Ekspresi Hypoxia Inducible Factor-1α pada Jaringan Endometriosis
LAMPIRAN 1.
Universitas Sumatera Utara
Universitas Sumatera Utara
LAMPIRAN 2.
PEMERIKSAAN HIF1-α KELOMPOK KASUS (ENDOMETRIOSIS)
No
No.PA
Nama
Usia
Paritas
(thn)
Stadium
Histopatologi
Endometriosis
Jaringan
Diagnosa
Ekspresi HIF1-α
Observer 1
Observer 2
+2
+2
1
R/HS/3/13
Ny. N
31
P0A0
3
Kista endometriosis
Kista endometriosis
2
R/HS/4/13
Ny. A
27
P0A0
4
Kista endometriosis
Kista endometriosis
+1
+1
3
R/HS/7/13
Ny. E
30
P0A0
4
Kista endometriosis
Kista endometriosis
+2
+2
4
R/HS/9/13
Ny.I
32
P0A0
3
Endometriosis
Kista endometriosis
+1
+1
5
R/HS/12/13
Ny. S
29
P0A0
3
Kista endometriosis
Kista endometriosis
+1
+1
6
R/HS/13/13
Ny. Z
43
P0A0
4
Kista endometriosis
Kista endometriosis
+3
+3
7
R/HS/14/13
Ny. N
38
P0A0
4
Kista endometriosis
Kista endometriosis
+2
+3
8
R/HS/17/13
Ny. Y
50
P0A0
2
Kista endometriosis
Kista endometriosis
+2
+2
9
R/HS/18/13
Ny. R
35
P0A0
4
Endometriosis
Kista endometriosis
+1
+1
10
R/HS/19/13
Ny. N
42
P0A0
3
Kista endometriosis
Kista endometriosis
+2
+3
11
R/HS/21/13
Ny. J
27
P0A0
4
Kista endmoetriosis
Kista endometriosis
+3
+3
12
R/HS/23/13
Ny. W
20
P0A0
3
Kista endometriosis
Kista endometriosis
+3
+3
13
R/HS/24/13
Ny. H
44
P0A0
3
Kista endometriosis
Kista endometriosis
+3
+3
14
R/HS/29/13
Ny.N
26
P0A0
4
Kista endometriosis
Kista endometriosis
+2
+3
15
R/HS/33/13
Ny.L
24
P0A0
3
Kista endometriosis
Kista endometriosis
+3
+2
16
R/HS/64/13
Ny.D
39
P0A0
2
Kista endometriosis
Kista endometriosis
+2
+2
17
R/HS/65/13
Ny.A
24
P0A0
4
Kista endometriosis
Kista endometriosis
+2
+2
18
R/HS/66/13
Ny.E
33
P0A0
3
Kista endometriosis
Kista endometriosis
+3
+3
19
R/HS/67/13
Ny.N
18
P0A0
2
Kista endometriosis
Kista endometriosis
+1
+1
20
R/HS/71/13
Ny.M
26
P0A0
3
Kista endometriosis
Kista endometriosis
+1
+1
21
R/HS/84/13
Ny.J
39
P0A0
3
Kista endometriosis
Kista endometriosis
+2
+2
22
R/HS/96/13
Ny.N
19
P0A0
2
Kista endometriosis
Kista endometriosis
+3
+3
23
R/HS/97/13
Ny.N
19
P0A0
2
Kista endometriosis
Kista endometriosis
+2
+2
Universitas Sumatera Utara
PEMERIKSAAN HIF1-α KELOMPOK KONTROL (ENDOMETRIUM NORMAL)
No
No.PA
Nama
Usia
Paritas
(thn)
1
B/02/13
2
3
Histopatologi
Diagnosa
Ekspresi HIF1-α
Jaringan
Observer 1
Observer 2
Kista ovarium permagna
+1
+1
Ny.T
43
P3A1
Endometrium normal
B/03/13
Ny.I
41
P3A0
Endometrium normal
Mioma uteri
+1
+1
B/04/13
Ny.P
40
P3A0
Endometrium normal
Mioma uteri subserosum
