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SubjectArea: phama@logy
Toximlogy
Publisher: Chinese Joumal of phama@logy and Toxj@logy

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Chin J pharmaco! Toxicot, Vol 29 , Suppl

1, July 2015

I

chinese Journal of pharmacology and roxicology
2015 Jr,:ly Volume 29 Supplement
1

(Founded in November 19g6)

Contents
PLENARY LECTURES
The lysophospholipid receptor modulator, fingolirnods from traditional Chinese
medicine to FDA_approved drug
Pharmacophenomics and traditional Chinese medicine
Trials and tribulations of developing natural product drugs
chinese traditional medicine is characterized by inducing multi{arget effects ..
IUPHAR, Guide to pharmacology and natural products

Jerold

.--

Dayue Darrel

""

CHUN I
DUAN
1

DavidJ. NEWMAN 2

.'.....

Jun-tian ZI:IANG 3
Michael SPEDDING 3

".

INVITED LECTURES
Small molecule modulators of lysine ace$ltransferases from natural
soutc€S: lmplication in therapeutics

.

.#,H:::HY :

Natural product inspired drug discovery
Pharmacological studies of herbs against hepatic fibrosis
... yi_Tsau HUANG 5
A story about berberine -............
.. Jian-dongJIANG, yan-xing HAN, Lu_lu
WANG 6
Discovery of active components in herbal medicines using chromatographic
separation coupled with online bioactivity assay

opposite ansiosenic

';"";;;;;;;;;r;"

"";;;;;;;r;;;; "";;;;,;.;;, ,;......
",,-, ;3,,:*'',X11,,XT,?,""'
FAN, Xue_jun LI 6
Sheng_1un

Theautophagy.lysosomepathwayasthenovettargetsofnaturalproducts

"::::::::l::.::::i:"-"

**

application of tanshinones in reversing muttidrus resistance in
coton cancer ceils

;;;; .;; ;;; ,; ;; .;""

Errect or LW-AFC ,
"
neuroimmun-onoduration abnormarities in

Applps1 and sAMpg

,

"" "*,,,r"

mouse

;;;;;, ";,*-

...............

;,ffdT##:"":

', ' '
wen-xia zHou,Jian-hui VANG, Bing CFENG, Yan HUANG,
xao-rui CHENG, yong-xiang ZI{ANG B
..'
-.1
Natural
^,^. -l autophagy
enhancers lrom chinese medicine uncariarhynchophylla(Miq.)
Jacks.(Gouteng), Molecular targets
and neuroprotection .......
Min LI g
Endothelial protective effects and mechanisms of the No releasing
effects of the antihypertensive herb, ;;;;r*
venetum"""

"""

Mohammad Rais MUSTAFA, Lau

Crosstalk between cell death modalities as a pharmacological target .........
Phytomedicines: Resolution for inflammatory disorders
Potentlal application of gamma-tocotrienol as a novel chemosensitizer
in gastric cancer
Epigenetic alterations and cancer chemoprevention by dietary polyphenols

Marc

......

yeh-Siang

10

DIEDERICH

10

SHyUR

11

Lie-Fen

Gautam

...

t1.

'ETHI
A,jay GonL 72

Research and development of Brahmi, a medicinal plant for memory
improvement
Komkanok INGKANINAN,
Nanteetip LIMPEANCHoB, Sakchai WITTAYA-AR-EEKUL, Krongkam
cHoorlp, pomnarin TAEpAwARApRt K,

Nuwat TAEPAWARAPR(IK, Jintanapom WATTANATHoRN, Seewaboon
SIREERATAWoNG, warapom purALLrN,
Watoo PHROMPITTAYARAT, Hnoyuki

TANAKA

Paraptosis: a way to overcome apoptotic resistance in cancer
cells

.-.........

B

Kyeong Sook

CHOI

13

Antagonistic effects of Ganoderma polysaccharides on tumor
evasion from immune surveillance ......... zhi-bin LIN 14
standardization, prec'linical and clinical evaluation of epimedium extracts
for post-menopausal osteoporosis,.breast and prostate

cancers

""-""

Eu-Leong

YoNG, Ryan zL LM,

Ee

Min TAN, Sun FENG, Li JLriv, Inthnni R

Research on the research of pharmacological activities of traditional
chinese

medicine

Translating natural prodttcts into new drugs aM food supplements
for aging-associated diseases

INDRAN 15
He (Henry) sI_rN i5

... Simon Ming yuen rFF 76
Elucidation of possible mechanisms and active ingredients of Kampo (Japanese
traditional) medicines on immune and
neural system
................
Haruki

yAMADA

16

+A^tY+Et+q-++.t2015+7 Affi29+Ert1

il

ChinJPharmacol Toxicot, Vol 29. Suppt 1. Juty2015

Targeting K-raswith semisynthetic andrographolide derivatives, A valid approach in the discovery of potential anticancer
drug leads
Johnson STANSLAS, Chamg Choon WONG, Hui Chyn WONG, Shun Ying QUAH,
Pran Kishore DEB, Sreenivasa Rao SAGiNEEDU, Khozirah

SFIAARI

17

Trends in the exploration of medicinal plants and their clinical uses
Developing programmable biological functionalities for autonomous microbial

factories

..-.-...- Akot rraA'rrrE

17

w. CHANG

18

Mattherv

'"*::::::l::::::T::::::: :::""^::::::::':T::::::'::: ::i::l':::l ::*l*'#x':.;*. ; , ;,

Using integratlve approaches to discover new oncology drugs and study metastasis --.--.-.. IGrhy Qian LUo, Afu

;,

FU

19

""i::l::::T:::::::i::::':l:::::::::::::i:i:::ltlilli'lt i:'::T::::::111"T::"Jr.;.;.*";; ;.
lntegration of chemical and quantitative proteomics for the identification of drug targets

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27

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21

YOUNG SCIENTIST PRESENTATION
2-ttlethorystypardrone induces |NOS expression by HrOr-dependent JNK activation for multiple cancer cell death
Jiao-lin BAO, Wei LIN, Wen-wen ZHAO, Jin-jian LU, Qing-rven ZHANG, Xu-ping CHEN
Determining relaxin-3/RXFP3 activation by inhibition of forskolin induced cAMP assay
Dawe

wen SLN,
22

Jayakody

GS

*"::::::::"ll

......

