Toxicity and teratogenic tests of ethanol extract of Artocarpus champeden stembark Repository - UNAIR REPOSITORY
38th Meeting of National Workang Group on lndotlI
ISBN : 978-602-96839-{-2
978-602-96839-2-9
n
r-Eil
rroceeolugE
lnternational Conference On Medicinal Plants
TbeEutwe of Medicina[ Plants:
jtoa Peail b lti,dlclre
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7
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b.
-a
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I
-|It
tl
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,
Organized by
NM/}
W
POKJAN
oGrt dl.r
Lan*da, Ad.lndraai,
6d'iJt Lad.lti trtrga
tnrit
E- FT-\.
,
1-
I
z).
ISBN : 978-602-96899-1-2
ISBN of Volume l: 978-602-96839-2-9
PROCEEDIN€ OF'
INTESN.ETIONJI.L CONFERENCE ON
MEDICIN*.L PIJTIITS
in occasion of
the 38tt Meeting of National Working Group on lndonesian Medicinal Plant
21-21July 20lO
Surabaya, Indonesia
Editors:
Elisabeth C. Widjajakusuma
Kuncoro Foe
Sendy Junedi
Bambang Soekardjo
Retno Anday'ani
Achmad Fudholi
Lucia Hendriati
-{ngelica Kresnamurti
Organizing Committee
TACULTYOTPflASIIACY
rdluYr. n*malr. ctrrrtouc UNIyE&SIry
in collaboration with
National Working Group on lndonesian Medicinal Plants
and German Academic exchange Service
Arcculiag of Intenatiot d[ Coflfereflce ofl
5't'Lef,icina[
Qhnts - SuraSoy, In[onesit 21-21 1u0 2010
PREFACE
Earth is perfectly made by God for His people to live. lt consists of different bodies of land and
water where thousands of species of plants and animals can be found. The human race is called to
explore this order, to examine it with due care and to make use of it for the benefits of human
being. Since very early in human history, people have relied on medicinal plants to cure them of
their various ills. This can be partly attributed to the simple yet highly effective forms of traditaonal
medicine. Knowledge of medicinal plants is a part of the lndonesian national heritage known as
laruL. To facilitate networking, collaboration, exchange of information, experiences and and
knowledge id the key issues of medicinal plants deveiopment, the Faculty of Pharmacy of widya
Mandala Catholic University Surabaya in collaboration with National Working Group on
lndonesian Medicinal Plants (POKJANA5 TOI) and German Academic Exchange Service (DAAD) held
the lnternational Conference on Medicinal Plants on 2!-22 luly 2010 in Surabaya. The conference
a
in
pharmacology, pharmacognosy, ethnobotany, standardizatlon,
cultivation, cell culture and chemistry for medicinal and aromatic plant species. T-here were over
250 participants, 8 plenary speakers, 101 contributed speakers in oral presentation, and 101
provided
evaluation
posters presented.
The papers contained in the first volume of the proceeding report the submitted papers on The
Future of Medicinal Plants: From Plant to Medicine'. Keynote speakers and authors of selected
contributed oral and poster presentations were given the opportunity to submit a manuscript for
publication.
The conference organizers gratefully acknowledge the financial and other support from the
fqllowing:
National Working Group on lndonesian Medicinal Plants (POKJANAS TOI)
cerman Academic Exchange Service (DAAD)
PT. Landson
PT. Guiati 59
PT. Pasifik Sarana Cantik
Herbal Plus
I hope that this publication will raise international awareness of the value of medicinal plants ln
lndonesia and hence makBs a eontribution towards promotjng the proper use of medi€inal plante.
