The Influence Of Niosome System (Span 20/60-Choleaterol) on the Preparation Characteristics and the Release of Diclofenac Sodium from HPC-HEC Gel Based. Repository - UNAIR REPOSITORY
I
ISBN:97&97$95117+1
GOF
ITIAITASSAR INTEBNAf,IONAL STUP'OSruII
oN PTTABITACEUTICAL SCIENCE (!IIPS)
Flakassar - Squth Sulawesi
Indonesia
March l9-2O,2OOg
\
.--!
-/
,
1
FffiurryCIfihry
HEs@dH6o
tljtlflqsqt
a
ffiDAAD ffiffitrHiTflffi\
PenerbilCV21COM Maka
-r'
tll?Jl
Makassar Internasional Symposium
on Pharmaceutical Science
MIPS
Recent. Progress
2OO9
in Drug Discouery
Editors:
h{arianti A. h{anggan
Elly Wahy'uddin
Yulia Yusrini D.
Aryadi Arsyad
Lukman lr.{.
Yayu }vl. E.
Mufidah
Subehan
Habibie
Firsan
March 19.20th,2009
lvlakassaq Indonesia
r--
I l-T€) (l
)II I;9 \
J'lJJ
tvtrk^ru. lnternasional Symposium
on Pharmaceutical Science
1,1 trltns zoos
SECRETARIAT
Faculty of Pharmacy, Hasanucldin Unilcrsiry
Kampus Llnhas Tiurirlanrca
Perintis Kenrerdekarn Kn.r.10 Street
Mrkrs-.ar, South Sultlcsi, h-rtlonesir 90245
Telp. No' +62 411 5EE556, +62 411 580216
Fax. No: +62 411 590663
E-nuil, maka..srrmips(,\'ahoo.conr
'Website: uuv.unhas.ac.icl/farnasi/mips
E
Makassar International Sl,mposium
on Pharmaceutical Science
B
.a
B
3
B
MIPS
2OO9
A1l rights reserveil. No part of this publicirtion rnry be reproduccr'I, storcd in a rctriclal system, or transmittecl, in urry
form or by any means, electronic, mechanical, photocopying,
recorcling, or otlrerwise, lvithout the prior permission of thc
publisher.
Makassar International Symposium
on Pharmaceutical Science
MIPS 2OO9
No responsibiliry is assumed by the publisher {or :rny injury
and or daurage to persons or property as a matter of procluct
liaf iliry, nrgligence or orheru ise or from rny use or ol,eration
of ar.ry nedrod, proclucts, instructions or idcas containetl in
the materill herein.
O 2008
by CV.21.COM Makassar
ISBN 978-979-95 1 17-6- 1 (Hard Covcr Fomat)
r
Preface From The Editor
fFlhe Procoeding cont.rins the paper.' lo be pre>enLI ed at the Makass.rr lntern,rli('nal 51 mposium
! on Ph.,r.aceuticaI Science llrllPS; to bc hcld ir
I
M.lkotr", during March l9'r',rnd 20 '200q.
The main purpose of MIPS lvas to address young scientist from locals and regions to be actively involved in
drug discovery activities. Thc symposium celebrated the
2"'1 anniversary of Faculty of Pharmacy Hasanuddin University.
The symposinm brougl-rt together researchers rvorking in pharmaceutical innov;rtion, pharmaccutical cl-rernistry and clinical diagnostics, hcrbal medicine, marine
natural products, pharmacentical technology and pharmaceutical care, and included researchers from Cerm;rny, Nederland, Japan and Malaysia. Scicntitic reports
were presented at this symposium but the full reports
arc .rvail.rble in these proceedings.
The significant aspects related to thc papers included
in the proceedings is a number of papers har.e been \'vritten by graduate students
We gratefully acknowledge the support of the participants for their verbal and written contributions. Contributions for the proceedings were sought from all participants and all papers received were carefully referred by
peer reviews.
E
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Makassar, July 2009
Marianti A. Manggau
EDITOR
itlarianti A.
YLrlia
1r4lrrrggau
Elly WaLyLrddin
Yusrini D
H:rbibie
Firsan
(Pic[rre)
Muiidah
Srrbehan
Lukman M.
