”PENGARUH BERBAGAI DOSIS FILTRAT DAUN COCOR BEBEK (Kalanchoe pinnata L.) TERHADAP PENURUNAN SUHU TUBUH TIKUS PUTIH (Rattus norvegicus) HIPERTERMIA”

”PENGARUH BERBAGAI DOSIS FILTRAT DAUN COCOR BEBEK
(Kalanchoe pinnata L.) TERHADAP PENURUNAN SUHU TUBUH TIKUS
PUTIH (Rattus norvegicus) HIPERTERMIA”
Oleh: YUNI WIJAYANTI ( 04330056 )
Biology
Dibuat: 2009-04-22 , dengan 7 file(s).

Keywords: dosis filtrat daun cocor bebek dan suhu tubuh
tikus putih

ABSTRACT
Fever is situation of body temperature above normal as effect of make-up of center arrangement
of temperature in hipotalamus which in influencing by IL-I. Fever usually happened effect of
body of terpapar infection of mikroorganisme (virus, bacterium, parasite). Fever also can
because of factor of[is non infection like immured complex, or inflammation (other peradangan).
When bacterium or virus come into body, various phabocyte type or leucocyte discharge “ Iihat
vitamin cause of fever (endogen pirogen)” later on trigger production of prostaglandin E2 i]
anterior hipotalamus, what later;then improve temperature nilai-ambang and happened by fever.
leaf of Cocor bebek (Kalanchoe pinnata L.) functioning as antipiretik. Compound Beta of
sitosterol dissolve in blood and structure almost loo like with prostaglandin.
This research aim to to know influence various dose of filtrat leaf of cocor parrot to degradation

of white mouse body temperature and to know most effective dose of leaf filtrat of cocor parrot
to degradation of white mouse body temperature.
This research is executed in Chemical Laboratory UMM. this Method Research is True
Experimental Research, with The Pretest-Posttest Control Group Design, sampling technique of
Simple Random Sampling with plan attempt of Complete Random Device, with research sampel
24 white mouse tail of male (8 treatment group by 3 restating times). This research variable, that
is free variable: dose of filtrat leaf of cocor parrot, varibel depended: degradation of mouse body
temperature, control variable: mouse gender, mouse age, heavy of mouse body, vaccine dose of
DPT, condition of white mouse cage, food type, and beverage. Technique data collecting is
indirect perception because using materials and appliance. Data is here in after analysed with
ANAVA and Test of Duncan’S Bedasarkan result of analysis of varians obtained one way F
count > F tables of at level of signifikansi 1% meaning there influence various dose of filtrat leaf
of cocor parrot to degradation of white mouse body temperature seen is big degradation of body
temperature at perception 6 hour after fever. From result of test of Duncan’S 1% dose of filtrat
leaf of cocor parrot most effective degrade mouse body temperature reach its dropsy temperature
return group of H (dose of filtrat leaf of cocor parrot 4,5 ml / mouse tail) this result not differ
reality with group of B (Parasetamol 0,083 mg / mouse tail).
Result of research of menunjukan that Leaf filtrat of cocor parrot can be used as drug of
antipiretik effective at dose 4,5 ml / mouse tail after 6 hour consume leaf filtrat of cocor bebek
body temperature return normally (dropsy).


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