Prosiding IUPHAR Conference on the Pharmacology of Natural and Traditional Medicine 2015
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Special Issue of the IUPHAR Conference on the Pharmacology
of Natural and Traditional Medicine 2015
Jrly 22-24, 2015, Singapore
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chinese Journal of pharmacology and roxicology
2015 July Volume 2g Supplement I
(
Founded in November 19g6)
Contents
PLENARV LECTURES
The lysophospholipid receptor modulator. lingolimod3 from traditional
Chinese medicine to FDA-approved drug
...'.','.
;;;,;.;;;
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Trials
and tribuhtbns
.ftnrLl
l)ey,ut- l)arrei
of developing natural producl drugs
chinese tradilional medkine is characterized by inducing multi-largel
efrects ....
IUPHAR. Gulle to pharmacology and nalural products
'
Dirvi{l
...'.
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I
I
Nl-l!irl\.{AN
:
ZHANC
j}
St,Hi)DIN(i
3
.J.
Jun-tiau
Mn'h;rcl
CIIUN
DUAN
TNVITED LECTURES
srnall rnolecule modulators of lysine acetyllranslerases from natural
sourcesl Implicaflon in therapeutics
Nalural prcdrct insplred drug
discovery
Pharmacologir:al studies of herbs against hepa$c
A story about berbetine
"""""""'
"*::L::.:::'::.:::*"rls
opposite ansro$nic
.. Chrisnn:r L.l_. CI_lAl +
... yi-Tsru HUAN(i i
fibrosis
-fi:n-rlongJlAli-Ci. y;rrr--tirg HAN. l.rr-lrr WANG (r
in herbalmedicines usins cfirornarographic separation
coupted with ontine bioactivity assay
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",.* ;$ilHj
FAN' xrr,*jun
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Lr
The autophagy-lysosome pathway as the novel targets of natural
products .................... ....:..i:: Hau-rrring
SIIIiN
The potentiar or therapeufic application of tanshinones in
reversing multidrug rwistance in colon cancer cells ............
il " ;;. ; ;;
d"*"d',.,,
;; ;; ;;. ; ;;; *;. *"ril';,I,ff #i,.ffi' J
neurdfirnm-orrcdrhirn abnonnaririss h Applpsl and sAMpg
mo,se
*.*,","*.*"*;;;"#T#:H*:TJ#:,,ixl"ffi;li#,i,ffi H;:?ffi:;"Tff;,;i,l,1ll;*i
and neuroprotection .....^..
Endothalial protective eflects anct nEchanisms
ol the No
releasing eflec-ts
..........,..... Nlin Lt {)
ol ttle anfihypertensive herb, Agocynum
Crossilalk bettareen cell d6alh modalities as a pharmacological
target
Phytornedhines: Resolution for inflammatory disorders
Polential application of gammaaocotrienor as a novel
chemosensitizer in gastric @ncer
Epigenetb alterations and cancer chemoprevention
by dietary polyphenols
Research and devetopment of Brahmi. a medicinal plant
for msmory irnprovement
Nmtettip IIMPLANCI{()l}'
Nul\et -fAII'A\TARAPRUK'
S'rkch'ri wtTlAYA-AREEKUI
JirttaDapom
,
wAl lANA"|H0RN,
Krr:nskam
sscrwt*,
"I.ANAK,{
a way to overcorl€ apoptotic resistance in cancer-cells
Wltroo ltHR()MpITI AyARA-f. llircryrki
ct{(x)TIIr,
... Mrrr. I}IF.I)HUCII ll,
...... t ie-Fr.rr sHyUI{ lt
.a.,nr SL.FHI r
... Ajay Clr.)It ll
r
Konrkrrxrli INOKANINAN.
pr:rmrrarin rAEpAw,,tRApRLjK.
orr $Rl-I:ltATAw()N(i,
11n;,,1.r,111
p.JTALt-rN.
t.i
Paraplosis:
... Kver)[g Srxrk CI]()l t3
Antagonislic effects ol Ganderma polysaccharides
on tumor erasion from immune eurvaillance ......... zhi.bin
I,rN l{
$andardzatbn' predinilal ard clinical evaluation ol eprmxrtrn
extrets tor post-rn€nopausar osteoporosis, breast and prostate
Caneers
.....".,. Er-LcongyONC.RlanZLill,r{,
Ie Mlr.l.AN.SunFEN(i. l_rJUN, InrhnrriRINI)I{AN
Besearch on lhe ressarch of pharmacologicsl a,ivitbs
of traditional chinese medicine
H,r (t{rnn,) sUN
Translat*E natural profuc*s irto new drugs ani food srpflenrents
for aging-a6socialed dseass ... si,xrrr i\{ur* yuen
Elrcftlation of possible mechanisms and active ingredients
of Kampo ( Japanese traditional
neural syslem
......,....
.
)
Lllli
15
t5
l(,
medicines on immune ard
.. .".........,-...:.
H,rnrki
YAM,\DA
16
l
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l!Jt+-5+rf..,i+.t2015+7 A'i,29{i}*t'l
1
chlnJPhamacatToxicot. vol 29, Suppl 1'July2015
of potenlial anticancer
Targeting K-ras wrth semisynthetb andrographolide derivatives: A valid approach in lhe discovery
('itrrron
Shun Ytrg ()UAII'
WONG.
WON(;. Hui Chvrt
Johnxxr STANSLAS, Chanrg
drug leacls
[,r,rn Kirhorr.
l)liB. Srrent.rr;r llao SA(ilNEEl)t.i.
Klrozinrh
SHAART
17
uses
Trends in the exploration of medicinal phnts and their clinical
Developing programrnable biological functionallties lor autonomous microbial
""""'
laclories
Ak"' naArHE
lvlatthtrt'\rv''
*'1*"":1::::::*::: i: **::::*::::T:::::l:i:*T:::::::ffi:l'$ffi;;;;:;,;;.,
Using integratfve approadres to discover new oncologty drugs and study metastasis
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lnlegration of chemical and quantilative proteomics lor the identilication of drug targels
'*:::::::::::::::::*':::::*
"""
Kathl' Qi'ru
17
CIIANG ltl
;,,
Ji-gng WAN(;
ll
i]ff:ll: [Tl";;;;;;, ;;;;;;
;,
(-firtg-vxrg LIN,
Yd,NG SCIENTIST PBESENTANON
lor mJtipe carer cdl dedl """ Wcrr S;I.JN.
z-ireho)q6typtrdtorE induces illpS epressirn by HrQ-dependent Jlfi aciivatbn
22
CIIEN
xirrpirre
zl-IA(). Jin-jiur l.U, Qirrg,'rrctr zHAltic;,
Ji:ro-lin BA(), srci I IN. \I.'err-rren
I
)R'
I
lerr
"
Jayaktrdy JlrI,
Determining rehxin-3/RXFP3 activation by inhibition of forskolin indrrced cAMP assay
t2
L),rrvc CS
Efiec,t
ol osthole.
a
Fnrcrtus cnidiidenvednature coumarin, on oslsogenesis and bone healing
in mhe
Zhongmng ZHAN(;. Wing Narrg LF-UN(i, (lhun Wai CHAN 23
YirYin sll:W' sog,uxl ZAIIEISEI)E]IlZAl)E'lI'
Usage o{ lresh medlcinal plants and users' prceptions in Singapore ".'""'