Yap Mulsiani Evirry
:::
Welcome Message on the Symposiunl
from Dean of Pharmacy Faculfy
ltor
t is gre,rt ple.rswe ior rne ro be hrre this rrrornitrg
for the special evenl rvhiclr is part of the -\Ial.,s,.rl
Internalional 51 mposiLurr on Plr.unncetriica.l Scieuce rlrttPs) end also p.y1 ol the 2nc1 arutir-ers.r5.
oi Faculty oi Pharmact-, Hasanuddin Liniversi$; helt1
in l\,Iakassar 19th to 20th oJ lvla-rch 2009.
In this svlnposiurn there are mote than 71 assal',
thesG anrl dissertations of in r.iho and in r'ir,o sfuclies
hat e been !',ublishecl, describing tire Phirmaceutical
Itrnovation, Pharrnmer-rtiral Chemj-stry i,urti Clinical
Diagnostic, Herbal \Iedicine, lr.Iarine Natruirl Prodr"tcts, Pharm.:ceutical Teclurolog,, and Pharmaceutical
J
I
I
I
:esent-
osium
reld in
ng scl-
ved in
ed the
n
Uni-
rvorkchem-
rarine
pharernarports
lports
Care.
We rvould
national
at-rd
ited speakers, and all par.ticipa:rts,
inlerr.r,'iro
rnat e this s,vrnposium possible.
Our deep appreciation to a-11 members of the orgarfzjng collrnittee Ior thek great effolt and tine they
hate spent to rnake tlris meeting success. I rLr.r1y, rr,-e
hope thal participanls have a great ctiscu-csion md rr'e
al1 can benelit from this syml
'o5iurn.
luded
L
ir-n
lile to tha:ik to the n.rtional
writ-
rticiontrirrticiby
"d
tr{alassar, July 2009
EllyWahy'uddin
Steering Co.
Elly \\'ehluCin (Coordinator Picrure)
Tadjuddin Naid
lrarvan Yusuf
\{oaika Schaefer*orti:rg
Burkh;rl Illeuser
Shigetoshi Kadotr
Farime Kalle
Svaihruddie KaCir
Amran !!as Trodl'ung
Ers Frrrrrina Sabn
\\./ira Bahrri \urJin
S;ahan:CCin K*im
Organling Co.
\,{arianri A. \langgru
{Coordinetor)
Gemini Alarr
Subehan
,i.i.ryan
i{,.rfiCsh
Heri;anto
Recent Progress in Drug Discovery March 2009
CONTENTS
Transfbrnration of Cocrystalline Phase in Binary Mixtule of Trimethoprir:r
and Sulf'amethoxazole by Slurry Technique
Eri:ttl Zain.
i
l'evel C.
Stuttit'ltpt. Sunclai .\'. Soetuntluntl.lu:ul
llalin
Evaluation ofAnti-erretic use in pediatrics rvith Retinoblastoma at Dharmais Cancer Hospital (National Cancer Center)
.4-t
F:.i.t ofACF
dn MCF-7
lrlls
grotlIh (pi0)
3.
ilitt'i,t, t di S l'ehutetu ond Di,1ir-dh Siti Rahnuh
Quality of Life Research on Geriatric Patients with Multipathology in Sard-
jito Hospital Yogyakarta
Dlah .lD,oni ]'enrittt.ttu
t*,
s**,,
*{
iaffi
Gr%
?
ls*
i :e.i ol.\Cl: of i\1( l;-l
c!Lts (r]l(r)
i.lndi
Oktiosdri and I Devo l'tltu l)ranontard
4.
The Influence of Morinda citrifolia, L. Fruit E\tract as Ad-iuvant on IgY Pr.oduction Raised in Laying Chickens against Avian InflLrenza Vaccine
Edioti S!:rsntito utd St'i lldt'inurti
5.
