Association of PDGFRA Gene Polymorphisms and Early-onset Myopia in South Sumatera - Diponegoro University | Institutional Repository (UNDIP-IR)
Attachment 1. Statistic analysis of myopia risk factors questionnaire
sex * eye_status Crosstabulation
eye_status
myopia
sex
female
Count
% within row
male
Total
67
61.2%
38.8%
100.0%
9
24
33
27.3%
72.7%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within row
Total
26
Count
% within row
normal
41
Chi-Square Tests
Value
Pearson Chi-Square
a
1
.001
8.865
1
.003
10.462
1
.001
10.176
b
Continuity Correction
Likelihood Ratio
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
Fisher's Exact Test
Exact Sig. (1sided)
.003
Linear-by-Linear
Association
10.075
N of Valid Cases
100
1
.002
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 16.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for sex (female /
male)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
4.205
1.692
10.448
2.244
1.245
4.043
.534
.370
.770
100
81
.001
Crosstab
eye_status
myopia
parental_history_of
myopia
parents with myopia
Count
% within row
parents without
myopia
Count
% within row
Total
Count
% within row
normal
Total
35
13
48
72.9%
27.1%
100.0%
15
37
52
28.8%
71.2%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2sided)
df
19.391a
1
.000
Continuity Correction
17.668
1
.000
Likelihood Ratio
20.077
1
.000
Pearson Chi-Square
b
Exact Sig. (2sided)
Fisher's Exact Test
.000
Linear-by-Linear
Association
N of Valid Cases
19.197
1
.000
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 24.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
parental_history_of_myopia
(parents with myopia / parents
without myopia)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
6.641
2.769
15.927
2.528
1.595
4.006
.381
.232
.625
100
82
Exact Sig. (1sided)
.000
Crosstab
eye_status
myopia
paternal_grandparents paternal grandparents
_history_of_myopia
with myopia
Count
paternal grandparents
without myopia
Count
% within row
% within row
Total
Total
9
31
71.0%
29.0%
100.0%
28
41
69
40.6%
59.4%
100.0%
Count
% within row
normal
22
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig. (2sided)
a
1
.005
Continuity Correction
6.732
1
.009
Likelihood Ratio
8.088
1
.004
Pearson Chi-Square
7.901
b
Fisher's Exact Test
Exact Sig. (1sided)
.009
Linear-by-Linear
Association
N of Valid Cases
7.822
1
.005
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 15.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
paternal_grandparents_histor
y_of_myopia (paternal
grandparents with myopia /
paternal grandparents without
myopia)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
3.579
1.437
8.913
1.749
1.216
2.516
.489
.272
.876
100
83
.004
Crosstab
eye_status
myopia
normal
Total
maternal_grandparent maternal grandparents Count
s_history_of_myopia with myopia
% within row
16
9
25
64.0%
36.0%
100.0%
maternal grandparents Count
without myopia
% within row
34
41
75
45.3%
54.7%
100.0%
Total
Count
% within row
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig. (2sided)
a
1
.106
Continuity Correction
1.920
1
.166
Likelihood Ratio
2.641
1
.104
Pearson Chi-Square
2.613
b
Fisher's Exact Test
Exact Sig. (1sided)
.165
Linear-by-Linear
Association
N of Valid Cases
2.587
1
.108
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 12.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Lower
Upper
Odds Ratio for
maternal_grandparents_histor
y_of_myopia (maternal
grandparents with myopia /
maternal grandparents without
myopia)
2.144
.842
5.459
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
1.412
.961
2.075
.659
.375
1.155
100
84
.083
Crosstab
eye_status
myopia
sibling_history_of
myopia
sibling with myopia
Count
% within row
sibling without
myopia
Count
% within row
Total
Count
% within row
normal
Total
29
14
43
67.4%
32.6%
100.0%
21
36
57
36.8%
63.2%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2sided)
df
a
1
.002
Continuity Correction
7.997
1
.005
Likelihood Ratio
9.338
1
.002
Pearson Chi-Square
9.180
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
.004
9.088
1
.003
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 21.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
sibling_history_of_myopia
(sibling with myopia / sibling
without myopia)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
3.551
1.541
8.181
1.831
1.229
2.726
.516
.321
.828
100
85
Exact Sig. (1sided)
.002
eye_status
myopia
frequency_of_outdoor_ rare(1-2 times per
activity
week)
Count
normal
29
21
50
% within row
58.0%
42.0%
100.0%
frequent (≥3 times per Count
week)
% within row
21
29
50
42.0%
58.0%
100.0%
50
50
100
50.0%
50.0%
100.0%
Total
Count
% within row
Chi-Square Tests
Value
Asymp. Sig. Exact Sig. (2- Exact Sig. (1(2-sided)
sided)
sided)
df
2.560a
1
.110
Continuity Correction
1.960
1
.162
Likelihood Ratio
2.571
1
.109
Pearson Chi-Square
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Total
.161
2.534
1
.081
.111
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 25.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
frequency_of_outdoor_activity
(rare(1-2 times per week) /
frequent (≥3 times per week))
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.907
.862
4.220
1.381
.924
2.065
.724
.484
1.083
100
86
Crosstab
eye_status
myopia
≤ 2 hours per day Count
duration_of_outdoor
activity
% within row
Total
61
55.7%
44.3%
100.0%
16
23
39
41.0%
59.0%
100.0%
Count
% within row
Total
27
> 2 hours per day Count
% within row
normal
34
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig. (2sided)
2.060a
1
.151
Continuity Correction
1.513
1
.219
Likelihood Ratio
2.068
1
.150
Pearson Chi-Square
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.218
2.039
1
.153
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 19.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
duration_of_outdoor_activity
(≤2 hours per day / > 2 hours
per day)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.810
.802
4.085
1.359
.877
2.105
.751
.511
1.102
100
87
.109
Crosstab
eye_status
myopia
frequency_of_readi ≥6 times per week Count
ng
% within row
Total
26
69.2%
30.8%
100.0%
32
42
74
43.2%
56.8%
100.0%
Count
% within row
Total
8
2
hours per day / ≤2 hours per
day)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
2.852
.995
8.173
1.556
1.069
2.264
.545
.271
1.096
100
89
.039
Crosstab
eye_status
myopia
lighting_while_reading
dim
Count
% within row
bright
Total
19
52.6%
47.4%
100.0%
40
41
81
49.4%
50.6%
100.0%
Count
% within row
Total
9
Count
% within row
normal
10
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.799
Continuity Correction
.000
1
1.000
Likelihood Ratio
.065
1
.799
Pearson Chi-Square
.065
b
Exact Sig. (2- Exact Sig. (1sided)
sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
1.000
.064
1
.800
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 9.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
lighting_while_reading (dim /
bright)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.139
.419
3.097
1.066
.659
1.723
.936
.556
1.575
100
90
.500
Crosstab
eye_status
myopia
frequency_of_watching 0-6 times per week Count
_television
% within row
Total
55
52.7%
47.3%
100.0%
21
24
45
46.7%
53.3%
100.0%
Count
% within row
Total
26
≥ 7 times per week Count
% within row
normal
29
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
a
1
.546
Continuity Correction
.162
1
.688
Likelihood Ratio
.364
1
.546
Pearson Chi-Square
.364
b
Fisher's Exact Test
Exact Sig. (1sided)
.688
Linear-by-Linear
Association
N of Valid Cases
.360
1
.549
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 22.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
frequency_of_watching_televi
sion (0-6 times per week / ≥7
times per week)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.275
.579
2.807
1.130
.757
1.686
.886
.600
1.310
100
91
.344
Crosstab
eye_status
myopia
duration_of_watching
television
> 4 hours per day Count
% within row
Total
35
51.4%
48.6%
100.0%
32
33
65
49.2%
50.8%
100.0%
Count
% within row
Total
17
≤ 4 hours per day Count
% within row
normal
18
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
.044a
1
.834
Continuity Correction
.000
1
1.000
Likelihood Ratio
.044
1
.834
Pearson Chi-Square
b
Fisher's Exact Test
Exact Sig. (1sided)
1.000
Linear-by-Linear
Association
N of Valid Cases
.044
1
.835
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 17.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
duration_of_watching_televisi
on (> 4 hours per day / ≤4
hours per day)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.092
.480
2.484
1.045
.696
1.567
.957
.631