JpT, Herr DR,
22

on osteosenesis and bone hea'|ins in mice

i i*::111*:::::::::: """"'in, Zhong-rong ZHANG, \d/ing Nang LEUNG, Chun Wai CHAN 23

Usage of fresh medicinal plants and users' perceptions in Singapore .....-... yin-yin SIEW, Sogand ZAREISEDEHIZADEH,
'Wei-Guang SEETOH,
Soek-Ying NEO, Chay-Hoon TAN, Hwee-Ling KOH
24
yue ltANG, Xjn-na WANG,
Preparation of hypocrellin B nanoparticlesfor photodynamic therapy
Albert Wingnang LEUNG, Chuan-shan XU
24
PFMG1 promotes osteoblast differentiation and prevents osteoporotic bone loss

Liy:an LI,

Pan

WANG, Zhao

.WANG

25

Anti-malaria drug artesunate protects bronchial epithelium from DNA damage induced by asthma
Tze Khee CHAN, WN Felicia TAN, Bevin P ENGELWARD, WS Fred WONG 25
generation
Ca2- influx and ROS
trigger CDDO-Me-induced dilation of the ER and apoptosis in breasl cancer cells

""

"

In Young KIM, Soo Ah JEONG, A Reum LEE, Mi Jin YOON, Hyeseong CHO, Jong-Soo LFF, Kyeong Sook

^*':::'1:::l:::1)::::11
zYz4sl Protects *ro"T:::I::

""""""""'

CHOI

26

:::::::::fiff;l";."jnT;:il::',Ji'":;;;; ;,;;;;;_;

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ZHU

27

apoptosis by enhancins MnsoD and SrAr3 interaction
:'"r.|111,.::1r0**
"' Shan-shan LUO, Ya-qi SHEN, Li-ming MA, Xian-feng GU, Yi-zhun

CARDIOVASCULAR PHARMACOLOGY
Components of traditional Chinese medicine inhibit platelet aggregation by blocking ADP receptor subtypes p2y, and
P2Yp
""""' Xiao-liang WANG, Yi-y-g LI, Hong-yan YANG, Shaofeng XU, Ling WANG 28
Sesamol inhibits atherogenic LDL-induced endothelial cell senescence in vivo and in vrtro
Hong-kai HUANG,

F*Sy, CHEN, Kuan-hsiang TING, Chrh-chung FENG, Chiarning CHANG, Chu-huang CH-EN, Ming-yr SHEN
29
lmprovement of lipid profile and atherogenic index in rat treated wilh Cymbopogon citratus Stapf water elcract
Nuntiya SOMPARN, Suphaket SAENTFIAWEEUK, Jarinyapom NAOWABOOT, Atcharapom THAEOMOR 30

='"::

::'::::::

:::::::

::::i:::T;:;:::lHffi:T :ffi':':nffiffi:H ffffi":ffi[r*,,

Protective effect of salvianolic acid A against isoproterenol-induced myocardial infarction in mice

Lian-hua FANG, Ziran NIU, Tian-yi YUAN, Li Li, Yue-hua Wang, Guan-hua DIJ 31
A comprehensive cardiotoxicity assay by combining high{hroughput multiple ion channel screening with human cardiomyo...-.. He-ming WEI, Jian-jun WU, Ying Ying CHttNG, Cai Hong KOH,
cyte-based action potential validation
Zhen-feng

LIU, Stuart COOK, Winston SHIM, Tan Mei LAN

............

31

Protective eflects ol scutellarin on vascular dysfunction caused by hypertension in SHR rats
eing-qing LI,
Zhi-ying V/ENG, Min ZFIANG, Chen CFIEN, Xao-hua DU, Pei-hua PEN(i. Vi/en-juan WIJ, Jun ZHANG, Wei-nrin YANG 32
Effect of elhanolic e)dract ol Physalis minima on lowering blood pressure in DOCA-salts hypertensive rat models

"""' Nur PERMATASARI.

Dian NUGRAHENI\IY, Saifurrohman

33
:

!

!

f Ar\,9+Er&4-++.t-2015+7

11

'429+v3il1

ChinJPharmacol Toxicol , Vot 29, Suppt .l , Juty2015

Effects of scutellarin on PKG in HCtt/ECs after hypoxia

roxygenation

flI

yang LI, ZLn-y"rng wENG, Min ZFIANG.