Chlorotbrm Fraction ofAreca (Areca calechu I-.) Induces ,Apoptosis antl
Decreases Bcl-2 Erpression on IVICF-7 Cells
E.t .Vle0o,lto. Sri Hun.lo)'uni und R.tttlo ,Tst oh Susidoti
(9 The Influence of Niosome System (SPAN 20160-Cholesterol)
on
.I'he
Plepa-
ration Characteristics and Released of Diclofenac Sodium from HPC: HEC
Gel Based
Esti llendnttli. liriek I' r\on{i, Desv Drt'i List.i'ot1i u,xl lkt l?Lt.tstlitt Prib-r,'
Recent Progress in Drug Discovery March 2009
a)'s. L) As
26. Inr.entorl," Rclocation- Antimiclobial and Phytochemical Screcnings of
Some Tladitional Metiicinal PIants olSoLrth East Sulanesi (Zinqibcraceae)
So h id i
ivc I{eart
Rus I in
o
nd
.
i
rJi ut t.-'r,ult
17. Antibacte: ial Propelties 01'Sonrc 'l'raclirional l\.ledicinal Plants Of Sourh
East Sularvesi (lndonesia)
lltrslitt, lrilion.;*ilt at .\Lthilin !
w
:aneplrora
r l.
28. Histamin Content In Sorne Fishery, Producrs Distributed ln The Nlarket In
tl
Makassar
slail{pll.1)
12002-2A07
,14et4
\Iahe
Llt'(klaft o
29. Formulation ofCacao Bean (Theobroma cacao Linn) In Scrub Cream
Pokki
ll,
Sv-ulurr R.
.\i Nidh, ,Sulnd leni ontl.htsriti.
I
l)
30. Ethnoparmacy and Chcntical Component Identification Stud1, of Pen ot
Herb (Passiflora foctida L.) at 3 Ethnic of South Sularvesi-
'los cilLtalatus
,lktsut lloskiond -.lhtndd.,1s,1i.lt in ond Iskondar Ztlkotnoin
3I
Leaf and In
-. -::.n(r
, : -:\1,
Lho.rrlillrntoie
|rJuceJ b\ blr(;l:
llll8)
Dibenzyli-
. Formulation of Ethanol Extracts Betel Nut (Areca calhecu) as \,louthrvash
,\'lud:uklir Revu, F,rninq l'akki. Nursiah Ha:-1in, fi"lndibu ancl .l,ltrjhurio
32. The Dissolution Test of Formulation Phenylbutazone Tablets Using Polysorbate-80
Aw an llvas Tamljung
33. Design of Oral Multiple Dose Simulator Program rlith One Compartment
Model
apy In Ds
Yt!sridcli
tract Cream
d Histopa-
:. .i::ir\ \rIh l)enroro\: : .:h.C1\l lbr.arh
group
34. A Computer Application for Simulation of Drug Plasma Concentration of
Amoxicillin, Ciprofloxacin, and Tetracycline after Oral Multiple Dose Administration
Ytsria.li
l! l:arl
35. Novel CYP3,A4 and CYP2D6 lnhibitors from Indonesian Medicinal Plants
Subehon. Shigetoshi
lvlenl Leaf
ells
Nk-l Antagonist Administration On Dopaminergic Cell Death
In Parkinson's Disease Animal Model
36. The Effect Of
Yu
Antibody
ry
h)
Kdiota dnd l?s hho Te:uka
I ia
tlt sr i,t i Dj/tb it'
37. Zidovudin Analysis Method Validation in Plasma in vitro Using HPLC
Yahdiana Harahap, Ri:ka ,hulalusia and Tania Swyo
Against
-,. :'rr.r lir.tida
L (pl
lll
38. Efibct Of Bitter Melon (lVlornordica Charantia) Leaves Juice On lmmunoglobulin N{ (lgm) And lmmunbglobulin G (Igg) Activity Of Male Mice
(Mus Musculus)
y'rie Ari:dndi K.. Hajar Ashtti. Ronggct llledianto,,l. ond
rcarp
ihfidah
39. Test Effect Extract Etanol Leaves Murbei (Morus alba L.) as Antimalaria to
Male Mice (Mus musculus) Use in vivo Method
Devi lirliana. Rtsli and,lsni ,4nin
:::.11
Progress jn Drug
ty March 2009
9
r
Recent Progress in Drug Discovery March 2009
40. lsolarion Endofit l\4icrobial ofTurbinalia I\{urayana Searveetl
ttt6li. .Vu:dkkit Bdit:
iul
-luinulluh
4l Anrimicrobial Activiry of fiassia alata L n-Butanol Exttact tiot.n \\'ait'r'
South Sularvesi Toward a Range of Microorganisrns by Bioautographl'TLC
.1t,tinullah, Ilusli. llttbihit' arxl T"ttitrtl.lbidin
42. Analysis ofNeern Leaves (Azadirachta Indica A. Juss) Ethanolic Extract Effect on Immunoglobuline M (lgM) Activity of Male Mice (Mus musculus)
ahicli cf rL.[ o.l]onr;tlllllrlorc
menilrlllc
((-\U)
LnJured
bl
bl (lF
Itt lJl
Itahihie,
Kus
tltrtlttno. .\lttiaDli
1.
