PENGARUH KADAR GLUKOSA DARAH SEWAKTU TERHADAP KELUARAN NEUROLOGIK PADA PENDERITA STROKE ISKEMIK FASE AKUT NONDIABETIK - Diponegoro University | Institutional Repository (UNDIP-IR)
62
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JUDUL PENELITIAN
PENGARUH KADAR GLUKOSA DARAH SEWAKTU TERHADAP
KELUARAN NEUROLOGIK PADA PENDERITA STROKE ISKEMIK
FASE AKUT NONDIABETIK
INSTANSI PELAKSANA
: RS DR. KARIADI SEMARANG
PERSETUJUAN SETELAH PENJELASAN
(INFORMED CONSENT)
Berikut ini naskah yang akan dibacakan pada Responden / Keluarga
Responden Penelitian :
Bapak / Ibu / Sdr Yth
Anda terpilih sebagai responden penelitian yang berhubungan dengan kadar
glukosa darah sewaktu sebagai faktor risiko pada penderita stroke yang anda /
keluarga anda alami.
Tindakan yang akan Bapak / Ibu / Sdr alami :
Dilakukan anamnesis (menggunakan kuesioner) dan pemeriksaan fisik
neurologik (menggunakan palu reflek dan senter).
Pengambilan sampel darah untuk pemeriksaan kadar glukosa darah
yang akan dilaksanakan 2 kali, pertama saat pasien masuk ke bangsal
rawat inap penyakit saraf dan kedua setelah 24 jam berikutnya.
Dilakukan penilaian status neurologik menggunakan skor NIHSS pada
perawatan hari ke 0, 1 dan saat pasien pulang atau hari ke 7.
Terimakasih atas kerjasama Bapak / Ibu / Sdr.
Setelah mendengar dan memahami penjelasan peneliti, dengan ini saya
menyatakan SETUJU / TIDAK SETUJU untuk ikut sebagai responden
penelitian.
Semarang, ................................
Peserta penelitian
(
Saksi
)
(
Peneliti
)
(dr. Edward Y.N)
76
DAFTAR PERTANYAAN DATA DASAR PENELITIAN
NO.
1
2
3
4
PERTANYAAN
IDENTITAS
Nomor penelitian
Tanggal pemeriksaan
Nama
Alamat
5
6
7
Nomor CM/Register
Tanggal/jam masuk RS
Jenis kelamin
8
9
Umur (tahun)
Status perkawinan
10
Pendidikan
11
Pekerjaan
12
13
14
ANAMNESIS
Defisit neurologis
Tanggal/jam serangan
Kedinian datang ke RS
15
Riwayat DM
16
Riwayat hipertensi
17
Riwayat merokok
18
PEMERIKSAAN FISIK
Tinggi badan (cm)
JAWABAN
1. Laki-laki
2. Perempuan
1. Kawin
2. Janda/duda
3. Belum kawin
1. SD
2. SLTP
3. SLTA
4. S1
5. Tidak sekolah
1. PNS / TNI
2. Wiraswasta
3. Pedagang
4. Buruh / Tani
5. Tidak bekerja
1. < 48 jam
2. 49 - 72 jam
1. Ya
2. Tidak
1. Ya
2. Tidak
1. Ya
2. Tidak
77
19
20
Berat badan (kg)
Body Mass Index
21
22
23
24
25
26
Glasgow Coma Scale
Tekanan darah (mmHg)
Nadi (x/menit)
Suhu (°C)
Pernafasan (x/menit)
Jantung
27
Pemeriksaan EKG
31
PEMERIKSAAN NEUROLOGIS
Skor NIHSS < 48 jam onset
Skor NIHSS 49 - 72 jam onset
Skor NIHSS hari ke 7 onset
PEMERIKSAAN PENUNJANG
Lokasi infark
32
33
34
35
36
Kadar Hb (gr%)
Leukosit (mm3)
Trombosit (mm3)
Hematokrit (%)
Kadar glukosa darah sewaktu
37
38
39
40
Kadar kolesterol total (mg%)
Kadar Trigliserida (mg%)
Kadar HDL (mg%)
Kadar LDL (mg%)
KETERANGAN
Alasan pulang sebelum hari ke 7
onset
28
29
30
41
1. Kurus (< 18,5)
2. Nomal (18,5-25)
3. Overweight (25-30)
4. Obesitas (> 30)
1. Normal
2. Tidak normal
1. Normal
2. Tidak normal
1. Kortikal
2. Subkortikal
3. Batang otak
4. Campuran
5. Normal
1. < 48 jam onset
2. 49 - 72 jam onset
3. Hari ke 7 onset
78
NATIONAL INSTITUTES OF HEALTH STROKE SCALES (NIHSS)
NIHSS
1a
1b
1c
2
3
4
5a
5b
6a
Derajat kesadaran
0 = sadar penuh
1 = somnolen
2 = stupor
3 = tidak respon atau hanya terdapat reflek
Menjawab pertanyaan
0 = dapat menjawab dua pertanyaan dengan benar (misalnya bulan apa
sekarang dan usia pasien)
1 = hanya dapat menjawab satu pertanyaan dengan benar / tidak dapat
berbicara karena terpasang pipa endotrakeal atau disartria
2 = tidak dapat menjawab kedua pertanyaan dengan benar / afasia / stupor
Mengikuti perintah
0 = dapat melakukan dua perintah dengan benar (misalnya buka dan tutup
mata, kepal dan buka tangan pada sisi yang sehat)
1 = hanya dapat melakukan satu perintah dengan benar
2 = tidak dapat melakukan kedua perintah dengan benar
Gerakan mata konyugat horisontal
0 = normal
1 = kelumpuhan parsial
2 = deviasi konyugat yang kuat atau paresis konyugat total pada kedua
mata, tidak dapat diatasi dengan manuver okulosefalik
Lapangan pandang pada tes konfrontasi
0 = tidak ada gangguan
1 = hemianopia parsial
2 = hemianopsia total
3 = hemianopsia bilateral (termasuk juga buta kortikal)