Chen CHEN, Xiao-hua DU, Pei-hua PENG,'Vr'en-juan WIJ, Xuan LIU. Wei-min

yANG

33

Novel derivative of Danshensu acts as anti-thrombotic agent for modulation of protein disulfide isomerase family member
"+'--""""""
ERp57
Guo-zhen CUI, Ltr-chen SFIAN, Lin GUO, Ivan Keung CHU,
Guo-hui LI, Quan QUAN, Yun ZFIAO, Chenong-meng CHONG, Zaijun ZHANG, Pei YU, Pui-man HOI, ye-wei SLIN,
Yu-qiang WANG, Simon ming-yuen

LEE

34

Pinocembrin inhibits angiotensin ll -induced vasoconstriction in a Ca2--dependent and Ca2*-independent manner through
blocking AT, R in the rat aorta
Li LI, Hai-guang yANG, Xiao-bin PANG, Bai-nian CFIEN, Li GAO,
Le WANG, Shou-bao \VANG, Tian-fi YUAN, Su-bo WANG, De-pei LIU, Guan-hua

DU

35

cardioprotective and chemosensitizing effects of novel Danshensu derivatives
Liang WANG,
Lu-chen SFIAN, Guo-zhen CUI, Judy Yuet-Wa CFIAN, Jing-jing LI, Qing-w-en ZHANG, Maggie Pui-Man HOI, yu-qiang WANG,

Simon Ming-Yuen LEE
35
Antithrombotic effect ol a novel tissue plasminogen activator from the venom of Gtoydius brevicaudusviper..................
""""' Yun-lu XU, Li-li LIN, Jin-hua ZHANG, Jian-1i CHEN, Zhi-qiang WIJ, Guo-ru WIJ, Jian-zhong LIN 36
Effect of Scurrula atropurpurea on blood pressure and angiotensin ll of deoxycorticosterone acetate-salt hypertensive rats

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Sesamin
enhances nitric oxide bioactivity in aortas of spontaneously hypertensive rats

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yANG, Xiang KONG, Wei LI 3g
Jie_ren
Combined antihypertensive effect of GSY and metoprolol, based on endothelium-dependent vasodilatation function ......
Bo LI, Jie SU, Shan-shan LEI, Zheng-biao YANG, Ze-u'u JIN, Hui-ming HU, En-rvei ZHU, Gui-uran LyU, Su-hong CHEN 38

Study on establishing hypertension animal models by adverse lifestyles and the antihypertensive effect of traditional
....,. Guiyuan LYU, Bo LI, Su Jie, Na SHI, Chao-qun XIA, CH_EN, Su-hong CHEN 39
ChineSe medicine
ei
NEUROSCIENCE
Traditional Chinese herbal medicine for vascular

...... Dianne BAUTISTA, ya-nan ZHrJ, yong
dementia
'Wen-prn LI,
Edwrn SY CHAN, Christopher CHEN
Effects of DL0410 on the learning and memory deficit in APPIPS1 transgenic Alzheimer's disease model mice

il,*;; ; ;;;:F:;:

41

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Yang-ou DENG, Xiao-qiang LYU, Shi-ing WU, yong-gang

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LIU

42

;;;; ;;";; ; ;;;,;;"::'ff#il:o**#
" U YANG,

40

DU

Rong YAN, Ran-yao YANG, Ai-lin LIU, Guan-hua
Chinese herbal medicine formula SYM prevents brain calcification in a murine nrodel of IBGC

*"::

you,

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neurodeseneration' a ce'|rcu'|ture studv

l'*"i:::::ll::::.asainst
.....---. Xue-xian KUAI, Cuicui YANG, Wen-bin GAO, Lin LI, l2n ZHANG
Fuzi promoted the formation of myelin sheath in schwann cells induced by high glucose

42

"""""""""
"' Tian-tian LYU,Jrng FIAN, Hong-liang WANG, Yan WU, Gar-mei FIAO,Jie HE, Wei r,yANG 43
Multi-targets antidefrBsant mechanism oI the bis-benzylisoquinoline 7-O-ethylfangchinolines lnvolvement of noradrenergic,
dopaminergic and AMPAergic

systems

Zlao-fu SHENG, Xiang:yu CLII,
Xue-qiong ZHANG, Sheng-jie LI, Qrng CAO, Yuan-li HUANG, Ya-ping XU,Jin-zhi SONG, Hui DING, Zhi-ge
LIN, C,uang YANG, Yong-he
44

Sr-y-g CUI, Bin YU,

ZHANG

Effects of Gastrcdia elataard Uncaria rhyrchqhyllawater eldract on cerebral ischemic rat revealed by LC-FTICR-MS metabolomics approach
"' Jia Wen )flAN, Tao HUAN, Liang LI, Wing Nang LEt NG, Chun Wai CHAN 44

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Analysis of potential amirp acid biomarkers in brain tissue ard the effect of qalangin on cerebral ischemia
Jian GAO,

Cf,-g

CF{EN, Fei-peng DUAN,Jing FANG, Shao-jing

U

46

Effect of Naojian Tablet on cerebral ischemic injury and its prevention mechanism

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pathway, at least

Lin-lin YIN Yong-yan GHEN, Zhao QU, Li ZHANG, Qi Y/ANG, Qi ZHANG, Lin
mediates the fast onset of antidepressant like natural product

-.--.

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ZHANG, Fei GUO, Zhi-'Wen FU, Bing ZflANG, Cheng-Gang HUANG, yang

jJ

LI

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48

v

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29

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Chin J Pharmacol Toxicol, Vol 29, Suppt

1, July 2015
i

Effect ol Tong-Qiao-Huo-Xue decoction on the expressions of related proteins of the blood-brain barrier and analysis of constitu" Nng WANG, l,r-li LI, Qi-zhongJIN, Ya-lang LIU,
ents in cerebrospinal fluid of cerebral ischemic rats """"""'
Guang-yun W'ANG,*r'an

V',^NG

activation

|ayakody JPT, Dawe

INFLAMMATION AND IMMUNOLOGY

:::::* :::11

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49

Development ol an ERK1/2 activation assay to determine relaxin-VRXFPt!