-\lttttgg,tu' .\lufitltth tottl''lutit'tulloh
43. The Antimicrobial Activity olTurbinaria sp Ethyl Acetate Extract To\\'ard a
Few Microorganism by
B
ioautography-TLC.
iltt:okki- B.tit., llusli, Zeuustrtrtl' und Zuintl lhitlin
Trans
Mixtu
by Slu
T
44. Anti Platelet Aggregation and Free Radical Scavenging Activities of Mezzetia parviflora Becc. Woodbark Ethanolic Extract
.\hrfcfuh, .\kn'ianti ,l.l'langgtttr, llasyim Boriw and (ienini -llan
45. In Vitro and itt Vivo Stutly : Anlinricroba Properties and TLC Bioautography
Profiling on Vibrio colera, and AntidialThoea Activity of Permot Herb (Passillora foetida Linn.) Extract from South Sulawesi to Mice (mus muscultts)'
..\sni .-lmin. Mirauti,,lbd. Alalik' lirsa Hanlal'lni, lJe itld und Lt!knan ltrbussy
Il.prcseItirli!t prli.n) oiloplnrr_
iersic
neuron liitrrLrutlon rn thr SNc
46. The Influence of Polyvinylpyrroliclone K-30 to the Dissolution Rate
Phenylbutazone Prepared in Solid Dispersion
Lotifah Rahnnn, ,llil'ah Putrantodnd lraran Seti6,'a,t
of
(fl7il)
47. Single Drop Microextraction in Pharmaceuticals Analysis
(ianden Supriya lo
48. Soil Actinomycetes ofPodor Coastal in Larantuka, East Flores: Isolation
and Primary Screening for Antimicrobial Activities
Sortini lvl. |ltrtsir Djitle, Ilsmar and Sesilit Bulu Olel
49. Gastrointestinal Absorption Of Griseofulvin From Liquid Organic Acids
And Esters In Rats
Sl,ahru&lin Kadir firsan Nc,in , Teruo lvhraktni and Noboru lhta
50. Possible Factors Behind the Enhanced Castrointestinal Absorption
eofulvin from Liquid Organic Acid Ester Solutions in Rats
Slahrucldin Katlir Sumarheni, Yulia Yusrini Dilbir, Noboru YqIa'
ofCris-
51. Effect of Humidity Aging on Disintegration' Dissolution and Curnulative
Urinary Excretion of calcium p-aminosalicylate formulation
$'ahn.ldin Kadit, Sartini and S
mat
heni
52. Anti-atherosclerosis Effect ofPhysalis angulata Herb in Hypercholesterol-
emic Mice
f,ldrianli ,4. \langgau. Lu*nan illllslhnin, Ge isi '1lam, S1'aharudin Kosittt' llabibie
Recent Progress in Drug DiscoverY Marc
2009
Irtroduc
I
RESEARCH
- -
ThelnfluenceofNiosomeSystem(Span20/60-Cholesterol)
of
nn The Preparation Characteristics and Released
Diclofenac Sodium from I[PC: HEC Gel Based
Ika Rossalia Pribadi
Esti Hendradi, Thtiek Purwanti, Desy Dwi Listyani.and
universitv sunbava' Indoncsia
;;;.^il;;iah;;"cutics
or ru"ultvirehirmacv' Airlangga
Abstract
on the
influence ofniosome system(Span.20"6Gilholesterol)
The present study was designed to i[testigate the
( l: l) gel based. Niosome is vesicle
ttpc-ItEc
from
charactenslics preparation and diclolenac sJium relemed
Jcholesterol The compostion ofniosome system ofdiclofenac
svstem v',as made from surfactant non ionic-r'"^ulation
of
ISBN:97&97$95117+1
GOF
ITIAITASSAR INTEBNAf,IONAL STUP'OSruII
oN PTTABITACEUTICAL SCIENCE (!IIPS)
Flakassar - Squth Sulawesi
Indonesia
March l9-2O,2OOg
\
.--!
