Mathematical modeling of the effect of boosting tumor infiltrating lymphocyte in immunotherapy

10 12
10 10

Cell count

10 8
10 6
10 4

Tumor calls
NK cells
CD8+T cells
Circulating tymphocytes

10 2
10 0
0

20

40


60
Time (days)

80

100

120

10 12
10 10

Cell count

10 8
10 6
Tumor calls
NK cells
CD8+T cells

Circulating tymphocytes

10 4
10 2
10 0 0

20

40

60

80

100

120

Time (days)


10 12
10 10

Cell count

10 8
10 6
10 4

Tumor calls
NK cells
CD8+T cells
Circulating tymphocytes

10 2
10 0
0

20


40

60
Time (days)

80

100

120

10 12
10 10

Cell count

10 8
10 6
10 4


Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

10 2
10 0

0

20

40

60
Time (days)

80

100


120

10 12
10 10

Cell count

10 8
10 6
10 4

Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

10 2
10 0


0

20

40

60

80

100

120

10 12
10 10

Cell count

10 8

10 6
Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

10 4
10 2
10 0

0

20

40

60
Time (days)

80


100

120

10 12
10 10

Cell count

10 8
10 6
Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

10 4
10 2
10 0


0

20

40

60
Time (days)

80

100

120

10 12
10 10

Cell count


10 8
10 6
Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

10 4
10 2
10 0

0

20

40

60
Time (days)

80

100

120

10 12
10 10

Cell count

10 8
10 6
Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

10 4
10 2
10 0

0

20

40

60
Time (days)

80

100

120

10 12
10 10

Cell count

10

Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

8

10 6
10 4
10 2
10 0

0

20

40

60
Time (days)

80

100

120

10 12
10 10

Cell count

10

Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

8

10 6
10 4
10 2
10 0
0

20

40

60
Time (days)

80

100

120

10 12
10 10

Cell count

10

Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

8

10 6
10 4
10 2
10 0
0

20

40

60
Time (days)

80

100

120

10 12
10 10

Cell count

10

Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

8

10 6
10 4
10 2
10 0

0

20

40

60
Time (days)

80

100

120

10 12
10 10

10 6
10 4
10 2
10 0
0

20

40

60
Time (days)

80

100

120

10 12
10 10

Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

Cell count

10 8
10 6
10 4
10 2
10 0

0

20

40

60
Time (days)

80

100

120

10 12
10 10

Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

10 8
Cell count

Cell count

10

Tumor Cells
NK Cells
CD8+T Cells
Circulating Lymphocytes

8

10 6
10 4
10 2
10 0

0

20

40

60
Time (days)

80

100

120