Paresis wajah
0 = normal
1 = paresis ringan (sulkus nasolabialis mendatar, terdapat asimetri)
2 = paresis parsial (paresis total/hampir total wajah bagian bawah)
3 = paresis total (tidak ada gerakan dari wajah atas dan bawah)
Motorik lengan kiri
0 = tidak ada simpangan bila pasien disuruh mengangkat lengannya pada
posisi 90°/45° selama 10 detik
1 = lengan menyimpang ke bawah sebelum 10 detik
2 = lengan terjatuh ke kasur atau badan atau tidak dapat diluruskan secara
penuh
3 = tidak dapat melawan gravitasi
4 = tidak ada gravitasi
9 = tidak dapat diperiksa
Motorik lengan kanan (idem)
Motorik tungkai kiri
0 = tidak ada simpangan bila pasien disuruh mengangkat tungkai pada
posisi 30° selama 5 detik
1 = tungkai menyimpang ke bawah sebelum 5 detik
2 = tungkai terjatuh ke kasur atau tidak dapat diluruskan secara penuh
3 = tidak dapat melawan gravitasi
4 = tidak ada gravitasi
9 = tidak dapat diperiksa
1
2
3
79
6b
7
Motorik tungkai kanan (idem)
Ataksia anggota badan
0 = tidak
1 = pada satu sisi
2 = pada kedua sisi
9 = tidak dapat diperiksa
8
Sensorik
0 = normal
1 = defisit ringan-sedang
2 = defisit berat (gangguan rasa raba pada wajah, lengan dan tungkai)
9
Bahasa terbaik
0 = tidak ada afasia
1 = afasia ringan sedang
2 = afasia berat
3 = mutisme
10 Disartria
0 = artikulasi normal
1 = disartria ringan sedang (masih dapat dimengerti)
2 = disartria berat
9 = tidak dapat diperiksa
11 Neglect / tidak ada atensi
0 = tidak ada
1 = gangguan bilateral dari salah satu modalitas berikut : pengenalan
personal, visual, taktil, dan spasial
2 = gangguan pada lebih dari satu modalitas
SKOR TOTAL NIHSS
80
HASIL ANALISIS DATA
Je nis ke lam in * Kate gori NIHSS hari ke 7 Cros s tabulation
Ringan
Jenis kelamin
Laki-laki
Perempuan
Total
Count
% of Total
Count
% of Total
Count
% of Total
7
21,9%
5
15,6%
12
37,5%
Kategori NIHSS hari ke 7
Sedang
Berat
Sangat berat
9
1
2
28,1%
3,1%
6,3%
7
1
0
21,9%
3,1%
,0%
16
2
2
50,0%
6,3%
6,3%
Total
19
59,4%
13
40,6%
32
100,0%
Des criptives
Umur
Mean
95% Conf idence
Interval f or Mean
Statistic
53,94
50,58
Low er Bound
Upper Bound
Std. Error
1,649
57,30
5% Trimmed Mean
Median
Varianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
53,85
53,00
86,964
9,325
34
74
40
13
,188
-,155
,414
,809
um ur 51 * Kategori NIHSS hari k e 7 Cross tabulation
Ringan
umur
51
30)
Count
% w ithin
Count
% w ithin
BMI
BMI
BMI
BMI
7
35,0%
4
40,0%
1
50,0%
12
37,5%
Kategori NIHSS hari ke 7
Sedang
Berat
Sangat berat
11
1
1
55,0%
5,0%
5,0%
5
0
1
50,0%
,0%
10,0%
0
1
0
,0%
50,0%
,0%
16
2
2
50,0%
6,3%
6,3%
Total
20
100,0%
10
100,0%
2
100,0%
32
100,0%
82
Des criptives
GDS < 48 jam
Mean
95% Confidence
Interval for Mean
Low er Bound
Upper Bound
5% Trimmed Mean
Median
Variance
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Statistic
117,47
106,74
Std. Error
5,260
128,20
115,69
106,00
885,289
29,754
73
194
121
35
1,073
,639
,414
,809
Tes ts of Norm ality
a
GDS < 48 jam
Kolmogorov-Smirnov
Statistic
df
Sig.
,187
32
,006
Statistic
,904
Shapiro-Wilk
df
32
Sig.
,008
a. Lilliefors Signif icance Correction
Des criptives
GDS 49 - 72 jam
Mean
95% Conf idence
Interval f or Mean
Low er Bound
Upper Bound
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Statistic
115,06
105,46
Std. Error
4,707
124,66
113,52
108,00
708,899
26,625
71
182
111
32
1,070
,772
,414
,809
Tes ts of Nor m ality
a
GDS 49 - 72 jam
Kolmogorov-Smirnov
Statistic
df
Sig.
,160
32
,036
a. Lillief ors Signif icance Correc tion
Statistic
,906
Shapiro-Wilk
df
32
Sig.
,009
83
Des criptives
KOL. TOTA L
TRIGLISERIDA
HDL
LDL
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Low er Bound
Upper Bound
Low er Bound
Upper Bound
Low er Bound
Upper Bound
Low er Bound
Upper Bound
Statistic
202,75
189,81
Std. Error
6,344
215,69
202,83
202,50
1287,742
35,885
129
280
151
44
-,034
-,110
122,13
102,73
,414
,809
9,512
141,52
117,31
105,00
2895,145
53,807
61
273
212
48
1,492
1,850
43,81
40,82
,414
,809
1,468
46,81
43,40
40,50
68,931
8,302
32
63
31
11
,772
-,061
125,56
114,71
,414
,809
5,322
136,42
124,92
122,50
906,190
30,103
79
184
105
38
,427
-,530
,414
,809
84
Tes ts of Normality
a
KOL. TOTAL
TRIGLISERIDA
HDL
LDL
Kolmogorov-Smirnov
Statistic
df
Sig.