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Vitamin E isoform y-tocotrienol alleviates cigarette snoke-induced chronic obstructive pulmonary disease ".... Hong Yong PEH,
'Wan Shun Daniel TAN, Tze Khee CHAN, Chen Wei POW, Choon Nam ONG, \Vai-Shiu Fred WONG
51
ln vitro and in vivo pharmacological investigations of Pinus roxburght? for prevention of oxidative, inllammatory responses
against

osteoporosis

Sharma

ADITI, Goyal ROHIT, Bhattacharya

S

52

lsofuranodiene protect D-galactosamin/lipopolysacchride induced liver injury in rats """.'"""' Wen-pingLI,Jingxhan SHI,
\2
Filippo MAGGI, Xiu-ping CFIEN
SRS27, a semisynthetic diterpenoid lactone, inhibits airway inllammation and hyper-responsiveness via NF-xB pathway in

an allergic mouse asthma model -..-.....
Jonathan Chee lVoei LIM, Fera Yiqian GOH, Sreenivasa Rao SAGINEEDU,
53
Audrey Chee Hui YONG, Shiran Mohd SIDIK, Nordin Ha.li LAJIS, Wai-Shiu Fred WONG, Johrxon STANSLAS
Non-typeable haemophilus influenzae-induced exacerbation on a cigarette smoke lung injury model, Protective effect of
andrographolide....-.......-.-.-'..- Wan-shun Daniel TAN, Hong-yong PEH, Chu-hui PANG,'Wu-peng LIAO, Tze-khee CHAN,

5't
Suk-hiang LAU, Vincent T. K. CHOW, Wai-shiu Fred WONG
Anti-malarial drug, artesunate, as a novel therapeutic drug target for airway wall remodeling in asthma
Sheryl TAN, Benjamin ONG, Chang CF{ENG, Wanxing Eugene HO, John K.C TAM, Alastair G. STEWART,

Trudi HARRIS, Wai-Shiu Fred WONG, Thai

TRAN

54

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Pharmacokinetic ol nasal curcuffiill: An approach for asthma medication

..-

SIM, Preeti Singh CHAUHAN, Ruchi CHAWLA, D DASH, Rashnri SINGH 57
with
antibiotics
against Staphylococcus aureus and MRSA
Synergistic effect of rosmarinic acid
Sanmuga Priya EKAMBARAM, Nathiya MARAPPAN, Vinodhini VISWANATHAN, Sabari Srinivasan G, Ajay B 58
Protective effects of NYG-1 on CClo-induced acute liver injury in rats ""'.""" Hong-liang LI, Xuan-bin WANG, Ming LIU,
Subhashini

59
Yi-bin FENG, Qiu-fang ZHANG
Fructus
and
Lonicerae
Japonitn vivo and in vitro anti-arthritic efficacy of a herlcal formula consisting of Rosae Muftiflorae
Brian Chi Yan CHENG, Hui GUO, Tao SU, Xiu-qiong FU, Ting LI, Zhi-Iing YU 59
cae Flos
sulfonate
sodium on chronic hepatic injury by regulating the T lymphocyte subsets in mice
Protective eflects of 3'-daidzein

... J-g ZENG, Rui.zhen LtU, Gui-lin WEI, Liang-dong LI, Zhi-hua HUANG 60
lcaritin requires phosphatidylinositol 3 kinase./Akt signaling to counteract skeletal muscle atrophy following mechanical
........:.--.... Zong-kang ZF{ANG, Jie LI, Wingnang LEUNG, Ge ZHANG, Bao-ting ZHANG 61
unloading....'

..:...............

Anti-inflammation and anti-fibrosis actions of resveratrol on experimental pneumoconiosis
Jie LI, Zong-kang ZFIANG,Yue QU, Wing-Nang LELING, Bao-ring

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gastric ulcer rats
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of Nigella sativaL. to gastric mucous of indomethacin-induced

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ZHANG

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61

62

Umi KALSUM, Renata PRIMASARI, Dewa AYU, Mudjiwijono HANDARU 63
ln vitro aN in vivo immunomodulatory activities of polysaccharides purified from four species of Dendrobium ""'-"""...
Lei SHI, Hui CAI, Seng Poon ONG, Feng TIAN 64
inllammatory response in murine
lipopolysaccharide-induced
from
Denis
Benth
suppresses
taxiflora
The compounds
......-....
..'.
Ai-jen YANG, Hsrlin CHIU, Mingyu CFIAO, Jui-cfung CHEN 64
Rav{2M.7 cells
Eftect of mangosteen (Garcinia mangostana Linn) peel extract on migration of endothelial cells treated with lipopolysac..'... Dian NUGRAHENNY, Nur PERMATASARI, Adianto JAYANAGARA, Tinn Andri WI-IASTUTI,
charide
Djanggan

SARGOWO

65

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ChinJpharmacol Toxicot,Vot 29,Suppt 1,Juty2015

Methanolic extract of ceplukan leal ( Physalis minima
ectomized rats

L.

)

V

attenuates ventricular fibrosis through inhibition of TNF-q in ovariLestari BAYU, Pemratasari NL.IR, SarfurRohman MoFIAMMAD 65

Cucurbitacin E induces apoptosis and attenuates activation of hepatic stellate cells via Pl3K,/Akt-AMpK-mTOR signaling
pathfiay
You-li YAO, Li-hua LIAN, Shuang JIANG, Ji*irg NAN, Yan-ling WU 66
lnhibitory activity of Cinnamamum Cassia extract on hypersensitivity in mice ..........
........ Seunggyeong LEE,
Jungbin SONG, Donghun LEE, Young-Sik KIM, Hl,rrn Soo KIM, Hailing GUO, Juyeon PARK, Hocheol KIM
67
P2X7 receptor inhibitor suppressed extracellular ATP,TLPS-primed human hepatic stellate cells activation via downregulating NLRP3 inflammasome
Shuang JIANG, Quan JIN, Yan-ling WIJ, you-li yAO, Ji-xing NAN, Li-hua LIAN 67
Possible role of mitochondrial permeability transition pore in hepatoprotective potentials of epigallocatachin gallate in paracetamol induced hepatotoxicity in rats
Gurfateh SINGH, Deepika BHATIA, SLHARIKUMAR 68

METABOLIC DISEASES
Active component

of

lsatidis Radix on insulin resistance in diabetes mellitus

Zhen JIANG, Mo-xiang

LIU

rat

.............