Dr.phil.nat. Elisabeth Catherina Widjajakusuma
Conference Chairman
ll
ISBN : 97&602-96839-2-9 (vol l)
lProceding of Intemationa[ Qotfere'nce on 9le&cinatrP{an* - Suru\ata, fatonesit 21-21
!u$
2010
CONTENT
Page
Preface
lt
Methods for the Evaluation ot Bioavailability of t{atural DrugE
Mona Tawab, Manfred Schubert-Zsilavecz
X
lntroduction of Tropical Woody Plant Extractives of Beauty and Health Science
Prof. Tohru Mitsunaga
xt
Herbal Manufacturint Methods Offered by Modern Science and Technolo3y
Mr. Jimmy Sidharta
x
Experimental Design and Sample Size Determination: A Computer Simulation
for lmproving the Precision of an Experiment
Prof. Henk van Wilgenburg
x
Jorru in Maintaining Optimal Health
dr. Arijanto Jonosewoyo, SpPD
xtv
Key lssues in Modernization of Traditional Chinese Medicine
xv
t
Prof. De-An Guo
Guidance to the Efficient and Comprehensive Development of Phytopfiarmaaa
Dr. Mona Tawab, Prof. Manfred Schubert-Zsilavecs
xvi
Modern Science and Technology for Herbal Beauty Product
lr. Dwi Mayasari Tjahjono, S.Pd. Dipl. Cidesco, Dipl. Cibtac
xvii
Antibacterial Activity
of
Eugenol Oerivatives Prepared
from Chemical
1
Transformations
I Made Sudarma
Antibacterial Activity Ethanol Papaya lCarlca papaya) Leaf Extract &ainst
Staphylocoocus Aureus and Salmonella Typhl
Diana Chusna Mufida And Elly Nurus Sakinah
lll
ISBN : 97&602-96839.2-9 (vol l)
7
M4
€ ,EiE "itioraf
Confmnce oa 9!.efrtinttetanx ' SumSay* Ifltofleti4 21-21
lut
2010
SthnobotaBical, Proximate, and Phytochemical Studies ol Areca vestiaria Gis*e
(Pinang Yaki)
Herny E.l. Simbala And Trina E. Tallei
Optimization of Topical Patch Containing of Kaempferia Oil
(Koemperia galangol
Lucia Hendriati
Determination
of
Marker Compound
of
9
15
Artocdrpus champeden Spreng,
2t
Stembark Extract And Validation of The Analysis Method Using HPLC
Ni Putu
Ariantari, Lidya Tumewu, Agriana Rosmalina Hidayati, Aty
Widyawaruyanti, Achmad Fuad Hafid
lsolation of oligomerstilbenoids From Stem Batk
Endemic of South East Sulawesi
ot
Votica tlavofirens Sloot
29
Siti Hadijah Sabarwati, Nohong, Euis H. Hakim, Yana M. Syah, Sutriadi S, Zaeni A
Antlmicrobial And Anticancer Activity of curcusone B lsolated From stem Bark
ol lotropha curcas
l. Sahidin, Ardiansyah, M. Taher, S. Arsad,5.J-A. lchwan, l. latip, B.M. Yamin, and
54
S.N. Baharum
Screening of Medicinal Plants of South Sumatera
Atainst Organism From Skin lnfection
Salni, Hanifa Marisa, Harmida
Long Term Effect
of
Ethanolic Extract
for Antibacterial Activity
oI
Fenugreek Seeds
47
47
lfrlgonello foenum-gruecum t.) on White Rat Liver Function
Kurnia Agustini, Sriningsih, Lestari Rahayu
Analysis of Plasma Malondialdehide (Mda) Concentration By Giving Shallot's
Extortion Water lAllium ascalonicum L.l on Hypercholesterolemic Mice
lsmawati, Enikarmila Asni, M.Yulis Hamidy
54
Chemical Constituents from Shorea faguetiono(Dipterocarpaceae)
Rohaiza Saat, Laily B. Din, Wan Yaacob Wan Ahmad
60
1V
ISBN : 97&602-96839-2-9 (vol l)
tPraceeding of
Intemationa[ 6o{erence on *!.edicina{lPhnts - Sura'aya, Inlonxia. 21-21 Ju$ 2010
and