-/
,
1
FffiurryCIfihry
HEs@dH6o
tljtlflqsqt
a
ffiDAAD ffiffitrHiTflffi\
PenerbilCV21COM Maka
-r'
tll?Jl
Makassar Internasional Symposium
on Pharmaceutical Science
MIPS
Recent. Progress
2OO9
in Drug Discouery
Editors:
h{arianti A. h{anggan
Elly Wahy'uddin
Yulia Yusrini D.
Aryadi Arsyad
Lukman lr.{.
Yayu }vl. E.
Mufidah
Subehan
Habibie
Firsan
March 19.20th,2009
lvlakassaq Indonesia
r--
I l-T€) (l
)II I;9 \
J'lJJ
tvtrk^ru. lnternasional Symposium
on Pharmaceutical Science
1,1 trltns zoos
SECRETARIAT
Faculty of Pharmacy, Hasanucldin Unilcrsiry
Kampus Llnhas Tiurirlanrca
Perintis Kenrerdekarn Kn.r.10 Street
Mrkrs-.ar, South Sultlcsi, h-rtlonesir 90245
Telp. No' +62 411 5EE556, +62 411 580216
Fax. No: +62 411 590663
E-nuil, maka..srrmips(,\'ahoo.conr
'Website: uuv.unhas.ac.icl/farnasi/mips
E
Makassar International Sl,mposium
on Pharmaceutical Science
B
.a
B
3
B
MIPS
2OO9
A1l rights reserveil. No part of this publicirtion rnry be reproduccr'I, storcd in a rctriclal system, or transmittecl, in urry
form or by any means, electronic, mechanical, photocopying,
recorcling, or otlrerwise, lvithout the prior permission of thc
publisher.
Makassar International Symposium
on Pharmaceutical Science
MIPS 2OO9
No responsibiliry is assumed by the publisher {or :rny injury
and or daurage to persons or property as a matter of procluct
liaf iliry, nrgligence or orheru ise or from rny use or ol,eration
of ar.ry nedrod, proclucts, instructions or idcas containetl in
the materill herein.
O 2008
by CV.21.COM Makassar
ISBN 978-979-95 1 17-6- 1 (Hard Covcr Fomat)
r
Preface From The Editor
fFlhe Procoeding cont.rins the paper.' lo be pre>enLI ed at the Makass.rr lntern,rli('nal 51 mposium
! on Ph.,r.aceuticaI Science llrllPS; to bc hcld ir
I
M.lkotr", during March l9'r',rnd 20 '200q.
The main purpose of MIPS lvas to address young scientist from locals and regions to be actively involved in
drug discovery activities. Thc symposium celebrated the
2"'1 anniversary of Faculty of Pharmacy Hasanuddin University.
The symposinm brougl-rt together researchers rvorking in pharmaceutical innov;rtion, pharmaccutical cl-rernistry and clinical diagnostics, hcrbal medicine, marine
natural products, pharmacentical technology and pharmaceutical care, and included researchers from Cerm;rny, Nederland, Japan and Malaysia. Scicntitic reports
were presented at this symposium but the full reports
arc .rvail.rble in these proceedings.
The significant aspects related to thc papers included
in the proceedings is a number of papers har.e been \'vritten by graduate students
We gratefully acknowledge the support of the participants for their verbal and written contributions. Contributions for the proceedings were sought from all participants and all papers received were carefully referred by
peer reviews.
E
'6
o
E
o
E
o
G
o
:(g
o
o
(E
ta
(!
=
o,
o
o
(\t
Makassar, July 2009
Marianti A. Manggau
EDITOR
itlarianti A.
YLrlia
1r4lrrrggau
Elly WaLyLrddin
Yusrini D
H:rbibie
Firsan
(Pic[rre)
Muiidah
Srrbehan
Lukman M.