Ji-ping LI, Tian-jiao HU,
68

lnvestigating the prescription compatibility of Rhodiolarosea, Cordycepsmititaris, and Rhubarb root for the treatment of
metabolic syndrome
Jin-ying TIAN, Ling CHEN, Xiao-lin ZHANG, Jing HAN, pei-cheng ZHANG,.Fei yE 69
,*i:*::::i:::::::
reaf extracr improves insutin sensirivity in hish{at diet-induced obese mice

"""'

Suphaket SAENTAWEESUK Jannyapom

Potential tole of Tinosporacordifolia extract in prevention of diabetic
Roshni REVANKAR, Vikrarn SARANGAM, Shekhar DETHE

.,"t"111.1_,
Errecr or row

::::::::*ite

NAowABoor,

complications

Nuntiya

soMpARN 7o
pratibha NADIG,
70

fat brownins throush ausmentins FGF21 expression in brown adipose tissue

morecurar;",;;;;;r.;"

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ono",";;;.;;;;;;,;ffi::l}";lll:,1il1-i#I'i'il;#-..;y

..1'

'lVen-tong

CUI, Wen-zhe YANG, Zht-qiang WANG, Bo-lu ZHOU, Da-li LUO 72
Ganoderma Lucidum polysaccharide peptides protect kidney from renal ischemia reperfusion injury via counteracting
oxidative stress """"
Dan-dan ZHONG, Hong-kai WANG, Ming LIU, ying-liJlA, Ming HUANG, Hong ZHOU,
Shu-qian LIN, Zhi-bin LIN, Bao-xue YANG
72
Role of metabolomics assisting the pharmacological activity and molecular mechanism in panax notoginseng

""""' XueJIANG, So-Hyun KIM, Lin-fang HUANG, Hyung-Kyoon CHOI 73
Role of TRPM2 ion channel, an oxidative stress sensor, in hyperglycemia-induced pro-inflammaotry lL-1p in
human mono-

cytes """"'
Hui-ling TSENG, Chi-reng VONG, pui-man HOI 74
Effects of Liuwei Dihuang decoction and its compatible prescriptions on the function of hypothalamus-pituitary-adrenal
axis
.... NingJIANG, Si-di LI, .W.en-xia ZHOU, yong_xiang ZHANG 74
in senescence-accelerated mouse ........
Behavior and metabolomics study of the anti-aging effects of Scutellaia baicalensis Georgi ertract on D-galactose-induced

rats """""'
Yu-shi ZHOU,Yan-Gn CHANG, Guan-hua DU, Xue-mei eIN 75
Effect of Urena lobata leaves elrtract on glucagon like peptide-1 serum level by inhibition ol dipeptidyl peptidase-lV
on
diabetic rats
Yudi PLTRNOMO, Djoko wahono s, suriman B SUMITRO, M Aris wIDoDo 76
Anti-hyperglycemic effect of ethanolic leaves extract, hexane and water ot Urena lobata on diabetic rats induced
by high
fructose diets and streptozotocin
-..... yudi PURNOMO, Dori WAHyUNINGTYAS, M ATis WIDODO

*i1:::

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76

1ffi',:Jl:":::I"T::J:[".:',11, ;;;

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of animal models for hyperuricemia and the apprication of rradirionar chinese medicine
Su-hong CFIEN, Min-xia PANG, Yi"ry"re M4 Hui-ming HU, Rui-li yU, Gui-yuan LyU
7g

CANCER
Potential role of nimbolide in chemoprevention.and therapy of prostate cancer
Jingwen 2HANG,
Muthu K- SHANMUGAM, Amudha DEIVASIGAMANI, Alan Prem KUMAR, Kam Man HUI, Gauam SETHI
7g
Ascochlorin overcomes chemoresistance and regulates the plasticity of doxorubicin induced EMT via
modulation of the
NF-xB pathway in hepatocellular carcinoma
Xiao-yrn DAI, Kwang Seok AHN, Chulwon KIM,
Muthu K SIIANMUGAM, Feng LI, Ji-zhong SHI, A.lan Prem KIIMAR , Ling-ztn WANG, Boon Cher GOH,
Junji MAGAE,
Tina H ONG, Kam M HL]I, Gautam SETHI
79
Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite
downregulation of
proliferative biomarkers
..--.. Feng LI, Muthu K. SFIANMUGAM, Kodappully Sivaraman st\,tsEN,
Fan WANG,
Tina H ONG, Ser Yue LOO, Mahadeva MM SWAMY, Somnath MANDAL, Alan Prem KUMAR, Boon Cher
GOH, Tapas KLTNDU,

\i

+gliry+h+rEii+.t

2015+7 A'1;29 +r€11

1

chin J Pharmacol Toxicol , Vol 29, Suppt 't , July 2015
i,

Kwang Seok AIIN, Ling-zhi WANG, Kam lvlan HUI, Gautam

SETHI

80

Glycyrrhetinic acid-triggered cytoprotective autophagy via inositol-requiring enzyme 1c-c-Jun N-terminal kinase cascade in
.-.... Zheng-hai TANG, Le{e ZFIANG, Ting LI,
non-small cell lung cancer cells

