Immunomodulator Activity Of An Isolate From Artocarpus Champeden 2011
ISSN : 2089 - 6069
Proceedings
INDONESIAN SOCIETY OF CANCER CHEMOPREVENTION (ISCC)
October 11th - 12 th, 2011
Graha Widya Bhakti
DRN Building
Serpong, October 11th- :12th 20:1:1
Gedung Graha Widya Bhakti Puspiptek
ISSN : 2089- 6069
ISSN : 2o8g - 6o6g
Indonesian Society Of Cancer Chemoprevention
(ISCC)
The International Seminar on Translational
Research in Cancer Chemoprevention
2011
Serpong, October l.l.th -12th 201.1.
Gedung Gra ha Widya Bhakti Puspi ptek
ISSN : 2089- 6o6g
Indonesian Society Of Cancer Chemoprevention
(ISCC)
The International Seminar on Translational Research in
. Cancer Chemoprevention
ＲＰｾＱ＠
Proceedings The International Seminar on Translational qesea rch in
Cancer Chernoprevention
Serpong, October 11th
2011
- 12th 2011
Gedung Graha Widya Bhakti Puspiptek
Kawasan Puspiptek Serpong, Tangerang, Banten
ISS N : 2089 - 6o6g
Date published:
07
May 2 0 12
1531.4
Serpong, October 11th - 12th 2011
Gedung Graha Widya Bhakti Puspiptek
ISSN : 2089- 6069
PROCEEDINGS
·Indonesian Society Of Cancer Chemoprevention
The International Seminar on Translational Research in
Cancer Chemoprevention (ISCC) 2011
Serpong1 October 11th- 12th 2011
Gedung Graha Widya Bhakti Puspiptek
Kaw asan Puspiptek Serpong, Tangerang, Banten
ｾＵＳ
ｾＴ＠
Edito rs
Dr. Linar Zalina r Udin (PPKimia- LIPI)
Prof. Dr. Edy Meiyanto, M. Si., Apt.(Gadjah Ma da Universit y)
Dr. Muha mmad Hanafi, APU (PPKim ia - LIP!)
Yul ia Anita, M .Si (PPKimia-:- LI P!)
Haki ki Melani, M.Si (PPKimia- LI PI)
Published:
07
May
ＲＰｾ＠
ISSN : 2089- 6069
Serpong, October 11th- 12th zou
Gedung Graha W idya Bhakti Puspiptek
R-o6
lnvitro Antioxidan Activity Of Zingiber
Officina!e, Piper Retrojractum, And Their
Combinations
Hendri Wasito*, Heny
Ekowati, Fitri Fauziah
Hayati
R-29
Jintan Hitam (Nigella sativa) and Temu
Putih
(Curcuma
zedoaria)
Extract
Combination Activity on T 47D and MCF7
Cell Line and its Form ulation
R-21
Computer Algorithm Based On Discriminant · Jenie.I.L,Pandjaitan.M,
Method For Cervic Cancer Detection
Rusyadi.R, Busono.P,
Heny Ekowati*,
Dhadhaf}g Wahyu
Kurniawan
68- Tl
72
-n
78- 8o
SiJtanto.H
P-og
Anticancer Activity Agents, Triterpen From
Bark 'Nood Of Calophyllum Hosei Ridley
P-10
Isolation, Toxicity And Cytotox ic Of Fatty
Ac id Derivatives From Calophyllum
Macrophyllum Hook. F
Jamilah Abbas1 .
Frengk?, Berna Elya 2
90-95
R-o8
lmmunomociulator Activity Of An isolate
From Artocarpus Champeden Spreng. On
Cytotoxicity Function Of
Cd8+ Of Mice
Kartini
g6 -101
R-23
Prevalence Of Cervical Cancer In Endemic
Area (Red Light District) of Parung- West
Java And Their Characterization Of Isolated
Human Papilloma Viru s (Hpv) From Infected
Human
Pandjaitan.M,
Yulinintan.K, Sugiarto,
Pasaribu.N, Santoso.F.
102-106
P-1. 2
Screening OfAnti oxida nt Activities Of
Selected Plants From The Family
MegawatF, M.Hanaji,
Puspa 0 . Lotulung, Lia
meiliawati, Ngadiman,
Soja fajriah
107- J.l2
Misgiati
113 - n8
Euphorbiaceae, Moraceae And
Anacardiaceae
P-13
Antica ncer Potential Of Jam ur Dew a Extract
(Agaricus Blazei Murill) On Cervi ca l Cancer
Cells
Jamilah Abbas
81 - 89
Serpong, October 11th ‐ 12th 2011
Gedung Graha Widya Bhakti Puspiptek
R‐
ISSN : 2089 ‐ 6069
Immunomodulator Activity Of An Isolate From
Artocarpus Champeden Spreng. On Cytotoxicity Function Of
Cd8+ Of Mice
Kartini
Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya
Corresponding author: Faculty of Pharmacy University of Surabaya,
Jl. Raya Kalirungkut Surabaya 60293, kartini240777@gmail.com
Abstract
Research of traditional medicine is important to maximize the utilization of natural
resources. Artocarpus champeden Spreng. is one of medicinal plants that must be
studied because a lot of diseases have been treated traditionally with this plant, such
as cancer. Phenolic compounds such as flavonoid, tannin, phenilpropane derivative
and simple phenol contained in medicinal plant have been proved for their
immunomodulator activity. This study was conducted to explore whether flavonoid of
Artocarpus champeden could also increase the activity of immunocompetent cell that
play an important role in immunity against cancer especially to Cytotoxic T
Lymphocyte (CD8+). Assay of cytotoxicity of CD8+ by MLR (Mixed Lymphocyte
Response) showed that DE. 6.4 fraction (contain flavonoids) could not stimulate the
activation of CD8+ significantly (p
Proceedings
INDONESIAN SOCIETY OF CANCER CHEMOPREVENTION (ISCC)
October 11th - 12 th, 2011
Graha Widya Bhakti
DRN Building
Serpong, October 11th- :12th 20:1:1
Gedung Graha Widya Bhakti Puspiptek
ISSN : 2089- 6069
ISSN : 2o8g - 6o6g
Indonesian Society Of Cancer Chemoprevention
(ISCC)
The International Seminar on Translational
Research in Cancer Chemoprevention
2011
Serpong, October l.l.th -12th 201.1.