,100
32
,200*
,189
32
,005
,177
32
,012
,140
32
,115
Statistic
,986
,842
,925
,943
Shapiro-Wilk
df
32
32
32
32
Sig.
,938
,000
,028
,089
*. This is a low er bound of the true signif icance.
a. Lillief ors Signif icance Correction
Je nis ke lam in * Kate gori NIHSS hari 7Gabung Cr os stabulation
Jenis kelamin
Laki-laki
Perempuan
Total
Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
7
12
7,1
11,9
5
8
4,9
8,1
12
20
12,0
20,0
Total
19
19,0
13
13,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Ass ociation
N of Valid Cas es
Value
,009 b
,000
,009
,008
df
1
1
1
1
Asy mp. Sig.
(2-s ided)
,926
1,000
,926
Exac t Sig.
(2-s ided)
Exac t Sig.
(1-s ided)
1,000
,607
,927
32
a. Computed only for a 2x2 table
b. 1 cells (25,0%) have expec ted count less than 5. The minimum expec ted count is
4,88.
85
Riw ayat Hipe rte ns i * Kategori NIHSS hari 7Gabung Cross tabulation
Riw ayat Hipertens i +
Total
Count
Expected Count
Count
Expected Count
Count
Expected Count
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
9
16
9,4
15,6
3
4
2,6
4,4
12
20
12,0
20,0
Total
25
25,0
7
7,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases
Value
,110 b
,000
,108
df
1
1
1
,106
Asymp. Sig.
(2-sided)
,740
1,000
,742
1
Ex act Sig.
(2-sided)
Ex act Sig.
(1-sided)
1,000
,535
,744
32
a. Computed only for a 2x 2 table
b. 2 cells (50,0%) hav e expec ted count les s than 5. The minimum expected count is
2,63.
Dis lipide m ia * Kategori NIHSS hari 7Gabung Cros stabulation
Dislipidemia
+
-
Total
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
11
14
9,4
15,6
1
6
2,6
4,4
12
20
12,0
20,0
Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count
Total
25
25,0
7
7,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases
Value
2,060b
,987
2,302
1,996
df
1
1
1
1
Asymp. Sig.
(2-sided)
,151
,320
,129
Ex act Sig.
(2-sided)
Ex act Sig.
(1-sided)
,212
,161
,158
32
a. Computed only for a 2x 2 table
b. 2 cells (50,0%) hav e expec ted count les s than 5. The minimum expected count is
2,63.
86
Me rokok * Kategori NIHSS hari 7Gabung Cros stabulation
Merokok
+
Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count
Total
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
3
6
3,4
5,6
9
14
8,6
14,4
12
20
12,0
20,0
Total
9
9,0
23
23,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases
Value
,093 b
,000
,094
df
1
1
1
,090
Asymp. Sig.
(2-sided)
,761
1,000
,760
1
Ex act Sig.
(2-sided)
Ex act Sig.
(1-sided)
1,000
,546
,764
32
a. Computed only for a 2x 2 table
b. 1 cells (25,0%) hav e expec ted count les s than 5. The minimum expected count is
3,38.
Infark Miokard * Kategori NIHSS hari 7Gabung Cros stabulation
Inf ark Miokard
+
-
Total
Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
5
4
3,4
5,6
7
16
8,6
14,4
12
20
12,0
20,0
Total
9
9,0
23
23,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases
Value
1,742b
,835
1,708
1,687
df
1
1
1
1
Asymp. Sig.
(2-sided)
,187
,361
,191
Ex act Sig.
(2-sided)
Ex act Sig.
(1-sided)
,240
,180
,194
32
a. Computed only for a 2x 2 table
b. 1 cells (25,0%) hav e expec ted count les s than 5. The minimum expected count is
3,38.
87
Kolmogorov Smirnov BMI dengan NIHSS hari ke 7
Fr eque ncies
BMI
Kategori NIHSS
Ringan
Sedang+Berat+
Sangat Berat
Total
N
12
20
32
Tes t Statis ticsa
Mos t Ex treme
Dif f erences
BMI
,067
,067
,000
,183
1,000
A bs olute
Positive
Negative
Kolmogorov-Smirnov Z
A sy mp. Sig. (2-tailed)
a. Grouping V ariable: Kategori NIHSS hari 7Gabung
Skor NIHSS Skor NIHSS < 48 jam
c. Skor NIHSS hari ke 7 = Skor NIHSS < 48 jam
d. Skor NIHSS hari ke 7 < Skor NIHSS 49 - 72 jam
e. Skor NIHSS hari ke 7 > Skor NIHSS 49 - 72 jam
f . Skor NIHSS hari ke 7 = Skor NIHSS 49 - 72 jam
g. Skor NIHSS 49 - 72 jam < Skor NIHSS < 48 jam
h. Skor NIHSS 49 - 72 jam > Skor NIHSS < 48 jam
i. Skor NIHSS 49 - 72 jam = Skor NIHSS < 48 jam
Tes t Statisticsb
Z
A sy mp. Sig. (2-tailed)
Skor NIHSS
hari ke 7 Skor NIHSS
< 48 jam
-4,268a
,000
a. Based on positive ranks .
b. Wilc oxon Signed Ranks Tes t
Skor NIHSS
hari ke 7 Skor NIHSS
49 - 72 jam
-4,089a
,000
Skor NIHSS
49 - 72 jam Skor NIHSS
< 48 jam
-2,392a
,017
91
20
15
10
5
0
73 81 86 92 93 97 100 103 105 107 108 113 116 119 125 127 135 140 141 157 163 168 186 194
gds_0
D_NIHSS2
30
20
10
0
Observed
-10
Linear
0
100
200
300
400
GDS_0
D_NIHSS2 = selisih NIHSS 48 jam onset dengan hari ke 7 onset
92
Cas e Proces s ing Sum m ary
GDS_0
Positivea
Negative
Mis sing
V alid N
(listw ise)
3
33
1
Larger values of the tes t res ult variable(s ) indicate
stronger ev idenc e f or a positive ac tual s tate.
a. The positive ac tual s tate is 105.