LU, Chung-hang LEUNG, XJu-ping CHEN, Yiuo WANG, Jin-jian

LU

iI

i
;

81

I

ln vitro and in vivo effect of artesunate against prostate concer: Targetting STAT3 pathway to combat disease progression

j

Jia-hong

AIAMELU, Kwang Seok AHN, Kodappully Sivaraman SIVEEN, AlanPrem KUMAR, Gautam SETHI 81
Garcinol suppresses the groMh of human hepatocellular carcinoma by inducing abrogation of STAT3 phosphorylation,
acetylation and dimerization -...-- Muthu K SFIANMUGAM, Snehajyoti CHATIERJEE, Peramaiyan RAJENDRAN, Feng LI,
Nachiyappan

Parijat SENAPATI, KwongFai

WONG, Ajan Prem KtIIvtAR-John M LI-JK Kam Man HUI, Gautam SETHI, Tapas K

Liguzinediol protects against apoptosis irrduced by doxorubicin in HrC,
Yuan YAO, Xiang WIJ, Wei LI, Hui-min

cells

KLINDU

g2

83

RNA helicase DDX20 as a surrogate marker of statin activity in invasive breast

....'.-..

cancer

Chao WANG,

Beiying QIU, Jean Paul THIERY, Gautam SETHI, Patrick J. CASEY, Celestial T. YAP, Soo Chin LEE, Vinay TERGAONKAR,
84
AIan Prem KUMAR

Anti-emetic mechanisms of Xiaobanxia Tang decoction on the chemotherapy-induced pica model in rats .....-..
.-"" Gong-chang YU, Yong ZHANG, Ke NIE 84
Specific growth inhibition by alteration of metabolic pathway using Chinese herbal medicine in tyrosine kinase inhibitor
resistant non-small cell lung

cancer

Xing-xing FAN, Maria Pik WONG, Zhi-rvei CAO, Jian-lin WU,

Hua ZHOU, Zhi-hong JIANG, Liang LIU, Elaine Lai-han

LEUNG

85

'*"":::l':::::::::r:::::: I":::HT::"J:[[#:l'"Til::::r""J[?:':l:]::1ffi':;;:T;#"'*
Targeting the undruggable KRAS: ln vrtro anticancer property oI andrographolide and its semisynthetic analogues in
pancreatic adenocarcinoma cell lines harbouring oncogenic mutant K-ras -------'-... Michelle Siying TAN, Yuan Han TEH,
Kok Lian HO,

Sreenivasa

Rao SAGINEEDU, Johnson

STANSLAS

-*:*::::1::::::11:::':*:::: *ffi:*:ffi"#;:i::$'tr;:ffi:?::T."Jiltrl[:_::':H",

87

"

lnvivoand in vitro structure and relationship analysis of andrographolide derivatives: ldentifying AGL-2 as a novel anti-

agent

Jing-jing LI, Yu-ran PENG, Shang LI, Judy Yuet-Wa CHAN,
ZHOU, Simon Ming-Yuen LEE
88
Cytotoxic effect some fractions of parasitic tea tree (Scurrulla atropurpurea Danser) and its potential for DNA demethylation
in silha approach ... Ni Luh Punr Eka SUDIWATI, Mulyohadi ALI, Edi Priyo UTOMO, AULANI'AM, Tacit NURSETA 89
. Zb,-ytng WENG,
Mechanisms of eriocalyxin B on antileukemia activity by human cDNA microaway .-.---..-..
90
Huihui XIANG. Ying-li WU, Ma-ling LI, Han-dong SUN

angiogenesis

Guo-zhen CUI, Guo-chun

A plant sesquiterpene lactone and its derivative reduce cutaneous side effect of vemurafenib, a BRAF inhibitor drug to treat

...---

melanoma
SHYUR

late Stage
Lie-Fen

Antiangiogenic

Meng-ring CHANG, Jia-hua FENG, Kyoko NAKAGAWA-GOTO, Kuo-Hsiung LEE,
90

effect of berberine a-hydroxy-6-decanoylethyl sulfonate on Lewis lung carcinoma ...

QI

91

ZHU

92

Jing LIN, Hui

NAruRAL PRODUCT INNOVATION AND TECHNOLOGY
lnorganic nanoparticles for hydrophobic anticancer drug

delivery

Xiao-ming

Killing effect of the combined treatment of ultrasound and hypocrellin B on Candida
Albert WingNang LEUNG, Margaret IP, Xin-na

.WANG,

Pan

WANG

albicans

Chuan-shan

XU,
92

A fast screening method for multFresidue pesticide analysis of TCM herbs using liquid chromatography-quadrupole-time-offlightrnass

spectrometry

HPTLC Analysis of multi-ingredient traditional Chinese medicine
Leng NEO, Feng

TIAN

Xue-jia XLIE, Hong YANG, Feng

supplement

Wing-nang LELTNG, Chuan-slran

TIAN

93

.....- Marrin CAI, Sheena GOH,
93

Evaluation ol photodynamic efficiency of an endogenous enzyme-NQo1 activated

hypericin

.-.

XU

Qi-cai XIAO,
94

ldentification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening
Li-juan LIU, Ka-Ho LEUNG, Daniel Shiu-Hin CHAN, Dik-Lung MA, Chung-Hang
Pharmacophore modeling for the identification of small-molecule inhibitors of

TACE

LEUNG

95

Li-juan LIU, Ka-Ho LELTNIG,

Sherg UN, Dniel Shiu-Hn CI{AN, Dewi SUSANTI, Werdong R-ArO, Philip Wai Hong CHAN, Dk-I:trE MA, Chung:Hrng
Effect of sonodynamic action of hypocrellin B on biofilm-producing Enterococcus faecalis
'WANG, He-yu HUA, Chuans-han XU
Xin-na WANG, Margaret IP, Albert Wing-Nang LEUNG, Pan

:
1.