:"1
KolI
wei-(iuang Slj[.T()H, scrck-Yifig l.lEt.). Chal--Htxrn TAN, tl*'ee'Li$g
WANG'
Xirr-nr
Ytr
JIANG'
Preparatbn of hypocrellin B nanoparlicleslor Photodynamic therapy
Altxrt Wingurrg LFUNG. (lhrrurshan XU
PFMGI promotes osleoblast diflerenliation and prevents osleoporotic bone loss
24
WANG
25
by asthma
Anti-rnalaria drug artesunale protscts bronchial epithelium from DNA damage induce'd
WS Fred WONC
ENGELWARD,
(:HAN.
WN Felici.r'l'Ali. ll*'irr P
Tt Khee
cancer cells
influx and ROS generation trigger CDDo-Me-induced dilation ol the ER and apoptosis in broasl
25
Ca?.
.,.... In yotng KIM,
o**::Y
Soo
Li'yrrao Ll. Pan WANCi, 7.hao
AhJF()NC, A t{cruuLEF.. N,liJin YtlON. H-vcseongCllO.Jong-Soo ttit-' KyeongSook
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26
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;;; ;,
CARBIOVASCULAR P}IARMACOLOGY
ADP receptor sublpes P2Y, and
Components of haditional Chinese medicine inhbit platelet aggregation by blocking
Shao[rltl XU" ling \\'AN(; :ll
YANC,
Horrg'y;rn
......"'
LI,
Xino-liapg WANC. Yi-yng
f7yr?
H('trg-k'rr Iil':AN(;'
vitra
in
vivoand
Sesamol inhibits atherog€nh LDL-intfuced sndothelial cell ssnescence in
(:}lEN,
2q
(lhtr-lrtr,rng
SIIEN
Mi$g-ri
(ihi;r-nrurg
{:HAN(;,
ll.urg-,,rr r:iIEN. K,rn-hrieng TIN(i. Chih-chung FEN(i,
extract
water
Slapf
lmprowment o{ lipict profile and atherogenic index in rat lreated wtlh CymbopogOn ciretus
Atch.rnpott' 11;"15rr\lt)R '1{r
NA()WABO(-)1'.
SAINTHAWIEUK.
JarurYep0nr
Nrrnriya SOMTARN, Suph*er
,*:,y:*y*:::::::::i"l::,H:g'H::-#1iil1.?:i#ff l[T.TIt',f .:'ff ['i",,
proteclive eflect of salvianotie acid A against isoproterenol-induced myocardial inlarctbn in mice
\t "': i":'':'1":r'' i-rll 3l
l'ian-hrra FANC' ZFrarr Nttj"fian-r'i YUAN' t'i Li' Yur-ht::
ion channel screening w{t1 n:"i!''!r'ar cardiomyoA comprehensive cardiotoxiclry assay by combining high-throughput multiple
-...'. Ilerning wEI,Jiarrjtru wLl' Yi.s \'rr.: {-:-ir' \r'' r"rr ii'r:r'l KoH'
cyte-based action potential valfolation
Zhen-ii'rre Llti. Sturn (:OOK, Wirrston SHIM' Ten Mei I AN
:
']'r'::qtng l'l'
protective effects ol scutellarin on vascular dyslunclion caused by hypertension in sHR rats
.,} r.-:::;:: }.L\(;
.
.12
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i
l'i
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i.
Wen.luju
.i',:
(1H[N. Xiarr.hua l)LJ' Pr.i.hul PEN(i'
Zhi-ying wEN(;' Mirr ZHAN(.;, Chcn
"* "'!1T :i:1 ::::
:1
::',-',:: :'*:**::T,1ffi';.[',::i:T,-Y:X;"
.'
ff
,*,.,; ;,
+ sl fi
s:+4sry-,ib*
g. 2015
+ 7 n fr 29 lirii
r,J
I
Ghin
J Phamacet Toxbot, Vot 29, Suppl 1. July 2015
ilt
Effecls of scutellarin on pKG in HCMECs after
hypoxia roxygenafion
yir0g t.t, Zhi-!,ing wENc.
Mill ZHAN(1.
c'cn cllFlN' Xrao-hu:r r)LI. pci-hua IlF.Nc' wen-juarr wu, Xuan
LIU. weFrnin yAN(i
.1t]
t'Iovel derivative of Danshensu acts as anti'thrombotic
agenl tor modulation of protein disulfide isomerase
family men*er
EBpsz
ciuo-hui lt
Qua'l QUAN' Yuu
ZHAo,
Yu-qi;log WAI\i(;. Sirrron rruug-Freu
(ihcu,ng-rucng
LEE
cluo'ahen ctJI. Lu-rhen SHAN, l.in cU(), Iva,
Kcung cI.{tJ,
Ze{iurr zr{AN(i. pci yLr. }\ri,rnan IIOI, ycrrri
cH()NG.
St,:N,
.14
Pinocembrin inhibits angiotensin ll 'inaucao vasoconstrkltion
in a ca2-dependenr and ca2.-indepenthnt m'nner
through
blocking AT,FI in the rat aorta
Li Ll. tlaigr.rrrg yANG. xiao-bin pAN(i. B,ri-nian (IHEN.
t.i cA().
Lc WANG. Shorr-hao WANG, 'l-i:n-vi yUAN. Su-Lxr WAli(].
L)e_pei I"IU, Ciu.ur-hrrr l)U
-15
cardioprotective and chemosensitazing effects of novel
Danshensu derrvatives
Lilrng WANGLr'r't.hen sHAN' (irrn-zl:srr clul.JrrclvYuet-wa {-l}lAN,Jiilg-jingLl. (Jire-*.en
ZHANG. lllrggrie }\ri-Man
yFqiangwANc,
Sirnorr lr{ing-Ytrcn
Hol.
l.EE
-t5
Antithrombotic effect of a novel tissue plasrninogen
activator lrom the venom of Gtoydius brevknudusvaper........,...,.....
