The Comparison of Expression of Cyclin D and Retinoblastoma Mutant Protein in Hydatidiform Mole and in Normal Placenta (Perbandingan Ekspresi Cyclin D dan Protein Retinoblastoma Mutan pada Mola Hidatidosa dan Iaringan Plasenta Normal).
W ith in nmlkjihgfedcbaZYXWVUTSRQPONMLKJIHGFEDCBA
24 h o u r s o f life th e in fa n t sh o w e d no sig n o f visc o u s o b str u c tio n
n o r p e r fo r a tio n .
Th e fe tu s w a s fo u n d
to h a ve a n e n la r g e d sc r o tu m
c o n ta in in g a la r g e flu id c o lle c tio n w ith
d e n sitie s o f e c h o g e n ic ity, h ig h ly su g g e stive o f c a lc ific a tio n s.
E D IT O R IA L
IN D O N E S IA N
JO U R N A L
BOARD
O F O B S T E T R IC S
AND GYNECOLOGY
Majalah Obstetri dan Ginekologi IndonesianmlkjihgfedcbaZYXWVUTSRQPONMLK
Chief Editor
Dr. dr. Laila Nuranna, SpOG(K)
Vice Chief Editor
Dr. dr. Dwiana Ocviyanti, SpOG(K)
Dr. dr. Junita Indarti, SpOG
Managing Editor
Dr. dr. Ali Sungkar, SpOG(K)
Prof. dr. Med. Ali Baziad, SpOG(K)
Dr. dr. Budi Iman Santoso, SpOG(K)
dr.Omo Abdul Madjid, SpOG(K)
Dr. Med. Damar Prasmusinto, SpOG(K)
dr. Kartiwa Hadi Nuryanto, SpOG
dr. Herbert Situmorang, SpOG
dr. Yuditya Purwosunu, SpOG
Peer Reviewer
International Peer Reviewer
Prof. dr. Delfi Luthan, SpOG(K)cbaZYXWVUTSRQPONMLKJIHGFEDCBA
( M e d a n , E n d o kr in o lo g i
I m u n o lo g i R e p r o d u ks i)
Prof. dr. A. Kurdi Syamsuri, SpOG(K) ( P a le m b a n g , F e to m a te m a lt
Prof. Dr. dr. Andrijono, SpOG(K) ( J a ka r ta , O n ko lo g i G in e ko lo g i)
Prof. Dr. dr. Djamhoer Martaadisoebrata, SpOG(K), MSPH ( B a n d u n g , O b s te tr i G in e ko lo g i So s ia l)
Prof. Dr. dr. Johanes C. Mose, SpOG(K) ( B a n d u n g , F e to m a te r n a l)
Dr. dr. Tono Djuwantono, SpOG(K), M.Kes. ( B a n d u n g , E n d o kr in o lo g i I m u n o lo g i R e p r o d u ks i)
dr. Samodra Suparman, SpOG ( M a la n g , O b s te tr i G in e ko lo g i So s ia l)
Prof. dr. Samsulhadi, SpOG(K) ( Su r a b a ya , E n d o kr in o lo g i I m u n o lo g i R e p r o d u ks i)
dr. Amru Sofian, SpOG(K) ( P e ka n b a r u , O n ko lo g i G in e ko lo g i)
dr. Pribakti Budinurdjaja, SpOG(K) ( B a n ja r m a s in , U r o g in e ko lo g i)
Prof. dr. Eddy Suparman, SpOG(K) ( M a n a d o , E n d o kr in o lo g i I m u n o lo g i R e p r o d u ks i)
dr. Maria Flavia Loho, SpOG(K) (Manado, E n d o kr in o lo g i I m u n o lo g i R e p r o d u ks i)
Prof. Togas Tulandi, MD, MHCM
M c G ill
English Consultant
Administrative Staff
Publisher
First Published
Legal
Secretariat Address
~
by
T r id a s a
P r in te r ,
J a ka r ta .