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Yu LI, Chao LIN, Ya-yun ZHANG,

BIAN

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96

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ChinJ Pharmacot Toxicot, Vol 29, Suppl 1, Juty2o15

\,n

and its derivatives to rnutant and wi'|d'tvpe K-ras

.

Shun Ying QUAH, Pran KishoreDEB, Johnson STANSLAS 97
lntegrative database for multi-compound drug discovery in complementary medicine ......... Sunyong yoo,
Jaejoon CHoI,
Moonshik SHIN, Suhyun HA, Kyungrin NOH, Ho.lung NAM, Doheon LEE
9g
Virtual screening and optimization of type ll inhibitors of JAK2 from a natural product library
Dik-Lung MA,

Daniel Shiu-Hin CHAN, Guo WEI, Haijing ZHONG, Hui YANG, Lai To LEUNG, Elizabeth A. Gt LLEN, pauline ChIU,
Yung-Chi CHENG, Chung-hang LELING
98
ldentifuing multi-component drug candidates in natural products via association rule mining
...... Suhyun HA,
Kyungrin

NoH,

Moonshik SHIN, Sunyong

Yoo,

Jaejoon

cHoI,

Hojung NAM, Doheon

LEE

99

OTHERS
Cistanchetubulosa (Schenk) R. Wight amelioratesbisphenol A-induced testicular and sperm toxicity in rats through stero!dogenesis and redox pathways .------.. ztu-hui JIANG, Wen-yan XIE, Meng WANG,
WANG, Xiao-ying ZHANG
Jian

100

Design, synthesis and bioevaluation of N-hydroxyquinolinones as potential anti-plasmodial, anti-bacterial and iron(
ll )chelating agents
Yan-bo TENG, Alice Soh-Meoy oNG, Laurenr RENIA, Christina Li-Lin CFIAI 101
Testa of Rhynchosia nulubilis down-regulates melanin synthesis in UVB-induced guinea pigs epidermal skin tissue
Hyun Jeong LEE, Donghun LEE, Jung-bin SONG, Young Sik KIM, Hai-ling GUC), Seunggveong LEE,
pARK,
Juyeon
KIM, Hocheol KIM
101
Comparative study of standardized Centella asiatica and combination of levodopa and benzerazid HCI on parkinson,s
model zebrafish """""" Husnul KHorlMAH, Wibi RIAWAN, LIZIYYANNIDA, ArrE NITRKHAIRINA, Mulyohadi
ALI,
M Aris WIDODO, Sutiman B SUMITRO
n2
Sun Yoeu

Effects ol Angelica sihensls on longitudinal bone growth rate in adolescent female rats ...... Hai-iing GUo, Donghun
LEE,
Young-Sik KIM, Jung-bin SONG, Hyun Soo KIM, HyunJung LEE, Sung Hyr:n LEE,
pARK,
Hocheol
KIM
103
Juyeon
Effect of Dioscorea batatas on longitudinal bone growth rate in adolescent female rats ...... Hyun Soo KIM, Donghun
LEE,

Young-Sik KIM, Jungbin SONG, Hyun Jung LEE, Seunggyeong LEE, Sung Hlun LEE,
103
Juyeon pARf(, Hocheol KIM
Basal repertoire of toxin-related transcripts in the zoanthid Protopatythoa variabitis (Cnidaria, Anthozoa) ...
Chen HUANG,
Jean-Etienne RL MORTIGHEM, HeGng ZHOU, Erica Parr6:ia LIMA, Paula Braga GOMES, Carlos Daniel pEREZ, Inchio LOU,

Simon Ming Yuen LEE, G Radis-BAPTISTA
1O4
Transcriptome analysis of leaves, roots and flowers of Panax notoginseng on ginsenoside and.alkaloid biosynthesis
and
amelioration of vascular insufficiency conditions by saponins from the flower buds
......... Bin-rui yANG,
Kwok-Kuen CHEUNG, Ming:hua LIU, Wai-Fung CHEUNG, Xin ZHOU, Rui-fang XIE, you-hua WANG, pui

Man HOI,

Kwok-Wing TSUI, Simon Ming-yuen LEE
105
Human urine metabolome in response to Fermentum rubrum (Hongqu capsules) by HlLlc-UHpLC-QToF.....
Hong YANG, Edmund J. D. LEE, Seok Hrvee KOO, Feng TIAN 106
ldentification of genetic factors modulating doxorubicin-associated cytotoxicity by calcium
...... yingJun LIM,
ThiThuyTrang NGLIYEN, Melanie Hui Min FAN, Kim Kiat LIM, Wee Han ANG,
Chuan
TONG,
Kenneth Hon-Kim BAN,
Joo
Stephen

Ee Sin

CHEN

106

Discovery o, novel thieno[3,2-b]pyrrole S-carboxamides as potent inhibitors of Chikungunya virus
K C CHING, Y W KAM, Lisa FP NG, Chrisrina L.L CHAI 107
Substrate-dependent inhibition of human cytochrome P45O 3A catalytic activity by specific isomers of vitamin ............
E

...