1.451
100
92
.500
Crosstab
eye_status
myopia
television_viewing_distance ≤ 60 cm
Count
% within row
> 60 cm
% within row
34
5
39
12.8%
100.0%
16
45
61
26.2%
73.8%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within row
Total
87.2%
Count
Total
normal
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
35.351a
1
.000
Continuity Correction
32.955
1
.000
Likelihood Ratio
38.554
1
.000
Pearson Chi-Square
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.000
34.997
1
.000
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 19.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
television_viewing_distance
(≤60 cm / > 60 cm)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
19.125
6.376
57.369
3.324
2.145
5.149
.174
.076
.399
100
93
.000
Crosstab
eye_status
myopia
lighting_while_watching
television
dim
Count
% within row
bright
% within row
16
10
26
38.5%
100.0%
34
40
74
45.9%
54.1%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within row
Total
61.5%
Count
Total
normal
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
a
1
.171
Continuity Correction
1.299
1
.254
Likelihood Ratio
1.884
1
.170
Pearson Chi-Square
1.871
b
Fisher's Exact Test
Exact Sig. (1sided)
.254
Linear-by-Linear
Association
1.852
N of Valid Cases
100
1
.174
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 13.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
lighting_while_watching_televi
sion (dim / bright)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.882
.756
4.690
1.339
.905
1.982
.712
.419
1.208
100
94
.127
Crosstab
eye_status
myopia
frequency_of_using
gadget_for_academic
activity
> 4 times per week Count
% within row
≤ 4 times per week Count
% within row
Total
Count
% within row
normal
Total
25
20
45
55.6%
44.4%
100.0%
25
30
55
45.5%
54.5%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Pearson Chi-Square
a
1
.315
.646
1
.421
1.012
1
.314
1.010
b
Continuity Correction
Likelihood Ratio
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
Fisher's Exact Test
Exact Sig. (1sided)
.422
Linear-by-Linear
Association
N of Valid Cases
1.000
1
.317
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 22.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
frequency_of_using_gadget_f
or_academic_activity (> 4
times per week / ≤ 4 times per
week)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.500
.679
3.312
1.222
.828
1.805
.815
.543
1.223
100
95
.211
Crosstab
eye_status
myopia
duration_of_using_gadget > 4 hours per day Count
_for_academic_activity
% within row
≤4 hours per day
Count
% within row
Total
Count
% within row
normal
Total
9
9
18
50.0%
50.0%
100.0%
41
41
82
50.0%
50.0%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2sided)
df
a
1
1.000
Continuity Correction
.000
1
1.000
Likelihood Ratio
.000
1
1.000
Pearson Chi-Square
.000
b
Exact Sig. (2sided)
Fisher's Exact Test
1.000
Linear-by-Linear
Association
N of Valid Cases
.000
1
1.000
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 9.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Lower
Upper
Odds Ratio for
duration_of_using_gadget_for
_academic_activity (> 4 hours
per day / ≤4 hours per day)
For cohort eye_status =
myopia
1.000
.360
2.774
1.000
.600
1.666
For cohort eye_status =
normal
N of Valid Cases
1.000
.600
1.666
100
96
Exact Sig. (1sided)
.602
Crosstab
eye_status
myopia
frequency_of_using
gadget_for_pleasure
>4 times per week Count
% within row
≤ 4 times per week Count
% within row
Total
Count
% within row
normal
21
48
56.3%
43.8%
100.0%
23
29
52
44.2%
55.8%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. Exact Sig. (2- Exact Sig. (1(2-sided)
sided)
sided)
df
a
1
.230
Continuity Correction
1.002
1
.317
Likelihood Ratio
1.446
1
.229
Pearson Chi-Square
1.442
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
.317
1.428
1
.158
.232
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 24.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Lower
Upper
Odds Ratio for
frequency_of_using_gadget_f
or_pleasure (>4 times per
week / ≤4 times per week)
1.621
.735
3.573
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
1.272
.857
1.886
.784
.525
1.172
100
97
Total
27
Crosstab
eye_status
myopia
duration_of_using
gadget_for_pleasure
> 4 hours per day Count
% within row
% within row
34
52.9%
47.1%
100.0%
32
34
66
48.5%
51.5%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within row
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.673
Continuity Correction
.045
1
.833
Likelihood Ratio
.178
1
.673
Pearson Chi-Square
.178
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.833
.176
1
.417
.674
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is
17.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
duration_of_using_gadget_for
_pleasure (> 4 hours per day /
≤4 hours per day)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.195
.522
2.737
1.092
.730
1.634
.913
.596
1.399
100
98
Total
16
≤ 4 hours per day Count
Total
normal
18
Attachment 2. Statistical analysis of corneal curvature
Independent Samples Test
Levene's
Test for
Equality of
Variances
t-test for Equality of Means
Corneal
curvatur
e
95%
Confidence
Interval of the
Difference
F
Right
eye
Equal
variances
assumed
Equal
variances
not
assumed
Left eye Equal
variances
assumed
Sig.
.164
.144
t
.686
df
-.943
98
.348 -.04600 .04877 -.14279 .05079
-.943 96.971
.348 -.04600 .04877 -.14280 .05080
.706 -1.061
Equal
variances
not
assumed
Std.
Mean Error
Sig. (2- Differe Differe
tailed) nce
nce Lower Upper
98
.291 -.05280 .04977 -.15157 .04597
-1.061 95.207
.291 -.05280 .04977 -.15161 .04601
Crosstab
Eye status
Myopia
CC right eye
Steeper
Count
Total
Total
35
29
64
54.7%
45.3%
100.0%
Count
15
21
36
%
Count
%
41.7%
50
50.0%
58.3%
50
50.0%
100.0%
100
100.0%
%
Flatter
Normal
99
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
Pearson Chi-Square
1.563a
1
.211
b
Continuity Correction
1.085
1
.298
Likelihood Ratio
1.568
1
.210
Fisher's Exact Test
.298
.149
Linear-by-Linear
1.547
1
.214
Association
N of Valid Cases
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is
18.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Lower
Upper
Odds Ratio for CC_right eye
(steeper/flatter)
1.690
.740
3.857
For cohort status_mata = miop
1.313
.840
2.051
For cohort status_mata = normal
.777
.528
1.142
N of Valid Cases
100
100
Crosstab
Eye status
Myopia
Corneal curvature
of the left eye
Normal
Total
≤7.8 mm
Count
34
30
64
>7.8mm
Count
Count
16
50
20
50
36
100
Total
Chi-Square Tests
Value
df
a
Pearson Chi-Square
Asymp.
Sig. (2sided)
.694
1
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.405
b
Continuity Correction
.391
1
.532
Likelihood Ratio
.696
1
.404
Fisher's Exact Test
.532
.266
Linear-by-Linear
.687
1
.407
Association
N of Valid Cases
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count
is 18.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence
Interval
Value
Lower
Upper
Odds Ratio for CC
left eye
(steeper/flatter)
1.417
.624
3.218
For cohort
status_mata = miop
For cohort
status_mata = normal
N of Valid Cases
1.195
.776
1.841
.844
.570
1.248
100
101
T-Test
Independent Samples t-Test
Levene's
Test for
Equality of
Variances
t-test for Equality of Means
95%
Confidence
Interval of the
Difference
F
CC
right
eye
Equal
variances
assumed
CC
left
eye
Equal
variances
not
assumed
Equal
variances
assumed
Equal
variances
not
assumed
Sig.
t
df
1.080 .301 -1.429
Sig.
(2Mean
tailed Differenc Std. Error
)
e
Difference Lower Upper
98 .156
-.07370
.05156
- .02863
.1760
2
-1.370 57.190 .176
-.07370
.05381
- .03405
.1814
4
98 .061
-.09904
.05228
- .00471
.2027
9
-1.836 58.874 .071
-.09904
.05393
- .00888
.2069
6
.623 .432 -1.894
102
T-Test
Independent Samples Test
Levene's
Test for
Equality of
Variances
F
Corneal
curvatur
e of the
left eye
Equal
variances
assumed
Sig.
t
df
.489 .488 1.170
Equal
variances
not
assumed
t-test for Equality of Means
95% Confidence
Interval of the
Difference
Sig.
Std.
(2- Mean Error
taile Differe Differe
d)
nce
nce
Lower
Upper
48 .248 .11558 .09877
-.08302
.31418
.940 9.850 .370 .11558 .12294
-.15892
.39008
Crosstab for table 18
Corneal curvature
right eye
steeper
Sex
Total
left eye
flatter
Total
steeper
flatter
Total
Myopic
male
Count
7
2
9
7
2
9
Myopic
female
Count
28
13
41
27
14
41
Count
35
15
50
34
16
50
103
Mann-Whitney Test for table 19.
Sex
CC right eye in myopic
subjects
male
N
Mean Rank
Sum of Ranks
9
26.94
242.50
female
41
25.18
1032.50
Total
50
Test Statisticsb
Corneal curvature for the right
eye
Mann-Whitney U
Wilcoxon W
Z
Asymp. Sig. (2-tailed)
Exact Sig. [2*(1-tailed
Sig.)]
a. Not corrected for ties.