Conservatlon Effort of Burahol Species lStelechocorpus
burohol (Blume) Hook & Thomson)
Research Statues
66
Tati Rostiwati, Tuti Herawati, Melani Kurnia Riswati
Ecology of Kepel (stelechocorpus burohol (Blume) Hook, F.&Thomson)
Purwodadl Botanical Garden
ln
73
Solikin
Effect of Additional Antioxidant of Fruit Extract of Kepel
(Stelechocarpus buraholl in Sernen Diluent to The Quality
Spermatozoa
Rina Priastini And Flora Rumiati
80
ot Bex
Babbiys
Acceleration ol ln-vitrc Getmination of Fenugreek
lTri go n el I o fo e nu m - g ra e c u m L, I
lis Rahmawati, Ahmad Saufi
oe
ln Wtrc 9rcduclion of Secondary Metabolites from
Gynura pseudochiro (tour.) D.C,
91
Maria G. M. Purwanto, Anna Ruanto, l. B. Artadhana, Tjie Kok, Selvy Theodorus,
Michael William Tanojo
Anti-lnflammatory Activity of Single and Combination Tlnospora
Andrcgrophis poniculatd oecoc1.ion in Albino Rats
c
spo and
97
Firdaus, Lestari Rahayu
Larvacide Effect of Ethanol Extract Ol Plperis nigrl fructus against
Aedes oegypti Linn. Lerva
Sajekti Palupi, Meyta, Kartini
100
Determination of Chlorophylls and Carotenoids Content in Three Major Teas
based on Peak Area from HPLC Chromatogram
103
Wahyu Wijaya, Heriyanto, Budhi Prasetyo, Leenawaty Limantara
Bacterial Cellulose as Separating Agent
Plants, A Preliminary Study
Surjani Wonorahardjo
for Useful Compounds in Medicinal
ttz
ISBN : 97&602-968i19-2-9 (vol l)
.?roccc6ng of Intemationat Confcrerree on X,l.eticinattPht* - Sura6a1a, Intoncsia 21-21
Eioflavonoid quercetin lmproves The lnsulin Resistance in Diet-lnduced
Rat Model
Heni Fatmawati, Candra Bumi
Toxic Compounds Extracted Frcm Eugenia un
rora
I
!ut!
2O1O
Obesity
Against T47D Cell tine
119
727
Nita Supriyati, Esti Wahyu Widowati
q/totoxic Potential of Garlic Exlrad lAllium sotivuml
Al Munawir
133
lsolation And ldentification c-Mangostin As A Marker Compound from
Gorcinio mangostono L Hull
Lince Yarni, lltizam Nasrullah, Sri Murhandini, Winiati P. Rahayu
141
,,
vitro Anti-Malarial Activity Triterpenoid Pentacyclics from
Erythrlna variegoto against Prasmodium falciparum
Tati Herlina, Dikdik Kurnia, Suseno Amien, And Unang Supratman
745
The Comparison Antioxidant, Antiaggregation of Various Tea Extract
lComellia sinensls L,l
757
Wahyu Widowati, Tati Herlina, Hana Ratnawati, Tjandrawati
lsolation and ldentification Toxic Oxoaporphinoid Alkaloid ,com Stclechocorpus 150
burahol Hook F. & Thoms. Stem Bark (Annonaceae)
Clara Sunardi, Kosasih Padmawinata, L. B. S. Kardono, Asep Gana
Strusture
of
Steroids
in
Stelechocarpus burahol Hook F.
& Thomson
Stem
164
Sark
Clara Sunardi
Several Standard Parameter and Phytochemical Sreening of
Stelechocaryus burohol HookF. & Thomson Stem Bark
Clara Sunardi
169
Mutagenic Etlect ol Curcuma zedoario Dry Extract by Ames Test
773
Rina Adriany, Eka Rusmawati, Murtiningsih, Fitria Rahmi, Tuti Erlina
vt
ISBN : 97&602-96839-2.9 (vol l)
L
ISBN : 978-602-96839-{-2
978-602-96839-2-9
n
r-Eil
rroceeolugE
lnternational Conference On Medicinal Plants
TbeEutwe of Medicina[ Plants:
jtoa Peail b lti,dlclre
b--
7
)
uY
\
L- I
\
I
I
I
E-
!