0
0
4
B/05/13
Ny.J
42
P4A0
Endometrium normal
Susp. ca ovarium
0
0
5
B/06/13
Ny.N
41
P2A0
Endometrium normal
Kista ovarium
+1
+1
6
B/07/13
Ny.L
46
P3A0
Endometrium normal
Susp. ca ovarium
0
0
7
B/08/13
Ny.S
37
P1A0
Endometrium normal
Mioma uteri + kista ovarium
0
0
8
B/09/13
Ny.S
25
P1A0
Endometrium normal
Mioma uteri
2
1
0
9
B/10/14
Ny.N
42
P4A0
Endometrium normal
Kista ovarium susp.malignancy
0
10
B/11/14
Ny.A
42
P3A0
Endometrium normal
Mioma uteri
0
0
11
B/14/14
Ny.P
27
P2A0
Endometrium normal
Mioma uteri
2
1
12
B/15/14
Ny.W
43
P1A0
Endometrium normal
Susp. ca ovarium
0
0
13
B/16/14
Ny. W
44
P2A1
Endometrium normal
Mioma uteri
+1
+1
14
B/17/14
Ny.T
36
P2A0
Endometrium normal
Mioma uteri
0
0
15
B/18/14
Ny.J
45
P4A1
Endometrium normal
Tumor ovarium padat
+2
+1
16
B/19/14
Ny.M
48
P2A0
Endometrium normal
Susp. ca ovarium
+2
+2
17
B/20/14
Ny.E
37
P1A0
Endometrium normal
Mioma uteri
0
0
B/21/14
Ny.D
41
P2A1
Endometrium normal
Mioma uteri
+1
+1
19
B/22/14
Ny.H
33
P2A0
Endometrium normal
Mioma uteri
+1
+1
20
B/23/14
Ny.L
45
P2A0
Endometrium normal
Susp.ca ovarium
+2
+2
21
B/24/14
Ny.P
41
P1A0
Endometrium normal
Tumor ovarium padat
+1
+1
22
B/12/14
Ny.A
43
P3A0
Endometrium normal
Mioma uteri
0
0
23
B/01/13
Ny.K
26
P2A0
Endometrium normal
Mioma uteri
0
0
18
Universitas Sumatera Utara
LAMPIRAN 3.
ANALISA STATISTIK
Frequencies
Crosstab
DIAGNOSA
NON
ENDOMETRIOSIS ENDOMETRIOSIS
KEL_USIA
18-30
Count
% within DIAGNOSA
31-40
12
3
15
52.2%
13.0%
32.6%
7
5
12
30.4%
21.7%
26.1%
4
15
19
17.4%
65.2%
41.3%
23
23
46
100.0%
100.0%
100.0%
Count
% within DIAGNOSA
>=41
Count
% within DIAGNOSA
Total
Count
% within DIAGNOSA
Total
Crosstab
DIAGNOSA
NON
ENDOMETRIOSIS ENDOMETRIOSIS
KEL_PARITAS
.00
Count
% within DIAGNOSA
1-2
23
0
23
100.0%
.0%
50.0%
0
14
14
.0%
60.9%
30.4%
0
9
9
.0%
39.1%
19.6%
23
23
46
100.0%
100.0%
100.0%
Count
% within DIAGNOSA
>=3
Count
% within DIAGNOSA
Total
Count
% within DIAGNOSA
Total
STADIUM
Frequency
Valid
Percent
Valid Percent
Cumulative Percent
2.00
5
21.7
21.7
21.7
3.00
10
43.5
43.5
65.2
Universitas Sumatera Utara
4.00
8
34.8
34.8
Total
23
100.0
100.0
100.0
Crosstabs
OBSERVER1 * OBSERVER2 Crosstabulation
Count
OBSERVER2
.00
OBSERVER1
1.00
2.00
3.00
Total
.00
11
0
0
0
11
1.00
0
13
0
0
13
2.00
0
3
9
3
15
3.00
0
0
1
6
7
11
16
10
9
46
Total
Symmetric Measures
Asymp. Std.
Value
Measure of Agreement
Kappa
Error
.795
N of Valid Cases
a
Approx. T
.070
b
Approx. Sig.
