Hubungan Antara Tumor-Infiltrating Lymphocytes (TlLS) dan Grading Histopatologi Pada Triple Negative Breast Cancer (TNBC)

ii

ABSTRAK
Kanker payudara tipe triple negatif adalah kanker payudara yang tidak
mengekspresikan reseptor estrogen (ER), reseptor progesetron (PR) dan human
epidermal growth factor receptor2 (HER-2). Kanker payudara triple negative
(TNBC) mencakup 20-25% dari semua kanker payudara. Tumor-Infiltrating
Lymphocytes (TILs) adalah satu tipe sel darah putih yang terdapat di tumor and
fungsinya adalah untuk membunuh sel-sel tumor and ketampilannya sering
diasosiasi dengan prognosis yang lebih baik.Tujuan penelitian ini adalah untuk
melihat hubungan antara Tumor-Infiltrating Lymphocytes (TILs) dan grading
histopatologi pada Triple Negative Breast Cancer.Penelitian ini merupakan
penelitian analitik korelasi dengan desain cross sectional (potong lintang) dengan
metode total sampling dan dilakukan di RSUP Haji Adam Malik Medan. Hasil
penelitian dijumpai pasien terbanyak pada kelompok usia 50-59 tahun yaitu
sebanyak 58,8%. Pasien Triple Negative Breast Cancer paling banyak dijumpai
mempunyai grading histopatologi yang Grade II. Grading histopatologi terbanyak
dijumpai pada status minimal Tumor-Infiltrating Lymphocytes (TILs) dan
sebanyak 9 orang dengan grading histopatologi yang Grade II.
Kata Kunci: Triple Negative Breast Cancer , grading histopatologi, TumorInfiltrating Lymphocytes

Universitas Sumatera Utara

iii

ABSTRACT
Triple Negative Breast Cancer is a type of breast cancer that does not
express estragon receptors (ER), progesterone receptors and human-epidermal
growth factor receptor (HER-2). Approximately 20-25% of all breast cancer
patients has Triple negative breast cancer (TNBC)
Tumour-Infiltrating
Lymphocytes is a tye of white blood cells that exist around the tumour and
functions to kill tumour cells and the existence of the cells are always correlated
with better prognosis for the patients. The purpose of this is to observe the
relationship between Tumour-Infiltrating Lymphocytes (TILs) and the
histopatological grading of triple negative breast cancer. This research is an
analytical type of research with a cross sectional design and using total sampling
method which is done in RSUP Haji Adam Malik Medan Hospital. The total
number of sample for this research is 17 patients. The result of this research
concluded that the highest age group that was diagnosed with triple negative
breast cancer is 50-59 years old which is at 58,8%. Histopatological grading of

grade II is the most common with the triple negative breast cancer patient.
Histopatological grading is most commonly found with minimal Tumour Infiltrating lymphocytes (TILs) and with 9 patient with Grade II histopatological
grading.
Keywords: Triple Negative Breast Cancer, histopatological grading, Tumour-

Infiltrating Lymphocytes(TILs)

Universitas Sumatera Utara