Andri Trop Med Plant

Tit le :
The I m por t a nce of solve nt flow r a t e on t he e x t ra ct ion of Andr ogr a pholide
Re se a r che r ( s) :
A.C. Kum or o* and M. Hasan* *
I nst it ut ion:
Depart m ent of Chem ical Engineering, Facult y of Engineer ing, Univer sit y of Malaya 50603 Kuala
Lum pur
Abst r a ct :
Andrographis paniculat a NEES has been ext ensively used in t r adit ional m edicine and helps against
fever, dysent ery, diar rhoea, inflam m at ion, and sore t hroat . Andr ographolide, t he m ain com ponent
of t his plant was ext r act ed from t he leaves w it h super crit ical car bon dioxide ext ract or at 40 º C and
100 bar. The effect of supercrit ical solvent flow rat e ( ranging from 0.5 t o 4 m L/ m in) on t he ext ract
yield and select ivit y w as st udied. The ext r act yield incr eased wit h solvent flow rat e. However
furt her increase of solvent flow rat e decreased t he t ot al yield. This m ay due t o int rapart icle
diffusion resist ance effect in t he ext ract ion process. The opt im um solvent flow rat e was 2m L/ m in.
Ke yw or ds:
andrographolide; CO2 ext ract or, flow rat e; supercrit ical fluid ext ract ion; yield