I
D
'l
a
I
T
-1
E
#
b.
-a
t
;
I
-|It
tl
'til
,
Organized by
NM/}
W
POKJAN
oGrt dl.r
Lan*da, Ad.lndraai,
6d'iJt Lad.lti trtrga
tnrit
E- FT-\.
,
1-
I
z).
ISBN : 978-602-96899-1-2
ISBN of Volume l: 978-602-96839-2-9
PROCEEDIN€ OF'
INTESN.ETIONJI.L CONFERENCE ON
MEDICIN*.L PIJTIITS
in occasion of
the 38tt Meeting of National Working Group on lndonesian Medicinal Plant
21-21July 20lO
Surabaya, Indonesia
Editors:
Elisabeth C. Widjajakusuma
Kuncoro Foe
Sendy Junedi
Bambang Soekardjo
Retno Anday'ani
Achmad Fudholi
Lucia Hendriati
-{ngelica Kresnamurti
Organizing Committee
TACULTYOTPflASIIACY
rdluYr. n*malr. ctrrrtouc UNIyE&SIry
in collaboration with
National Working Group on lndonesian Medicinal Plants
and German Academic exchange Service
Arcculiag of Intenatiot d[ Coflfereflce ofl
5't'Lef,icina[
Qhnts - SuraSoy, In[onesit 21-21 1u0 2010
PREFACE
Earth is perfectly made by God for His people to live. lt consists of different bodies of land and
water where thousands of species of plants and animals can be found. The human race is called to
explore this order, to examine it with due care and to make use of it for the benefits of human
being. Since very early in human history, people have relied on medicinal plants to cure them of
their various ills. This can be partly attributed to the simple yet highly effective forms of traditaonal
medicine. Knowledge of medicinal plants is a part of the lndonesian national heritage known as
laruL. To facilitate networking, collaboration, exchange of information, experiences and and
knowledge id the key issues of medicinal plants deveiopment, the Faculty of Pharmacy of widya
Mandala Catholic University Surabaya in collaboration with National Working Group on
lndonesian Medicinal Plants (POKJANA5 TOI) and German Academic Exchange Service (DAAD) held
the lnternational Conference on Medicinal Plants on 2!-22 luly 2010 in Surabaya. The conference
a
in
pharmacology, pharmacognosy, ethnobotany, standardizatlon,
cultivation, cell culture and chemistry for medicinal and aromatic plant species. T-here were over
250 participants, 8 plenary speakers, 101 contributed speakers in oral presentation, and 101
provided
evaluation
posters presented.
The papers contained in the first volume of the proceeding report the submitted papers on The
Future of Medicinal Plants: From Plant to Medicine'. Keynote speakers and authors of selected
contributed oral and poster presentations were given the opportunity to submit a manuscript for
publication.
The conference organizers gratefully acknowledge the financial and other support from the
fqllowing:
National Working Group on lndonesian Medicinal Plants (POKJANAS TOI)
cerman Academic Exchange Service (DAAD)
PT. Landson
PT. Guiati 59
PT. Pasifik Sarana Cantik
Herbal Plus
I hope that this publication will raise international awareness of the value of medicinal plants ln
lndonesia and hence makBs a eontribution towards promotjng the proper use of medi€inal plante.