9.367
.000
46
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
OBSERVER1 * DIAGNOSA Crosstabulation
DIAGNOSA
NON
ENDOMETRIOSIS
OBSERVER1
.00
Count
% within OBSERVER1
1.00
Count
% within OBSERVER1
2.00
Count
ENDOMETRIOSIS
Total
0
11
11
.0%
100.0%
100.0%
6
7
13
46.2%
53.8%
100.0%
10
5
15
Universitas Sumatera Utara
% within OBSERVER1
3.00
33.3%
100.0%
7
0
7
100.0%
.0%
100.0%
23
23
46
50.0%
50.0%
100.0%
Count
% within OBSERVER1
Total
66.7%
Count
% within OBSERVER1
Chi-Square Tests
Value
df
Asymp. Sig. (2-sided)
a
3
.000
Likelihood Ratio
26.729
3
.000
N of Valid Cases
46
Pearson Chi-Square
19.744
a. 2 cells (25.0%) have expected count less than 5. The minimum expected count is
3.50.
OBSERVER1 * STADIUM Crosstabulation
STADIUM
2.00
OBSERVER1
1.00
Count
% within STADIUM
2.00
3.00
Total
2
6
20.0%
30.0%
25.0%
26.1%
3
3
4
10
60.0%
30.0%
50.0%
43.5%
1
4
2
7
20.0%
40.0%
25.0%
30.4%
5
10
8
23
100.0%
100.0%
100.0%
100.0%
Count
% within STADIUM
Total
3
Count
% within STADIUM
4.00
1
Count
% within STADIUM
3.00
Chi-Square Tests
Asymp. Sig. (2Value
Pearson Chi-Square
Likelihood Ratio
Linear-by-Linear Association
N of Valid Cases
Df
sided)
a
4
.827
1.521
4
.823
.002
1
.962
1.500
23
Universitas Sumatera Utara
Chi-Square Tests
Asymp. Sig. (2Value
Pearson Chi-Square
Likelihood Ratio
Linear-by-Linear Association
N of Valid Cases
Df
sided)
a
4
.827
1.521
4
.823
.002
1
.962
1.500
23
a. 9 cells (100.0%) have expected count less than 5. The minimum expected count
is 1.30.
Universitas Sumatera Utara
LAMPIRAN 4.
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
LAMPIRAN 2.
PEMERIKSAAN HIF1-α KELOMPOK KASUS (ENDOMETRIOSIS)
No
No.PA
Nama
Usia
Paritas
(thn)
Stadium
Histopatologi
Endometriosis
Jaringan
Diagnosa
Ekspresi HIF1-α
Observer 1
Observer 2
+2
+2
1
R/HS/3/13
Ny. N
31
P0A0
3
Kista endometriosis
Kista endometriosis
2
R/HS/4/13
Ny. A
27
P0A0
4
Kista endometriosis
Kista endometriosis
+1
+1
3
R/HS/7/13
Ny. E
30
P0A0
4
Kista endometriosis
Kista endometriosis
+2
+2
4
R/HS/9/13
Ny.I
32
P0A0
3
Endometriosis
Kista endometriosis
+1
+1
5
R/HS/12/13
Ny. S
29
P0A0
3
Kista endometriosis
Kista endometriosis
+1
+1
6
R/HS/13/13
Ny. Z
43
P0A0
4
Kista endometriosis
Kista endometriosis
+3
+3
7
R/HS/14/13
Ny. N
38
P0A0
4
Kista endometriosis
Kista endometriosis
+2
+3
8
R/HS/17/13
Ny. Y
50
P0A0
2
Kista endometriosis
Kista endometriosis
+2
+2
9
R/HS/18/13
Ny. R
35
P0A0
4
Endometriosis
Kista endometriosis
+1
+1
10
R/HS/19/13
Ny. N
42
P0A0
3
Kista endometriosis
Kista endometriosis
+2
+3
11
R/HS/21/13
Ny. J
27
P0A0
4
Kista endmoetriosis
Kista endometriosis
+3
+3
12
R/HS/23/13