".,..... yun-ltr X(r. Li-li LIi_\.Jin-hu,r ZHAN(;. Ii.rrr.ii CHF_N, Zhi-qinrg WU. (iuo-tu
Wt.i.Jhn-zhung LIN 36
Effect of *urruta atrapurpurea on btood pressure and
angiotersin lt ol deoxycorticoslerone ac€tate-satt
hypertensive rats
"",d;;;;;;;;;;r;;;;;;;*;;;;;;;;;;,*;;;J;i:,,1:::'*^:}:,.,,:,Til,*x
i;
sesamin enhances nitric oxirje bioactivity in aortas of spontaneousry
hypertensive rats ..........
Jic-ren yANG. Xiang KONG. Wei LI -1S
cornbined antihypertensive etfect ol GSY and metoprolol,
based on endotheliumdependent vasodihtatbn
funetion ......
&r I-l' Jic SU' sha''sh;in I Et' Zhe[5biao YANC. zr'rr"*
JlN. lJui-uring HU, l..n-q.ci lHU. (irri-y,rn LyU, su-ix:ng L-HEN .]t
study on establishing hlryertension animal models by
a&erse rGtvrr" and the antihypertensfue effect ol traditional
Chinese mediCine
.-.... Cui-urrrn I yLI. llo LI. Su
Iic. N.r SHl, Ch.urqun XIA,
CfmN, Su-hong
ei
CHEN
.19
NEUROSCIENCE
Traditional Chinese herbal medicine for vascular
dementia
I)i;rone IIALjTIS'I'A, y:r-n*n ZI{LJ, yong yOl.J,
Wen-r,rrn Ll, Ed*in Sy CHAN, (ihristophrr ('IHEN
4tl
Effeds of DLo410 on the lsamirE and npnnry delicft
in Applpsi ransgenic Aldreiner,s dmase nrodel
mice
chi,,"*;
**r**
Elfects of oryrnatrine
il;,**";;;;;;,;^ffHH;T',#".'*l:.ill:l:::l:ll:::.:]:1..:,
cr cahium charnsls
{-_her:g WAN(;. Xu.ur XU,Jun-vu l.tiO,,firq,*rrr
and GA&{ release in mice urder neuropalhic pain mrdition
l.lu
4l
*,*;;,*,;;,,r*-; "*i*lffiHiH:Hfitr":h;,'*: T ll::::::..l.
Fuzi promored
tte
Xrn,xiarr KUAI, (luir_rri yAl.,Ki, Wrrr-hio GA(-), l-rn l.I^
Lur ZI,IANG "l?
fonnation of nyerin sheath in scfrwann celb irrduced
ry hi$ guco$e
Htffi'fr l[,ffiffi J#:Im, : XJH;:
"*;; ",*"; ;#T"#
systerng
dopan*nergb and AMPABTglc
str-ving
cL'I' Bin YL" xrrc-girxrg ZHANG,
LIN, (iuerrg YAN(i. Yonshc ZHAN(;
Effecrs d caesttdia etata atfr thcaria
shrrlg-.iie Ll.
Qirg
(-{),
Zurtir
SHENG, Xirrq4.nr CtJt.
yurm-li IIL'ANIC. y:r-ping
XU, Jin-zhi soN'-(i. }Itri
lrN(i,
Zri-ge
+{
rat rer/eat€d by LGFnCR-[itS mst$do
mics approach
"'-" .rr'r wtrr XIAN. tao IIU.\N. Li;rng LI. wirg Nurg ,_EUN(;. clnur wai c[AN
"li
Effects d leirahdroxystihene glrcosicle in Parkinson,s
disease nace rnodel indLced by MpIp
rwdwlyr{water eilract ofl cerebral hcfpr*;
*,";; s*.* '"*i; ;,*;***
'
"
, -. .. .
.
^: @ential
Ana[,sb
^--._,^' ot
ant'no
eid
;
*
; ;#*ffi::.:1.:*::
:l::y:.*:, ll:.: I'
Cui'cui YAN(i' Xuc-xiil KU.AI. Y:r-li l.l, Li ;/.HAN(i. Lin U,
Lerr 7IIAN(: dr,
triornar*ers in brain tissue ard.the effect ol gahngin
on cerebral isctrernia
"litls FAN{;. Shxrjing
Lt
46
.,..,. l{ongpirig L(")N(). p:rn MIIN(;, yu;rn.rhan
HAN. yu-txrry; WAMi .t7
of cornd irlclcid $ycoside on experinBntal autoimnure ernephalornyelitb
attenualim trrcugh JAwsrAT s(yuling
pdhuay' at least psrtially
Lin-lil YlN, Yor:51arr CI-IIIN, zluo QLi. t.i z{ANc, q wAN(;.
Ql zt{AN(;. Llx I I 17
Elfect
'*o*.L.y*.rec€Sor
fl
and Gsl(3p rnedates the fast onset of antidepressanr fike natural
rcert
.'.. Qi ZIIANC. I,ci ('it{-), Z}ri-\I/en lrLJ. I3lrg Z-.1 I.AN(;.
Chcng-Grng IIUANC, yarg
Ll lB
:
i
i
f FjlSstiF$4A+*"t2015+7n'1,2StlSJ'l I
n
Ellect of Tongr(Jao.Huo-Xue decoctirrr on ths etgessiors cf related
ents in c€rgbrospird flukl cf cerebral iscfiernic rats'.....'.'....
(irungyun WAN(;, Yur \t/Al'J(i
ChinJPhamacolToxit;ol,Yot29,Suppl 1.July2015
prcfioarxs
d corstitu'
Mng wAN(;. Li'ti U. (li'zhrtrgJIN. Y.r-6ng Llu.
of the Uood-brain barrier ard analysis
"
+r
Darobpntent ol an ERK1/2 activalkn assay lo determire relaxh-VHXFP3
ectlvatim
Jrvakrit\ JPT. lhsc CS
3r
IiFLAITIATTON AI{D NMN.fiCLOGY
Andogaphdide reslores sterc*! s€nsitivity to btock LPs,,lFtv-incfr.Eed lL-? and aiMay l{/per-resporx;iveness in nfi)e ""
'lAN, Wai-Shiu Fred W()N(; 3l
Wn-pcrrg LlA0. W:rn Slrur l)anicl
Vrtamin E iscform y-toccfriernl albviates cigardte snroke-lrduced cfrronic obstructive pulmmary disease
W.rn Shun Dlriel TAN. Tze Khee (:HAN, Clhen Wcr P()W, (llmon Nern ()NG. Wai-Shir.r Frt'tl W()N(i
ln vitn
"""
Horrp Yorrg PEH.