b. Grouping Variable: Sex
171.500
1032.500
-.328
.743
.747a
104
Attachment 3. Statistical analysis of PDGFRA gene polymorphism
Crosstab
eye_status
Myopia
rs7676985
mutant allele (+)
Count
% within rs7676985
mutant allele (-)
% within rs7676985
33
39.4%
60.6%
100.0%
37
30
67
55.2%
44.8%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs7676985
Total
20
Count
Total
Normal
13
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.137
Continuity Correction
1.628
1
.202
Likelihood Ratio
2.229
1
.135
Pearson Chi-Square
2.216
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.202
2.194
1
.139
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 16.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs7676985
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
.527
.226
1.231
.713
.444
1.147
1.354
.923
1.984
100
105
.101
Crosstab
eye_status
Myopia
rs17084051
mutant allele (+)
Count
% within rs17084051
mutant allele (-)
% within rs17084051
21
55
61.8%
38.2%
100.0%
16
29
45
35.6%
64.4%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs17084051
Total
34
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
6.828a
1
.009
Continuity Correction
5.818
1
.016
Likelihood Ratio
6.912
1
.009
Pearson Chi-Square
b
Fisher's Exact Test
Exact Sig. (1sided)
.015
Linear-by-Linear
Association
N of Valid Cases
6.760
1
.009
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 22.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs17084051
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
2.935
1.296
6.647
1.739
1.114
2.713
.592
.397
.884
100
106
.008
Crosstab
eye_status
Myopia
rs7677751
mutant allele (+)
Count
% within rs7677751
mutant allele (-)
% within rs7677751
15
47
68.1%
31.9%
100.0%
18
35
53
34.0%
66.0%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs7677751
Total
32
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.001
Continuity Correction
10.277
1
.001
Likelihood Ratio
11.841
1
.001
Pearson Chi-Square
11.602
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.001
11.486
1
.001
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 23.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs7677751
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
4.148
1.798
9.573
2.005
1.313
3.061
.483
.305
.766
100
107
.001
Crosstab
eye_status
Myopia
rs2307049
mutant allele (+)
Count
% within rs2307049
mutant allele (-)
% within rs2307049
38
69
44.9%
55.1%
100.0%
19
12
31
61.3%
38.7%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs2307049
Total
31
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.130
Continuity Correction
1.683
1
.195
Likelihood Ratio
2.306
1
.129
Pearson Chi-Square
2.291
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.194
2.268
1
.132
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 15.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs2307049
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
.515
.217
1.223
.733
.500
1.075
1.423
.870
2.326
100
108
.097
Crosstab
eye_status
Myopia
rs7682912
1
Count
% within rs7682912
2
% within rs7682912
19
45
57.8%
42.2%
100.0%
24
31
55
43.6%
56.4%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs7682912
Total
26
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig. Exact Sig. (2- Exact Sig. (1(2-sided)
sided)
sided)
df
a
1
.159
Continuity Correction
1.455
1
.228
Likelihood Ratio
1.987
1
.159
Pearson Chi-Square
1.980
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
.228
1.960
1
.162
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is
22.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs7682912 (1
/ 2)
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.768
.797
3.919
1.324
.896
1.957
.749
.495
1.133
100
109
.114
Crosstab
eye_status
Myopia
rs7660560
mutant allele (+)
Count
% within rs7660560
mutant allele (-)
% within rs7660560
19
39
51.3%
48.7%
100.0%
30
31
61
49.2%
50.8%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs7660560
Total
20
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.838
Continuity Correction
.000
1
1.000
Likelihood Ratio
.042
1
.838
Pearson Chi-Square
.042
b
Exact Sig. (2sided)
Fisher's Exact Test
Exact Sig. (1sided)
1.000
Linear-by-Linear
Association
N of Valid Cases
.042
1
.838
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 19.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs7660560
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.088
.487
2.430
1.043
.700
1.553
.959
.639
1.438
100
110
.500
Crosstab
eye_status
Myopia
rs2114039
mutant allele (+)
Count
% within rs2114039
mutant allele (-)
% within rs2114039
20
47
57.4%
42.6%
100.0%
23
30
53
43.4%
56.6%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs2114039
Total
27
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.161
Continuity Correction
1.445
1
.229
Likelihood Ratio
1.974
1
.160
Pearson Chi-Square
1.967
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.229
1.947
1
.163
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 23.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs2114039
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.761
.796
3.893
1.324
.893
1.963
.752
.500
1.130
100
111
.115
Crosstab
eye_status
Myopia
CC_kanan
steeper cornea
Count
% within CC_kanan
flatter cornea
% within CC_kanan
29
64
54.7%
45.3%
100.0%
15
21
36
41.7%
58.3%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within CC_kanan
Total
35
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
1.563a
1
.211
Continuity Correction
1.085
1
.298
Likelihood Ratio
1.568
1
.210
Pearson Chi-Square
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.298
1.547
1
.214
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 18.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for CC_kanan
(steeper cornea / flatter
cornea)
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.690
.740
3.857
1.313
.840
2.051
.777
.528
1.142
100
112
.149
Crosstab
eye_status
Myopia
CC_kiri
steeper cornea
Count
% within CC_kiri
flatter cornea
30
64
53.1%
46.9%
100.0%
16
20
36
44.4%
55.6%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within CC_kiri
Total
34
Count
% within CC_kiri
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig. (2- Exact Sig. (1sided)
sided)
a
1
.405
Continuity Correction
.391
1
.532
Likelihood Ratio
.696
1
.404
Pearson Chi-Square
.694
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
.532
.687
1
.266
.407
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 18.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for CC_kiri
(steeper cornea / flatter
cornea)
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.417
.624
3.218
1.195
.776
1.841
.844
.570
1.248
100
113
Attachment 4. Statistical analysis of pedigree, progressivity, and refractive power
rs7676985 * pedigree_trans Crosstabulation
pedigree
one
multigeneration generation
Total
rs7676985 mutant allele
positive
Count
12
1
13
mutant allele
negative
Count
26
11
37
Count
38
12
50
Total
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
a
2.561
1.496
1
1
.110
.221
3.024
1
.082
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.147
2.510
1
.107
.113
50
rs17084051 * pedigree_trans Crosstabulation
pedigree
Multi
generation
one
generation
Total
rs17084051 mutant allele
positive
Count
26
8
34
mutant allele
negative
Count
12
4
16
Count
38
12
50
Total
114
Chi-Square Tests
Value
Pearson ChiSquare
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp. Sig. Exact Sig. Exact Sig.
(2-sided) (2-sided) (1-sided)
df
a
1
.910
.000
1
1.000
.013
1
.910
.013
1.000
.013
1
.586
.910
50
rs7677751 * pedigree_trans Crosstabulation
pedigree
Multi
one
generation generation Total
rs7677751
mutant allele
positive
Count
25
7
32
mutant allele
negative
Count
13
5
18
Count
38
12
50
Total
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.220a
.015
1
1
.639
.901
.217
1
.641
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.735
.216
1
50
115
.642
.444
Crosstab
pedigree
Multi
one
generation generation
rs2307049
Total
Total
mutant allele Count
positive
25
6
31
mutant allele Count
negative
Count
13
6
19
38
12
50
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.965a
.411
1
1
.326
.521
.947
1
.331
.946
1
.331
.496
.258
50
Crosstab
pedigree
multigener
one
ation
generation
Total
rs7682912 mutant allele
positive
Count
19
7
26
mutant allele
negative
Count
19
5
24
Count
38
12
50
Total
116
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.254a
.030
1
1
.614
.863
.255
1
.614
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.745
.249
1
.433
.618
50
Crosstab
Pedigree
Multi
one
generation generation
Total
rs7660560 mutant allele
positive
Count
18
2
20
mutant allele
negative
Count
20
10
30
Count
38
12
50
Total
117
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
3.582a
2.417
1
1
.058
.120
3.914
1
.048
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.091
3.510
1
.057
.061
50
Crosstab
pedigree
Multi
one
generation generation
rs2114039
Total
Total
mutant allele Count
positive
23
4
27
mutant allele Count
negative
Count
15
8
23
38
12
50
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp. Sig. Exact Sig.
(2-sided)
(2-sided)
df
2.715a
1.731
1
1
.099
.188
2.736
1
.098
2.661
1
.103
.183
50
118
Exact Sig.
(1-sided)
.094
Crosstab
Count
Progressivity
high
Right CC
low
Total
Steeper cornea
5
30
35
Flatter cornea
3
8
12
42
15
50
Total
Chi-Square Tests
Value
Pearson ChiSquare
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.255a
1
.614
.007
1
.933
.247
1
.619
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.683
.250
1
.451
.617
50
Crosstab
Progressivity
high
Left CC
low
Total
Steeper cornea
5
29
34
Flatter cornea
3
8
13
42
16
50
Total
119
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.132a
.000
1
1
.716
1.000
.130
1
.719
.699
.130
1
.505
.719
50
Crosstab
Count
progressivity
high
rs7676985
low
Total
mutant allele positive
4
9
13
mutant allele negative
4
8
33
42
37
50
Total
Chi-Square Tests
Value
Pearson Chi-Square 2.851a
Continuity
1.560
Correctionb
Likelihood Ratio
2.571
Fisher's Exact Test
Linear-by-Linear
2.794
Association
N of Valid Cases
50
Asymp.
Sig. (2sided)
df
1
1
.091
.212
1
.109
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.181
1
120
.095
.109
Crosstab
Count
progressivity
high
low
Total
rs17084051 mutant allele
positive
7
27
34
mutant allele
negative
1
15
16
8
42
50
Total
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp. Exact
Sig. (2- Sig. (2- Exact Sig.
sided) sided) (1-sided)
df
a
1.664
.768
1
1
.197
.381
1.911
1
.167
.409
1.631
1
.194
.202
50
Crosstab
Count
progressivity
high
rs7677751
low
Total
mutant allele
positive
7
25
32
mutant allele
negative
1
17
18
8
42
50
Total
121
Value
Asymp.
Sig. (2sided)
df
Pearson Chi-Square 2.283a
Continuity
1.230
b
Correction
Likelihood Ratio
2.622
Fisher's Exact Test
Linear-by-Linear
2.237
Association
N of Valid Cases
50
1
1
.131
.267
1
.105
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.231
1
.132
.135
Crosstab
progressivity
high
rs2307049
low
Total
mutant allele
positive
6
25
31
mutant allele
negative
2
17
19
8
Chi-Square Tests
42
50
Total
Value
Asymp.
Sig. (2sided)
df
Exact Sig. Exact Sig.
(2-sided) (1-sided)
Pearson Chi-Square .683a
1
.409
Continuity
.184
1
.668
Correctionb
Likelihood Ratio
.718
1
.397
Fisher's Exact Test
.693
Linear-by-Linear
.669
1
.413
Association
N of Valid Cases
50
a. 2 cells (50.0%) have expected count less than 5. The minimum
expected count is 3.04.
b. Computed only for a 2x2 table
122
.342
Crosstab
Count
progressivity
high
rs7682912
low
Total
mutant allele
positive
5
21
26
mutant allele
negative
3
21
24
42
50
Total
8
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.421a
.069
1
1
.517
.793
.425
1
.514
.412
1
.521
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.704
.399
50
Crosstab
Count
progressivity
high
rs7660560
low
Total
mutant allele
positive
3
17
20
mutant allele
negative
5
25
30
8
42
50
Total
123
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
Exact Sig.
(2-sided)
.025a
.000
1
1
.875
1.000
.025
1
.874
1.000
.024
1
Exact Sig.
(1-sided)
.599
.876
50
Crosstab
Count
progressivity
high
rs2114039
low
Total
mutant allele positive
5
22
27
mutant allele negative
3
8
20
42
23
50
Total
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp. Sig. Exact Sig.
(2-sided)
(2-sided)
df
.277a
.019
1
1
.599
.889
.280
1
.597
.271
1
.602
.711
50
124
Exact Sig.
