Hubungan Perubahan Kadar Faktor Fibrinolisis Darah Ibu Dengan Kadar Gas Darah Tali Pusat Pada Preeklampsia
Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor fibrinolisis ...,2003 .
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Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor fibrinolisis ...,2003 .
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Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor fibrinolisis ...,2003 .
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Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor fibrinolisis ...,2003 .
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Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor fibrinolisis ...,2003 .
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Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor fibrinolisis ...,2003 .
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Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor fibrinolisis ...,2003 .
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Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor fibrinolisis ...,2003 .
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HUBUNGAN PERU BAHAN KADAR FAKTOR FIBRINOUSIS DARAH
IBU DENGAN KADAR GAS DARAH TAU PUSAT PADA
PREEKLAMPSIA
,
ABSTRAK.
Preeklampsia merupakan salah satu penyebab utama kematian ibu dan
perinataldi Indonesia, walaupun begitu etiologinya sampai sekarang masih
belum jelas. Namun demikian suatu ciri khas dari preklampsia yang telah
lama dikenal, yaitu dijumpai adanya penumpukan fibrin pada jaringan
periglomerular dan plasenta. Hal ini menirnbulkan konsep akan adanya
gangguan fibrinolisis pada preeklampsia yang merupakan faktor utama
timbulnya kegagalan fungsi pada organ-organ tubuh. Dan sisi Jain, pada
preeklampsia sering dijumpai penyulit yaitu adanya asidosis baik pada ibu
maupun janin I bayL Namun sejauh ini tidak jelas apakah gangguan
fibrinolisis tersebut berhubungan dengan terjadinya gangguan keseimbangan
asam-basa tersebut, Oleh karena itu tujuan 'penelitian ini adalah untuk
menyelidiki apakah ada hubunqan antara faktor fibrinolisls ibu dengan
gangguan gas darah tali pusat. Penelitian dilakukan setelah mendapat
persetujuan dari Komite Etik Penelitian Bidang Kesehatan
Fakultas
Kedokteran, Universitas Sumatera Utara dan informed consent dari subjek
yang ditelitL Ada 74 ibu yang direkrut, terdiri dari 37 ibu preeklampsla dan 37
ibu hamilnormal. Darah ibu diambil untuk pemeriksaan faktor fibrinolisis dan
darah tali pusat untuk pemeriksaan analisis gas darah serta faktor fibrinolisis.
Hasil menunjukkan bahwa seluruh taktor fibrinolisis ibu preeklampsia
meningkat kecuali antigen PAI-2 menurun bermakna. pH menurun, tetapi H-
C03 dan P-C02 meningkat dibandingkan dengar. ibu hamil normal. Dijumpai
adanya hubungan yang bermakna antara kadar antigen PAI-2 dan aktivitas
PAI-1 ibu dengan . pH tali pusat.· Sebagai tambahan penelitian ini juga
rnenunjukkan adanya hubungan yang bermakna antara aktivitas dan antigen
u-PA, antigen PAI,"2 dengan luaran anak. Sebagai kesimpulan penelitian ini
mendukung .hipotesis bahwa faktor fibrinolisis ibu dalam hal ini PAI-2
mempunyai hUbungan yang bermakna dengan pH darah tali pusat.
Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor
VI\{ fibrinolisis ...,2003 .
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THE CORRELATIONS BETWEEN MOTHER'S FIBRINOLYTIC FACTORS
AND UMBILICAL CORD'S BLOOD GASSES IN PREECLAMPSIA
ABSTRACT
Preeclampsia is one of the main causes of maternal and perinatal deaths,
however the etiology of preeclampsia so far is still unkown. Despite the
uncertainity of the etiology, preeclampsia is hallmarked by the findings of
fibrin deposition in various organs such as in periglomerular space and in
placenta, These leads to the concept that there is disorder in fibrinolysis in
preeclampsia which may play an important role in the development of organ
failures On the other hand, preeclampsia is frequently complicated by
acidosis in both the mother and the foetus, nevertheless it is not clear
whether the fibrinolytic disorders correlates with the degree of acid-base
imbalance. Therefore, the aim of the study: is to find out whether there is
correlation between fibrinolytic factors
umblical cord's blood gasses.
of preeclamptic mothers and their
After obtaining the approval from the
University of Sumatra Utara, Medical School's 'Ethical Committee and the
informed consents from the subjecits,
74 women consisting of 37
preeclamptic mothers, 37 normal pregnant women were recruited in is study.
Blood samples were taken from the mother for the assay of fibrinolytic factors
and from the umbilical cord for blood gas analysis and assay of fibrinolytic
factors. The results demonstrated that all the level of fibrinolytic factors
increased in women with preeclampsia except, the level of PAI-2 antigen
'
which was significantly decreased. The level of pH decreased whilst HC03and pC02 increased compared to normal pregnancy. There were significant
correlations between the level of pH of the umbilical cords and the levels of
maternal PAI-2 antigen, PAI-1 activity. In addition, the study also showed that
there were significant correlations between the u-PA activity, u-PA antigen,
PAI-2 antigen and the foetal outcomes. ln conclusions, this study supports
the hypothesis that fibrinolytic factors of the mother in this case the antigen of
PAI-2 and the activity of PAI-1 correlate with the pH pf the umbilical cords.
vv fibrinolisis ...,2003 .
Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor
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HUBUNGAN PERU BAHAN KADAR FAKTOR FIBRINOUSIS DARAH
IBU DENGAN KADAR GAS DARAH TAU PUSAT PADA
PREEKLAMPSIA
,
ABSTRAK.
Preeklampsia merupakan salah satu penyebab utama kematian ibu dan
perinataldi Indonesia, walaupun begitu etiologinya sampai sekarang masih
belum jelas. Namun demikian suatu ciri khas dari preklampsia yang telah
lama dikenal, yaitu dijumpai adanya penumpukan fibrin pada jaringan
periglomerular dan plasenta. Hal ini menirnbulkan konsep akan adanya
gangguan fibrinolisis pada preeklampsia yang merupakan faktor utama
timbulnya kegagalan fungsi pada organ-organ tubuh. Dan sisi Jain, pada
preeklampsia sering dijumpai penyulit yaitu adanya asidosis baik pada ibu
maupun janin I bayL Namun sejauh ini tidak jelas apakah gangguan
fibrinolisis tersebut berhubungan dengan terjadinya gangguan keseimbangan
asam-basa tersebut, Oleh karena itu tujuan 'penelitian ini adalah untuk
menyelidiki apakah ada hubunqan antara faktor fibrinolisls ibu dengan
gangguan gas darah tali pusat. Penelitian dilakukan setelah mendapat
persetujuan dari Komite Etik Penelitian Bidang Kesehatan
Fakultas
Kedokteran, Universitas Sumatera Utara dan informed consent dari subjek
yang ditelitL Ada 74 ibu yang direkrut, terdiri dari 37 ibu preeklampsla dan 37
ibu hamilnormal. Darah ibu diambil untuk pemeriksaan faktor fibrinolisis dan
darah tali pusat untuk pemeriksaan analisis gas darah serta faktor fibrinolisis.
Hasil menunjukkan bahwa seluruh taktor fibrinolisis ibu preeklampsia
meningkat kecuali antigen PAI-2 menurun bermakna. pH menurun, tetapi H-
C03 dan P-C02 meningkat dibandingkan dengar. ibu hamil normal. Dijumpai
adanya hubungan yang bermakna antara kadar antigen PAI-2 dan aktivitas
PAI-1 ibu dengan . pH tali pusat.· Sebagai tambahan penelitian ini juga
rnenunjukkan adanya hubungan yang bermakna antara aktivitas dan antigen
u-PA, antigen PAI,"2 dengan luaran anak. Sebagai kesimpulan penelitian ini
mendukung .hipotesis bahwa faktor fibrinolisis ibu dalam hal ini PAI-2
mempunyai hUbungan yang bermakna dengan pH darah tali pusat.
Mohammad Thambrin Tanjung : hubungan perubahan kadar faktor
VI\{ fibrinolisis ...,2003 .
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THE CORRELATIONS BETWEEN MOTHER'S FIBRINOLYTIC FACTORS
AND UMBILICAL CORD'S BLOOD GASSES IN PREECLAMPSIA
ABSTRACT
Preeclampsia is one of the main causes of maternal and perinatal deaths,
however the etiology of preeclampsia so far is still unkown. Despite the
uncertainity of the etiology, preeclampsia is hallmarked by the findings of
fibrin deposition in various organs such as in periglomerular space and in
placenta, These leads to the concept that there is disorder in fibrinolysis in
preeclampsia which may play an important role in the development of organ
failures On the other hand, preeclampsia is frequently complicated by
acidosis in both the mother and the foetus, nevertheless it is not clear
whether the fibrinolytic disorders correlates with the degree of acid-base
imbalance. Therefore, the aim of the study: is to find out whether there is
correlation between fibrinolytic factors
umblical cord's blood gasses.
of preeclamptic mothers and their
After obtaining the approval from the
University of Sumatra Utara, Medical School's 'Ethical Committee and the
informed consents from the subjecits,
74 women consisting of 37
preeclamptic mothers, 37 normal pregnant women were recruited in is study.
Blood samples were taken from the mother for the assay of fibrinolytic factors
and from the umbilical cord for blood gas analysis and assay of fibrinolytic
factors. The results demonstrated that all the level of fibrinolytic factors
increased in women with preeclampsia except, the level of PAI-2 antigen
'
which was significantly decreased. The level of pH decreased whilst HC03and pC02 increased compared to normal pregnancy. There were significant
correlations between the level of pH of the umbilical cords and the levels of
maternal PAI-2 antigen, PAI-1 activity. In addition, the study also showed that
there were significant correlations between the u-PA activity, u-PA antigen,
PAI-2 antigen and the foetal outcomes. ln conclusions, this study supports
the hypothesis that fibrinolytic factors of the mother in this case the antigen of
PAI-2 and the activity of PAI-1 correlate with the pH pf the umbilical cords.
vv fibrinolisis ...,2003 .
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