pengaruh daun kemangi terhadap perbaikan gejala skizophrenia
THE INFLUENCE OF OCIMUM SANCTUM AS AN ADJUVANT THERAPY IN
IMPROVEMENT CLINICAL FEATURES AND COGNITIF FUNCTION OF
SCHIZOPHRENIA PATIENT WHO GET RISPERIDON
Anisa*, Saidah Syamsuddin**
*Participant Of PPDS I Psychiatryc Department Of Medical Faculty UNHAS
**Consultant of Psychiatryc Department Of Medical Faculty UNHAS
Abstract
Background : Ocimum sanctum has already known worl wide as traditional herbal medicine. Long time
ago people have using Ocimum sanctum to cure diseases. Ocimum sanctum is one of Indonesian tradional
medicine. Previous syudy in animal laboratory (rats) showed significant association between Ocimum
sanctum (Basil Leaf) and stress. Ocimum sanctum known to have property as an antioxidant, anti
inflammation, anti psychotic, neurprotector, etc. Few studies evaluated effect of Ocimum sanctum in
Schizophrenia patients.
Methods : In this experimental study we analyzed 2 (two) groups of patients. Each group contains 10
(ten) Schizophrenia patients. One group take Risperidon only and the other group take Risperidon
combine with Ocimum sanctum. Each group was given Risperidon 2 mg per day each 12 hour via oral.
One group combine with Ocimum sanctum, every patients take 2 pils of Ocimum sanctum leaf per day
each 8 hour via oral. All of the procedura was done after meal time. After 2 hours taking Risperidon, we
give the patients Ocimum sanctum. Patients were evaluated using PANSS and MOCA-INA score
admission and after 14 days of treatment.
Results : PANSS score significantly decreased after 14 days taking Ocimum sanctum compared to
control group that take Risperidon only ( p ≥ 0,05 ). MOCA-INA score significantly increased after 14
days taking Ocimum sanctum compared to control group that take Risperidon only ( p ≥ 0,05 ).
Conclusion : By giving Ocimum sanctum as an adjuvant therapy in Schizophrenia patients can help in
improvement of clinical features and cognitive function in Schizophrenia patients.
Keywords : Ocimum sanctum, Basil leaf, Risperidon, Schizophrenia
1
Gr. 1. PANSS Score of Control Group, admission and after 14 days treatment with
Risperidon only.
200
180
160
140
120
pans1
pans2
100
80
60
40
20
0
pc
sf
oc
su
si
hz
mn
mt
jr
tr
Tabel 1. PANSS Score Normality test of Control Group.
2
Tests of Normality
Kolmogorov-Smirnova
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
panss1
.208
10
.200*
.919
10
.345
panss2
.161
10
.200*
.946
10
.622
a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Tabel 2. PANSS Score Pair T Test of Control Group.
Paired Samples Test
Paired Differences
95% Confidence Interval of
Std. Error
Mean
Std. Deviation
Pair 1 panss1 - panss2 2.19000E
1
8.60814
Mean
2.72213
the Difference
Lower
15.74211
t
df
Sig. (2-tailed)
Upper
28.05789
8.045
9
Gr. 2. PANSS Score of Eksperimental Group, admission and after 14 days of
treatment with Risperidon and Ocimum sanctum.
3
.000
250
200
150
panss1
panss2
100
50
0
hd
ys
ly
aj
sm
rn
by
ik
aw
am
Tabel 3. PANSS Score Normality Test of Eksperimental Group.
4
Tests of Normality
Kolmogorov-Smirnova
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
PANSS1
.176
10
.200*
.922
10
.374
PANSS2
.254
10
.068
.849
10
.056
a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Tabel 4. PANSS Score Pair T Test of Eksperimental Group.
Paired Samples Test
Paired Differences
95% Confidence
Interval of the
Difference
Mean
Pair 1 PANSS1 PANSS2
6.2200
0E1
Std.