Dr.phil.nat. Elisabeth Catherina Widjajakusuma
Conference Chairman
ll
ISBN : 97&602-96839-2-9 (vol l)
lProceding of Intemationa[ Qotfere'nce on 9le&cinatrP{an* - Suru\ata, fatonesit 21-21
!u$
2010
CONTENT
Page
Preface
lt
Methods for the Evaluation ot Bioavailability of t{atural DrugE
Mona Tawab, Manfred Schubert-Zsilavecz
X
lntroduction of Tropical Woody Plant Extractives of Beauty and Health Science
Prof. Tohru Mitsunaga
xt
Herbal Manufacturint Methods Offered by Modern Science and Technolo3y
Mr. Jimmy Sidharta
x
Experimental Design and Sample Size Determination: A Computer Simulation
for lmproving the Precision of an Experiment
Prof. Henk van Wilgenburg
x
Jorru in Maintaining Optimal Health
dr. Arijanto Jonosewoyo, SpPD
xtv
Key lssues in Modernization of Traditional Chinese Medicine
xv
t
Prof. De-An Guo
Guidance to the Efficient and Comprehensive Development of Phytopfiarmaaa
Dr. Mona Tawab, Prof. Manfred Schubert-Zsilavecs
xvi
Modern Science and Technology for Herbal Beauty Product
lr. Dwi Mayasari Tjahjono, S.Pd. Dipl. Cidesco, Dipl. Cibtac
xvii
Antibacterial Activity
of
Eugenol Oerivatives Prepared
from Chemical
1
Transformations
I Made Sudarma
Antibacterial Activity Ethanol Papaya lCarlca papaya) Leaf Extract &ainst
Staphylocoocus Aureus and Salmonella Typhl
Diana Chusna Mufida And Elly Nurus Sakinah
lll
ISBN : 97&602-96839.2-9 (vol l)
7
M4
€ ,EiE "itioraf
Confmnce oa 9!.efrtinttetanx ' SumSay* Ifltofleti4 21-21
lut
2010
SthnobotaBical, Proximate, and Phytochemical Studies ol Areca vestiaria Gis*e
(Pinang Yaki)
Herny E.l. Simbala And Trina E. Tallei
Optimization of Topical Patch Containing of Kaempferia Oil
(Koemperia galangol
Lucia Hendriati
Determination
of
Marker Compound
of
9
15
Artocdrpus champeden Spreng,
2t
Stembark Extract And Validation of The Analysis Method Using HPLC
Ni Putu
Ariantari, Lidya Tumewu, Agriana Rosmalina Hidayati, Aty
Widyawaruyanti, Achmad Fuad Hafid
lsolation of oligomerstilbenoids From Stem Batk
Endemic of South East Sulawesi
ot
Votica tlavofirens Sloot
29
Siti Hadijah Sabarwati, Nohong, Euis H. Hakim, Yana M. Syah, Sutriadi S, Zaeni A
Antlmicrobial And Anticancer Activity of curcusone B lsolated From stem Bark
ol lotropha curcas
l. Sahidin, Ardiansyah, M. Taher, S. Arsad,5.J-A. lchwan, l. latip, B.M. Yamin, and
54
S.N. Baharum
Screening of Medicinal Plants of South Sumatera
Atainst Organism From Skin lnfection
Salni, Hanifa Marisa, Harmida
Long Term Effect
of
Ethanolic Extract
for Antibacterial Activity
oI
Fenugreek Seeds
47
47
lfrlgonello foenum-gruecum t.) on White Rat Liver Function
Kurnia Agustini, Sriningsih, Lestari Rahayu
Analysis of Plasma Malondialdehide (Mda) Concentration By Giving Shallot's
Extortion Water lAllium ascalonicum L.l on Hypercholesterolemic Mice
lsmawati, Enikarmila Asni, M.Yulis Hamidy
54
Chemical Constituents from Shorea faguetiono(Dipterocarpaceae)
Rohaiza Saat, Laily B. Din, Wan Yaacob Wan Ahmad
60
1V
ISBN : 97&602-96839-2-9 (vol l)
