CURRICULUM BLOCK: THE ENDOCRINE SYSTEM, METABOLISM AND

Learning Outcome Learning Objectives Educati- onal strategy Learning Resourc es Student assess ment 1. Comprehend the hormone action 1.1. Describe the transport of hormone in the blood 1.2. Describe the control of hormone secretion 1.3. List the endocrine disease 1.4. Mention the therapeutic strategies in endocrine disorders 0 Intro.le c 1 IL 2 SGD 3 Pleno Refferen ces MCQ 2. Summarize the pituitary gland function and provide initial management andor refer patient with pituitary disorders 2.1. Recognize the anatomy of pituitary 2.2. Summarize the pituitary hormone axis 2.3. Recognize the type of pituitary tumor and differential diagnosis of pituitary tumor 2.4. Interpret the endocrine tests of hypothalamic-pituitary function 2.5. Describe the clinical features of pituitary adenoma 2.6. Summarize the course and the condition associated with pituitary adenoma, including prolactinoma, acromegaly, gigantisme, growth hormone deficiency. 2.7. Summarize the normal physiologic hormone function of posterior pituitary 2.8. Describe the clinical features of diabetes insipidus 4 Intro.le c 5 IL 6 SGD 7 SE 8 Pleno MCQ 3. Summarize the insulin action, provide initial management andor refer patient with diabetes mellitus DM 3.1 Recognize the characteristics of pancreas and the secretory product associated with each cell type 3.1. Understand major stimuli and inhibitors of insulin secretion. Summarize the cellular mechanism involved in glucose-induced insulin secretion 3.2. Understand major biologic actions of insulin and the target organs. Able indicate which metabolic pathways of fuel metabolism are affected by insulin 3.3. Explain how the blood glucose control by insulin 3.4. Recognize the major biologic actions of glucagon and the target organs, indicate which metabolic pathway of fuel metabolism are affected by glucagons 9 Intro.le c 10 IL 11 S GD 12 Pl eno PBL 13 MCQ Udayana University Departement of Medicine Education, DME 6