(1-sided)
.448
Crosstabulation
Count
Refractive power
medium
myop
High myop
low
myop
Total
rs7676985 mutant allele
positive
0
2
11
13
mutant allele
negative
3
4
30
37
3
6
41
50
Total
Test Statistics
a
Diotpri
Most Extreme
Differences
Absolute
.081
Positive
.081
Negative
.000
.251
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs7676985
rs17084051 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs17084051 mutant allele
positive
1
4
29
34
mutant allele
negative
2
2
12
16
3
6
41
50
Total
a
Test Statistics
Diotpri
Most Extreme
Differences
Absolute
.103
Positive
.000
Negative
-.103
.340
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs17084051
125
rs7677751 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs7677751 mutant allele
positive
2
3
27
32
mutant allele
negative
1
3
14
18
3
6
41
50
Total
a
Test Statistics
Diotpri
Most Extreme
Differences
Absolute
.066
Positive
.007
Negative
-.066
.224
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs7677751
rs2307049 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs2307049 mutant allele
positive
2
4
25
31
mutant allele
negative
1
2
16
19
3
6
41
50
Total
126
Test Statisticsa
Most Extreme
Differences
Diotpri
Absolute
.036
Positive
.036
Negative
.000
.122
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs2307049
rs7682912 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs7682912 mutant allele
positive
2
2
22
26
mutant allele
negative
1
4
19
24
3
6
41
50
Total
a
Test Statistics
Diotpri
Most Extreme
Differences
Absolute
.054
Positive
.035
Negative
-.054
.192
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs7682912
127
rs7660560 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs7660560 mutant allele
positive
1
2
17
20
mutant allele
negative
2
4
24
30
3
6
41
50
Total
a
Test Statistics
Diotpri
Most Extreme
Differences
Absolute
.050
Positive
.050
Negative
.000
.173
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs7660560
rs2114039 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop
medium
myop
low myop
Total
rs2114039 mutant allele
positive
1
3
23
27
mutant allele
negative
2
3
18
23
3
6
41
50
Total
Test Statisticsa
Diotpri
Most Extreme Differences Absolute
.069
Positive
.000
Negative
-.069
.244
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs2114039
128
129
SNP
No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
rs7660560
B
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
C
+
+
-
D
+
+
-
Genotipe
GA
GG
GA
GA
GA
GA
GG
GA
GA
GA
GA
GG
GG
GA
GA
GG
GG
GG
GG
GA
GG
GG
GG
GG
GG
GG
GG
GA
GG
GA
GG
GA
GA
GA
GA
GG
GG
GG
GG
GG
GG
GG
GG
GG
GA
GA
GG
GG
GG
GG
GG
GG
GA
GA
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
rs2114039
B
C
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
Genotipe
TC
TC
TT
TC
CC
CC
TT
TC
TC
TC
TT
TT
TT
TC
TT
TT
TT
TT
TT
TC
TC
TC
TT
TT
TC
TT
TT
CC
TT
CC
CC
TT
TC
TC
TT
TT
TC
TT
CC
TT
TT
TC
TT
CC
CC
TC
TT
CC
TC
TC
TT
CC
TC
TC
SNP
No.
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
rs7660560
B
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
C
-
allele
T
C
C
D
-
Genotipe
GG
GA
GA
GA
GG
GA
AA
GG
GG
GG
GG
GG
GA
GA
GA
GA
GA
GG
GG
GG
GG
GG
GG
GA
GG
GG
GG
GG
GG
GA
GG
GG
GG
GG
GA
GG
GA
GG
GA
GG
GG
GG
GA
GA
GG
GG
primer product (bp)
set A
516/318
set B
516/252
set C
520/463
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
rs2114039
B
C
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
allele
T
C
C
Genotipe
TT
TT
TC
TT
TT
TC
CC
TT
CC
TT
TT
TT
TC
TC
TC
CC
TC
TT
TT
TT
TT
TC
TT
TC
TT
TT
TT
TT
TT
TC
TT
TT
TT
TT
CC
TT
CC
TT
CC
TT
TT
TT
TC
TC
TT
TT
primer product (bp)
set A
516/318
set B
516/252
set C
520/463
KUESIONER FAKTOR RISIKO MIOPIA
Judul Penelitian:
Association of PDGFRA Gene Polymorphism and Early-Onset
Myopia in South Sumatera Ethnic Group
Nama
Tanggal lahir
Alamat
:
:
:
Mohon lingkari jawaban yang Anda pilih.
A. Jenis Kelamin:
1. Laki-laki
2. Perempuan
B. Status mata:
1. Kedua mata normal
2. Kedua mata memakai kacamata minus
3. Satu mata normal, satu mata memakai kacamata minus
C. Jumlah orang tua Anda yang memiliki mata minus:
1. Tidak ada
2. Satu orang : ayah/ibu (lingkari salah satu)
3. Dua orang
D. Jumlah orang tua dari ayah Anda yang memiliki mata minus:
1. Tidak ada
2. Satu orang : nenek/kakek (lingkari salah satu)
3. Dua orang atau lebih
E. Jumlah orang tua dari ibu Anda yang memiliki mata minus:
1. Tidak ada
2. Satu orang : nenek/kakek (lingkari salah satu)
3. Dua orang atau lebih
F. Jumlah saudara kandung Anda yang memiliki mata minus: …….. orang.
Bila mata Anda TIDAK MINUS, pertanyaan dilanjutkan ke pohon keluarga.
Bila mata Anda MINUS, pertanyaan dilanjutkan ke nomor D dan seterusnya.
G. Anda pertama kali dinyatakan memiliki mata minus pada tahun …..
H. Sebelum Anda dinyatakan memiliki mata minus, frekuensi Anda melakukan
aktivitas di luar ruangan adalah (sekolah dan aktivitas yang termasuk
akademik sekolah tidak dimasukkan) :
1. Tidak pernah
2. Jarang (1-2 kali per minggu)
3. Sering (≥3 kali per minggu)
I. Sebelum Anda dinyatakan memiliki mata minus, durasi Anda melakukan
aktivitas di luar ruangan adalah (sekolah dan aktivitas yang termasuk
akademik sekolah tidak dimasukkan) :
1. < 30 menit
2. 30 menit-2 jam per hari
3. >2 jam per hari
J. Sebelum Anda dinyatakan memiliki mata minus, bagaimana frekuensi Anda
melakukan kegiatan membaca untuk kesenangan:
1. Jarang (1-2 kali per minggu)
2. Cukup sering (3-5 kali per minggu)
3. Sering (≥6 kali per minggu)
K. Sebelum Anda dinyatakan memiliki mata minus, bagaimana durasi Anda
melakukan kegiatan membaca untuk kesenangan:
1. < 30 menit per hari
2. 30 menit - 2 jam per hari
3. >2 jam per hari
L. Pencahayaan di ruangan saat Anda membaca adalah:
1. Agak gelap
2. Remang-remang
3. Terang
M. Sebelum Anda dinyatakan memiliki mata minus, frekuensi Anda melakukan
kegiatan menonton televisi:
1. Jarang (1-2 kali per minggu)
2. Cukup sering (3-6 kali per minggu)
3. Sering (≥7 kali per minggu)
N. Sebelum Anda dinyatakan memiliki mata minus, waktu yang Anda habiskan
untuk menonton televisi adalah:
1. < 1 jam per hari
2. 1-4 jam per hari
3. >4 jam per hari
O. Sebelum Anda dinyatakan memiliki mata minus, berapa kira-kira jarak posisi
duduk Anda dengan televisi pada saat menonton?
1. Dekat ( 60 cm)
P. Sebelum Anda dinyatakan memiliki mata minus, bagaimana pencahayaan di
ruangan saat Anda menonton televisi?
1. Redup
2. Terang
Q. Setelah Anda dinyatakan memiliki mata minus, apakah Anda menonton TV
menggunakan kacamata?