51
and in vivo pharmacologirxl investigations ot Pinus roxbutghii for prevention of oxidativ€, inflammatory responses
Shanur AlltTl. Gital R()HI'I' Bhrttachrry.r S 53
against osteoporosis
wen-piug Ll, Jir:g'slriur 5HI'
lsofuranodbne protect D-galactosamin/lipopolysacctrride induced liver iniury ln rats """""""'
Frhppo MAGC!.
t
i
XirPirrg
;l
CHEN
pathway in
SRS27. a semhynthetic diterpenoid hctone. inhibits alnrvay inllammation and hyper-reoponsiveness via NF-KB
SA(;INEEL)LJ.
(lhcr
Rao
Srerniv:ts,t
Yiqi;rn
GOH.
Wo*i [-lM. Ft'm
an albrgic mouse asthma modgl
Jonrrhan
53
Audrcy Chee Hui YON(;, Shir;ur Mohd SlDtK. Nordin H.rji LAIS, Wai'Shitr Fred W()NC. Johnvrn STANSI
.........
AS
Non-typeable haemophilus influenzae-irduced exacerbatbn on a cigarette smoke lung inlury rnodel; Protective efiecl o{
andrggraphdide.......'........'.'.. \$.rn-sllrn l)anit'l TAN, Hongr.ong PEH. Chu-lrtri PANG, Wulertg LIAO' Tzr-khec CIIAN.
Suk-hialg LAU. Vintrent T. K. CHOW, Wai-rhitr Frcd
W()NG
5'l
Aili-malarial drug, artesunale, as a novel lherapeutic drug target lor ainray wall remodeling in asthma
'fAM, Alastair G. STEWAR'f.
Sherll TAN, llenjamrn ON(I, Chang CIIEN(,1" Wan-ring Eugxrne HO, John l(.(i
5'+
Tnxli P'IARRIS. Wai-Shiu Frert WONC, Thri TI{AN
***::::::'"*
o*"Y:::
**:
T*;'H:"n *T H I',:JIJ:,,*,i:::ff ;Kffi .:,,i ri',;"
:::':::::1
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;,.:";,
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;,
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il;; ;;;
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;.
Pharmacrkineth ol nasal curcumin: An approach for asthma medilatlon
.'. Subhashini SlNl, Preed Snrgh tlHAtltIAN. Rr"rrhr CIL{WI.A, l) [)ASH, l{.rshnri SINCII 57
Synergistic effect ol rosmarinic acid wifi antibiolics against Slaphylomcus aureus and MFSA
(;. Ajay B Stl
Suunul5r pnya UKAMBARAM. Nathiy.r MARAPPAN, Vurodhini VISWANATHAN. Sahari Sritriv.rs.ur
.'.....,....
protectiv€ efrecls of NYG-1 on CCl.-induced acute liver inlury in rats
Flougliang LI, Xurn-trin \uAN(;, Ming I ltJ'
ZHANG
se
lcaritin requires phosphatidylinositol
... Jing ZLNC. Rui-zhen t.lU. Cti-lin WEl. Lrarrgrdorrg L,l, Zlri-hrr.r fILiAN(i 6(l
kinase/AK signaling to counteract skelsbl muscle atrophy lollowing mechanical
Zorqg-kmg ZHANG. Jie LI. Wing:nlrs LEUN(i. (ie 7.HANC, Eorrting ZHANC 6l
Yihh
FENG, tliu-hng
ln vivo atfi in vitrc anti-arthritic etlicacy ol a herbal formula oonsisting ol Fosa€ Multiflorae Frwtus ard Lqticcrae Japni'
"l'.xr SLI, Xiu-qiong [:U. Tilg I.l. Zhr-lirrg YU 59
Bri:rn Chi Yan (IHENG, I Iui CU(),
CAe F,5,S
protective eflects of 3'-dairtzein sutfonate sodium on chronic hepatic inlury by reguhting the T lymphocyte subsels in mice
unlgadkq.....
3
Anti-inllammation and anti-librosis actions ol resvsratrol on experimental pneumoconiosis
.'...' Jie LI. Znng'kang ZIIAN(i.Yue QU, WingNang LEUNC. Iho'ting Zl.lANC 6l
Enhanced scratching elbited by a pruritogen and an algogen in a mouse model of contact hypersensitivity
Kai l;LJ, Lirruo Ql"J. Stcvcrt C. SHIMADA. tlong NlF. [Iohtn I'I LaM()'l'l[ 62
protective stf€ct of N@tta sattve L. to gastric mucous of irdomethacin-induced gastlic ulcer rats "' ' ' ' " ' ' '
urrri I(A-LSLJM. Rcilata PRIMASARI, DeR'a AYU, Mudjiwiiono HAtIDARI.I 63
ln vitro snd in viw immunomoduhlory acrivitles o{ polysatnharides purified lrom tour species ol Dendrabium
l.ci SHl, Llur CAI, Seng l\rort ON(i. l;crrg TIAN 61
response in murine
The compounds lrom Denis latrifura Benlh suppresses tipopotysaccharide-induced inffammatory
(}4
(:HAO.
(lHlU.
.... Ai-jrn YANC, t{si.lin
Ming*pr
Jui'ching CIIEN
Raup64.7 cells ...........
treated wi$t lipopolysacEffect ol mangosroen (Garcinia merrgostana unn) peel extract on migralion of endotlrelial cells
Adiurto
......
l,tsl{MAT,tSARl.
JAYANAGARA, Tirin Andri WIHAS I U]'l'
Dirtl NUGRAHENNY, Nur
charide
lljangan SARCi()WO
fr5
f H 4rr+ S.*.i?+ *,i
201s
+
7 fr fr
8*$+,1
1
Chin J Phantwol Toxicof, Vol 29, Suppl 1. July 2o1S
Methanolie exlract of ceplukan leal t P/rlaa/rb minima L.
ectomized
rals
)
v
att€nuates venlricular librosis through inhibition of TNF-q in ovariLrst;ri llAYU, l)emutasrri NUR, SaifurRotunan MOIIAMMAD (r.5
cucurbitacin E induces apoptosis and attenuates acttualion of hepatic stellate
cells via pl3K/Ak-AMpK-mToR signaling
pathway
You'li YAo. Li'hue LIAN. shuangJlANc. Jr-xing NAN. yen-ling wU 6(,
lnhibitory aclivrty ol Cinnamamum Cassk extract on hypersensitivity in mice
Seuulgycong L[E,
Junghin soN(;. l)onchuu l.FE' Young-sik KIM, Hr.rur Srxr KIM. Hailirrg GU0.