Std. Error
Deviation
Mean
31.89148
10.08497
Sig. (2Lower
39.38621
Upper
85.01379
t
df
6.168
tailed)
9
.000
5
Gr. 3. MOCA-INA Score of Control Group, admission and after 14 days treatment with
Risperidon only.
25
20
15
moca1
moca2
10
5
0
pc
sf
oc
su
si
hz
mn
mt
jr
tr
Tabel 5. MOCA-INA Score Normality test of Control Group.
6
Tests of Normality
Kolmogorov-Smirnova
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
moca1
.258
10
.058
.816
10
.022
moca2
.382
10
.000
.774
10
.007
a. Lilliefors Significance Correction
Tabel 6. MOCA-INA Score Pair T Test of Control Group.
Paired Samples Test
Paired Differences
95% Confidence Interval of
the Difference
Std. Error
Mean
Pair 1
moca1 - moca2
Std. Deviation
-3.60000
Mean
1.34990
Lower
.42687
Upper
-4.56566
-2.63434
t
df
Sig. (2-tailed)
-8.433
9
Gr.4. MOCA-INA Score of Eksperimental Group, admission and 14 days after
treatment with Risperidon and Ocimum Sanctum.
30
25
20
moca1
moca2
15
10
5
0
hd
ys
ly
aj
sm
rn
by
ik
aw
am
7
.000
Tabel 7. MOCA-INA Score Normality Test of Eksperimental Group.
Tests of Normality
Kolmogorov-Smirnova
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
MOCA1
.293
9
.025
.827
9
.042
MOCA2
.145
9
.200*
.928
9
.464
a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Tabel 8. MOCA-INA Score Pair T Test of Eksperimental Group.
8
Paired Samples Test
Paired Differences
95% Confidence
Interval of the
Difference
Mean
Pair 1 MOCA1 MOCA2
Std.
Std. Error
Deviation
Mean
Sig. (2Lower
Upper
t
df
tailed)
7.0000
3.09121
.97753
-9.21132
-4.78868
-7.161
9
.000
0
9
IMPROVEMENT CLINICAL FEATURES AND COGNITIF FUNCTION OF
SCHIZOPHRENIA PATIENT WHO GET RISPERIDON
Anisa*, Saidah Syamsuddin**
*Participant Of PPDS I Psychiatryc Department Of Medical Faculty UNHAS
**Consultant of Psychiatryc Department Of Medical Faculty UNHAS
Abstract
Background : Ocimum sanctum has already known worl wide as traditional herbal medicine. Long time
ago people have using Ocimum sanctum to cure diseases. Ocimum sanctum is one of Indonesian tradional
medicine. Previous syudy in animal laboratory (rats) showed significant association between Ocimum
sanctum (Basil Leaf) and stress. Ocimum sanctum known to have property as an antioxidant, anti
inflammation, anti psychotic, neurprotector, etc. Few studies evaluated effect of Ocimum sanctum in
Schizophrenia patients.
Methods : In this experimental study we analyzed 2 (two) groups of patients. Each group contains 10
(ten) Schizophrenia patients. One group take Risperidon only and the other group take Risperidon
combine with Ocimum sanctum. Each group was given Risperidon 2 mg per day each 12 hour via oral.
One group combine with Ocimum sanctum, every patients take 2 pils of Ocimum sanctum leaf per day
each 8 hour via oral. All of the procedura was done after meal time. After 2 hours taking Risperidon, we
give the patients Ocimum sanctum. Patients were evaluated using PANSS and MOCA-INA score
admission and after 14 days of treatment.
Results : PANSS score significantly decreased after 14 days taking Ocimum sanctum compared to
control group that take Risperidon only ( p ≥ 0,05 ). MOCA-INA score significantly increased after 14
days taking Ocimum sanctum compared to control group that take Risperidon only ( p ≥ 0,05 ).
Conclusion : By giving Ocimum sanctum as an adjuvant therapy in Schizophrenia patients can help in
improvement of clinical features and cognitive function in Schizophrenia patients.
