RESPON IMUN SELULER PADA PENDUDUK YANG TERPAPAR BISING PESAWAT UDARA DI SEKITAR BANDARA ADI SUMARMO BOYOLALI: Kajian Tentang General Reaction Score, Kortisol, Jumlah dan Aktivitas Sel Nk pada Wanita.

Dr. Hartono, dr, M.Si
NIP 196507271997021001
Sebagai Staf Pengajar pada Fakultas Kedokteran
Lahir di Surakarta, 27 Juli 1965

FK
1

Riwayat Pendidikan:
 S-1. Universitas Sebelas Maret. 1992.
Bidang Ilmu: Kedokteran Umum
 S-2. Pascasarjana Universitas Sebelas Maret. 2002.
Bidang Ilmu: Ilmu Lingkungan
 S-3. Pascasarjana Universitas Gadjah Mada. 2010.
Bidang Ilmu: Ilmu Kedokteran dan Kesehatan

Judul Disertasi
THE CELLULAR IMMUNE RESPONSE OF PEOPLE WITH AIRCMFT
NOISE EXPOSURE IN THE AREA OF THE ADI SUMARMO AIRPORT
OF BOYOLALI
A Study On General Reaction Score, Cortisol, The Number Of Natural

Killer Cell And Natural Killer Cell Activities In Women
RESPON IMUN SELULER PADA PENDUDUK YANG TERPAPAR BISING PESAWAT
UDARA DI SEKITAR BANDARA ADI SUMARMO BOYOLALI: Kajian
Tentang General Reaction Score, Kortisol, Jumlah dan Aktivitas Sel Nk
pada Wanita
Exposure to noise contri.butes to a
health risk. There is sufficient scientific
evidence that aircraft noise exposure
could
induce
hearing
impairment,
hypertension
and
ischemic
heart
disease, annoyance, sleep disturbances,
and decreased school performance.
Other evidence as changes in the
immune system and birth defects is

limited. The aims of the research is to
find out the effect of the aircraft noise
on the, 1) General Reaction Score (GRS)
2) circulating levels of cortisol, 3)
number
of
Natural
Killer
cell
(CD56+CDI6+CD3-), and Natural Killer
cell activities of people in the area of
The Adi Sumarmo Airport of Boyolali.
The research finding is expected to
contribute to the science development
and
to
give
benefits
for
local

government and people in the Area of

Paparan bising pesawat udara dapat
berisiko terhadap kesehatan. Terdapat
banyak bukti yang menunjukkan bahwa
paparan bising pesawat udara dapat
menyebabkan
gangguan
pendengaran,
hipertensi,
penyakit
jantung
iskemik,
ketergangguan (annoyance), gangguan tidur
dan penurunan prestasi sekolah. Sedangkan
efek terhadap perubahan pada sistem imun
dan lahir cacat, bukti-bukti masih terbatas.
Penelitian ini bertujuan untuk mengetahui
pengaruh bising pesawat udara terhadap 1)
General Reaction Score (GRS) 2) kadar

kortisol
darah
3)
jumlah
sel
NK
(CD56+CDI6+CD3-) dan aktivitas sel NK pada
penduduk di sekitar bandara Adi Sumarmo
Boyolali. Hasil penelitian. diharapkan dapat
memberikan kontribusi pada pengembangan
ilmu pengetahuan dan memberikan manfaat
pada pemerintah daerah dan masyarakat
sekitar bandara Adi Sumarmo Boyolali

Adi Sumarmo Airport in preventing the
effect of aircraft noise. The research
design was an analytical survey with a
cross sectional approach, taking location
at the Dibal and the Gagak Sipat Village,
Ngemplak Sub district, Boyolali District,

Central of Java Province, Indonesia. The
research was conducted from July 2008
to
June
2009.
The
number"of
respondents was 39. They were divided
into 3 groups; Group 1 was exposed
92.29dB of noise level (13 respondents);
Group 2 was exposed 71.79 dB of noise
level (13 respondents); and Group 3 was
exposed 52.17 dB of noise level (13
respondents). The samples were taken
using simple random sampling. The data
were analyzed by Pearson Correlation
and Kruskal-Wallis one way Anova
followed by Multiple Comparisons test
The Kruskal-Wallis one way Anova test
was showed that there were a

significant difference of 1) General
Reaction Score (GRS) 2) circulating
cortisol levels, 3) the number of Natural
Killer Cell and Natural Killer Cell
activities, in the groups of respondents
as proven by the value ofp < 0,05. The
Pearson Correlation test was showed
that there were a positive association
between
General
Reaction
Score
induced by aircraft noi"se exposure with
1) circulating levels of Cortisol (r =
0.473 ; p = 0.02), 2) the number of
Natural Killer Cell (r = 0.451; P = 0.04)
and 3) negative association between
General Reaction Score with Natural
Killer Cell activities (r = - 0.554; P =
0.00). Based on the results of the

analysis, a conclusion was drawn that
there was a significant effect of the
aircraft noise on the 1) General Reaction
Score 2) circulating levels of Cortisol, 3)
the number of Natural Killer cell, and
Natural Killer cell activities of people in
the area of the Adi Sumarmo Airport of
Boyolali.

khususnya dalam upaya-upaya preventif
terhadap efek paparan bising. Rancangan
penelitian adalah survei analitik dengan
pendekatan
cross
sectional,
dengan
mengambil lokasi di Desa Dibal dan Gagak
Sipat, Kecamatan Ngemplak, Kabupaten
Boyolali: Penelitian dilaksanakan dari bulan
Juli 2008 sampai dengan bulan Juni 2009.

Jumlah keseluruhan sampel 39, terbagi
dalam 3 kelompok ; kelompok I terpapar
bising intensitas 92,29 dB (13 responden);
kelompok II terpapar bising intensitas 71,79
dB (13 responden); kelompok III terpapar
bising intensitas 52,17dB (13 responden).
Pengambilan sampel dengan cara simple
random
sampling.
Data
dianalisis
menggunakan Pearson Correlation dan
Kruskal- Wallis one way Anova diikuti
dengan Multiple Comparisons test. Hasil uji
Kruskal-Wallis one way Anova menujukkan
ada perbedaan rag signifikan antar kelompok
terhadap 1) General Reaction Score (GRS)
2) kadar kortisol 3) jumlah sel NK dan
aktivitas sel NK, yang ditunjukkan dari nilai
p