Jrryeon pARK. Hoeheol K114
67
P2X7 receptor inhibitor suppressed e)dracellular ATPAPS-primed human
hepalic stellate colls aclvatbn via downregulating NLBP3 inllammasome
shurng JIAN(i. Qum JlN. Yil-ling wu. yr-rtrli yAo,
Ji-xing NAN, Li-hua LIAN 67
Possible role of rnitochondrial penneability transitbn pora in hepatoprotective potentials
of epigaflocatachin gallate in paracetarnol induced hepatotoxi{ity in rats
Gurtitrh slN(;H, Dccpika l}HATlA. $IFIARIKLJMAR 68
METABOLIC OISEASES
Active component
ol
lsatidis Radix on insulin resistance in diabetos mellitus
-flAN(i. IVftr-xiang LIU
lnvestigating the prescription compatibility
rat
.... .. . . . .. .
.
Ji-pnrg Ll. Tian-jia
cN il-uss/R
coDEN Zt-t'zEw
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ZHONGGUO YAOLIXUE YU DULIXUE ZAZHI
Cfritxese
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Special Issue of the IUPHAR Conference on the Pharmacology
of Natural and Traditional Medicine 2015
Jrly 22-24, 2015, Singapore
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chinese Journal of pharmacology and roxicology
2015 July Volume 2g Supplement I
(
Founded in November 19g6)
Contents
PLENARV LECTURES
The lysophospholipid receptor modulator. lingolimod3 from traditional
Chinese medicine to FDA-approved drug
...'.','.
;;;,;.;;;
",";;;;;;;;;;;;;;
Trials
and tribuhtbns
.ftnrLl
l)ey,ut- l)arrei
of developing natural producl drugs
chinese tradilional medkine is characterized by inducing multi-largel
efrects ....
IUPHAR. Gulle to pharmacology and nalural products
'
Dirvi{l
...'.
'
I
I
Nl-l!irl\.{AN
:
ZHANC
j}
St,Hi)DIN(i
3
.J.
Jun-tiau
Mn'h;rcl
CIIUN
DUAN
TNVITED LECTURES
srnall rnolecule modulators of lysine acetyllranslerases from natural
sourcesl Implicaflon in therapeutics
Nalural prcdrct insplred drug
discovery
Pharmacologir:al studies of herbs against hepa$c
A story about berbetine
"""""""'
"*::L::.:::'::.:::*"rls
opposite ansro$nic
.. Chrisnn:r L.l_. CI_lAl +
... yi-Tsru HUAN(i i
fibrosis
-fi:n-rlongJlAli-Ci. y;rrr--tirg HAN. l.rr-lrr WANG (r
in herbalmedicines usins cfirornarographic separation
coupted with ontine bioactivity assay
",;;;'";;;;;;;;;;;;;;;;;;; ;;;,;;,;
,l"f,il:,J'
",.* ;$ilHj
FAN' xrr,*jun
{t
Lr
The autophagy-lysosome pathway as the novel targets of natural
products .................... ....:..i:: Hau-rrring
SIIIiN
The potentiar or therapeufic application of tanshinones in
reversing multidrug rwistance in colon cancer cells ............
il " ;;. ; ;;
d"*"d',.,,
;; ;; ;;. ; ;;; *;. *"ril';,I,ff #i,.ffi' J
neurdfirnm-orrcdrhirn abnonnaririss h Applpsl and sAMpg
mo,se
*.*,","*.*"*;;;"#T#:H*:TJ#:,,ixl"ffi;li#,i,ffi H;:?ffi:;"Tff;,;i,l,1ll;*i
and neuroprotection .....^..
Endothalial protective eflects anct nEchanisms
ol the No
releasing eflec-ts
..........,..... Nlin Lt {)
ol ttle anfihypertensive herb, Agocynum
Crossilalk bettareen cell d6alh modalities as a pharmacological
target
Phytornedhines: Resolution for inflammatory disorders
Polential application of gammaaocotrienor as a novel
chemosensitizer in gastric @ncer
Epigenetb alterations and cancer chemoprevention
by dietary polyphenols
Research and devetopment of Brahmi. a medicinal plant
for msmory irnprovement
Nmtettip IIMPLANCI{()l}'
Nul\et -fAII'A\TARAPRUK'
S'rkch'ri wtTlAYA-AREEKUI
JirttaDapom
,
wAl lANA"|H0RN,
Krr:nskam
sscrwt*,
"I.ANAK,{
a way to overcorl€ apoptotic resistance in cancer-cells
Wltroo ltHR()MpITI AyARA-f. llircryrki
ct{(x)TIIr,
... Mrrr. I}IF.I)HUCII ll,
...... t ie-Fr.rr sHyUI{ lt
.a.,nr SL.FHI r
... Ajay Clr.)It ll
r
Konrkrrxrli INOKANINAN.
pr:rmrrarin rAEpAw,,tRApRLjK.
orr $Rl-I:ltATAw()N(i,
11n;,,1.r,111
p.JTALt-rN.
t.i
Paraplosis:
... Kver)[g Srxrk CI]()l t3
Antagonislic effects ol Ganderma polysaccharides
on tumor erasion from immune eurvaillance ......... zhi.bin
I,rN l{
$andardzatbn' predinilal ard clinical evaluation ol eprmxrtrn
extrets tor post-rn€nopausar osteoporosis, breast and prostate
Caneers
.....".,. Er-LcongyONC.RlanZLill,r{,
Ie Mlr.l.AN.SunFEN(i. l_rJUN, InrhnrriRINI)I{AN
Besearch on lhe ressarch of pharmacologicsl a,ivitbs
of traditional chinese medicine
H,r (t{rnn,) sUN
Translat*E natural profuc*s irto new drugs ani food srpflenrents
for aging-a6socialed dseass ... si,xrrr i\{ur* yuen
Elrcftlation of possible mechanisms and active ingredients
of Kampo ( Japanese traditional
neural syslem
......,....
.
)
Lllli
15
t5
l(,
medicines on immune ard
.. .".........,-...:.
H,rnrki
YAM,\DA
16
l
.f,14
l!Jt+-5+rf..,i+.t2015+7 A'i,29{i}*t'l
1
chlnJPhamacatToxicot. vol 29, Suppl 1'July2015
of potenlial anticancer
Targeting K-ras wrth semisynthetb andrographolide derivatives: A valid approach in lhe discovery
('itrrron
Shun Ytrg ()UAII'
WONG.