Keywords : Ocimum sanctum, Basil leaf, Risperidon, Schizophrenia
1
Gr. 1. PANSS Score of Control Group, admission and after 14 days treatment with
Risperidon only.
200
180
160
140
120
pans1
pans2
100
80
60
40
20
0
pc
sf
oc
su
si
hz
mn
mt
jr
tr
Tabel 1. PANSS Score Normality test of Control Group.
2
Tests of Normality
Kolmogorov-Smirnova
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
panss1
.208
10
.200*
.919
10
.345
panss2
.161
10
.200*
.946
10
.622
a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Tabel 2. PANSS Score Pair T Test of Control Group.
Paired Samples Test
Paired Differences
95% Confidence Interval of
Std. Error
Mean
Std. Deviation
Pair 1 panss1 - panss2 2.19000E
1
8.60814
Mean
2.72213
the Difference
Lower
15.74211
t
df
Sig. (2-tailed)
Upper
28.05789
8.045
9
Gr. 2. PANSS Score of Eksperimental Group, admission and after 14 days of
treatment with Risperidon and Ocimum sanctum.
3
.000
250
200
150
panss1
panss2
100
50
0
hd
ys
ly
aj
sm
rn
by
ik
aw
am
Tabel 3. PANSS Score Normality Test of Eksperimental Group.
4
Tests of Normality
Kolmogorov-Smirnova
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
PANSS1
.176
10
.200*
.922
10
.374
PANSS2
.254
10
.068
.849
10
.056
a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Tabel 4. PANSS Score Pair T Test of Eksperimental Group.
Paired Samples Test
Paired Differences
95% Confidence
Interval of the
Difference
Mean
Pair 1 PANSS1 PANSS2
6.2200
0E1
Std.
Std. Error
Deviation
Mean
31.89148
10.08497
Sig. (2Lower
39.38621
Upper
85.01379
t
df
6.168
tailed)
9
.000
5
Gr. 3. MOCA-INA Score of Control Group, admission and after 14 days treatment with
Risperidon only.
25
20
15
moca1
moca2
10
5
0
pc
sf
oc
su
si
hz
mn
mt
jr
tr
Tabel 5. MOCA-INA Score Normality test of Control Group.
6
Tests of Normality
Kolmogorov-Smirnova
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
moca1
.258
10
.058
.816
10
.022
moca2
.382
10
.000
.774
10
.007
a. Lilliefors Significance Correction
Tabel 6. MOCA-INA Score Pair T Test of Control Group.
Paired Samples Test
Paired Differences
95% Confidence Interval of
the Difference
Std. Error
Mean
Pair 1
moca1 - moca2
Std. Deviation
-3.60000
Mean
1.34990
Lower
.42687
Upper
-4.56566
-2.63434
t
df
Sig. (2-tailed)
-8.433
9
Gr.4. MOCA-INA Score of Eksperimental Group, admission and 14 days after
treatment with Risperidon and Ocimum Sanctum.
30
25
20
moca1
moca2
15
10
5
0
hd
ys
ly
aj
sm
rn
by
ik
aw
am
7
.000
Tabel 7. MOCA-INA Score Normality Test of Eksperimental Group.
Tests of Normality
Kolmogorov-Smirnova
Statistic
df
Shapiro-Wilk
Sig.
Statistic
df
Sig.
MOCA1
.293
9
.025
.827
9
.042
MOCA2
.145
9
.200*
.928
9
.464
a. Lilliefors Significance Correction
*. This is a lower bound of the true significance.
Tabel 8. MOCA-INA Score Pair T Test of Eksperimental Group.
8
Paired Samples Test
Paired Differences
95% Confidence
Interval of the
Difference
Mean
Pair 1 MOCA1 MOCA2
Std.
Std. Error
Deviation
Mean
Sig. (2Lower
Upper
t
df
tailed)
7.0000
3.09121
.97753
-9.21132
-4.78868
-7.161
9
.000
0
9