.25 ± 27.25
83.78 ± 19.42

68.31 ± 23.50
65.90 ± 1974

65.23 ± 27.04
16.96±7.77

76.04 ± 27.25
17.86±8.35

45.53 ± 12.97
43.28 ± 13.95

37.79 ± 9.74
35.01 ± 9.97

11.43 ± 2.52
10.78 ± 2.73

8.80 ± 2.82
8.04 ± 2.79

87.85 ± 65.41
52.84 ± 48.23

91.43 ± 38.80
49.58 ± 26.26

44.16 ± 16.60
33.55 ± 17.99

32.98 ± 13.49
27.61 ± 12.86

25.55 ± 10.46
19.06 ± 9.60

16.93 ± 8.05
13.89 ± 7.01

247.13 ± 97.03
63.68±26.03

272.26 ± 110.46

64.85±31.19

178.18 ± 62.38
154.02 ± 45.57

166.85 ± 55.51
148.18 ± 44.62

45.27± 17.02
38.60 ± 10.16

38.35 ± 15.28
33.88 ± 12.75

257.62 ± 209.45

265.06 ± 173.28

90.83 ± 68.16
63.68 ± 93.98

69.71 ± 60.98
33.40 ± 135.46

TCR: total calorie requuirement, ID: indigestible dextrin, PS: phytosterol

Subjects LDL cholesterol levels
Before the, intervention the level of LDL cholesterol
of both ID and FS group were 158.81 ± 17.74 mg/
dL and 176.18 ± 25.31 mg/dL, respectively. After the
intervention there was a signiicant reduction in LDL
cholesterol level among the ID group by 20.93 ±
12.65 mg/dL (13.24%) with p value of