MICROBIOLOGY PPT LECTURE NOTES | Karya Tulis Ilmiah

Actinomyces &
Nocardia

Actinomyces
A.israelii,
A.naeslundii;
 Gram positive;
sulfur granule;
 Related to
decay tooth
and
peridentitis


ACTINOMYCES
Anaerobic, filamentous, gram
positive bacillus
• Exhibit true branching



“Mykes” – Greek for “fungus”
Thought by early microbiologist to
be fungi because of:
• Morphology
• Disease they cause

Clinical specimens:Actinomycosis-pus

ACTINOMYCOSIS
Not highly virulent
(Opportunist)
• Component of Oral Flora




Periodontal pockets
Dental plaque
Tonsilar crypts

• Take advantage of injury
to penetrate mucosal
barriers




Coincident infection
Trauma
Surgery

Actinomycosis


A chronic suppurative and granulomatous 肉肉
肉 disease of the cervico-facial, thoracic or
abdominal areas

ACTINOMYCOSIS
Form indurated masses with fibrous

walls and central loculations with
pus
• Pus contains "Sulfur Granules"
Gritty, yellow white
 Average diameter - 2mm
 Composed of mineralized “mycelial” mass


 
Chronic infection
• Form burrowing sinus tracts to skin or
mucus membranes


Discharge purulent material

Actinomycosis - sulfur granule

Pulmonary Actinomycosis






15% of cases
Aspiration of organism
from the oropaharynx
Slowly progressive
process involving lung
and pleura
• May be mistaken for
malignancy



Chest pain, fever, wgt
loss and hemoptysis

Mycetoma
( 足足足足

Streptomyces
species?

Nocardiosis




Subcutaneous
infections, pulmonary
infections, and brain
abscesses
N. asteroides; N.
brasiliensis

Lab. Diagnosis


Clinical

Specimens:Sputum,Pus,Biopsy tissue

Sulfamethoxazole-Trimethoprim