Yap Mulsiani Evirry
:::
Welcome Message on the Symposiunl
from Dean of Pharmacy Faculfy
ltor
t is gre,rt ple.rswe ior rne ro be hrre this rrrornitrg
for the special evenl rvhiclr is part of the -\Ial.,s,.rl
Internalional 51 mposiLurr on Plr.unncetriica.l Scieuce rlrttPs) end also p.y1 ol the 2nc1 arutir-ers.r5.
oi Faculty oi Pharmact-, Hasanuddin Liniversi$; helt1
in l\,Iakassar 19th to 20th oJ lvla-rch 2009.
In this svlnposiurn there are mote than 71 assal',
thesG anrl dissertations of in r.iho and in r'ir,o sfuclies
hat e been !',ublishecl, describing tire Phirmaceutical
Itrnovation, Pharrnmer-rtiral Chemj-stry i,urti Clinical
Diagnostic, Herbal \Iedicine, lr.Iarine Natruirl Prodr"tcts, Pharm.:ceutical Teclurolog,, and Pharmaceutical
J
I
I
I
:esent-
osium
reld in
ng scl-
ved in
ed the
n
Uni-
rvorkchem-
rarine
pharernarports
lports
Care.
We rvould
national
at-rd
ited speakers, and all par.ticipa:rts,
inlerr.r,'iro
rnat e this s,vrnposium possible.
Our deep appreciation to a-11 members of the orgarfzjng collrnittee Ior thek great effolt and tine they
hate spent to rnake tlris meeting success. I rLr.r1y, rr,-e
hope thal participanls have a great ctiscu-csion md rr'e
al1 can benelit from this syml
'o5iurn.
luded
L
ir-n
lile to tha:ik to the n.rtional
writ-
rticiontrirrticiby
"d
tr{alassar, July 2009
EllyWahy'uddin
Steering Co.
Elly \\'ehluCin (Coordinator Picrure)
Tadjuddin Naid
lrarvan Yusuf
\{oaika Schaefer*orti:rg
Burkh;rl Illeuser
Shigetoshi Kadotr
Farime Kalle
Svaihruddie KaCir
Amran !!as Trodl'ung
Ers Frrrrrina Sabn
\\./ira Bahrri \urJin
S;ahan:CCin K*im
Organling Co.
\,{arianri A. \langgru
{Coordinetor)
Gemini Alarr
Subehan
,i.i.ryan
i{,.rfiCsh
Heri;anto
Recent Progress in Drug Discovery March 2009
CONTENTS
Transfbrnration of Cocrystalline Phase in Binary Mixtule of Trimethoprir:r
and Sulf'amethoxazole by Slurry Technique
Eri:ttl Zain.
i
l'evel C.
Stuttit'ltpt. Sunclai .\'. Soetuntluntl.lu:ul
llalin
Evaluation ofAnti-erretic use in pediatrics rvith Retinoblastoma at Dharmais Cancer Hospital (National Cancer Center)
.4-t
F:.i.t ofACF
dn MCF-7
lrlls
grotlIh (pi0)
3.
ilitt'i,t, t di S l'ehutetu ond Di,1ir-dh Siti Rahnuh
Quality of Life Research on Geriatric Patients with Multipathology in Sard-
jito Hospital Yogyakarta
Dlah .lD,oni ]'enrittt.ttu
t*,
s**,,
*{
iaffi
Gr%
?
ls*
i :e.i ol.\Cl: of i\1( l;-l
c!Lts (r]l(r)
i.lndi
Oktiosdri and I Devo l'tltu l)ranontard
4.
The Influence of Morinda citrifolia, L. Fruit E\tract as Ad-iuvant on IgY Pr.oduction Raised in Laying Chickens against Avian InflLrenza Vaccine
Edioti S!:rsntito utd St'i lldt'inurti
5.