6. CURRICULUM BLOCK: THE ENDOCRINE SYSTEM, METABOLISM AND

DISORDERS 3.5. Summarize the pathophysiologic basis for the major symptoms of diabetes mellitus 3.6. Mention the diagnostic criteria of prediabetes and diabetes 3.7. Describe the clinical features of type 1 and type 2 diabetes and other types of diabetes 3.8. Summarize the pathogenesis of beta cell dysfunction and insulin resistance glucose toxicity and lipotoxicity of the beta cell 3.9. Recognize the acute and chronic complication of diabetes 3.10.Plan the prevention of type 2 diabetes 3.11.Plan the strategy of therapy in diabetes 3.12.Recognize the drugs use in treatment of diabetes insulin secretogogues, insulin sensitiziser, thiazolidinediones, alfa glucosidase inhibitor 3.13.Summarize the acute and chronic complication of diabetes 3.14.Plan the management of hypoglycemia and acute hyperglycemia 4. Summarize and select the appropriate drug in patient with lipid metabolism disorders 4.1. Summarize the lipid transport and the role of plasma lipoprotein 4.2. Recognize the disorders of lipoprotein metabolism 4.3. Summarize the mechanism of action of drugs in lipid disorder 4.4. Describe the prevention of lipid disorder 4.5. Plan a rational drugs treatment regimen based on a set of baseline serum lipid values 14 In tro.lec 15 IL 16 S GD 17 Pl eno 18 C BL MCQ 5. Summarize the energy balanced and heat metabolism, and provide management in patient with obesity and metabolic syndrome 5.1. Summarize the mechanism of heat production and body heat loss 5.2. Summarize the energy metabolism 5.3. Define the criteria obesity 5.4. Describe the pathogenesis of obesity 5.5. Recognize the complication of obesity 5.6. Define the criteria of metabolic syndrome 5.7. Describe the pathogenesis of metabolic syndrome 19 In tro.lec 20 IL 21 S GD 22 P leno 23 C BL MCQ Udayana University Departement of Medicine Education, DME 7 6. Provide initial management andor refer patient with thyroid disorders 6.1. Summarize the organization of the thyroid and secretory cells present in thyroid 6.2. Recognize the function of a thyroid follicle cells and follow the different process involved in this function with particular emphasis on the location of each action within the cell or follicle 6.3. Summarize the biosyntesis, transport, and autoregulation of thyroid hormone 6.4. Explain the thyroid hormone action 6.5. Recognize the disorder of thyroid gland, including problem of overundersecretion and thyroid nodule 6.6. Describe the clinical features symptoms, signs, and laboratory findings and the management of Grave’s disease 6.7. Describe the clinical features and management of hypothyroidism 24 In tro.lec 25 IL 26 S GD 27 P leno 28 C BL MCQ 7. Summarize the mineral metabolism calcium and phosphate and parathyroid hormone functions 7.1. Summarize the mineral metabolism, including calcium and phosphate and the rule of hormones 7.2. Describe the secretion and action of PTH 7.3. Summarize the rule of PTH, Ca, vit D, and calcitonin. 29 In tro.lec 30 IL 31 S GD 32 P leno 8. Provide initial management andor refer patient with adrenal disorders 8.1. Summarize the regulation of synthesis and secretion of cortisol, aldosterone, and the weak androgen DHEA. 8.2. Summarize the major actions of glucocorticoid on metabolism, inflammation, permissive effects and the stress concept.. 8.3. Summarize the mechanisms of action for mineralocorticoids 8.4. Summarize the pathophysiology and clinical features of cushing syndrome 8.5. Recognize the diagnostic test for cushing syndrome 33 In tro.lec 34 IL 35 S GD 36 P leno 9. Provide initial management andor refer patient with congenital hypothyroid and ambiguous genital 9.1. Recognize clinically, laboratory and provide initial management, and refer patient with abnormalities in sexual determination and differentiation 37 In tro.lec 38 IL 39 S GD 40 P leno MCQ Udayana University Departement of Medicine Education, DME 8 41 42 Note: Intro. Lec = Introductory lecture 0 IL = Individual learning 1 SGD = Single group discussion 2 Pleno = Plenary lecture 3 PBL = Problem based learning Udayana University Departement of Medicine Education, DME 9 Mastery of Basic Knowledge with Its Clinical and Practical Implication 1. Comprehend the hormone action 2. Summarize the pituitary gland function, provide initial management, andor refer patient with pituitary disorders 3. Summarize, provide initial management, andor refer patient with diabetes mellitus 4. Summarize and select the appropriate drugs in patient with lipid metabolism disorders 5. Summarize the energy balanced and heat metabolism, and provide management in patient with obesity and metabolic syndrome 6. Provide initial management andor refer patient with thyroid disorders 7. Summarize the mineral metabolism calcium and phosphate and parathyroid hormone function 8. Provide initial management andor refer patient with adrenal disorders 9. Provide initial management andor refer patient with congenital hypothyroid and ambiguous genital Skills 1. History taking 2. Physical examination of metabolic syndrome waist circumference, body mass index, thyroid nodule 3. Interpreting the laboratory result of blood sugar, A1C, lipid profile, hormone level 4. Communication with patient, family and community 5. Assessing data base, extracting relevant information Personal behavior Awareness to: 1. Lifestyle as a risk factors of diabetes mellitus and metabolic syndrome 2. Early treatment and proper management of metabolic disease to prevent chronic complication of diabetes mellitus, metabolic syndrome, and other hormonal disorder. Community aspect: 1. Risk assessment and disease screening of diabetes mellitus and metabolic syndrome 2. Cost effectiveness of prevention, screening, and treatment of the disease 3. Utilization of health system facilities 4. Health prevention and health promotion Udayana University Departement of Medicine Education, DME 10

7. GENERAL LEARNING OUTCOME