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Prevalence of Fluconazole Resistance in Cryptococcus neoformans Isolates from HIV1

Prevalence of Fluconazole Resistance in Cryptococcus neoformans
Isolates from HIV+ Patients in Kampala, Uganda
Beatrice Achan*1, D Boulware2, D Meya1,2,3, K Nielsen2, and Cryptococcal Optimal ART
Timing Trial
1

Makerere Univ, Kampala, Uganda; 2Univ of Minnesota, Minneapolis, US; and 3Infectious
Disease Inst, Kampala, Uganda

Background: Widespread use of fluconazole to treat or prevent fungal
infections in HIV+ persons increases selective pressure for resistance.
Fluconazole resistant Cryptococcus neoformans have been reported
worldwide, including 16% of Ugandan C. neoformans isolates in the 1990s.
In Sub-Saharan Africa, 10-week survival rates after cryptococcal meningitis
are

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