Induksi Polifenol Mahkota Dewa dan Apopt
Med Indones
Induksi Polifenol M
Mahkota
Dewa
Artikel Asli
MEDIA MEDIKA
INDONESI ANA
Hak Cipta©2012 oleh Fakultas Kedokteran Universitas Diponegoro dan Ikatan Dokter Indonesia Wilayah Jawa Tengah
Induksi Polifenol Mahkota Dewa dan
Apoptosis Sel Kanker Paru Mencit Strain Balb/C:
Analisis pada Up-Regulation Bax dan Down-Regulation Bcl-2
Theopilus W. Watuguly *, Tjahjono **, Martha Kaihena ***, Syahran Wael ****
ABSTRACT
Mahkota Dewa polyphenol induction and apoptosis cell lung cancer in Balb/c strain mice analysis on up-regulation bax and downregulation Bcl-2
Background: This research is aimed to prove the role of Mahkota Dewa polyphenol in the up-regulation Bax and down-regulation in
strain Balb/c mice which inducted with benzo(a)pyrene (BaP).
Method: Post test control group design with 30 strain Balb/c mice sample, aged 1-2 weeks, weighed 20-30 grams, healthy mice
condition. All mice inducted with BaP and then randomized into 2 groups, which were the control group and the treatment group
(polyphenol 50mg). The development of the lung carcinogenesis was observed by tissue surgery in the 8th, 17th and 26th week. The
data collected include expression examination Bax and Bcl-2. The data analysis was conducted by Kruskal-Wallis, Mann-Whitney
and correlation test of Spearman's with significance degree of p
Induksi Polifenol M
Mahkota
Dewa
Artikel Asli
MEDIA MEDIKA
INDONESI ANA
Hak Cipta©2012 oleh Fakultas Kedokteran Universitas Diponegoro dan Ikatan Dokter Indonesia Wilayah Jawa Tengah
Induksi Polifenol Mahkota Dewa dan
Apoptosis Sel Kanker Paru Mencit Strain Balb/C:
Analisis pada Up-Regulation Bax dan Down-Regulation Bcl-2
Theopilus W. Watuguly *, Tjahjono **, Martha Kaihena ***, Syahran Wael ****
ABSTRACT
Mahkota Dewa polyphenol induction and apoptosis cell lung cancer in Balb/c strain mice analysis on up-regulation bax and downregulation Bcl-2
Background: This research is aimed to prove the role of Mahkota Dewa polyphenol in the up-regulation Bax and down-regulation in
strain Balb/c mice which inducted with benzo(a)pyrene (BaP).
Method: Post test control group design with 30 strain Balb/c mice sample, aged 1-2 weeks, weighed 20-30 grams, healthy mice
condition. All mice inducted with BaP and then randomized into 2 groups, which were the control group and the treatment group
(polyphenol 50mg). The development of the lung carcinogenesis was observed by tissue surgery in the 8th, 17th and 26th week. The
data collected include expression examination Bax and Bcl-2. The data analysis was conducted by Kruskal-Wallis, Mann-Whitney
and correlation test of Spearman's with significance degree of p