Ny. W
20
P0A0
3
Kista endometriosis
Kista endometriosis
+3
+3
13
R/HS/24/13
Ny. H
44
P0A0
3
Kista endometriosis
Kista endometriosis
+3
+3
14
R/HS/29/13
Ny.N
26
P0A0
4
Kista endometriosis
Kista endometriosis
+2
+3
15
R/HS/33/13
Ny.L
24
P0A0
3
Kista endometriosis
Kista endometriosis
+3
+2
16
R/HS/64/13
Ny.D
39
P0A0
2
Kista endometriosis
Kista endometriosis
+2
+2
17
R/HS/65/13
Ny.A
24
P0A0
4
Kista endometriosis
Kista endometriosis
+2
+2
18
R/HS/66/13
Ny.E
33
P0A0
3
Kista endometriosis
Kista endometriosis
+3
+3
19
R/HS/67/13
Ny.N
18
P0A0
2
Kista endometriosis
Kista endometriosis
+1
+1
20
R/HS/71/13
Ny.M
26
P0A0
3
Kista endometriosis
Kista endometriosis
+1
+1
21
R/HS/84/13
Ny.J
39
P0A0
3
Kista endometriosis
Kista endometriosis
+2
+2
22
R/HS/96/13
Ny.N
19
P0A0
2
Kista endometriosis
Kista endometriosis
+3
+3
23
R/HS/97/13
Ny.N
19
P0A0
2
Kista endometriosis
Kista endometriosis
+2
+2
Universitas Sumatera Utara
PEMERIKSAAN HIF1-α KELOMPOK KONTROL (ENDOMETRIUM NORMAL)
No
No.PA
Nama
Usia
Paritas
(thn)
1
B/02/13
2
3
Histopatologi
Diagnosa
Ekspresi HIF1-α
Jaringan
Observer 1
Observer 2
Kista ovarium permagna
+1
+1
Ny.T
43
P3A1
Endometrium normal
B/03/13
Ny.I
41
P3A0
Endometrium normal
Mioma uteri
+1
+1
B/04/13
Ny.P
40
P3A0
Endometrium normal
Mioma uteri subserosum
0
0
4
B/05/13
Ny.J
42
P4A0
Endometrium normal
Susp. ca ovarium
0
0
5
B/06/13
Ny.N
41
P2A0
Endometrium normal
Kista ovarium
+1
+1
6
B/07/13
Ny.L
46
P3A0
Endometrium normal
Susp. ca ovarium
0
0
7
B/08/13
Ny.S
37
P1A0
Endometrium normal
Mioma uteri + kista ovarium
0
0
8
B/09/13
Ny.S
25
P1A0
Endometrium normal
Mioma uteri
2
1
0
9
B/10/14
Ny.N
42
P4A0
Endometrium normal
Kista ovarium susp.malignancy
0
10
B/11/14
Ny.A
42
P3A0
Endometrium normal
Mioma uteri
0
0
11
B/14/14
Ny.P
27
P2A0
Endometrium normal
Mioma uteri
2
1
12
B/15/14
Ny.W
43
P1A0
Endometrium normal
Susp. ca ovarium
0
0
13
B/16/14
Ny. W
44
P2A1
Endometrium normal
Mioma uteri
+1
+1
14
B/17/14
Ny.T
36
P2A0
Endometrium normal
Mioma uteri
0
0
15
B/18/14
Ny.J
45
P4A1
Endometrium normal
Tumor ovarium padat
+2
+1
16
B/19/14
Ny.M
48
P2A0
Endometrium normal
Susp. ca ovarium
+2
+2
17
B/20/14
Ny.E
37
P1A0
Endometrium normal
Mioma uteri
0
0
B/21/14
Ny.D
41
P2A1
Endometrium normal
Mioma uteri
+1
+1
19
B/22/14
Ny.H
33
P2A0
Endometrium normal
Mioma uteri
+1
+1
20
B/23/14
Ny.L
45
P2A0
Endometrium normal
Susp.ca ovarium
+2
+2
21
B/24/14
Ny.P
41
P1A0
Endometrium normal
Tumor ovarium padat
+1
+1
22
B/12/14
Ny.A
43
P3A0
Endometrium normal
Mioma uteri
0
0
23
B/01/13
Ny.K
26
P2A0
Endometrium normal
Mioma uteri
0
0
18
Universitas Sumatera Utara
LAMPIRAN 3.