U n ive r s ity,
M o n tr e a l
( M ilto n
Leo n g
C h a ir
in R e p r o d u c tive
M e d ic in e ,
C a na da )
dr. Denny Khusen
Gretha Basuki, Frachma Della Siregar, Eko Subaktiansyah
Indonesian Society of Obstetrics and Gynecology
July 1st 1974
Information Ministers Decision Republic of Indonesia No. 016IKHSIDIT.PIIUaJ74
PKMI Building, Ground Floor
Kramat Sentiong Street 49A, Central Jakarta, 10450, Indonesia
Telephone: 021-3916670, Facsimile: 021-3916671
E-mail: ijog-indonesia@gmaiLcom;[email protected]
www.indonesia.digitaljournals.org/index.phpIIJOG
ISSN
0303 -
7924
In d o n e s
214
M a r r is ka
e t a l nmlkjihgfedcbaZYXWVUTSRQPONMLKJIHGFEDCBA
Research Report
J
G yn e c o l KJIHGFEDCBA
O b s te t
I
T h e C o m p a r iso n o f E x p r e ssio n o f C y c lin D a n d R e tin o b la sto m a M u ta n t
P r o te in in H y d a tid ifo r m M o le a n d in N o r m a l P la c e n ta
P e r b a n d in g a n
pa da
Cyclin D dan
E ks p r e s i
M o la
Keika Marriska,
D e p a r tm e n t
F a c u lty
P r o te in
d a n I a r in g a n
H id a tid o s a
R e tin o b la s to m a
P la s e n ta
M u ta n
Norma l
udi M. Hidayat Tono Djuwantono
o f O b s te tr ic s
o f M e d ic in e
a n d G yn e c o lo g y
U n ive r s ity
D r . H a sa n
Sa d ikin
o f P a d ja d ja r a n /
H o s p ita l
Ba ndung
Abstract
Ab s tr a k
Objective:
To know the expression of cyclin Oland
mutant
tinoblastoma
in hydatidiform
mole and to know the pathogenesis
hydatidiform
mole pregnancy.
reof
.
Method: Research specimens were taken from hydatidiform
mole trophoblastic
tissue in Or. Hasan Sadikin Hospital and networking. Specimen preparations
were stained with Immunohistochemistry and examined
under a light microscope
without knowing the
status of the patient. Significance
of the result was tested through
the Mann-Whitney
test, Fisher exact, and McNeman square test.
Result: Significant
differences
in the expression
of cyclin 01
between the hydatidiform
mole study groups and normal placental
tissue research groups (p
24 h o u r s o f life th e in fa n t sh o w e d no sig n o f visc o u s o b str u c tio n
n o r p e r fo r a tio n .
Th e fe tu s w a s fo u n d
to h a ve a n e n la r g e d sc r o tu m
c o n ta in in g a la r g e flu id c o lle c tio n w ith
d e n sitie s o f e c h o g e n ic ity, h ig h ly su g g e stive o f c a lc ific a tio n s.
E D IT O R IA L
IN D O N E S IA N
JO U R N A L
BOARD
O F O B S T E T R IC S
AND GYNECOLOGY
Majalah Obstetri dan Ginekologi IndonesianmlkjihgfedcbaZYXWVUTSRQPONMLK
Chief Editor
Dr. dr. Laila Nuranna, SpOG(K)
Vice Chief Editor
Dr. dr. Dwiana Ocviyanti, SpOG(K)
Dr. dr. Junita Indarti, SpOG
Managing Editor
Dr. dr. Ali Sungkar, SpOG(K)
Prof. dr. Med. Ali Baziad, SpOG(K)
Dr. dr. Budi Iman Santoso, SpOG(K)
dr.Omo Abdul Madjid, SpOG(K)
Dr. Med. Damar Prasmusinto, SpOG(K)
dr. Kartiwa Hadi Nuryanto, SpOG
dr. Herbert Situmorang, SpOG
dr. Yuditya Purwosunu, SpOG
Peer Reviewer
International Peer Reviewer
Prof. dr. Delfi Luthan, SpOG(K)cbaZYXWVUTSRQPONMLKJIHGFEDCBA
( M e d a n , E n d o kr in o lo g i
I m u n o lo g i R e p r o d u ks i)
Prof. dr. A. Kurdi Syamsuri, SpOG(K) ( P a le m b a n g , F e to m a te m a lt