WON(;. Hui Chvrt
Johnxxr STANSLAS, Chanrg
drug leacls
[,r,rn Kirhorr.
l)liB. Srrent.rr;r llao SA(ilNEEl)t.i.
Klrozinrh
SHAART
17
uses
Trends in the exploration of medicinal phnts and their clinical
Developing programrnable biological functionallties lor autonomous microbial
""""'
laclories
Ak"' naArHE
lvlatthtrt'\rv''
*'1*"":1::::::*::: i: **::::*::::T:::::l:i:*T:::::::ffi:l'$ffi;;;;:;,;;.,
Using integratfve approadres to discover new oncologty drugs and study metastasis
**::i::::yl:i:::::: ::::::l::::::l:
*:'-:'*:'i::'l:::
"'
*
*
l::::::::1::::::-:"1;l
;,
Ltj()' Alir Fti lq
::::::*i:11*[;T:r;;.;;;
lnlegration of chemical and quantilative proteomics lor the identilication of drug targels
'*:::::::::::::::::*':::::*
"""
Kathl' Qi'ru
17
CIIANG ltl
;,,
Ji-gng WAN(;
ll
i]ff:ll: [Tl";;;;;;, ;;;;;;
;,
(-firtg-vxrg LIN,
Yd,NG SCIENTIST PBESENTANON
lor mJtipe carer cdl dedl """ Wcrr S;I.JN.
z-ireho)q6typtrdtorE induces illpS epressirn by HrQ-dependent Jlfi aciivatbn
22
CIIEN
xirrpirre
zl-IA(). Jin-jiur l.U, Qirrg,'rrctr zHAltic;,
Ji:ro-lin BA(), srci I IN. \I.'err-rren
I
)R'
I
lerr
"
Jayaktrdy JlrI,
Determining rehxin-3/RXFP3 activation by inhibition of forskolin indrrced cAMP assay
t2
L),rrvc CS
Efiec,t
ol osthole.
a
Fnrcrtus cnidiidenvednature coumarin, on oslsogenesis and bone healing
in mhe
Zhongmng ZHAN(;. Wing Narrg LF-UN(i, (lhun Wai CHAN 23
YirYin sll:W' sog,uxl ZAIIEISEI)E]IlZAl)E'lI'
Usage o{ lresh medlcinal plants and users' prceptions in Singapore ".'""'
:"1
KolI
wei-(iuang Slj[.T()H, scrck-Yifig l.lEt.). Chal--Htxrn TAN, tl*'ee'Li$g
WANG'
Xirr-nr
Ytr
JIANG'
Preparatbn of hypocrellin B nanoparlicleslor Photodynamic therapy
Altxrt Wingurrg LFUNG. (lhrrurshan XU
PFMGI promotes osleoblast diflerenliation and prevents osleoporotic bone loss
24
WANG
25
by asthma
Anti-rnalaria drug artesunale protscts bronchial epithelium from DNA damage induce'd
WS Fred WONC
ENGELWARD,
(:HAN.
WN Felici.r'l'Ali. ll*'irr P
Tt Khee
cancer cells
influx and ROS generation trigger CDDo-Me-induced dilation ol the ER and apoptosis in broasl
25
Ca?.
.,.... In yotng KIM,
o**::Y
Soo
Li'yrrao Ll. Pan WANCi, 7.hao
AhJF()NC, A t{cruuLEF.. N,liJin YtlON. H-vcseongCllO.Jong-Soo ttit-' KyeongSook
Y* :l:::*
:i::Y :::,l',;ffiH :*T.Tl ;:ili:,I[:l.":,;;
**.::*::1"**:::'"'
;;;;,,;;.
CIIOI
26
;;;;,,
:T:::1ff:*TTJ::",:',"iiffi:T,-ffiT^T,:1,fi1lff1;:
;;; ;,
CARBIOVASCULAR P}IARMACOLOGY
ADP receptor sublpes P2Y, and
Components of haditional Chinese medicine inhbit platelet aggregation by blocking
Shao[rltl XU" ling \\'AN(; :ll
YANC,
Horrg'y;rn
......"'
LI,
Xino-liapg WANC. Yi-yng
f7yr?
H('trg-k'rr Iil':AN(;'
vitra
in
vivoand
Sesamol inhibits atherog€nh LDL-intfuced sndothelial cell ssnescence in
(:}lEN,
2q
(lhtr-lrtr,rng
SIIEN
Mi$g-ri
(ihi;r-nrurg
{:HAN(;,
ll.urg-,,rr r:iIEN. K,rn-hrieng TIN(i. Chih-chung FEN(i,
extract
water
Slapf
lmprowment o{ lipict profile and atherogenic index in rat lreated wtlh CymbopogOn ciretus
Atch.rnpott' 11;"15rr\lt)R '1{r
NA()WABO(-)1'.
SAINTHAWIEUK.
JarurYep0nr
Nrrnriya SOMTARN, Suph*er
,*:,y:*y*:::::::::i"l::,H:g'H::-#1iil1.?:i#ff l[T.TIt',f .:'ff ['i",,
proteclive eflect of salvianotie acid A against isoproterenol-induced myocardial inlarctbn in mice
\t "': i":'':'1":r'' i-rll 3l
l'ian-hrra FANC' ZFrarr Nttj"fian-r'i YUAN' t'i Li' Yur-ht::
ion channel screening w{t1 n:"i!''!r'ar cardiomyoA comprehensive cardiotoxiclry assay by combining high-throughput multiple
-...'. Ilerning wEI,Jiarrjtru wLl' Yi.s \'rr.: {-:-ir' \r'' r"rr ii'r:r'l KoH'
cyte-based action potential valfolation
Zhen-ii'rre Llti. Sturn (:OOK, Wirrston SHIM' Ten Mei I AN
:
']'r'::qtng l'l'
protective effects ol scutellarin on vascular dyslunclion caused by hypertension in sHR rats
.,} r.-:::;:: }.L\(;
.
.12
{]*;
i
l'i
\t
i.
Wen.luju
.i',:
(1H[N. Xiarr.hua l)LJ' Pr.i.hul PEN(i'
Zhi-ying wEN(;' Mirr ZHAN(.;, Chcn
"* "'!1T :i:1 ::::
:1
::',-',:: :'*:**::T,1ffi';.[',::i:T,-Y:X;"
.'
ff
,*,.,; ;,
+ sl fi
s:+4sry-,ib*
g. 2015
+ 7 n fr 29 lirii
r,J
I
Ghin
J Phamacet Toxbot, Vot 29, Suppl 1. July 2015
ilt
Effecls of scutellarin on pKG in HCMECs after
hypoxia roxygenafion
yir0g t.t, Zhi-!,ing wENc.
