CORRELATION BETWEEN CHILD PUGH SCORE AND CYSTATIN C IN LIVER CIRRHOSIS PATIENTS | Mulya | Acta Interna: The Journal of Internal Medicine 3860 11613 1 PB
Ganda Hidayat, et al
REFERENCES
1. Darmojo, B. 2004. Melalui Menua Sehat dan
Aktif Menuju Masa Usia Lanjut yang Berhasil,
Naskah Lengkap KONAS III & TINAS II
Pergemi, Yogyakarta
2. Guralnik, J.M., Eisensstaedt, R.S., Ferrucci, L.,
Klein, H.G., & Woodman, R.C. 2004.Prevalence
of Anemia in Persons 65 Years and Older in the
United States: Evidence for a High Rate of
Unexplained Anemia. Blood; 104:2263- 2268
3. Panjaitan, S. 2003. Beberapa Aspek Anemia pada
Penyakit Kronik pada Lanjut Usia. Penelitian
Cross Sectional di Bagian / SMF Ilmu Penyakit
Dalam Fakultas Kedokteran USU / RSUP H.
Adam Malik Medan
4. Penninx, B.W., Guralnik, J.M., Onder, G. 2003.
Anemia and decline in physical performance
among older persons. Am J Med; 115: 104–110
5. Penninx, B.W., Pahor, M., Cesari, M., Corsi,
A.M., Woodman, R.C., Bandinelli, S., et al.
2004. Anemia Is Associated with Disability and
Decreased Physical Performance and Muscle
Strength in the Elderly. J Am Geriatri Soc 52:
719–724
6. Patel, K.V., Guralnik, J.M. 2009. Prognostic
Implications of Anemia in Older Adults.
haematologica ; 94: 1-2
14
Acta Interna - The Journal of Internal Medicine
7. Chaves, P.H., Semba, R.D., Leng, S.X.,
Woodman, R.C., Ferrucci, L., Guralnik, J.M., et
al. 2005. Impact of Anemia and Kardiovascular
Disease on Frailty Status of Community
Dwelling Older Women: The Women's Health
and Aging Studies I and II. (Abstracts). J
Gerontol A Biol Sci Med Sci; 60:729-35
8. Shechtman, O., Mann, W.C., Justiss, M.D.,
Tomita, M. 2004. Grip Strength in The Frail
Elderly. (Abstracts). Am J Phys Med Rehabil; 83:
819-826
9. Ranganathan, V.K., Siemionow, V., Sahgal, V.,
Yue, G.H. 2001. Effects of Aging on Hand
Function. American Geriatrics Society; 49:
1478-1484
10. Pieterse, S., Manandhar, M., Ismail, S. 2002.
The Association between Nutritional Status and
Handgrip Strength in Older Rwanda Refugees.
European Journal of Clinical Nutrition; 56: 933939
11. Lier, A.M.V., Payette, H. 2003. Determinants of
Handgrip Strength in Free- Living Elderly at
Risk of Malnutrition. disability and
rehabilitation; 25 (20): 1181–1186
12. Kamarul, T .,Ahmad, T.S., Loh. W.Y.C. 2006.
Hand Grip Strength in The Adult Malaysian
Population. Journal of Orthopaedic Surgery;
14(2): 172-177
ORIGINAL ARTICLE
CORRELATION BETWEEN CHILD PUGH SCORE AND CYSTATIN C IN
LIVER CIRRHOSIS PATIENTS
Deshinta Putri Mulya 1, Siti Nurdjanah 2, Neneng Ratnasari 2
1 Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
2 Division of Gastro-Entero Hepatology, Department of Internal Medicine, Dr. Sardjito General Hospital, Yogyakarta
ABSTRACT
Background. Renal dysfunction is a serious
problem and it provides a poor prognosis for
patients with advanced liver cirrhosis. This
condition can progress to kidney failure, which is
known as hepatorenal syndrome. Cystatin C
utilization as a marker of decreased kidney function
in patients with liver cirrhosis has been widely
proven. Data on how far the severity of liver
cirrhosis can affect the decline in renal function has
not been widely known.
Objective. This study aimed is to verify
correlation between the severity degree of the liver
(Child Pugh/CP score) with levels of Cystatin C
serum.
Methods. This study was a cross sectional
study. Population studied were patients with liver
cirrhosis who visited the clinic of Gastroenterohepatology and treated in the Department of
Internal Medicine ward Dr. Sardjito Hospital Yogyakarta during October 2009 - March 2010.
Data were analyzed with a computer; the analysis of
the CP score correlation with increased levels of
Cystatin C using Spearman correlation for data not
normally distributed.
Result. We found 48 research subjects
during the month of October 2009 - March 2010. The
subjects were 35 male (72.9%) and 13 female
(27.1%) with average age 53.1 ± 11.9 years old.
