MICROBIOLOGY PPT LECTURE NOTES | Karya Tulis Ilmiah

Hemorrhogic Fever Virus
Hantaar Virus or HEMORRHAGIC FEVER
with renal syndrome virus ( HFRS ）
Xing Jiang Hemorrhogic Fever Virus

Dept. of microbiology and parasitology

Hantaar Virus
(HEMORRHAGIC FEVER with renal
syndrome virus )

Morphology
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Spherical, 80-120nm
Nucleocapsid: Helical,
3 segments, 2 proteins
- nucleocapsid ('N'),

RNA polymerase ('L')
Envelope: 2
glycoproteins, G1 and
G2,

Biological properties
1.
2.
3.

ssRNA with long, medium,short segments
Antigens 6 serotypes (I- VI)
Resistance: weak

Epidemiology
1.

2.

3.

Natural host : rodents (deer mouse
(Peromyscus maniculatus), cotton rat
(Sigmodon hispidus), marsh rice rat (Oryzomys
palustris) , white-footed mouse (Peromyscus
leucopus), other carriers)
Transmission : Droplet and rodent excreta
spread
Season and district

Clinical syndromes

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Headache;
Pink in face , neck
Fever
marked bleeding tendency
Lower blood pressure
Urine with Protein
multi-organ failure

Pathogenicity
Clinical manifestations:
5 phases
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Fever phase
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Hypotension phase
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Auria phase
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Polyuria phase
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convalescent phase

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Pathogenesis
Viral direct damage
Immunopathogenesis
Laboratory diagnosis
Cultivation: Vero-E6 cell and A549 cell
Serological diagnosis: IgM/IgG
indirect immunofluorescent assay
ELISA-IgM
Inactivated vaccine

Xing Jiang Hemorrhogic Fever
Virus






Spherical, 80-120nm
Nucleocapsid: Helical,
3 segments, 2 proteins nucleocapsid ('N'),
RNA polymerase ('L')
Envelope: 2
glycoproteins, G1 and
G2,

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


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

Vector and Host
Animal Host
Hyalomma asiaticum
Season: April and May
Inactivated vaccine