Gedung Gra ha Widya Bhakti Puspi ptek
ISSN : 2089- 6o6g
Indonesian Society Of Cancer Chemoprevention
(ISCC)
The International Seminar on Translational Research in
. Cancer Chemoprevention
ＲＰｾＱ＠
Proceedings The International Seminar on Translational qesea rch in
Cancer Chernoprevention
Serpong, October 11th
2011
- 12th 2011
Gedung Graha Widya Bhakti Puspiptek
Kawasan Puspiptek Serpong, Tangerang, Banten
ISS N : 2089 - 6o6g
Date published:
07
May 2 0 12
1531.4
Serpong, October 11th - 12th 2011
Gedung Graha Widya Bhakti Puspiptek
ISSN : 2089- 6069
PROCEEDINGS
·Indonesian Society Of Cancer Chemoprevention
The International Seminar on Translational Research in
Cancer Chemoprevention (ISCC) 2011
Serpong1 October 11th- 12th 2011
Gedung Graha Widya Bhakti Puspiptek
Kaw asan Puspiptek Serpong, Tangerang, Banten
ｾＵＳ
ｾＴ＠
Edito rs
Dr. Linar Zalina r Udin (PPKimia- LIPI)
Prof. Dr. Edy Meiyanto, M. Si., Apt.(Gadjah Ma da Universit y)
Dr. Muha mmad Hanafi, APU (PPKim ia - LIP!)
Yul ia Anita, M .Si (PPKimia-:- LI P!)
Haki ki Melani, M.Si (PPKimia- LI PI)
Published:
07
May
ＲＰｾ＠
ISSN : 2089- 6069
Serpong, October 11th- 12th zou
Gedung Graha W idya Bhakti Puspiptek
R-o6
lnvitro Antioxidan Activity Of Zingiber
Officina!e, Piper Retrojractum, And Their
Combinations
Hendri Wasito*, Heny
Ekowati, Fitri Fauziah
Hayati
R-29
Jintan Hitam (Nigella sativa) and Temu
Putih
(Curcuma
zedoaria)
Extract
Combination Activity on T 47D and MCF7
Cell Line and its Form ulation
R-21
Computer Algorithm Based On Discriminant · Jenie.I.L,Pandjaitan.M,
Method For Cervic Cancer Detection
Rusyadi.R, Busono.P,
Heny Ekowati*,
Dhadhaf}g Wahyu
Kurniawan
68- Tl
72
-n
78- 8o
SiJtanto.H
P-og
Anticancer Activity Agents, Triterpen From
Bark 'Nood Of Calophyllum Hosei Ridley
P-10
Isolation, Toxicity And Cytotox ic Of Fatty
Ac id Derivatives From Calophyllum
Macrophyllum Hook. F
Jamilah Abbas1 .
Frengk?, Berna Elya 2
90-95
R-o8
lmmunomociulator Activity Of An isolate
From Artocarpus Champeden Spreng. On
Cytotoxicity Function Of
Cd8+ Of Mice
Kartini
g6 -101
R-23
Prevalence Of Cervical Cancer In Endemic
Area (Red Light District) of Parung- West
Java And Their Characterization Of Isolated
Human Papilloma Viru s (Hpv) From Infected
Human
Pandjaitan.M,
Yulinintan.K, Sugiarto,
Pasaribu.N, Santoso.F.
102-106
P-1. 2
Screening OfAnti oxida nt Activities Of
Selected Plants From The Family
MegawatF, M.Hanaji,
Puspa 0 . Lotulung, Lia
meiliawati, Ngadiman,
Soja fajriah
107- J.l2
Misgiati
113 - n8
Euphorbiaceae, Moraceae And
Anacardiaceae
P-13
Antica ncer Potential Of Jam ur Dew a Extract
(Agaricus Blazei Murill) On Cervi ca l Cancer
Cells
Jamilah Abbas
81 - 89
Serpong, October 11th ‐ 12th 2011
Gedung Graha Widya Bhakti Puspiptek
R‐
ISSN : 2089 ‐ 6069
Immunomodulator Activity Of An Isolate From
Artocarpus Champeden Spreng. On Cytotoxicity Function Of
Cd8+ Of Mice
Kartini
Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya
Corresponding author: Faculty of Pharmacy University of Surabaya,
Jl. Raya Kalirungkut Surabaya 60293, kartini240777@gmail.com
Abstract
Research of traditional medicine is important to maximize the utilization of natural
resources. Artocarpus champeden Spreng. is one of medicinal plants that must be
studied because a lot of diseases have been treated traditionally with this plant, such
as cancer. Phenolic compounds such as flavonoid, tannin, phenilpropane derivative
and simple phenol contained in medicinal plant have been proved for their
immunomodulator activity. This study was conducted to explore whether flavonoid of
Artocarpus champeden could also increase the activity of immunocompetent cell that
play an important role in immunity against cancer especially to Cytotoxic T
Lymphocyte (CD8+). Assay of cytotoxicity of CD8+ by MLR (Mixed Lymphocyte
Response) showed that DE. 6.4 fraction (contain flavonoids) could not stimulate the
activation of CD8+ significantly (p