Introduction Directory UMM :Data Elmu:jurnal:A:Atherosclerosis:Vol152.Issue2.Oct2000:
Atherosclerosis 152 2000 135 – 141
Apolipoprotein E4 phenotype increases non-fasting serum triglyceride concentration in infants — the STRIP study
Anne Tammi
a,
, Tapani Ro¨nnemaa
b
, Jorma Viikari
b
, Eero Jokinen
c
, Helena Lapinleimu
d
, Christian Ehnholm
e
, Olli Simell
d
a
Cardiorespiratory Research Unit, Uni6ersity of Turku, Kiinamyllynkatu
10
, FIN-
20520
Turku, Finland
b
Department of Medicine, Uni6ersity of Turku, Kiinamyllynkatu
4
–
8
, FIN-
20520
Turku, Finland
c
Hospital for Children and Adolescents, Uni6ersity of Helsinki, Stenba¨ckinkatu II, FIN-
00290
Helsinki, Finland
d
Department of Pediatrics, Uni6ersity of Turku, Kiinamyllynkatu
4
–
8
, FIN-
20520
Turku, Finland
e
National Public Health Institute, P.B.
450
, FIN-
00101
Helsinki, Finland Received 25 January 1999; received in revised form 28 September 1999; accepted 15 October 1999
Abstract
As genetically determined apolipoprotein E apo E phenotypes influence serum cholesterol concentration, we analysed whether serum triglyceride values are also affected by the apo E phenotypes in infants. Non-fasting serum triglyceride values were
measured in 7- and 13-month-old participants in the STRIP project, a randomised, prospective trial aimed at reducing children’s exposure to known atherosclerosis risk factors n = 1062. The mean 9 S.D. non-fasting serum triglyceride concentrations in
7-month-old infants with apo E44 n = 36, E34 n = 209, E33 n = 412, and E23 n = 66 were 2.05 9 1.24, 1.81 9 0.90, 1.63 9 0.90, and 1.71 9 0.83 mmoll, respectively. Triglyceride concentrations were higher in infants with apo E44 or 34 than in
those with apo E33 P-value for difference 0.01 and 0.009, respectively. The apo E phenotype similarly influenced non-fasting serum triglyceride concentrations at the age of 13 months. The differences in serum triglyceride values in apo E4
+
infants apo E34 and 44 infants combined and apo E4
−
infants apo E23 and 33 infants combined occurred independently of the relative weight of the infant, milk type used at 7 months of age breast milk or formula, and time elapsed from the previous meal. To
conclude, apo E phenotypes regulate non-fasting serum triglyceride values in healthy infants. Apo E34 and apo E44 predispose infants to higher values than apo E33 phenotype, suggesting that the o4 allele may increase atherosclerosis risk also via it’s effect
on postprandial triglyceride metabolism. © 2000 Elsevier Science Ireland Ltd. All rights reserved.
Keywords
:
Triglycerides; Apo E; Infants; Breast milk; Cholesterol www.elsevier.comlocateatherosclerosis