Mill ZHAN(1.
c'cn cllFlN' Xrao-hu:r r)LI. pci-hua IlF.Nc' wen-juarr wu, Xuan
LIU. weFrnin yAN(i
.1t]
t'Iovel derivative of Danshensu acts as anti'thrombotic
agenl tor modulation of protein disulfide isomerase
family men*er
EBpsz
ciuo-hui lt
Qua'l QUAN' Yuu
ZHAo,
Yu-qi;log WAI\i(;. Sirrron rruug-Freu
(ihcu,ng-rucng
LEE
cluo'ahen ctJI. Lu-rhen SHAN, l.in cU(), Iva,
Kcung cI.{tJ,
Ze{iurr zr{AN(i. pci yLr. }\ri,rnan IIOI, ycrrri
cH()NG.
St,:N,
.14
Pinocembrin inhibits angiotensin ll 'inaucao vasoconstrkltion
in a ca2-dependenr and ca2.-indepenthnt m'nner
through
blocking AT,FI in the rat aorta
Li Ll. tlaigr.rrrg yANG. xiao-bin pAN(i. B,ri-nian (IHEN.
t.i cA().
Lc WANG. Shorr-hao WANG, 'l-i:n-vi yUAN. Su-Lxr WAli(].
L)e_pei I"IU, Ciu.ur-hrrr l)U
-15
cardioprotective and chemosensitazing effects of novel
Danshensu derrvatives
Lilrng WANGLr'r't.hen sHAN' (irrn-zl:srr clul.JrrclvYuet-wa {-l}lAN,Jiilg-jingLl. (Jire-*.en
ZHANG. lllrggrie }\ri-Man
yFqiangwANc,
Sirnorr lr{ing-Ytrcn
Hol.
l.EE
-t5
Antithrombotic effect of a novel tissue plasrninogen
activator lrom the venom of Gtoydius brevknudusvaper........,...,.....
".,..... yun-ltr X(r. Li-li LIi_\.Jin-hu,r ZHAN(;. Ii.rrr.ii CHF_N, Zhi-qinrg WU. (iuo-tu
Wt.i.Jhn-zhung LIN 36
Effect of *urruta atrapurpurea on btood pressure and
angiotersin lt ol deoxycorticoslerone ac€tate-satt
hypertensive rats
"",d;;;;;;;;;;r;;;;;;;*;;;;;;;;;;,*;;;J;i:,,1:::'*^:}:,.,,:,Til,*x
i;
sesamin enhances nitric oxirje bioactivity in aortas of spontaneousry
hypertensive rats ..........
Jic-ren yANG. Xiang KONG. Wei LI -1S
cornbined antihypertensive etfect ol GSY and metoprolol,
based on endotheliumdependent vasodihtatbn
funetion ......
&r I-l' Jic SU' sha''sh;in I Et' Zhe[5biao YANC. zr'rr"*
JlN. lJui-uring HU, l..n-q.ci lHU. (irri-y,rn LyU, su-ix:ng L-HEN .]t
study on establishing hlryertension animal models by
a&erse rGtvrr" and the antihypertensfue effect ol traditional
Chinese mediCine
.-.... Cui-urrrn I yLI. llo LI. Su
Iic. N.r SHl, Ch.urqun XIA,
CfmN, Su-hong
ei
CHEN
.19
NEUROSCIENCE
Traditional Chinese herbal medicine for vascular
dementia
I)i;rone IIALjTIS'I'A, y:r-n*n ZI{LJ, yong yOl.J,
Wen-r,rrn Ll, Ed*in Sy CHAN, (ihristophrr ('IHEN
4tl
Effeds of DLo410 on the lsamirE and npnnry delicft
in Applpsi ransgenic Aldreiner,s dmase nrodel
mice
chi,,"*;
**r**
Elfects of oryrnatrine
il;,**";;;;;;,;^ffHH;T',#".'*l:.ill:l:::l:ll:::.:]:1..:,
cr cahium charnsls
{-_her:g WAN(;. Xu.ur XU,Jun-vu l.tiO,,firq,*rrr
and GA&{ release in mice urder neuropalhic pain mrdition
l.lu
4l
*,*;;,*,;;,,r*-; "*i*lffiHiH:Hfitr":h;,'*: T ll::::::..l.
Fuzi promored
tte
Xrn,xiarr KUAI, (luir_rri yAl.,Ki, Wrrr-hio GA(-), l-rn l.I^
Lur ZI,IANG "l?
fonnation of nyerin sheath in scfrwann celb irrduced
ry hi$ guco$e
Htffi'fr l[,ffiffi J#:Im, : XJH;:
"*;; ",*"; ;#T"#
systerng
dopan*nergb and AMPABTglc
str-ving
cL'I' Bin YL" xrrc-girxrg ZHANG,
LIN, (iuerrg YAN(i. Yonshc ZHAN(;
Effecrs d caesttdia etata atfr thcaria
shrrlg-.iie Ll.
Qirg
(-{),
Zurtir
SHENG, Xirrq4.nr CtJt.
yurm-li IIL'ANIC. y:r-ping
XU, Jin-zhi soN'-(i. }Itri
lrN(i,
Zri-ge
+{
rat rer/eat€d by LGFnCR-[itS mst$do
mics approach
"'-" .rr'r wtrr XIAN. tao IIU.\N. Li;rng LI. wirg Nurg ,_EUN(;. clnur wai c[AN
"li
Effects d leirahdroxystihene glrcosicle in Parkinson,s
disease nace rnodel indLced by MpIp
rwdwlyr{water eilract ofl cerebral hcfpr*;
*,";; s*.* '"*i; ;,*;***
'
"
, -. .. .
.
^: @ential
Ana[,sb
^--._,^' ot
ant'no
eid
;
*
; ;#*ffi::.:1.:*::
:l::y:.*:, ll:.: I'
Cui'cui YAN(i' Xuc-xiil KU.AI. Y:r-li l.l, Li ;/.HAN(i. Lin U,
Lerr 7IIAN(: dr,
triornar*ers in brain tissue ard.the effect ol gahngin
on cerebral isctrernia
"litls FAN{;. Shxrjing
Lt
46
.,..,. l{ongpirig L(")N(). p:rn MIIN(;, yu;rn.rhan
HAN. yu-txrry; WAMi .t7
of cornd irlclcid $ycoside on experinBntal autoimnure ernephalornyelitb
attenualim trrcugh JAwsrAT s(yuling
pdhuay' at least psrtially
Lin-lil YlN, Yor:51arr CI-IIIN, zluo QLi. t.i z{ANc, q wAN(;.