1. Ya
2. Tidak
R. Sebelum Anda dinyatakan memiliki mata minus, frekuensi Anda melakukan
kegiatan menggunakan komputer/laptop/tablet/smartphone untuk keperluan
sekolah:
1. Tidak pernah
2. Jarang (1-3 kali per minggu)
3. Sering (> 4 kali per minggu)
S. Sebelum Anda dinyatakan memiliki mata minus, waktu yang Anda habiskan
untuk menggunakan komputer/laptop/tablet/smartphone untuk keperluan
sekolah adalah:
1. < 1 jam per hari
2. 1-4 jam per hari
3. > 4 jam per hari
T. Sebelum Anda dinyatakan memiliki mata minus, frekuensi Anda melakukan
kegiatan menggunakan komputer/PC/tablet/smartphone untuk keperluan di
luar sekolah:
1. Tidak pernah
2. Jarang (1-3 kali per minggu)
3. Sering (>4 kali per minggu)
U. Sebelum Anda dinyatakan memiliki mata minus, waktu yang Anda habiskan
untuk melakukan kegiatan menggunakan komputer/PC/tablet/smartphone
untuk keperluan di luar sekolah adalah:
1. < 1 jam per hari
2. 1-4 jam per hari
3. > 4 jam per hari
V. Pohon keluarga
sex * eye_status Crosstabulation
eye_status
myopia
sex
female
Count
% within row
male
Total
67
61.2%
38.8%
100.0%
9
24
33
27.3%
72.7%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within row
Total
26
Count
% within row
normal
41
Chi-Square Tests
Value
Pearson Chi-Square
a
1
.001
8.865
1
.003
10.462
1
.001
10.176
b
Continuity Correction
Likelihood Ratio
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
Fisher's Exact Test
Exact Sig. (1sided)
.003
Linear-by-Linear
Association
10.075
N of Valid Cases
100
1
.002
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 16.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for sex (female /
male)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
4.205
1.692
10.448
2.244
1.245
4.043
.534
.370
.770
100
81
.001
Crosstab
eye_status
myopia
parental_history_of
myopia
parents with myopia
Count
% within row
parents without
myopia
Count
% within row
Total
Count
% within row
normal
Total
35
13
48
72.9%
27.1%
100.0%
15
37
52
28.8%
71.2%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2sided)
df
19.391a
1
.000
Continuity Correction
17.668
1
.000
Likelihood Ratio
20.077
1
.000
Pearson Chi-Square
b
Exact Sig. (2sided)
Fisher's Exact Test
.000
Linear-by-Linear
Association
N of Valid Cases
19.197
1
.000
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 24.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
parental_history_of_myopia
(parents with myopia / parents
without myopia)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
6.641
2.769
15.927
2.528
1.595
4.006
.381
.232
.625
100
82
Exact Sig. (1sided)
.000
Crosstab
eye_status
myopia
paternal_grandparents paternal grandparents
_history_of_myopia
with myopia
Count
paternal grandparents
without myopia
Count
% within row
% within row
Total
Total
9
31
71.0%
29.0%
100.0%
28
41
69
40.6%
59.4%
100.0%
Count
% within row
normal
22
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig. (2sided)
a
1
.005
Continuity Correction
6.732
1
.009
Likelihood Ratio
8.088
1
.004
Pearson Chi-Square
7.901
b
Fisher's Exact Test
Exact Sig. (1sided)
.009
Linear-by-Linear
Association
N of Valid Cases
7.822
1
.005
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 15.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
paternal_grandparents_histor
y_of_myopia (paternal
grandparents with myopia /
paternal grandparents without
myopia)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
3.579
1.437
8.913
1.749
1.216
2.516
.489
.272
.876
100
83
.004
Crosstab
eye_status
myopia
normal
Total
maternal_grandparent maternal grandparents Count
s_history_of_myopia with myopia
% within row
16
9
25
64.0%
36.0%
100.0%
maternal grandparents Count
without myopia
% within row
34
41
75
45.3%
54.7%
100.0%
Total
Count
% within row
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig. (2sided)
a
1
.106
Continuity Correction
1.920
1
.166
Likelihood Ratio
2.641
1
.104
Pearson Chi-Square
2.613
b
Fisher's Exact Test
Exact Sig. (1sided)
.165
Linear-by-Linear
Association
N of Valid Cases
2.587
1
.108
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 12.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Lower
Upper
Odds Ratio for
maternal_grandparents_histor
y_of_myopia (maternal
grandparents with myopia /
maternal grandparents without
myopia)
2.144
.842
5.459
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
1.412
.961
2.075
.659
.375
1.155
100
84
.083
Crosstab
eye_status
myopia
sibling_history_of
myopia
sibling with myopia
Count
% within row
sibling without
myopia
Count
% within row
Total
Count
% within row
normal
Total
29
14
43
67.4%
32.6%
100.0%
21
36
57
36.8%
63.2%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2sided)
df
a
1
.002
Continuity Correction
7.997
1
.005
Likelihood Ratio
9.338
1
.002
Pearson Chi-Square
9.180
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
.004
9.088
1
.003
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 21.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
sibling_history_of_myopia
(sibling with myopia / sibling
without myopia)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
3.551
1.541
8.181
1.831
1.229
2.726
.516
.321
.828
100
85
Exact Sig. (1sided)
.002
eye_status
myopia
frequency_of_outdoor_ rare(1-2 times per
activity
week)
Count
normal
29
21
50
% within row
58.0%
42.0%
100.0%
frequent (≥3 times per Count
week)
% within row
21
29
50
42.0%
58.0%
100.0%
50
50
100
50.0%
50.0%
100.0%
Total
Count
% within row
Chi-Square Tests
Value
Asymp. Sig. Exact Sig. (2- Exact Sig. (1(2-sided)
sided)
sided)
df
2.560a
1
.110
Continuity Correction
1.960
1
.162
Likelihood Ratio
2.571
1
.109
Pearson Chi-Square
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Total
.161
2.534
1
.081
.111
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 25.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
frequency_of_outdoor_activity
(rare(1-2 times per week) /
frequent (≥3 times per week))
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.907
.862
4.220
1.381
.924
2.065
.724
.484
1.083
100
86
Crosstab
eye_status
myopia
≤ 2 hours per day Count
duration_of_outdoor
activity
% within row
Total
61
55.7%
44.3%
100.0%
16
23
39
41.0%
59.0%
100.0%
Count
% within row
Total
27
> 2 hours per day Count
% within row
normal
34
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig. (2sided)
2.060a
1
.151
Continuity Correction
1.513
1
.219
Likelihood Ratio
2.068
1
.150
Pearson Chi-Square
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.218
2.039
1
.153
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 19.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
duration_of_outdoor_activity
(≤2 hours per day / > 2 hours
per day)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.810
.802
4.085
1.359
.877
2.105
.751
.511
1.102
100
87
.109
Crosstab
eye_status
myopia
frequency_of_readi ≥6 times per week Count
ng
% within row
Total
26
69.2%
30.8%
100.0%
32
42
74
43.2%
56.8%
100.0%
Count
% within row
Total
8
2
hours per day / ≤2 hours per
day)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
2.852
.995
8.173
1.556
1.069
2.264
.545
.271
1.096
100
89
.039
Crosstab
eye_status
myopia
lighting_while_reading
dim
Count
% within row
bright
Total
19
52.6%
47.4%
100.0%
40
41
81
49.4%
50.6%
100.0%
Count
% within row
Total
9
Count
% within row
normal
10
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.799
Continuity Correction
.000
1
1.000
Likelihood Ratio
.065
1
.799
Pearson Chi-Square
.065
b
Exact Sig. (2- Exact Sig. (1sided)
sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
1.000
.064
1
.800
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 9.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
lighting_while_reading (dim /
bright)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.139
.419
3.097
1.066
.659
1.723
.936
.556
1.575
100
90
.500
Crosstab
eye_status
myopia
frequency_of_watching 0-6 times per week Count
_television
% within row
Total
55
52.7%
47.3%
100.0%
21
24
45
46.7%
53.3%
100.0%
Count
% within row
Total
26
≥ 7 times per week Count
% within row
normal
29
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
a
1
.546
Continuity Correction
.162
1
.688
Likelihood Ratio
.364
1
.546
Pearson Chi-Square
.364
b
Fisher's Exact Test
Exact Sig. (1sided)
.688
Linear-by-Linear
Association
N of Valid Cases
.360
1
.549
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 22.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
frequency_of_watching_televi
sion (0-6 times per week / ≥7
times per week)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.275
.579
2.807
1.130
.757
1.686
.886
.600
1.310
100
91
.344
Crosstab
eye_status
myopia
duration_of_watching
television
> 4 hours per day Count
% within row
Total
35
51.4%
48.6%
100.0%
32
33
65
49.2%
50.8%
100.0%
Count
% within row
Total
17
≤ 4 hours per day Count
% within row
normal
18
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
.044a
1
.834
Continuity Correction
.000
1
1.000
Likelihood Ratio
.044
1
.834
Pearson Chi-Square
b
Fisher's Exact Test
Exact Sig. (1sided)
1.000
Linear-by-Linear
Association
N of Valid Cases
.044
1
.835
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 17.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
duration_of_watching_televisi
on (> 4 hours per day / ≤4
hours per day)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.092
.480
2.484
1.045
.696
1.567
.957
.631
1.451
100
92
.500
Crosstab
eye_status
myopia
television_viewing_distance ≤ 60 cm
Count
% within row
> 60 cm
% within row
34
5
39
12.8%
100.0%
16
45
61
26.2%
73.8%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within row
Total
87.2%
Count
Total
normal
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
35.351a
1
.000
Continuity Correction
32.955
1
.000
Likelihood Ratio
38.554
1
.000
Pearson Chi-Square
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.000
34.997
1
.000
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 19.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
television_viewing_distance
(≤60 cm / > 60 cm)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
19.125
6.376
57.369
3.324
2.145
5.149
.174
.076
.399
100
93
.000
Crosstab
eye_status
myopia
lighting_while_watching
television
dim
Count
% within row
bright
% within row
16
10
26
38.5%
100.0%
34
40
74
45.9%
54.1%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within row
Total
61.5%
Count
Total
normal
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
a
1
.171
Continuity Correction
1.299
1
.254
Likelihood Ratio
1.884
1
.170
Pearson Chi-Square
1.871
b
Fisher's Exact Test
Exact Sig. (1sided)
.254
Linear-by-Linear
Association
1.852
N of Valid Cases
100
1
.174
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 13.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
lighting_while_watching_televi
sion (dim / bright)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.882
.756
4.690
1.339
.905
1.982
.712
.419
1.208
100
94
.127
Crosstab
eye_status
myopia
frequency_of_using
gadget_for_academic
activity
> 4 times per week Count
% within row
≤ 4 times per week Count
% within row
Total
Count
% within row
normal
Total
25
20
45
55.6%
44.4%
100.0%
25
30
55
45.5%
54.5%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Pearson Chi-Square
a
1
.315
.646
1
.421
1.012
1
.314
1.010
b
Continuity Correction
Likelihood Ratio
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
Fisher's Exact Test
Exact Sig. (1sided)
.422
Linear-by-Linear
Association
N of Valid Cases
1.000
1
.317
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 22.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
frequency_of_using_gadget_f
or_academic_activity (> 4
times per week / ≤ 4 times per
week)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.500
.679
3.312
1.222
.828
1.805
.815
.543
1.223
100
95
.211
Crosstab
eye_status
myopia
duration_of_using_gadget > 4 hours per day Count
_for_academic_activity
% within row
≤4 hours per day
Count
% within row
Total
Count
% within row
normal
Total
9
9
18
50.0%
50.0%
100.0%
41
41
82
50.0%
50.0%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. (2sided)
df
a
1
1.000
Continuity Correction
.000
1
1.000
Likelihood Ratio
.000
1
1.000
Pearson Chi-Square
.000
b
Exact Sig. (2sided)
Fisher's Exact Test
1.000
Linear-by-Linear
Association
N of Valid Cases
.000
1
1.000
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 9.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Lower
Upper
Odds Ratio for
duration_of_using_gadget_for
_academic_activity (> 4 hours
per day / ≤4 hours per day)
For cohort eye_status =
myopia
1.000
.360
2.774
1.000
.600
1.666
For cohort eye_status =
normal
N of Valid Cases
1.000
.600
1.666
100
96
Exact Sig. (1sided)
.602
Crosstab
eye_status
myopia
frequency_of_using
gadget_for_pleasure
>4 times per week Count
% within row
≤ 4 times per week Count
% within row
Total
Count
% within row
normal
21
48
56.3%
43.8%
100.0%
23
29
52
44.2%
55.8%
100.0%
50
50
100
50.0%
50.0%
100.0%
Chi-Square Tests
Value
Asymp. Sig. Exact Sig. (2- Exact Sig. (1(2-sided)
sided)
sided)
df
a
1
.230
Continuity Correction
1.002
1
.317
Likelihood Ratio
1.446
1
.229
Pearson Chi-Square
1.442
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
.317
1.428
1
.158
.232
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 24.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Lower
Upper
Odds Ratio for
frequency_of_using_gadget_f
or_pleasure (>4 times per
week / ≤4 times per week)
1.621
.735
3.573
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
1.272
.857
1.886
.784
.525
1.172
100
97
Total
27
Crosstab
eye_status
myopia
duration_of_using
gadget_for_pleasure
> 4 hours per day Count
% within row
% within row
34
52.9%
47.1%
100.0%
32
34
66
48.5%
51.5%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within row
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.673
Continuity Correction
.045
1
.833
Likelihood Ratio
.178
1
.673
Pearson Chi-Square
.178
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.833
.176
1
.417
.674
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is
17.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for
duration_of_using_gadget_for
_pleasure (> 4 hours per day /
≤4 hours per day)
For cohort eye_status =
myopia
For cohort eye_status =
normal
N of Valid Cases
Lower
Upper
1.195
.522
2.737
1.092
.730
1.634
.913
.596
1.399
100
98
Total
16
≤ 4 hours per day Count
Total
normal
18
Attachment 2. Statistical analysis of corneal curvature
Independent Samples Test
Levene's
Test for
Equality of
Variances
t-test for Equality of Means
Corneal
curvatur
e
95%
Confidence
Interval of the
Difference
F
Right
eye
Equal
variances
assumed
Equal
variances
not
assumed
Left eye Equal
variances
assumed
Sig.