Prof. Dr. dr. Andrijono, SpOG(K) ( J a ka r ta , O n ko lo g i G in e ko lo g i)
Prof. Dr. dr. Djamhoer Martaadisoebrata, SpOG(K), MSPH ( B a n d u n g , O b s te tr i G in e ko lo g i So s ia l)
Prof. Dr. dr. Johanes C. Mose, SpOG(K) ( B a n d u n g , F e to m a te r n a l)
Dr. dr. Tono Djuwantono, SpOG(K), M.Kes. ( B a n d u n g , E n d o kr in o lo g i I m u n o lo g i R e p r o d u ks i)
dr. Samodra Suparman, SpOG ( M a la n g , O b s te tr i G in e ko lo g i So s ia l)
Prof. dr. Samsulhadi, SpOG(K) ( Su r a b a ya , E n d o kr in o lo g i I m u n o lo g i R e p r o d u ks i)
dr. Amru Sofian, SpOG(K) ( P e ka n b a r u , O n ko lo g i G in e ko lo g i)
dr. Pribakti Budinurdjaja, SpOG(K) ( B a n ja r m a s in , U r o g in e ko lo g i)
Prof. dr. Eddy Suparman, SpOG(K) ( M a n a d o , E n d o kr in o lo g i I m u n o lo g i R e p r o d u ks i)
dr. Maria Flavia Loho, SpOG(K) (Manado, E n d o kr in o lo g i I m u n o lo g i R e p r o d u ks i)
Prof. Togas Tulandi, MD, MHCM
M c G ill
English Consultant
Administrative Staff
Publisher
First Published
Legal
Secretariat Address
~
by
T r id a s a
P r in te r ,
J a ka r ta .
U n ive r s ity,
M o n tr e a l
( M ilto n
Leo n g
C h a ir
in R e p r o d u c tive
M e d ic in e ,
C a na da )
dr. Denny Khusen
Gretha Basuki, Frachma Della Siregar, Eko Subaktiansyah
Indonesian Society of Obstetrics and Gynecology
July 1st 1974
Information Ministers Decision Republic of Indonesia No. 016IKHSIDIT.PIIUaJ74
PKMI Building, Ground Floor
Kramat Sentiong Street 49A, Central Jakarta, 10450, Indonesia
Telephone: 021-3916670, Facsimile: 021-3916671
E-mail: ijog-indonesia@gmaiLcom;[email protected]
www.indonesia.digitaljournals.org/index.phpIIJOG
ISSN
0303 -
7924
In d o n e s
214
M a r r is ka
e t a l nmlkjihgfedcbaZYXWVUTSRQPONMLKJIHGFEDCBA
Research Report
J
G yn e c o l KJIHGFEDCBA
O b s te t
I
T h e C o m p a r iso n o f E x p r e ssio n o f C y c lin D a n d R e tin o b la sto m a M u ta n t
P r o te in in H y d a tid ifo r m M o le a n d in N o r m a l P la c e n ta
P e r b a n d in g a n
pa da
Cyclin D dan
E ks p r e s i
M o la
Keika Marriska,
D e p a r tm e n t
F a c u lty
P r o te in
d a n I a r in g a n
H id a tid o s a
R e tin o b la s to m a
P la s e n ta
M u ta n
Norma l
udi M. Hidayat Tono Djuwantono
o f O b s te tr ic s
o f M e d ic in e
a n d G yn e c o lo g y
U n ive r s ity
D r . H a sa n
Sa d ikin
o f P a d ja d ja r a n /
H o s p ita l
Ba ndung
Abstract
Ab s tr a k
Objective:
To know the expression of cyclin Oland
mutant
tinoblastoma
in hydatidiform
mole and to know the pathogenesis
hydatidiform
mole pregnancy.
reof
.
Method: Research specimens were taken from hydatidiform
mole trophoblastic
tissue in Or. Hasan Sadikin Hospital and networking. Specimen preparations
were stained with Immunohistochemistry and examined
under a light microscope
without knowing the
status of the patient. Significance
of the result was tested through
the Mann-Whitney
test, Fisher exact, and McNeman square test.
Result: Significant
differences
in the expression
of cyclin 01
between the hydatidiform
mole study groups and normal placental
tissue research groups (p