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Analysis Of Protein Fas Expression And Caspase 3 Activated At The Supression Phase To Sperm Quantity By Androgen/Progestin Combination

Jurnal Biologi Sumatera, Juli 2007, hlm. 45 – 47
ISSN 1907-5537

Vol. 2, No. 2

ANALYSIS OF PROTEIN FAS EXPRESSION AND CASPASE 3 ACTIVATED
AT THE SUPRESSION PHASE TO SPERM QUANTITY BY
ANDROGEN/PROGESTIN COMBINATION
Syafruddin Ilyas
Departemen Biologi FMIPA Universitas Sumatera Utara, Jl. Bioteknologi No. 1,
Padang Bulan, Medan 20155

Abstract
Analysis studied to Fas protein expression and caspase 3 activated at the Sprague Dawley rat.
Administration of Androgen/Progestin was done at the suppression phase of sperm. I used experiment method
and completely randomized design with 4 treatments (0, 6, 12, 18 and 24 weeks) and 5 replications. Androgen
(2,5 mg) and progestin (1,25mg) combination injection with interval of 6 and 12 weeks respectively. Result of
research during 24 weeks was found tend to increase Fas protein expression and Caspase 3 activated. Between
Fas protein and caspase 3 activated was strong correlation (r=0,92) and difference significantly (P

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