tPraceeding of
Intemationa[ 6o{erence on *!.edicina{lPhnts - Sura'aya, Inlonxia. 21-21 Ju$ 2010
and
Conservatlon Effort of Burahol Species lStelechocorpus
burohol (Blume) Hook & Thomson)
Research Statues
66
Tati Rostiwati, Tuti Herawati, Melani Kurnia Riswati
Ecology of Kepel (stelechocorpus burohol (Blume) Hook, F.&Thomson)
Purwodadl Botanical Garden
ln
73
Solikin
Effect of Additional Antioxidant of Fruit Extract of Kepel
(Stelechocarpus buraholl in Sernen Diluent to The Quality
Spermatozoa
Rina Priastini And Flora Rumiati
80
ot Bex
Babbiys
Acceleration ol ln-vitrc Getmination of Fenugreek
lTri go n el I o fo e nu m - g ra e c u m L, I
lis Rahmawati, Ahmad Saufi
oe
ln Wtrc 9rcduclion of Secondary Metabolites from
Gynura pseudochiro (tour.) D.C,
91
Maria G. M. Purwanto, Anna Ruanto, l. B. Artadhana, Tjie Kok, Selvy Theodorus,
Michael William Tanojo
Anti-lnflammatory Activity of Single and Combination Tlnospora
Andrcgrophis poniculatd oecoc1.ion in Albino Rats
c
spo and
97
Firdaus, Lestari Rahayu
Larvacide Effect of Ethanol Extract Ol Plperis nigrl fructus against
Aedes oegypti Linn. Lerva
Sajekti Palupi, Meyta, Kartini
100
Determination of Chlorophylls and Carotenoids Content in Three Major Teas
based on Peak Area from HPLC Chromatogram
103
Wahyu Wijaya, Heriyanto, Budhi Prasetyo, Leenawaty Limantara
Bacterial Cellulose as Separating Agent
Plants, A Preliminary Study
Surjani Wonorahardjo
for Useful Compounds in Medicinal
ttz
ISBN : 97&602-968i19-2-9 (vol l)
.?roccc6ng of Intemationat Confcrerree on X,l.eticinattPht* - Sura6a1a, Intoncsia 21-21
Eioflavonoid quercetin lmproves The lnsulin Resistance in Diet-lnduced
Rat Model
Heni Fatmawati, Candra Bumi
Toxic Compounds Extracted Frcm Eugenia un
rora
I
!ut!
2O1O
Obesity
Against T47D Cell tine
119
727
Nita Supriyati, Esti Wahyu Widowati
q/totoxic Potential of Garlic Exlrad lAllium sotivuml
Al Munawir
133
lsolation And ldentification c-Mangostin As A Marker Compound from
Gorcinio mangostono L Hull
Lince Yarni, lltizam Nasrullah, Sri Murhandini, Winiati P. Rahayu
141
,,
vitro Anti-Malarial Activity Triterpenoid Pentacyclics from
Erythrlna variegoto against Prasmodium falciparum
Tati Herlina, Dikdik Kurnia, Suseno Amien, And Unang Supratman
745
The Comparison Antioxidant, Antiaggregation of Various Tea Extract
lComellia sinensls L,l
757
Wahyu Widowati, Tati Herlina, Hana Ratnawati, Tjandrawati
lsolation and ldentification Toxic Oxoaporphinoid Alkaloid ,com Stclechocorpus 150
burahol Hook F. & Thoms. Stem Bark (Annonaceae)
Clara Sunardi, Kosasih Padmawinata, L. B. S. Kardono, Asep Gana
Strusture
of
Steroids
in
Stelechocarpus burahol Hook F.
& Thomson
Stem
164
Sark
Clara Sunardi
Several Standard Parameter and Phytochemical Sreening of
Stelechocaryus burohol HookF. & Thomson Stem Bark
Clara Sunardi
169
Mutagenic Etlect ol Curcuma zedoario Dry Extract by Ames Test
773
Rina Adriany, Eka Rusmawati, Murtiningsih, Fitria Rahmi, Tuti Erlina
vt
ISBN : 97&602-96839-2.9 (vol l)
L