ROC Curve
1.00
.75
.50
.25
0.00
0.00
.25
.50
.75
1.00
1 - Specificity
Diagonal segments are produced by ties.
Are a Under the Cur ve
Test Result V ariable(s ): D_NIHSS2
A rea
.571
a
Std. Error
.112
A sy mptotic
b
Sig.
.689
A sy mptotic 95% Conf idence
Interval
Low er Bound Upper Bound
.351
.790
The test result variable(s ): D_NIHSS2 has at least one tie betw een the
positive actual state group and the negative actual state group. Statistic s
may be biased.
a. Under the nonparametric assumption
b. Null hypothesis: true area = 0.5
93
Coordinate s of the Curve
Test Res ult V ariable(s ): D_NIHSS2
Positive if
Greater Than
a
or Equal To
-1.00
.50
1.50
2.50
11.50
21.00
Sens itiv ity
1.000
1.000
.333
.000
.000
.000
1 - Specif ic ity
1.000
.667
.364
.152
.030
.000
The test result variable(s ): D_NIHSS2 has at leas t one tie
betw een the pos itiv e ac tual s tate group and the negative
ac tual s tate group.
a. The smallest c utof f value is the minimum
observ ed tes t value minus 1, and the largest cutoff
value is the maximum observ ed tes t value plus 1.
All the other cutof f v alues are the av erages of tw o
cons ecutive ordered obs erved test values.
Cor relations
Spearman's rho
GDS_0
D_NIHSS1
D_NIHSS2
Correlation Coeffic ient
Sig. (2-tailed)
N
Correlation Coeffic ient
Sig. (2-tailed)
N
Correlation Coeffic ient
Sig. (2-tailed)
N
GDS_0
1.000
.
36
.176
.306
36
-.149
.386
36
**. Correlation is s ignificant at the 0.01 level (2-tailed).
Cas e Proces s ing Sum m ary
GDS_0
Positivea
Negative
Mis sing
V alid N
(listw ise)
1
35
1
Larger values of the tes t res ult variable(s ) indicate
stronger ev idenc e f or a positive ac tual s tate.
a. The positive ac tual s tate is 107.
D_NIHSS1
.176
.306
36
1.000
.
36
.671**
.000
36
D_NIHSS2
-.149
.386
36
.671**
.000
36
1.000
.
36
94
ROC Curve
1.00
.75
.50
.25
0.00
0.00
.25
.50
.75
1.00
1 - Specificity
Are a Under the Cur ve
Test Result Variable(s ): D_NIHSS2
Area
1.000
a
Std. Error
.000
Asy mptotic
b
Sig.
.092
Asy mptotic 95% Conf idence
Interval
Low er Bound Upper Bound
1.000
1.000
a. Under the nonparametric assumption
b. Null hypothesis: true area = 0.5
Coordinate s of the Curve
Test Res ult V ariable(s ): D_NIHSS2
Positive if
Greater Than
a
or Equal To
-1.00
.50
1.50
2.50
11.50
21.00
Sens itiv ity
1.000
1.000
1.000
1.000
1.000
.000
1 - Specif ic ity
1.000
.686
.343
.114
.000
.000
a. The smallest c utof f value is the minimum
observ ed tes t value minus 1, and the largest cutoff
value is the maximum observ ed tes t value plus 1.
All the other cutof f v alues are the av erages of tw o
cons ecutive ordered obs erved test values.
95
Cas e Proces s ing Sum m ary
V alid N
(listw ise)
1
35
1
GDS_0
Positivea
Negative
Mis sing
Larger values of the tes t res ult variable(s) indicate
stronger ev idence for a positive ac tual s tate.
a. The positive actual s tate is 108.
ROC Curve
1.00
.75
.50
.25
0.00
0.00
.25
.50
.75
1.00
1 - Specificity
Diagonal segments are produced by ties.
Regression
V ariables Enter ed/Re m ovebd
Model
1
V ariables
Entered
GDS_0a
V ariables
Remov ed
.
Method
Enter
a. A ll requested variables entered.
b. Dependent Variable: D_NIHSS2
Model Sum m ary
Model
1
R
.114 a
R Square
.013
A djusted
R Square
-.016
a. Predictors: (Constant), GDS_0
Std. Error of
the Estimate
3.321
96
ANOVAb
Model
1
Regression
Residual
Total
Sum of
Squares
4.926
375.074
380.000
df
Mean Square
4.926
11.032
1
34
35
F
.447
Sig.
.508 a
a. Predictors: (Constant), GDS_0
b. Dependent Variable: D_NIHSS2
Coe fficientsa
Model
1
(Constant)
GDS_0
Unstandardiz ed
Coef f icients
B
Std. Error
2.521
1.393
-.006
.010
Standardized
Coef f icients
Beta
-.114
t
1.809
-.668
Sig.
.079
.508
a. Dependent Variable: D_NIHSS2
Cut off point kadar GDS 105 mg/dl :
Kate gori NIHSS hari 7Gabung * Hiper glike m ia Cross tabulation
Count
Kategori NIHSS
hari 7Gabung
Ringan
Sedang+Berat+
Sangat Berat
Hiperglikemia
Euglikemia
Hiperglikemia
7
5
Total
Nilai duga positif
= 11/20 = 55 %
Nilai duga negatif
= 7/12 = 58,3 %
Sensitivitas
= 11/16 = 68,75 %
Spesifisitas
= 7/16 = 43,75 %
Total
12
9
11
20
16
16
32
= (1-specificity) = 9/16 = 56,25 %
= (1-sensitivity) = 5/16 = 3,25 %
Likelihood ratio positive = 68,75 / 56,25 = 1,2
Likelihood ratio negative = 31,25 / 43,75 = 0,71
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75
JUDUL PENELITIAN
PENGARUH KADAR GLUKOSA DARAH SEWAKTU TERHADAP
KELUARAN NEUROLOGIK PADA PENDERITA STROKE ISKEMIK
FASE AKUT NONDIABETIK
INSTANSI PELAKSANA
: RS DR. KARIADI SEMARANG
PERSETUJUAN SETELAH PENJELASAN
(INFORMED CONSENT)
Berikut ini naskah yang akan dibacakan pada Responden / Keluarga
Responden Penelitian :
Bapak / Ibu / Sdr Yth
Anda terpilih sebagai responden penelitian yang berhubungan dengan kadar
glukosa darah sewaktu sebagai faktor risiko pada penderita stroke yang anda /
keluarga anda alami.