ANALISA STATISTIK
Frequencies
Crosstab
DIAGNOSA
NON
ENDOMETRIOSIS ENDOMETRIOSIS
KEL_USIA
18-30
Count
% within DIAGNOSA
31-40
12
3
15
52.2%
13.0%
32.6%
7
5
12
30.4%
21.7%
26.1%
4
15
19
17.4%
65.2%
41.3%
23
23
46
100.0%
100.0%
100.0%
Count
% within DIAGNOSA
>=41
Count
% within DIAGNOSA
Total
Count
% within DIAGNOSA
Total
Crosstab
DIAGNOSA
NON
ENDOMETRIOSIS ENDOMETRIOSIS
KEL_PARITAS
.00
Count
% within DIAGNOSA
1-2
23
0
23
100.0%
.0%
50.0%
0
14
14
.0%
60.9%
30.4%
0
9
9
.0%
39.1%
19.6%
23
23
46
100.0%
100.0%
100.0%
Count
% within DIAGNOSA
>=3
Count
% within DIAGNOSA
Total
Count
% within DIAGNOSA
Total
STADIUM
Frequency
Valid
Percent
Valid Percent
Cumulative Percent
2.00
5
21.7
21.7
21.7
3.00
10
43.5
43.5
65.2
Universitas Sumatera Utara
4.00
8
34.8
34.8
Total
23
100.0
100.0
100.0
Crosstabs
OBSERVER1 * OBSERVER2 Crosstabulation
Count
OBSERVER2
.00
OBSERVER1
1.00
2.00
3.00
Total
.00
11
0
0
0
11
1.00
0
13
0
0
13
2.00
0
3
9
3
15
3.00
0
0
1
6
7
11
16
10
9
46
Total
Symmetric Measures
Asymp. Std.
Value
Measure of Agreement
Kappa
Error
.795
N of Valid Cases
a
Approx. T
.070
b
Approx. Sig.
9.367
.000
46
a. Not assuming the null hypothesis.
b. Using the asymptotic standard error assuming the null hypothesis.
OBSERVER1 * DIAGNOSA Crosstabulation
DIAGNOSA
NON
ENDOMETRIOSIS
OBSERVER1
.00
Count
% within OBSERVER1
1.00
Count
% within OBSERVER1
2.00
Count
ENDOMETRIOSIS
Total
0
11
11
.0%
100.0%
100.0%
6
7
13
46.2%
53.8%
100.0%
10
5
15
Universitas Sumatera Utara
% within OBSERVER1
3.00
33.3%
100.0%
7
0
7
100.0%
.0%
100.0%
23
23
46
50.0%
50.0%
100.0%
Count
% within OBSERVER1
Total
66.7%
Count
% within OBSERVER1
Chi-Square Tests
Value
df
Asymp. Sig. (2-sided)
a
3
.000
Likelihood Ratio
26.729
3
.000
N of Valid Cases
46
Pearson Chi-Square
19.744
a. 2 cells (25.0%) have expected count less than 5. The minimum expected count is
3.50.
OBSERVER1 * STADIUM Crosstabulation
STADIUM
2.00
OBSERVER1
1.00
Count
% within STADIUM
2.00
3.00
Total
2
6
20.0%
30.0%
25.0%
26.1%
3
3
4
10
60.0%
30.0%
50.0%
43.5%
1
4
2
7
20.0%
40.0%
25.0%
30.4%
5
10
8
23
100.0%
100.0%
100.0%
100.0%
Count
% within STADIUM
Total
3
Count
% within STADIUM
4.00
1
Count
% within STADIUM
3.00
Chi-Square Tests
Asymp. Sig. (2Value
Pearson Chi-Square
Likelihood Ratio
Linear-by-Linear Association
N of Valid Cases
Df
sided)
a
4
.827
1.521
4
.823
.002
1
.962
1.500
23
Universitas Sumatera Utara
Chi-Square Tests
Asymp. Sig. (2Value
Pearson Chi-Square
Likelihood Ratio
Linear-by-Linear Association
N of Valid Cases
Df
sided)
a
4
.827
1.521
4
.823
.002
1
.962
1.500
23
a. 9 cells (100.0%) have expected count less than 5. The minimum expected count
is 1.30.
Universitas Sumatera Utara
LAMPIRAN 4.
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara
Universitas Sumatera Utara