.164
.144
t
.686
df
-.943
98
.348 -.04600 .04877 -.14279 .05079
-.943 96.971
.348 -.04600 .04877 -.14280 .05080
.706 -1.061
Equal
variances
not
assumed
Std.
Mean Error
Sig. (2- Differe Differe
tailed) nce
nce Lower Upper
98
.291 -.05280 .04977 -.15157 .04597
-1.061 95.207
.291 -.05280 .04977 -.15161 .04601
Crosstab
Eye status
Myopia
CC right eye
Steeper
Count
Total
Total
35
29
64
54.7%
45.3%
100.0%
Count
15
21
36
%
Count
%
41.7%
50
50.0%
58.3%
50
50.0%
100.0%
100
100.0%
%
Flatter
Normal
99
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
Pearson Chi-Square
1.563a
1
.211
b
Continuity Correction
1.085
1
.298
Likelihood Ratio
1.568
1
.210
Fisher's Exact Test
.298
.149
Linear-by-Linear
1.547
1
.214
Association
N of Valid Cases
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is
18.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Lower
Upper
Odds Ratio for CC_right eye
(steeper/flatter)
1.690
.740
3.857
For cohort status_mata = miop
1.313
.840
2.051
For cohort status_mata = normal
.777
.528
1.142
N of Valid Cases
100
100
Crosstab
Eye status
Myopia
Corneal curvature
of the left eye
Normal
Total
≤7.8 mm
Count
34
30
64
>7.8mm
Count
Count
16
50
20
50
36
100
Total
Chi-Square Tests
Value
df
a
Pearson Chi-Square
Asymp.
Sig. (2sided)
.694
1
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.405
b
Continuity Correction
.391
1
.532
Likelihood Ratio
.696
1
.404
Fisher's Exact Test
.532
.266
Linear-by-Linear
.687
1
.407
Association
N of Valid Cases
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count
is 18.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence
Interval
Value
Lower
Upper
Odds Ratio for CC
left eye
(steeper/flatter)
1.417
.624
3.218
For cohort
status_mata = miop
For cohort
status_mata = normal
N of Valid Cases
1.195
.776
1.841
.844
.570
1.248
100
101
T-Test
Independent Samples t-Test
Levene's
Test for
Equality of
Variances
t-test for Equality of Means
95%
Confidence
Interval of the
Difference
F
CC
right
eye
Equal
variances
assumed
CC
left
eye
Equal
variances
not
assumed
Equal
variances
assumed
Equal
variances
not
assumed
Sig.
t
df
1.080 .301 -1.429
Sig.
(2Mean
tailed Differenc Std. Error
)
e
Difference Lower Upper
98 .156
-.07370
.05156
- .02863
.1760
2
-1.370 57.190 .176
-.07370
.05381
- .03405
.1814
4
98 .061
-.09904
.05228
- .00471
.2027
9
-1.836 58.874 .071
-.09904
.05393
- .00888
.2069
6
.623 .432 -1.894
102
T-Test
Independent Samples Test
Levene's
Test for
Equality of
Variances
F
Corneal
curvatur
e of the
left eye
Equal
variances
assumed
Sig.
t
df
.489 .488 1.170
Equal
variances
not
assumed
t-test for Equality of Means
95% Confidence
Interval of the
Difference
Sig.
Std.
(2- Mean Error
taile Differe Differe
d)
nce
nce
Lower
Upper
48 .248 .11558 .09877
-.08302
.31418
.940 9.850 .370 .11558 .12294
-.15892
.39008
Crosstab for table 18
Corneal curvature
right eye
steeper
Sex
Total
left eye
flatter
Total
steeper
flatter
Total
Myopic
male
Count
7
2
9
7
2
9
Myopic
female
Count
28
13
41
27
14
41
Count
35
15
50
34
16
50
103
Mann-Whitney Test for table 19.
Sex
CC right eye in myopic
subjects
male
N
Mean Rank
Sum of Ranks
9
26.94
242.50
female
41
25.18
1032.50
Total
50
Test Statisticsb
Corneal curvature for the right
eye
Mann-Whitney U
Wilcoxon W
Z
Asymp. Sig. (2-tailed)
Exact Sig. [2*(1-tailed
Sig.)]
a. Not corrected for ties.
b. Grouping Variable: Sex
171.500
1032.500
-.328
.743
.747a
104
Attachment 3. Statistical analysis of PDGFRA gene polymorphism
Crosstab
eye_status
Myopia
rs7676985
mutant allele (+)
Count
% within rs7676985
mutant allele (-)
% within rs7676985
33
39.4%
60.6%
100.0%
37
30
67
55.2%
44.8%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs7676985
Total
20
Count
Total
Normal
13
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.137
Continuity Correction
1.628
1
.202
Likelihood Ratio
2.229
1
.135
Pearson Chi-Square
2.216
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.202
2.194
1
.139
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 16.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs7676985
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
.527
.226
1.231
.713
.444
1.147
1.354
.923
1.984
100
105
.101
Crosstab
eye_status
Myopia
rs17084051
mutant allele (+)
Count
% within rs17084051
mutant allele (-)
% within rs17084051
21
55
61.8%
38.2%
100.0%
16
29
45
35.6%
64.4%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs17084051
Total
34
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig. (2- Exact Sig. (2sided)
sided)
df
6.828a
1
.009
Continuity Correction
5.818
1
.016
Likelihood Ratio
6.912
1
.009
Pearson Chi-Square
b
Fisher's Exact Test
Exact Sig. (1sided)
.015
Linear-by-Linear
Association
N of Valid Cases
6.760
1
.009
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 22.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs17084051
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
2.935
1.296
6.647
1.739
1.114
2.713
.592
.397
.884
100
106
.008
Crosstab
eye_status
Myopia
rs7677751
mutant allele (+)
Count
% within rs7677751
mutant allele (-)
% within rs7677751
15
47
68.1%
31.9%
100.0%
18
35
53
34.0%
66.0%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs7677751
Total
32
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.001
Continuity Correction
10.277
1
.001
Likelihood Ratio
11.841
1
.001
Pearson Chi-Square
11.602
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.001
11.486
1
.001
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 23.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs7677751
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
4.148
1.798
9.573
2.005
1.313
3.061
.483
.305
.766
100
107
.001
Crosstab
eye_status
Myopia
rs2307049
mutant allele (+)
Count
% within rs2307049
mutant allele (-)
% within rs2307049
38
69
44.9%
55.1%
100.0%
19
12
31
61.3%
38.7%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs2307049
Total
31
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.130
Continuity Correction
1.683
1
.195
Likelihood Ratio
2.306
1
.129
Pearson Chi-Square
2.291
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.194
2.268
1
.132
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 15.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs2307049
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
.515
.217
1.223
.733
.500
1.075
1.423
.870
2.326
100
108
.097
Crosstab
eye_status
Myopia
rs7682912
1
Count
% within rs7682912
2
% within rs7682912
19
45
57.8%
42.2%
100.0%
24
31
55
43.6%
56.4%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs7682912
Total
26
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig. Exact Sig. (2- Exact Sig. (1(2-sided)
sided)
sided)
df
a
1
.159
Continuity Correction
1.455
1
.228
Likelihood Ratio
1.987
1
.159
Pearson Chi-Square
1.980
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
.228
1.960
1
.162
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is
22.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs7682912 (1
/ 2)
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.768
.797
3.919
1.324
.896
1.957
.749
.495
1.133
100
109
.114
Crosstab
eye_status
Myopia
rs7660560
mutant allele (+)
Count
% within rs7660560
mutant allele (-)
% within rs7660560
19
39
51.3%
48.7%
100.0%
30
31
61
49.2%
50.8%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs7660560
Total
20
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.838
Continuity Correction
.000
1
1.000
Likelihood Ratio
.042
1
.838
Pearson Chi-Square
.042
b
Exact Sig. (2sided)
Fisher's Exact Test
Exact Sig. (1sided)
1.000
Linear-by-Linear
Association
N of Valid Cases
.042
1
.838
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 19.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs7660560
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.088
.487
2.430
1.043
.700
1.553
.959
.639
1.438
100
110
.500
Crosstab
eye_status
Myopia
rs2114039
mutant allele (+)
Count
% within rs2114039
mutant allele (-)
% within rs2114039
20
47
57.4%
42.6%
100.0%
23
30
53
43.4%
56.6%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within rs2114039
Total
27
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
a
1
.161
Continuity Correction
1.445
1
.229
Likelihood Ratio
1.974
1
.160
Pearson Chi-Square
1.967
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.229
1.947
1
.163
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 23.50.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for rs2114039
(mutant allele (+) / mutant
allele (-))
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.761
.796
3.893
1.324
.893
1.963
.752
.500
1.130
100
111
.115
Crosstab
eye_status
Myopia
CC_kanan
steeper cornea
Count
% within CC_kanan
flatter cornea
% within CC_kanan
29
64
54.7%
45.3%
100.0%
15
21
36
41.7%
58.3%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within CC_kanan
Total
35
Count
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
1.563a
1
.211
Continuity Correction
1.085
1
.298
Likelihood Ratio
1.568
1
.210
Pearson Chi-Square
b
Exact Sig. (2sided)
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Exact Sig. (1sided)
.298
1.547
1
.214
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 18.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for CC_kanan
(steeper cornea / flatter
cornea)
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.690
.740
3.857
1.313
.840
2.051
.777
.528
1.142
100
112
.149
Crosstab
eye_status
Myopia
CC_kiri
steeper cornea
Count
% within CC_kiri
flatter cornea
30
64
53.1%
46.9%
100.0%
16
20
36
44.4%
55.6%
100.0%
50
50
100
50.0%
50.0%
100.0%
Count
% within CC_kiri
Total
34
Count
% within CC_kiri
Total
Normal
Chi-Square Tests
Value
Asymp. Sig.