Tindakan yang akan Bapak / Ibu / Sdr alami :
Dilakukan anamnesis (menggunakan kuesioner) dan pemeriksaan fisik
neurologik (menggunakan palu reflek dan senter).
Pengambilan sampel darah untuk pemeriksaan kadar glukosa darah
yang akan dilaksanakan 2 kali, pertama saat pasien masuk ke bangsal
rawat inap penyakit saraf dan kedua setelah 24 jam berikutnya.
Dilakukan penilaian status neurologik menggunakan skor NIHSS pada
perawatan hari ke 0, 1 dan saat pasien pulang atau hari ke 7.
Terimakasih atas kerjasama Bapak / Ibu / Sdr.
Setelah mendengar dan memahami penjelasan peneliti, dengan ini saya
menyatakan SETUJU / TIDAK SETUJU untuk ikut sebagai responden
penelitian.
Semarang, ................................
Peserta penelitian
(
Saksi
)
(
Peneliti
)
(dr. Edward Y.N)
76
DAFTAR PERTANYAAN DATA DASAR PENELITIAN
NO.
1
2
3
4
PERTANYAAN
IDENTITAS
Nomor penelitian
Tanggal pemeriksaan
Nama
Alamat
5
6
7
Nomor CM/Register
Tanggal/jam masuk RS
Jenis kelamin
8
9
Umur (tahun)
Status perkawinan
10
Pendidikan
11
Pekerjaan
12
13
14
ANAMNESIS
Defisit neurologis
Tanggal/jam serangan
Kedinian datang ke RS
15
Riwayat DM
16
Riwayat hipertensi
17
Riwayat merokok
18
PEMERIKSAAN FISIK
Tinggi badan (cm)
JAWABAN
1. Laki-laki
2. Perempuan
1. Kawin
2. Janda/duda
3. Belum kawin
1. SD
2. SLTP
3. SLTA
4. S1
5. Tidak sekolah
1. PNS / TNI
2. Wiraswasta
3. Pedagang
4. Buruh / Tani
5. Tidak bekerja
1. < 48 jam
2. 49 - 72 jam
1. Ya
2. Tidak
1. Ya
2. Tidak
1. Ya
2. Tidak
77
19
20
Berat badan (kg)
Body Mass Index
21
22
23
24
25
26
Glasgow Coma Scale
Tekanan darah (mmHg)
Nadi (x/menit)
Suhu (°C)
Pernafasan (x/menit)
Jantung
27
Pemeriksaan EKG
31
PEMERIKSAAN NEUROLOGIS
Skor NIHSS < 48 jam onset
Skor NIHSS 49 - 72 jam onset
Skor NIHSS hari ke 7 onset
PEMERIKSAAN PENUNJANG
Lokasi infark
32
33
34
35
36
Kadar Hb (gr%)
Leukosit (mm3)
Trombosit (mm3)
Hematokrit (%)
Kadar glukosa darah sewaktu
37
38
39
40
Kadar kolesterol total (mg%)
Kadar Trigliserida (mg%)
Kadar HDL (mg%)
Kadar LDL (mg%)
KETERANGAN
Alasan pulang sebelum hari ke 7
onset
28
29
30
41
1. Kurus (< 18,5)
2. Nomal (18,5-25)
3. Overweight (25-30)
4. Obesitas (> 30)
1. Normal
2. Tidak normal
1. Normal
2. Tidak normal
1. Kortikal
2. Subkortikal
3. Batang otak
4. Campuran
5. Normal
1. < 48 jam onset
2. 49 - 72 jam onset
3. Hari ke 7 onset
78
NATIONAL INSTITUTES OF HEALTH STROKE SCALES (NIHSS)
NIHSS
1a
1b
1c
2
3
4
5a
5b
6a
Derajat kesadaran
0 = sadar penuh
1 = somnolen
2 = stupor
3 = tidak respon atau hanya terdapat reflek
Menjawab pertanyaan
0 = dapat menjawab dua pertanyaan dengan benar (misalnya bulan apa
sekarang dan usia pasien)
1 = hanya dapat menjawab satu pertanyaan dengan benar / tidak dapat
berbicara karena terpasang pipa endotrakeal atau disartria
2 = tidak dapat menjawab kedua pertanyaan dengan benar / afasia / stupor
Mengikuti perintah
0 = dapat melakukan dua perintah dengan benar (misalnya buka dan tutup
mata, kepal dan buka tangan pada sisi yang sehat)
1 = hanya dapat melakukan satu perintah dengan benar
2 = tidak dapat melakukan kedua perintah dengan benar
Gerakan mata konyugat horisontal
0 = normal
1 = kelumpuhan parsial
2 = deviasi konyugat yang kuat atau paresis konyugat total pada kedua
mata, tidak dapat diatasi dengan manuver okulosefalik
Lapangan pandang pada tes konfrontasi
0 = tidak ada gangguan
1 = hemianopia parsial
2 = hemianopsia total
3 = hemianopsia bilateral (termasuk juga buta kortikal)
Paresis wajah
0 = normal
1 = paresis ringan (sulkus nasolabialis mendatar, terdapat asimetri)
2 = paresis parsial (paresis total/hampir total wajah bagian bawah)
3 = paresis total (tidak ada gerakan dari wajah atas dan bawah)
Motorik lengan kiri
0 = tidak ada simpangan bila pasien disuruh mengangkat lengannya pada
posisi 90°/45° selama 10 detik
1 = lengan menyimpang ke bawah sebelum 10 detik
2 = lengan terjatuh ke kasur atau badan atau tidak dapat diluruskan secara
penuh
3 = tidak dapat melawan gravitasi