Chlorotbrm Fraction ofAreca (Areca calechu I-.) Induces ,Apoptosis antl
Decreases Bcl-2 Erpression on IVICF-7 Cells
E.t .Vle0o,lto. Sri Hun.lo)'uni und R.tttlo ,Tst oh Susidoti
(9 The Influence of Niosome System (SPAN 20160-Cholesterol)
on
.I'he
Plepa-
ration Characteristics and Released of Diclofenac Sodium from HPC: HEC
Gel Based
Esti llendnttli. liriek I' r\on{i, Desv Drt'i List.i'ot1i u,xl lkt l?Lt.tstlitt Prib-r,'
Recent Progress in Drug Discovery March 2009
a)'s. L) As
26. Inr.entorl," Rclocation- Antimiclobial and Phytochemical Screcnings of
Some Tladitional Metiicinal PIants olSoLrth East Sulanesi (Zinqibcraceae)
So h id i
ivc I{eart
Rus I in
o
nd
.
i
rJi ut t.-'r,ult
17. Antibacte: ial Propelties 01'Sonrc 'l'raclirional l\.ledicinal Plants Of Sourh
East Sularvesi (lndonesia)
lltrslitt, lrilion.;*ilt at .\Lthilin !
w
:aneplrora
r l.
28. Histamin Content In Sorne Fishery, Producrs Distributed ln The Nlarket In
tl
Makassar
slail{pll.1)
12002-2A07
,14et4
\Iahe
Llt'(klaft o
29. Formulation ofCacao Bean (Theobroma cacao Linn) In Scrub Cream
Pokki
ll,
Sv-ulurr R.
.\i Nidh, ,Sulnd leni ontl.htsriti.
I
l)
30. Ethnoparmacy and Chcntical Component Identification Stud1, of Pen ot
Herb (Passiflora foctida L.) at 3 Ethnic of South Sularvesi-
'los cilLtalatus
,lktsut lloskiond -.lhtndd.,1s,1i.lt in ond Iskondar Ztlkotnoin
3I
Leaf and In
-. -::.n(r
, : -:\1,
Lho.rrlillrntoie
|rJuceJ b\ blr(;l:
llll8)
Dibenzyli-
. Formulation of Ethanol Extracts Betel Nut (Areca calhecu) as \,louthrvash
,\'lud:uklir Revu, F,rninq l'akki. Nursiah Ha:-1in, fi"lndibu ancl .l,ltrjhurio
32. The Dissolution Test of Formulation Phenylbutazone Tablets Using Polysorbate-80
Aw an llvas Tamljung
33. Design of Oral Multiple Dose Simulator Program rlith One Compartment
Model
apy In Ds
Yt!sridcli
tract Cream
d Histopa-
:. .i::ir\ \rIh l)enroro\: : .:h.C1\l lbr.arh
group
34. A Computer Application for Simulation of Drug Plasma Concentration of
Amoxicillin, Ciprofloxacin, and Tetracycline after Oral Multiple Dose Administration
Ytsria.li
l! l:arl
35. Novel CYP3,A4 and CYP2D6 lnhibitors from Indonesian Medicinal Plants
Subehon. Shigetoshi
lvlenl Leaf
ells
Nk-l Antagonist Administration On Dopaminergic Cell Death
In Parkinson's Disease Animal Model
36. The Effect Of
Yu
Antibody
ry
h)
Kdiota dnd l?s hho Te:uka
I ia
tlt sr i,t i Dj/tb it'
37. Zidovudin Analysis Method Validation in Plasma in vitro Using HPLC
Yahdiana Harahap, Ri:ka ,hulalusia and Tania Swyo
Against
-,. :'rr.r lir.tida
L (pl
lll
38. Efibct Of Bitter Melon (lVlornordica Charantia) Leaves Juice On lmmunoglobulin N{ (lgm) And lmmunbglobulin G (Igg) Activity Of Male Mice
(Mus Musculus)
y'rie Ari:dndi K.. Hajar Ashtti. Ronggct llledianto,,l. ond
rcarp
ihfidah
39. Test Effect Extract Etanol Leaves Murbei (Morus alba L.) as Antimalaria to
Male Mice (Mus musculus) Use in vivo Method
Devi lirliana. Rtsli and,lsni ,4nin
:::.11
Progress jn Drug
ty March 2009
9
r
Recent Progress in Drug Discovery March 2009
40. lsolarion Endofit l\4icrobial ofTurbinalia I\{urayana Searveetl
ttt6li. .Vu:dkkit Bdit:
iul
-luinulluh
4l Anrimicrobial Activiry of fiassia alata L n-Butanol Exttact tiot.n \\'ait'r'
South Sularvesi Toward a Range of Microorganisrns by Bioautographl'TLC
.1t,tinullah, Ilusli. llttbihit' arxl T"ttitrtl.lbidin
42. Analysis ofNeern Leaves (Azadirachta Indica A. Juss) Ethanolic Extract Effect on Immunoglobuline M (lgM) Activity of Male Mice (Mus musculus)
ahicli cf rL.[ o.l]onr;tlllllrlorc
menilrlllc
((-\U)
LnJured
bl
bl (lF
Itt lJl
Itahihie,
Kus
tltrtlttno. .\lttiaDli
1.