(2-sided)
df
Exact Sig. (2- Exact Sig. (1sided)
sided)
a
1
.405
Continuity Correction
.391
1
.532
Likelihood Ratio
.696
1
.404
Pearson Chi-Square
.694
b
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
.532
.687
1
.266
.407
100
a. 0 cells (.0%) have expected count less than 5. The minimum expected count is 18.00.
b. Computed only for a 2x2 table
Risk Estimate
95% Confidence Interval
Value
Odds Ratio for CC_kiri
(steeper cornea / flatter
cornea)
For cohort eye_status =
Myopia
For cohort eye_status =
Normal
N of Valid Cases
Lower
Upper
1.417
.624
3.218
1.195
.776
1.841
.844
.570
1.248
100
113
Attachment 4. Statistical analysis of pedigree, progressivity, and refractive power
rs7676985 * pedigree_trans Crosstabulation
pedigree
one
multigeneration generation
Total
rs7676985 mutant allele
positive
Count
12
1
13
mutant allele
negative
Count
26
11
37
Count
38
12
50
Total
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
a
2.561
1.496
1
1
.110
.221
3.024
1
.082
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.147
2.510
1
.107
.113
50
rs17084051 * pedigree_trans Crosstabulation
pedigree
Multi
generation
one
generation
Total
rs17084051 mutant allele
positive
Count
26
8
34
mutant allele
negative
Count
12
4
16
Count
38
12
50
Total
114
Chi-Square Tests
Value
Pearson ChiSquare
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp. Sig. Exact Sig. Exact Sig.
(2-sided) (2-sided) (1-sided)
df
a
1
.910
.000
1
1.000
.013
1
.910
.013
1.000
.013
1
.586
.910
50
rs7677751 * pedigree_trans Crosstabulation
pedigree
Multi
one
generation generation Total
rs7677751
mutant allele
positive
Count
25
7
32
mutant allele
negative
Count
13
5
18
Count
38
12
50
Total
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.220a
.015
1
1
.639
.901
.217
1
.641
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.735
.216
1
50
115
.642
.444
Crosstab
pedigree
Multi
one
generation generation
rs2307049
Total
Total
mutant allele Count
positive
25
6
31
mutant allele Count
negative
Count
13
6
19
38
12
50
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.965a
.411
1
1
.326
.521
.947
1
.331
.946
1
.331
.496
.258
50
Crosstab
pedigree
multigener
one
ation
generation
Total
rs7682912 mutant allele
positive
Count
19
7
26
mutant allele
negative
Count
19
5
24
Count
38
12
50
Total
116
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.254a
.030
1
1
.614
.863
.255
1
.614
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.745
.249
1
.433
.618
50
Crosstab
Pedigree
Multi
one
generation generation
Total
rs7660560 mutant allele
positive
Count
18
2
20
mutant allele
negative
Count
20
10
30
Count
38
12
50
Total
117
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
3.582a
2.417
1
1
.058
.120
3.914
1
.048
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.091
3.510
1
.057
.061
50
Crosstab
pedigree
Multi
one
generation generation
rs2114039
Total
Total
mutant allele Count
positive
23
4
27
mutant allele Count
negative
Count
15
8
23
38
12
50
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp. Sig. Exact Sig.
(2-sided)
(2-sided)
df
2.715a
1.731
1
1
.099
.188
2.736
1
.098
2.661
1
.103
.183
50
118
Exact Sig.
(1-sided)
.094
Crosstab
Count
Progressivity
high
Right CC
low
Total
Steeper cornea
5
30
35
Flatter cornea
3
8
12
42
15
50
Total
Chi-Square Tests
Value
Pearson ChiSquare
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.255a
1
.614
.007
1
.933
.247
1
.619
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.683
.250
1
.451
.617
50
Crosstab
Progressivity
high
Left CC
low
Total
Steeper cornea
5
29
34
Flatter cornea
3
8
13
42
16
50
Total
119
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.132a
.000
1
1
.716
1.000
.130
1
.719
.699
.130
1
.505
.719
50
Crosstab
Count
progressivity
high
rs7676985
low
Total
mutant allele positive
4
9
13
mutant allele negative
4
8
33
42
37
50
Total
Chi-Square Tests
Value
Pearson Chi-Square 2.851a
Continuity
1.560
Correctionb
Likelihood Ratio
2.571
Fisher's Exact Test
Linear-by-Linear
2.794
Association
N of Valid Cases
50
Asymp.
Sig. (2sided)
df
1
1
.091
.212
1
.109
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.181
1
120
.095
.109
Crosstab
Count
progressivity
high
low
Total
rs17084051 mutant allele
positive
7
27
34
mutant allele
negative
1
15
16
8
42
50
Total
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp. Exact
Sig. (2- Sig. (2- Exact Sig.
sided) sided) (1-sided)
df
a
1.664
.768
1
1
.197
.381
1.911
1
.167
.409
1.631
1
.194
.202
50
Crosstab
Count
progressivity
high
rs7677751
low
Total
mutant allele
positive
7
25
32
mutant allele
negative
1
17
18
8
42
50
Total
121
Value
Asymp.
Sig. (2sided)
df
Pearson Chi-Square 2.283a
Continuity
1.230
b
Correction
Likelihood Ratio
2.622
Fisher's Exact Test
Linear-by-Linear
2.237
Association
N of Valid Cases
50
1
1
.131
.267
1
.105
Exact Sig. Exact Sig.
(2-sided) (1-sided)
.231
1
.132
.135
Crosstab
progressivity
high
rs2307049
low
Total
mutant allele
positive
6
25
31
mutant allele
negative
2
17
19
8
Chi-Square Tests
42
50
Total
Value
Asymp.
Sig. (2sided)
df
Exact Sig. Exact Sig.
(2-sided) (1-sided)
Pearson Chi-Square .683a
1
.409
Continuity
.184
1
.668
Correctionb
Likelihood Ratio
.718
1
.397
Fisher's Exact Test
.693
Linear-by-Linear
.669
1
.413
Association
N of Valid Cases
50
a. 2 cells (50.0%) have expected count less than 5. The minimum
expected count is 3.04.
b. Computed only for a 2x2 table
122
.342
Crosstab
Count
progressivity
high
rs7682912
low
Total
mutant allele
positive
5
21
26
mutant allele
negative
3
21
24
42
50
Total
8
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
.421a
.069
1
1
.517
.793
.425
1
.514
.412
1
.521
Exact Sig.
(2-sided)
Exact Sig.
(1-sided)
.704
.399
50
Crosstab
Count
progressivity
high
rs7660560
low
Total
mutant allele
positive
3
17
20
mutant allele
negative
5
25
30
8
42
50
Total
123
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp.
Sig. (2sided)
df
Exact Sig.
(2-sided)
.025a
.000
1
1
.875
1.000
.025
1
.874
1.000
.024
1
Exact Sig.