4 = tidak ada gravitasi
9 = tidak dapat diperiksa
Motorik lengan kanan (idem)
Motorik tungkai kiri
0 = tidak ada simpangan bila pasien disuruh mengangkat tungkai pada
posisi 30° selama 5 detik
1 = tungkai menyimpang ke bawah sebelum 5 detik
2 = tungkai terjatuh ke kasur atau tidak dapat diluruskan secara penuh
3 = tidak dapat melawan gravitasi
4 = tidak ada gravitasi
9 = tidak dapat diperiksa
1
2
3
79
6b
7
Motorik tungkai kanan (idem)
Ataksia anggota badan
0 = tidak
1 = pada satu sisi
2 = pada kedua sisi
9 = tidak dapat diperiksa
8
Sensorik
0 = normal
1 = defisit ringan-sedang
2 = defisit berat (gangguan rasa raba pada wajah, lengan dan tungkai)
9
Bahasa terbaik
0 = tidak ada afasia
1 = afasia ringan sedang
2 = afasia berat
3 = mutisme
10 Disartria
0 = artikulasi normal
1 = disartria ringan sedang (masih dapat dimengerti)
2 = disartria berat
9 = tidak dapat diperiksa
11 Neglect / tidak ada atensi
0 = tidak ada
1 = gangguan bilateral dari salah satu modalitas berikut : pengenalan
personal, visual, taktil, dan spasial
2 = gangguan pada lebih dari satu modalitas
SKOR TOTAL NIHSS
80
HASIL ANALISIS DATA
Je nis ke lam in * Kate gori NIHSS hari ke 7 Cros s tabulation
Ringan
Jenis kelamin
Laki-laki
Perempuan
Total
Count
% of Total
Count
% of Total
Count
% of Total
7
21,9%
5
15,6%
12
37,5%
Kategori NIHSS hari ke 7
Sedang
Berat
Sangat berat
9
1
2
28,1%
3,1%
6,3%
7
1
0
21,9%
3,1%
,0%
16
2
2
50,0%
6,3%
6,3%
Total
19
59,4%
13
40,6%
32
100,0%
Des criptives
Umur
Mean
95% Conf idence
Interval f or Mean
Statistic
53,94
50,58
Low er Bound
Upper Bound
Std. Error
1,649
57,30
5% Trimmed Mean
Median
Varianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
53,85
53,00
86,964
9,325
34
74
40
13
,188
-,155
,414
,809
um ur 51 * Kategori NIHSS hari k e 7 Cross tabulation
Ringan
umur
51
30)
Count
% w ithin
Count
% w ithin
BMI
BMI
BMI
BMI
7
35,0%
4
40,0%
1
50,0%
12
37,5%
Kategori NIHSS hari ke 7
Sedang
Berat
Sangat berat
11
1
1
55,0%
5,0%
5,0%
5
0
1
50,0%
,0%
10,0%
0
1
0
,0%
50,0%
,0%
16
2
2
50,0%
6,3%
6,3%
Total
20
100,0%
10
100,0%
2
100,0%
32
100,0%
82
Des criptives
GDS < 48 jam
Mean
95% Confidence
Interval for Mean
Low er Bound
Upper Bound
5% Trimmed Mean
Median
Variance
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Statistic
117,47
106,74
Std. Error
5,260
128,20
115,69
106,00
885,289
29,754
73
194
121
35
1,073
,639
,414
,809
Tes ts of Norm ality
a
GDS < 48 jam
Kolmogorov-Smirnov
Statistic
df
Sig.
,187
32
,006
Statistic
,904
Shapiro-Wilk
df
32
Sig.
,008
a. Lilliefors Signif icance Correction
Des criptives
GDS 49 - 72 jam
Mean
95% Conf idence
Interval f or Mean
Low er Bound
Upper Bound
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Statistic
115,06
105,46
Std. Error
4,707
124,66
113,52
108,00
708,899
26,625
71
182
111
32
1,070
,772
,414
,809
Tes ts of Nor m ality
a
GDS 49 - 72 jam
Kolmogorov-Smirnov
Statistic
df
Sig.
,160
32
,036
a. Lillief ors Signif icance Correc tion
Statistic
,906
Shapiro-Wilk
df
32
Sig.
,009
83
Des criptives
KOL. TOTA L
TRIGLISERIDA
HDL
LDL
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Mean
95% Conf idence
Interval f or Mean
5% Trimmed Mean
Median
V arianc e
Std. Deviation
Minimum
Max imum
Range
Interquartile Range
Skew nes s
Kurtosis
Low er Bound
Upper Bound
Low er Bound
Upper Bound
Low er Bound
Upper Bound
Low er Bound
Upper Bound
Statistic
202,75
189,81
Std. Error
6,344
215,69
202,83
202,50
1287,742
35,885
129
280
151
44
-,034
-,110
122,13
102,73
,414
,809
9,512
141,52
117,31
105,00
2895,145
53,807
61
273
212
48
1,492
1,850
43,81
40,82
,414
,809
1,468
46,81
43,40
40,50
68,931
8,302
32
63
31
11
,772
-,061
125,56
114,71
,414
,809
5,322
136,42
124,92
122,50
906,190
30,103
79
184
105
38
,427
-,530
,414
,809
84
Tes ts of Normality
a
KOL. TOTAL
TRIGLISERIDA
HDL
LDL
Kolmogorov-Smirnov
Statistic
df
Sig.
,100
32
,200*
,189
32
,005
,177
32
,012
,140
32
,115
Statistic
,986
,842
,925
,943
Shapiro-Wilk
df
32
32
32
32
Sig.