-\lttttgg,tu' .\lufitltth tottl''lutit'tulloh
43. The Antimicrobial Activity olTurbinaria sp Ethyl Acetate Extract To\\'ard a
Few Microorganism by
B
ioautography-TLC.
iltt:okki- B.tit., llusli, Zeuustrtrtl' und Zuintl lhitlin
Trans
Mixtu
by Slu
T
44. Anti Platelet Aggregation and Free Radical Scavenging Activities of Mezzetia parviflora Becc. Woodbark Ethanolic Extract
.\hrfcfuh, .\kn'ianti ,l.l'langgtttr, llasyim Boriw and (ienini -llan
45. In Vitro and itt Vivo Stutly : Anlinricroba Properties and TLC Bioautography
Profiling on Vibrio colera, and AntidialThoea Activity of Permot Herb (Passillora foetida Linn.) Extract from South Sulawesi to Mice (mus muscultts)'
..\sni .-lmin. Mirauti,,lbd. Alalik' lirsa Hanlal'lni, lJe itld und Lt!knan ltrbussy
Il.prcseItirli!t prli.n) oiloplnrr_
iersic
neuron liitrrLrutlon rn thr SNc
46. The Influence of Polyvinylpyrroliclone K-30 to the Dissolution Rate
Phenylbutazone Prepared in Solid Dispersion
Lotifah Rahnnn, ,llil'ah Putrantodnd lraran Seti6,'a,t
of
(fl7il)
47. Single Drop Microextraction in Pharmaceuticals Analysis
(ianden Supriya lo
48. Soil Actinomycetes ofPodor Coastal in Larantuka, East Flores: Isolation
and Primary Screening for Antimicrobial Activities
Sortini lvl. |ltrtsir Djitle, Ilsmar and Sesilit Bulu Olel
49. Gastrointestinal Absorption Of Griseofulvin From Liquid Organic Acids
And Esters In Rats
Sl,ahru&lin Kadir firsan Nc,in , Teruo lvhraktni and Noboru lhta
50. Possible Factors Behind the Enhanced Castrointestinal Absorption
eofulvin from Liquid Organic Acid Ester Solutions in Rats
Slahrucldin Katlir Sumarheni, Yulia Yusrini Dilbir, Noboru YqIa'
ofCris-
51. Effect of Humidity Aging on Disintegration' Dissolution and Curnulative
Urinary Excretion of calcium p-aminosalicylate formulation
$'ahn.ldin Kadit, Sartini and S
mat
heni
52. Anti-atherosclerosis Effect ofPhysalis angulata Herb in Hypercholesterol-
emic Mice
f,ldrianli ,4. \langgau. Lu*nan illllslhnin, Ge isi '1lam, S1'aharudin Kosittt' llabibie
Recent Progress in Drug DiscoverY Marc
2009
Irtroduc
I
RESEARCH
- -
ThelnfluenceofNiosomeSystem(Span20/60-Cholesterol)
of
nn The Preparation Characteristics and Released
Diclofenac Sodium from I[PC: HEC Gel Based
Ika Rossalia Pribadi
Esti Hendradi, Thtiek Purwanti, Desy Dwi Listyani.and
universitv sunbava' Indoncsia
;;;.^il;;iah;;"cutics
or ru"ultvirehirmacv' Airlangga
Abstract
on the
influence ofniosome system(Span.20"6Gilholesterol)
The present study was designed to i[testigate the
( l: l) gel based. Niosome is vesicle
ttpc-ItEc
from
charactenslics preparation and diclolenac sJium relemed
Jcholesterol The compostion ofniosome system ofdiclofenac
svstem v',as made from surfactant non ionic-r'"^ulation
of