(1-sided)
.599
.876
50
Crosstab
Count
progressivity
high
rs2114039
low
Total
mutant allele positive
5
22
27
mutant allele negative
3
8
20
42
23
50
Total
Chi-Square Tests
Value
Pearson Chi-Square
Continuity
Correctionb
Likelihood Ratio
Fisher's Exact Test
Linear-by-Linear
Association
N of Valid Cases
Asymp. Sig. Exact Sig.
(2-sided)
(2-sided)
df
.277a
.019
1
1
.599
.889
.280
1
.597
.271
1
.602
.711
50
124
Exact Sig.
(1-sided)
.448
Crosstabulation
Count
Refractive power
medium
myop
High myop
low
myop
Total
rs7676985 mutant allele
positive
0
2
11
13
mutant allele
negative
3
4
30
37
3
6
41
50
Total
Test Statistics
a
Diotpri
Most Extreme
Differences
Absolute
.081
Positive
.081
Negative
.000
.251
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs7676985
rs17084051 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs17084051 mutant allele
positive
1
4
29
34
mutant allele
negative
2
2
12
16
3
6
41
50
Total
a
Test Statistics
Diotpri
Most Extreme
Differences
Absolute
.103
Positive
.000
Negative
-.103
.340
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs17084051
125
rs7677751 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs7677751 mutant allele
positive
2
3
27
32
mutant allele
negative
1
3
14
18
3
6
41
50
Total
a
Test Statistics
Diotpri
Most Extreme
Differences
Absolute
.066
Positive
.007
Negative
-.066
.224
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs7677751
rs2307049 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs2307049 mutant allele
positive
2
4
25
31
mutant allele
negative
1
2
16
19
3
6
41
50
Total
126
Test Statisticsa
Most Extreme
Differences
Diotpri
Absolute
.036
Positive
.036
Negative
.000
.122
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs2307049
rs7682912 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs7682912 mutant allele
positive
2
2
22
26
mutant allele
negative
1
4
19
24
3
6
41
50
Total
a
Test Statistics
Diotpri
Most Extreme
Differences
Absolute
.054
Positive
.035
Negative
-.054
.192
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs7682912
127
rs7660560 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop medium myop low myop
Total
rs7660560 mutant allele
positive
1
2
17
20
mutant allele
negative
2
4
24
30
3
6
41
50
Total
a
Test Statistics
Diotpri
Most Extreme
Differences
Absolute
.050
Positive
.050
Negative
.000
.173
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs7660560
rs2114039 * LOWvsMEDIUMvsHIGH Crosstabulation
Count
Refractive power
High myop
medium
myop
low myop
Total
rs2114039 mutant allele
positive
1
3
23
27
mutant allele
negative
2
3
18
23
3
6
41
50
Total
Test Statisticsa
Diotpri
Most Extreme Differences Absolute
.069
Positive
.000
Negative
-.069
.244
1.000
Kolmogorov-Smirnov Z
Asymp. Sig. (2-tailed)
a. Grouping Variable: rs2114039
128
129
SNP
No.
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
rs7660560
B
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
C
+
+
-
D
+
+
-
Genotipe
GA
GG
GA
GA
GA
GA
GG
GA
GA
GA
GA
GG
GG
GA
GA
GG
GG
GG
GG
GA
GG
GG
GG
GG
GG
GG
GG
GA
GG
GA
GG
GA
GA
GA
GA
GG
GG
GG
GG
GG
GG
GG
GG
GG
GA
GA
GG
GG
GG
GG
GG
GG
GA
GA
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
rs2114039
B
C
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
-
Genotipe
TC
TC
TT
TC
CC
CC
TT
TC
TC
TC
TT
TT
TT
TC
TT
TT
TT
TT
TT
TC
TC
TC
TT
TT
TC
TT
TT
CC
TT
CC
CC
TT
TC
TC
TT
TT
TC
TT
CC
TT
TT
TC
TT
CC
CC
TC
TT
CC
TC
TC
TT
CC
TC
TC
SNP
No.
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
rs7660560
B
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
C
-
allele
T
C
C
D
-
Genotipe
GG
GA
GA
GA
GG
GA
AA
GG
GG
GG
GG
GG
GA
GA
GA
GA
GA
GG
GG
GG
GG
GG
GG
GA
GG
GG
GG
GG
GG
GA
GG
GG
GG
GG
GA
GG
GA
GG
GA
GG
GG
GG
GA
GA
GG
GG
primer product (bp)
set A
516/318
set B
516/252
set C
520/463
A
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
rs2114039
B
C
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
+
allele
T
C
C
Genotipe
TT
TT
TC
TT
TT
TC
CC
TT
CC
TT
TT
TT
TC
TC
TC
CC
TC
TT
TT
TT
TT
TC
TT
TC
TT
TT
TT
TT
TT
TC
TT
TT
TT
TT
CC
TT
CC
TT
CC
TT
TT
TT
TC
TC
TT
TT
primer product (bp)
set A
516/318
set B
516/252
set C
520/463
KUESIONER FAKTOR RISIKO MIOPIA
Judul Penelitian:
Association of PDGFRA Gene Polymorphism and Early-Onset
Myopia in South Sumatera Ethnic Group
Nama
Tanggal lahir
Alamat
:
:
:
Mohon lingkari jawaban yang Anda pilih.
A. Jenis Kelamin:
1. Laki-laki
2. Perempuan
B. Status mata:
1. Kedua mata normal
2. Kedua mata memakai kacamata minus
3. Satu mata normal, satu mata memakai kacamata minus
C. Jumlah orang tua Anda yang memiliki mata minus:
1. Tidak ada
2. Satu orang : ayah/ibu (lingkari salah satu)
3. Dua orang
D. Jumlah orang tua dari ayah Anda yang memiliki mata minus:
1. Tidak ada
2. Satu orang : nenek/kakek (lingkari salah satu)
3. Dua orang atau lebih
E. Jumlah orang tua dari ibu Anda yang memiliki mata minus:
1. Tidak ada
2. Satu orang : nenek/kakek (lingkari salah satu)
3. Dua orang atau lebih
F. Jumlah saudara kandung Anda yang memiliki mata minus: …….. orang.
Bila mata Anda TIDAK MINUS, pertanyaan dilanjutkan ke pohon keluarga.
Bila mata Anda MINUS, pertanyaan dilanjutkan ke nomor D dan seterusnya.
G. Anda pertama kali dinyatakan memiliki mata minus pada tahun …..
H. Sebelum Anda dinyatakan memiliki mata minus, frekuensi Anda melakukan
aktivitas di luar ruangan adalah (sekolah dan aktivitas yang termasuk
akademik sekolah tidak dimasukkan) :
1. Tidak pernah
2. Jarang (1-2 kali per minggu)
3. Sering (≥3 kali per minggu)
I. Sebelum Anda dinyatakan memiliki mata minus, durasi Anda melakukan
aktivitas di luar ruangan adalah (sekolah dan aktivitas yang termasuk
akademik sekolah tidak dimasukkan) :
1. < 30 menit
2. 30 menit-2 jam per hari
3. >2 jam per hari
J. Sebelum Anda dinyatakan memiliki mata minus, bagaimana frekuensi Anda
melakukan kegiatan membaca untuk kesenangan:
1. Jarang (1-2 kali per minggu)
2. Cukup sering (3-5 kali per minggu)
3. Sering (≥6 kali per minggu)
K. Sebelum Anda dinyatakan memiliki mata minus, bagaimana durasi Anda
melakukan kegiatan membaca untuk kesenangan:
1. < 30 menit per hari
2. 30 menit - 2 jam per hari
3. >2 jam per hari
L. Pencahayaan di ruangan saat Anda membaca adalah:
1. Agak gelap
2. Remang-remang
3. Terang
M. Sebelum Anda dinyatakan memiliki mata minus, frekuensi Anda melakukan
kegiatan menonton televisi:
1. Jarang (1-2 kali per minggu)
2. Cukup sering (3-6 kali per minggu)
3. Sering (≥7 kali per minggu)
N. Sebelum Anda dinyatakan memiliki mata minus, waktu yang Anda habiskan
untuk menonton televisi adalah:
1. < 1 jam per hari
2. 1-4 jam per hari
3. >4 jam per hari
O. Sebelum Anda dinyatakan memiliki mata minus, berapa kira-kira jarak posisi
duduk Anda dengan televisi pada saat menonton?
1. Dekat ( 60 cm)
P. Sebelum Anda dinyatakan memiliki mata minus, bagaimana pencahayaan di
ruangan saat Anda menonton televisi?
1. Redup
2. Terang
Q. Setelah Anda dinyatakan memiliki mata minus, apakah Anda menonton TV
menggunakan kacamata?
1. Ya
2. Tidak
R. Sebelum Anda dinyatakan memiliki mata minus, frekuensi Anda melakukan
kegiatan menggunakan komputer/laptop/tablet/smartphone untuk keperluan
sekolah:
1. Tidak pernah
2. Jarang (1-3 kali per minggu)
3. Sering (> 4 kali per minggu)
S. Sebelum Anda dinyatakan memiliki mata minus, waktu yang Anda habiskan
untuk menggunakan komputer/laptop/tablet/smartphone untuk keperluan
sekolah adalah:
1. < 1 jam per hari
2. 1-4 jam per hari
3. > 4 jam per hari
T. Sebelum Anda dinyatakan memiliki mata minus, frekuensi Anda melakukan
kegiatan menggunakan komputer/PC/tablet/smartphone untuk keperluan di
luar sekolah:
1. Tidak pernah
2. Jarang (1-3 kali per minggu)
3. Sering (>4 kali per minggu)
U. Sebelum Anda dinyatakan memiliki mata minus, waktu yang Anda habiskan
untuk melakukan kegiatan menggunakan komputer/PC/tablet/smartphone
untuk keperluan di luar sekolah adalah:
1. < 1 jam per hari
2. 1-4 jam per hari
3. > 4 jam per hari
V. Pohon keluarga