,938
,000
,028
,089
*. This is a low er bound of the true signif icance.
a. Lillief ors Signif icance Correction
Je nis ke lam in * Kate gori NIHSS hari 7Gabung Cr os stabulation
Jenis kelamin
Laki-laki
Perempuan
Total
Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
7
12
7,1
11,9
5
8
4,9
8,1
12
20
12,0
20,0
Total
19
19,0
13
13,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Ass ociation
N of Valid Cas es
Value
,009 b
,000
,009
,008
df
1
1
1
1
Asy mp. Sig.
(2-s ided)
,926
1,000
,926
Exac t Sig.
(2-s ided)
Exac t Sig.
(1-s ided)
1,000
,607
,927
32
a. Computed only for a 2x2 table
b. 1 cells (25,0%) have expec ted count less than 5. The minimum expec ted count is
4,88.
85
Riw ayat Hipe rte ns i * Kategori NIHSS hari 7Gabung Cross tabulation
Riw ayat Hipertens i +
Total
Count
Expected Count
Count
Expected Count
Count
Expected Count
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
9
16
9,4
15,6
3
4
2,6
4,4
12
20
12,0
20,0
Total
25
25,0
7
7,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases
Value
,110 b
,000
,108
df
1
1
1
,106
Asymp. Sig.
(2-sided)
,740
1,000
,742
1
Ex act Sig.
(2-sided)
Ex act Sig.
(1-sided)
1,000
,535
,744
32
a. Computed only for a 2x 2 table
b. 2 cells (50,0%) hav e expec ted count les s than 5. The minimum expected count is
2,63.
Dis lipide m ia * Kategori NIHSS hari 7Gabung Cros stabulation
Dislipidemia
+
-
Total
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
11
14
9,4
15,6
1
6
2,6
4,4
12
20
12,0
20,0
Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count
Total
25
25,0
7
7,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases
Value
2,060b
,987
2,302
1,996
df
1
1
1
1
Asymp. Sig.
(2-sided)
,151
,320
,129
Ex act Sig.
(2-sided)
Ex act Sig.
(1-sided)
,212
,161
,158
32
a. Computed only for a 2x 2 table
b. 2 cells (50,0%) hav e expec ted count les s than 5. The minimum expected count is
2,63.
86
Me rokok * Kategori NIHSS hari 7Gabung Cros stabulation
Merokok
+
Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count
Total
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
3
6
3,4
5,6
9
14
8,6
14,4
12
20
12,0
20,0
Total
9
9,0
23
23,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases
Value
,093 b
,000
,094
df
1
1
1
,090
Asymp. Sig.
(2-sided)
,761
1,000
,760
1
Ex act Sig.
(2-sided)
Ex act Sig.
(1-sided)
1,000
,546
,764
32
a. Computed only for a 2x 2 table
b. 1 cells (25,0%) hav e expec ted count les s than 5. The minimum expected count is
3,38.
Infark Miokard * Kategori NIHSS hari 7Gabung Cros stabulation
Inf ark Miokard
+
-
Total
Count
Ex pected Count
Count
Ex pected Count
Count
Ex pected Count
Kategori NIHSS hari
7Gabung
Sedang+
Berat+Sangat
Ringan
Berat
5
4
3,4
5,6
7
16
8,6
14,4
12
20
12,0
20,0
Total
9
9,0
23
23,0
32
32,0
Chi-Square Te s ts
Pearson Chi-Square
Continuity Correctiona
Likelihood Ratio
Fisher's Exact Test
Linear-by -Linear
Association
N of Valid Cases
Value
1,742b
,835
1,708
1,687
df
1
1
1
1
Asymp. Sig.
(2-sided)
,187
,361
,191
Ex act Sig.
(2-sided)
Ex act Sig.
(1-sided)
,240
,180
,194
32
a. Computed only for a 2x 2 table
b. 1 cells (25,0%) hav e expec ted count les s than 5. The minimum expected count is
3,38.
87
Kolmogorov Smirnov BMI dengan NIHSS hari ke 7
Fr eque ncies
BMI
Kategori NIHSS
Ringan
Sedang+Berat+
Sangat Berat
Total
N
12
20
32
Tes t Statis ticsa
Mos t Ex treme
Dif f erences
BMI
,067
,067
,000
,183
1,000
A bs olute
Positive
Negative
Kolmogorov-Smirnov Z
A sy mp. Sig. (2-tailed)
a. Grouping V ariable: Kategori NIHSS hari 7Gabung
Skor NIHSS Skor NIHSS < 48 jam
c. Skor NIHSS hari ke 7 = Skor NIHSS < 48 jam
d. Skor NIHSS hari ke 7 < Skor NIHSS 49 - 72 jam
e. Skor NIHSS hari ke 7 > Skor NIHSS 49 - 72 jam
f . Skor NIHSS hari ke 7 = Skor NIHSS 49 - 72 jam
g. Skor NIHSS 49 - 72 jam < Skor NIHSS < 48 jam
h. Skor NIHSS 49 - 72 jam > Skor NIHSS < 48 jam
i. Skor NIHSS 49 - 72 jam = Skor NIHSS < 48 jam
Tes t Statisticsb
Z
A sy mp. Sig. (2-tailed)
Skor NIHSS
hari ke 7 Skor NIHSS
< 48 jam
-4,268a
,000
a. Based on positive ranks .
b. Wilc oxon Signed Ranks Tes t
Skor NIHSS
hari ke 7 Skor NIHSS
49 - 72 jam
-4,089a
,000
Skor NIHSS
49 - 72 jam Skor NIHSS
< 48 jam
-2,392a
,017
91
20
15
10
5
0
73 81 86 92 93 97 100 103 105 107 108 113 116 119 125 127 135 140 141 157 163 168 186 194
gds_0
D_NIHSS2
30
20
10
0
Observed
-10
Linear
0
100
200
300
400
GDS_0
D_NIHSS2 = selisih NIHSS 48 jam onset dengan hari ke 7 onset
92
Cas e Proces s ing Sum m ary
GDS_0
Positivea
Negative
Mis sing
V alid N
(listw ise)
3
33
1
Larger values of the tes t res ult variable(s ) indicate
stronger ev idenc e f or a positive ac tual s tate.
a. The positive ac tual s tate is 105.