Subjects with CP-A were 9 patients (18.8%), CP-B
were 14 patients (29.2%) and CP-C were 25 patients
(52.1%). The range value of Cystatin C between CP
class shows CP-A 0.7 - 0.97 mg/L, CP-B 0.7 - 0.49
mg/L, and CP-C 0.7 – 2.49 mg/L (statistically
significant difference with p
REFERENCES
1. Darmojo, B. 2004. Melalui Menua Sehat dan
Aktif Menuju Masa Usia Lanjut yang Berhasil,
Naskah Lengkap KONAS III & TINAS II
Pergemi, Yogyakarta
2. Guralnik, J.M., Eisensstaedt, R.S., Ferrucci, L.,
Klein, H.G., & Woodman, R.C. 2004.Prevalence
of Anemia in Persons 65 Years and Older in the
United States: Evidence for a High Rate of
Unexplained Anemia. Blood; 104:2263- 2268
3. Panjaitan, S. 2003. Beberapa Aspek Anemia pada
Penyakit Kronik pada Lanjut Usia. Penelitian
Cross Sectional di Bagian / SMF Ilmu Penyakit
Dalam Fakultas Kedokteran USU / RSUP H.
Adam Malik Medan
4. Penninx, B.W., Guralnik, J.M., Onder, G. 2003.
Anemia and decline in physical performance
among older persons. Am J Med; 115: 104–110
5. Penninx, B.W., Pahor, M., Cesari, M., Corsi,
A.M., Woodman, R.C., Bandinelli, S., et al.
2004. Anemia Is Associated with Disability and
Decreased Physical Performance and Muscle
Strength in the Elderly. J Am Geriatri Soc 52:
719–724
6. Patel, K.V., Guralnik, J.M. 2009. Prognostic
Implications of Anemia in Older Adults.
haematologica ; 94: 1-2
14
Acta Interna - The Journal of Internal Medicine
7. Chaves, P.H., Semba, R.D., Leng, S.X.,
Woodman, R.C., Ferrucci, L., Guralnik, J.M., et
al. 2005. Impact of Anemia and Kardiovascular
Disease on Frailty Status of Community
Dwelling Older Women: The Women's Health
and Aging Studies I and II. (Abstracts). J
Gerontol A Biol Sci Med Sci; 60:729-35
8. Shechtman, O., Mann, W.C., Justiss, M.D.,
Tomita, M. 2004. Grip Strength in The Frail
Elderly. (Abstracts). Am J Phys Med Rehabil; 83:
819-826
9. Ranganathan, V.K., Siemionow, V., Sahgal, V.,
Yue, G.H. 2001. Effects of Aging on Hand
Function. American Geriatrics Society; 49:
1478-1484
10. Pieterse, S., Manandhar, M., Ismail, S. 2002.
The Association between Nutritional Status and
Handgrip Strength in Older Rwanda Refugees.
European Journal of Clinical Nutrition; 56: 933939
11. Lier, A.M.V., Payette, H. 2003. Determinants of
Handgrip Strength in Free- Living Elderly at
Risk of Malnutrition. disability and
rehabilitation; 25 (20): 1181–1186
12. Kamarul, T .,Ahmad, T.S., Loh. W.Y.C. 2006.
Hand Grip Strength in The Adult Malaysian
Population. Journal of Orthopaedic Surgery;
14(2): 172-177
ORIGINAL ARTICLE
CORRELATION BETWEEN CHILD PUGH SCORE AND CYSTATIN C IN
LIVER CIRRHOSIS PATIENTS
Deshinta Putri Mulya 1, Siti Nurdjanah 2, Neneng Ratnasari 2
1 Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
2 Division of Gastro-Entero Hepatology, Department of Internal Medicine, Dr. Sardjito General Hospital, Yogyakarta
ABSTRACT
Background. Renal dysfunction is a serious
problem and it provides a poor prognosis for
patients with advanced liver cirrhosis. This
condition can progress to kidney failure, which is
known as hepatorenal syndrome. Cystatin C
utilization as a marker of decreased kidney function
in patients with liver cirrhosis has been widely
proven. Data on how far the severity of liver
cirrhosis can affect the decline in renal function has
not been widely known.
Objective. This study aimed is to verify
correlation between the severity degree of the liver
(Child Pugh/CP score) with levels of Cystatin C
serum.
Methods. This study was a cross sectional
study. Population studied were patients with liver
cirrhosis who visited the clinic of Gastroenterohepatology and treated in the Department of
Internal Medicine ward Dr. Sardjito Hospital Yogyakarta during October 2009 - March 2010.
Data were analyzed with a computer; the analysis of
the CP score correlation with increased levels of
Cystatin C using Spearman correlation for data not
normally distributed.
Result. We found 48 research subjects
during the month of October 2009 - March 2010. The
subjects were 35 male (72.9%) and 13 female
(27.1%) with average age 53.1 ± 11.9 years old.
Subjects with CP-A were 9 patients (18.8%), CP-B
were 14 patients (29.2%) and CP-C were 25 patients
(52.1%). The range value of Cystatin C between CP
class shows CP-A 0.7 - 0.97 mg/L, CP-B 0.7 - 0.49
mg/L, and CP-C 0.7 – 2.49 mg/L (statistically
significant difference with p