The influence of fermented and non-fermented Sauropus Androgynus (L.) Merr. leaves extract on the hematopoiesis in the postnatal mice

Majalah llrnu Faal lndones~aVol a I L I

LUUY

The Influence of Fermented and Non-Fermented Sauropus
Androgynus (L.) Merr. Leaves Extract on The Hematopoiesis in
The Postnatal Mice
Pengaruh Fermentasi dan Non-Fermentasi Ekstrak Daun Sauropus Androgynus
(L.) Merr. pada Hematopoiesis pada Tikus Postnatal
Agik Suprayogi, Aryani S. Satyaningtijas, Nastiti Kusumorini, and Evrieolita E. Pantina
Department of Anatomy, Physiology and Pharmacology, Faculty of Veterinary Medicine
Boyor Agricultural University (IPB). JI. Agatis-Kampus IPB Darmaga-Bogor-16680, Indonesia,
Fax: 0062-251-629462, email: asupray@yahoo.com

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh dua bentuk ekstrak daun Sauropus
androgynus (SA) yaitu bentuk fermentasi dan non-fermentasi terhadap hematopoesis pada 36
tikus betina postnatal. Sampel dibagi menjadi 3 kelompok, masing-masing kelompok terdiri dari
12 tikus. Kelompok pertama adalah control diberikan air suling, kelompok kedua diberikan
ekstrak ferrnentasi SA (Fermentasi SA extract,FSA) , dan kelompok tiga diberikan ekstrak non
fermentas1 (non Ferrnentrasi SA extract, nFSA). Setiap grup diberikan minuman cairan 0,6%

selama 21 hari sebelum partus dan dilanjutkan hingga 1 minggu postnztal dengan dosis 1.68
glkg BBlhari. Pengambilan darah dilakukan intrakardiak dengan anastesi inhalasi pada hari ke-1
hingga hari ke-7 postnatal kemudian dilakukan pemeriksaan hematologis yaitu jumlah eritrosit.
ieukosit, hematokrit (Htj dan hemcglobin (Hb) yang dianalisa dengan menggunakan
hemoc~t~meter-neubauer,
Sahli, metode tabung kapiler. Hasii manunjukkan respon bemato!ogis
pos~t~f
terhadap kedua periakuarl. Jumlah eritrosit, leukosit, Ht dan Hb
meningkat secara
progresif dari hari pertama hingga hari ke-7 postnatal, den~ankemompok nFSA menunjukkan
peningkatan yang bermakna terutama pada Ht, Hb dan !eukosit dibandingkan dengan kelompok
FSA. Hal ini menunjukkan bahwa bentuk non fermentasi ekstrak daun SA memiliki respon
hernatoaoeisis yang iehih baik dibandingkan dengan bentuk fermentasinya.
Katb Kunci: Sauropus androgynus, nematopoiesis, postnatal, tikus

lNTRODUCilON
Sawopus androgynus (SA), a member
of Euphorbiaceae family, is a ieafy shrub
found in Malaysia, Indonesia, Southwest
China and Vietnam. The habitat aliitude is 31300 meters above sea level (Padmavathi

and Rao. 7990). Indoncqian believes that
Sauropus androgynus ~ l a n t supports
lactation in human beings. Mothers eat or
[eaves and
preparations
drink
SA
respectively, in order to increase their breast
feeding capacity (Soeparto, 1994). Even as a
traditional medicine, SAextract tablet has
been produced as a food supplement by an
lndones~an pharmaceutical
companies
bearing capiet, tablet and steeping for
human. For ruminants, SA powder and SA

extract administration could enhance ,milk
yield in lactating ewes. The enhancement of
milk yield in the cellular level of mammary
glznd could have Seen caused by two

importance factors such as, first there were
increasing of population of secretory cells
and the synthetic activiiies in the secretory
cells and seconds, the increase in nutrient
supply to the lactating mammary gland
(Suprayogi et al., 2001). For poultry
production, supplem~ntationof SA meal 30 g
per day to the broiler diet was effective to
improve feed conversion ratio without
reducing body
weight,
besides the
supplementation
could
reduce
fat
accumulation in broiler chickens. The

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