ROC Curve
1.00
.75
.50
.25
0.00
0.00
.25
.50
.75
1.00
1 - Specificity
Diagonal segments are produced by ties.
Are a Under the Cur ve
Test Result V ariable(s ): D_NIHSS2
A rea
.571
a
Std. Error
.112
A sy mptotic
b
Sig.
.689
A sy mptotic 95% Conf idence
Interval
Low er Bound Upper Bound
.351
.790
The test result variable(s ): D_NIHSS2 has at least one tie betw een the
positive actual state group and the negative actual state group. Statistic s
may be biased.
a. Under the nonparametric assumption
b. Null hypothesis: true area = 0.5
93
Coordinate s of the Curve
Test Res ult V ariable(s ): D_NIHSS2
Positive if
Greater Than
a
or Equal To
-1.00
.50
1.50
2.50
11.50
21.00
Sens itiv ity
1.000
1.000
.333
.000
.000
.000
1 - Specif ic ity
1.000
.667
.364
.152
.030
.000
The test result variable(s ): D_NIHSS2 has at leas t one tie
betw een the pos itiv e ac tual s tate group and the negative
ac tual s tate group.
a. The smallest c utof f value is the minimum
observ ed tes t value minus 1, and the largest cutoff
value is the maximum observ ed tes t value plus 1.
All the other cutof f v alues are the av erages of tw o
cons ecutive ordered obs erved test values.
Cor relations
Spearman's rho
GDS_0
D_NIHSS1
D_NIHSS2
Correlation Coeffic ient
Sig. (2-tailed)
N
Correlation Coeffic ient
Sig. (2-tailed)
N
Correlation Coeffic ient
Sig. (2-tailed)
N
GDS_0
1.000
.
36
.176
.306
36
-.149
.386
36
**. Correlation is s ignificant at the 0.01 level (2-tailed).
Cas e Proces s ing Sum m ary
GDS_0
Positivea
Negative
Mis sing
V alid N
(listw ise)
1
35
1
Larger values of the tes t res ult variable(s ) indicate
stronger ev idenc e f or a positive ac tual s tate.
a. The positive ac tual s tate is 107.
D_NIHSS1
.176
.306
36
1.000
.
36
.671**
.000
36
D_NIHSS2
-.149
.386
36
.671**
.000
36
1.000
.
36
94
ROC Curve
1.00
.75
.50
.25
0.00
0.00
.25
.50
.75
1.00
1 - Specificity
Are a Under the Cur ve
Test Result Variable(s ): D_NIHSS2
Area
1.000
a
Std. Error
.000
Asy mptotic
b
Sig.
.092
Asy mptotic 95% Conf idence
Interval
Low er Bound Upper Bound
1.000
1.000
a. Under the nonparametric assumption
b. Null hypothesis: true area = 0.5
Coordinate s of the Curve
Test Res ult V ariable(s ): D_NIHSS2
Positive if
Greater Than
a
or Equal To
-1.00
.50
1.50
2.50
11.50
21.00
Sens itiv ity
1.000
1.000
1.000
1.000
1.000
.000
1 - Specif ic ity
1.000
.686
.343
.114
.000
.000
a. The smallest c utof f value is the minimum
observ ed tes t value minus 1, and the largest cutoff
value is the maximum observ ed tes t value plus 1.
All the other cutof f v alues are the av erages of tw o
cons ecutive ordered obs erved test values.
95
Cas e Proces s ing Sum m ary
V alid N
(listw ise)
1
35
1
GDS_0
Positivea
Negative
Mis sing
Larger values of the tes t res ult variable(s) indicate
stronger ev idence for a positive ac tual s tate.
a. The positive actual s tate is 108.
ROC Curve
1.00
.75
.50
.25
0.00
0.00
.25
.50
.75
1.00
1 - Specificity
Diagonal segments are produced by ties.
Regression
V ariables Enter ed/Re m ovebd
Model
1
V ariables
Entered
GDS_0a
V ariables
Remov ed
.
Method
Enter
a. A ll requested variables entered.
b. Dependent Variable: D_NIHSS2
Model Sum m ary
Model
1
R
.114 a
R Square
.013
A djusted
R Square
-.016
a. Predictors: (Constant), GDS_0
Std. Error of
the Estimate
3.321
96
ANOVAb
Model
1
Regression
Residual
Total
Sum of
Squares
4.926
375.074
380.000
df
Mean Square
4.926
11.032
1
34
35
F
.447
Sig.
.508 a
a. Predictors: (Constant), GDS_0
b. Dependent Variable: D_NIHSS2
Coe fficientsa
Model
1
(Constant)
GDS_0
Unstandardiz ed
Coef f icients
B
Std. Error
2.521
1.393
-.006
.010
Standardized
Coef f icients
Beta
-.114
t
1.809
-.668
Sig.
.079
.508
a. Dependent Variable: D_NIHSS2
Cut off point kadar GDS 105 mg/dl :
Kate gori NIHSS hari 7Gabung * Hiper glike m ia Cross tabulation
Count
Kategori NIHSS
hari 7Gabung
Ringan
Sedang+Berat+
Sangat Berat
Hiperglikemia
Euglikemia
Hiperglikemia
7
5
Total
Nilai duga positif
= 11/20 = 55 %
Nilai duga negatif
= 7/12 = 58,3 %
Sensitivitas
= 11/16 = 68,75 %
Spesifisitas
= 7/16 = 43,75 %
Total
12
9
11
20
16
16
32
= (1-specificity) = 9/16 = 56,25 %
= (1-sensitivity) = 5/16 = 3,25 %
Likelihood ratio positive = 68,75 / 56,25 = 1,2
Likelihood ratio negative = 31,25 / 43,75 = 0,71