MICROBIOLOGY PPT LECTURE NOTES | Karya Tulis Ilmiah

Prion

Similar to Viruses Atypical
Agents
 Small
 Filterable
 Need host cells
 No machinery for energy generation of
protein synthesis

Different from viruses
 No dectectable virions in infected tissues
 No detectable virions in purified infectious
material
 If nucleic acid is present, very small
 Very resistant

 Resistant to or only
1.
2.
3.

4.
5.

partially inactivated
by
Formaldehyde
Ethanol
Glutaraldehyde
Ultraviolet and ionizi
ng irradiation
Non-ionic detergents


1.
2.

Inactivated by
Autoclaving
5%sodium
hypochlorite

3. Sodium hydroxide
4. Proteases, urea,
other protein
denaturants

Pathogensis









Kuru
CJD(Creutzfeldt Jakob disease)
GSS(Gerstmann Straussler-Scheinker syndrom
e)
FFI(Fetal familial insomnia)

Scrapie(sheep and goats)
Bovine spongiform encephalopathy
Transmissible mink encephalopathy
Chronic wasting disease of mule deer

Simplified model for prion disease.

How can this model explain the sporadic, acquired or
inherited form of the disease?

Why are there differences in prion dise
ases?