Swee Fen CHAI, Sumit BANSAI, AikJiang LAU 107
of i'is na'lura"v occurrins ana,oss
:"'some
...... Hai-shu LIN, Samuel Chao Ming yEO, Wan CHEN 10g
Pharmacological activities and herb-drug interaclions of Panax ginseng and its chemical components:
a review
"' HaiNing WEE, Hui-Chuing YEW, Hrvee-Ling KOH, Chay-Hoon TAN 109
Effect of soybean milk for 12 weeks in six-weeks-old male rats'testis, prostate, epididymis, seminal
vesicles and testos-

*"T::::::l::::::::::::::::::::::1:::l

terone

"""""""'

Nurdiana NLrR-DIANA, Imam SARWONO,

Feby ADIGI.INA, Zew

R SETYOFIADI,

Stephen

l{ARSoNo, priyo BITDIUTOMO,

M ALING

Structure-activity relationships for anti-inflammatory effect of fl avonoids
Riclcy YK MAN, Susan WS LEUNG

109
.,Peng ZF{ANG, Judith CW MAK,
110

Effect of Weiliuan of different prescriptions on gastrointestinal regulation factor in spleen-deficiency
rats
Xuan-xuan ZHU, Xue-fei ZFIANG, Shen-lin LIU 110
Regulative effect of aqueous extract of Eichhornia crassipes on the oxygen uptake capacity and motion
responses of mice
under weycool stress
Yu-xiang AN, Yuan YUAN, Man YAO, Xin ZHANG, Di ZHANG, yue ZFIAO 111

+AXtL+Er+4++.€.2015+7A'429Evir+1 1

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ChinJPharmacot Toxicol,Vol 29,Suppt 1,Juty2015

::: :Y::::::i'::::T:::: :1:.::::l:::::l::::T:1TI"""'fflT:n;

Anti-tick activity of some methanol plant extracts indigenous in Saudi
Ibrahim M- FI-ASHMAWY, Husein M.

Arabia

";,;;

Khaled

OMAR

B

;;,

AI-HARBI,
172

Polyprenols isolated lrom Picea abies L. spruc€ needles influence atorvastatin-mediated muscle strength weakness in
Wistar female rats ----'..-..-.
Baiba JANSONE, Zane DZIRXALE, Kaspan JEKABSONS,
Vladimin PILIPENKO, Ulnka BEITNERE, Raimon& SKUMBINS, Zrta FREIBERGA, Elga POPPELA, Ugis KIETNIEKS,
Ilona VANAGA, Karlis KLETNIEKS, Rua MUCENIECE, Vija KIUSA
1,13
Solubility and pharmacokinetics determination of chlorogeninc acid
Li ZHANG, wei-sheng XU, Su-bo WANG,
Guan-hua

DU, Yang LU

1,13

Uridine adenosine tetraphosphate acts as a pro-angiogenic factor in vitrolhrough purinergic P2Y receptors

Ilxan CHRIFI, Yan-juan XU, Dirk J DLINCKER,

S Jamal

MUSTAFA, Daphne MERKUS, Caroline

...

Zhi-chao ZtlOU,

CHENG

11,4

'"'':: ":l '::':: :::l :ll::T:::l::::l:::::: ::::::::::T',;T*:i'J:::*ff:ff:1l1"i,",,;;, ,
Fitness profiling links topoisomerase

ll

;,; ,;,

regulation of centromeric integrity to doxorubicin resistance in lission yeast

"""

Thi Thuy Trang NGLryEN, Juiia Sze Lynn LIM, Richard Ming Yi TANG, Lou-xin ZHANG, Ee Sin CHEN
115
plants
and malaria
Medicinal
Woon-Chien TENG, Hwee-Ling KOH 116

-*i::

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Effect of Urena lobata leaves extract on the improvements of lipid profiles on diabetic rats
Evaluation of antihyperlipidemic effect

acute hyperlipidemic

rats

Mohd. Zaini ASMAWI, Vikneswaran

;,.,
-.--......-

;;;"

;;,

.--..-.-----

Triari NIZUAR, Eko BAGUS, Yudi PURNOMO 117
ol Polygonum minus, a South East Asian salad plant in poloxamer 407-induced
.'-.----- Parayil Varghese CHRISTAPHER, Josephine Maria Arokiasrvamy CHRISTINA,

MURUGAfYAH

Cardioprotective effect of Urena lobata leaves extract on diabetic rats
Ahmat Baihaki , Elok Zaktyyatu Sholehah, Yudi Pumomo

118

-......-.---

Chandra Analis,
118

Effect of Urena lobata leaves extract on the inhibition of nephropathy diabetic complication

"' Pinta Surya KINANTI, Miranti SASTRANINGRUM, Yudi
Potency of Urena lobata leaves extract on the inhibition of vasculopathy on diabetic rats -.--'..-.
Dimas Bintoro KR-ESNA, A.l6en ARIPASFIA, Eka ST

PURNOMO

119

KMA BUDI, Yudi P1IRNOMO

120

tToa
*A4e+Er4:g**.t2015+7 n'429 iiigr,l 1

ChinJPharmacot Toxicot. vot 29, Suppl 1,Juty2015

h1

viously challenged cheek of 5 pL of a chemical solution(a normal saline vehicle alone or the vehicle containing eitherhistamine(5pg), BAMB-22 (1rrg) orbradykinin (2.65ug) andreturnedtothecontainerto
have its behavior recorded for another 30 min. RESULTS ln comparison with the mean numbers of sitedirected behaviors evoked by the injection of normal saline vehicle, bradykinin evoked significanly more
wipes but not more bouts of scratching whereas histamine and BAM8-22each elicited significanfly more
bouts of scratching but not more wipes. ln comparison with acetone treated controls, the CHS mice displayed a significantly greater number of bouts of spontaneous site-directed scratching and wiping to
the
SADBE challenged skin afterthe second challenge (scratching:1.2+0.67 ys 16.4+ 3.40, wiping: 1.0+
O.75 vs 27 .8+5.96 , respectively , P