Ql zt{AN(;. Llx I I 17
Elfect
'*o*.L.y*.rec€Sor
fl
and Gsl(3p rnedates the fast onset of antidepressanr fike natural
rcert
.'.. Qi ZIIANC. I,ci ('it{-), Z}ri-\I/en lrLJ. I3lrg Z-.1 I.AN(;.
Chcng-Grng IIUANC, yarg
Ll lB
:
i
i
f FjlSstiF$4A+*"t2015+7n'1,2StlSJ'l I
n
Ellect of Tongr(Jao.Huo-Xue decoctirrr on ths etgessiors cf related
ents in c€rgbrospird flukl cf cerebral iscfiernic rats'.....'.'....
(irungyun WAN(;, Yur \t/Al'J(i
ChinJPhamacolToxit;ol,Yot29,Suppl 1.July2015
prcfioarxs
d corstitu'
Mng wAN(;. Li'ti U. (li'zhrtrgJIN. Y.r-6ng Llu.
of the Uood-brain barrier ard analysis
"
+r
Darobpntent ol an ERK1/2 activalkn assay lo determire relaxh-VHXFP3
ectlvatim
Jrvakrit\ JPT. lhsc CS
3r
IiFLAITIATTON AI{D NMN.fiCLOGY
Andogaphdide reslores sterc*! s€nsitivity to btock LPs,,lFtv-incfr.Eed lL-? and aiMay l{/per-resporx;iveness in nfi)e ""
'lAN, Wai-Shiu Fred W()N(; 3l
Wn-pcrrg LlA0. W:rn Slrur l)anicl
Vrtamin E iscform y-toccfriernl albviates cigardte snroke-lrduced cfrronic obstructive pulmmary disease
W.rn Shun Dlriel TAN. Tze Khee (:HAN, Clhen Wcr P()W, (llmon Nern ()NG. Wai-Shir.r Frt'tl W()N(i
ln vitn
"""
Horrp Yorrg PEH.
51
and in vivo pharmacologirxl investigations ot Pinus roxbutghii for prevention of oxidativ€, inflammatory responses
Shanur AlltTl. Gital R()HI'I' Bhrttachrry.r S 53
against osteoporosis
wen-piug Ll, Jir:g'slriur 5HI'
lsofuranodbne protect D-galactosamin/lipopolysacctrride induced liver iniury ln rats """""""'
Frhppo MAGC!.
t
i
XirPirrg
;l
CHEN
pathway in
SRS27. a semhynthetic diterpenoid hctone. inhibits alnrvay inllammation and hyper-reoponsiveness via NF-KB
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Synergistic effect ol rosmarinic acid wifi antibiolics against Slaphylomcus aureus and MFSA
(;. Ajay B Stl
Suunul5r pnya UKAMBARAM. Nathiy.r MARAPPAN, Vurodhini VISWANATHAN. Sahari Sritriv.rs.ur
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protectiv€ efrecls of NYG-1 on CCl.-induced acute liver inlury in rats
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kinase/AK signaling to counteract skelsbl muscle atrophy lollowing mechanical
Zorqg-kmg ZHANG. Jie LI. Wing:nlrs LEUN(i. (ie 7.HANC, Eorrting ZHANC 6l
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ln vivo atfi in vitrc anti-arthritic etlicacy ol a herbal formula oonsisting ol Fosa€ Multiflorae Frwtus ard Lqticcrae Japni'
"l'.xr SLI, Xiu-qiong [:U. Tilg I.l. Zhr-lirrg YU 59
Bri:rn Chi Yan (IHENG, I Iui CU(),
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protective eflects of 3'-dairtzein sutfonate sodium on chronic hepatic inlury by reguhting the T lymphocyte subsels in mice
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Anti-inllammation and anti-librosis actions ol resvsratrol on experimental pneumoconiosis
.'...' Jie LI. Znng'kang ZIIAN(i.Yue QU, WingNang LEUNC. Iho'ting Zl.lANC 6l
Enhanced scratching elbited by a pruritogen and an algogen in a mouse model of contact hypersensitivity
Kai l;LJ, Lirruo Ql"J. Stcvcrt C. SHIMADA. tlong NlF. [Iohtn I'I LaM()'l'l[ 62
protective stf€ct of N@tta sattve L. to gastric mucous of irdomethacin-induced gastlic ulcer rats "' ' ' ' " ' ' '
urrri I(A-LSLJM. Rcilata PRIMASARI, DeR'a AYU, Mudjiwiiono HAtIDARI.I 63
ln vitro snd in viw immunomoduhlory acrivitles o{ polysatnharides purified lrom tour species ol Dendrabium
l.ci SHl, Llur CAI, Seng l\rort ON(i. l;crrg TIAN 61
response in murine
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Methanolie exlract of ceplukan leal t P/rlaa/rb minima L.
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cucurbitacin E induces apoptosis and attenuates acttualion of hepatic stellate
cells via pl3K/Ak-AMpK-mToR signaling
pathway
You'li YAo. Li'hue LIAN. shuangJlANc. Jr-xing NAN. yen-ling wU 6(,
lnhibitory aclivrty ol Cinnamamum Cassk extract on hypersensitivity in mice
Seuulgycong L[E,
Junghin soN(;. l)onchuu l.FE' Young-sik KIM, Hr.rur Srxr KIM. Hailirrg GU0.
Jrryeon pARK. Hoeheol K114
67
P2X7 receptor inhibitor suppressed e)dracellular ATPAPS-primed human
hepalic stellate colls aclvatbn via downregulating NLBP3 inllammasome
shurng JIAN(i. Qum JlN. Yil-ling wu. yr-rtrli yAo,
Ji-xing NAN, Li-hua LIAN 67
Possible role of rnitochondrial penneability transitbn pora in hepatoprotective potentials
of epigaflocatachin gallate in paracetarnol induced hepatotoxi{ity in rats
Gurtitrh slN(;H, Dccpika l}HATlA. $IFIARIKLJMAR 68
METABOLIC OISEASES
Active component
ol
lsatidis Radix on insulin resistance in diabetos mellitus
-flAN(i. IVftr-xiang LIU
lnvestigating the prescription compatibility
rat
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