Proceedings of MatricesFor IITTEP – ICoMaNSEd 2015
ISBN: 978-602-74204-0-3
Chemistry Page 105
4. Conclusion
Mangrove plant
Avicennia marina
is a promising source of natural product. From the present study, preliminary phytochemical analysis concluded that due to the presence of extra
phytochemical in test extracts, they are beneficial one for its biological activity. The observed antibacterial activities of the crude extract and the isolated compounds betulinic acid could
justify the traditional use of the plant for the treatment of different bacterial infections. Thus, further test is recommended on large number of bacterial strains to decide their potential as
candidates in development of antibacterial drugs.
Acknowledgements
Special gratitude to Direktorat Jendral Pendidikan Tinggi Republik Indonesia Dirjen Dikti for the opportunity to get research fund in Beasiswa Unggulan. Thanks to Research Center for
Chemistry Indonesian Institute of Sciences LIPI Serpong for NMR analysis, Microbiology Lab School of Life Technology ITB and Postgraduate Laboratory Padjadjaran University
for antibacterial testing.
References
Krause, R.M. 1992. The origin of plagues: old and new.
Sciences
, Vol.257, pp.1073-1078. Chambers, H.F. 1999. The changing epidemology of
Staphylococcus aureus
.
Emerg Infevt Dis
, Vol.7, pp.178-182. Karlowsky, J.A., Jones, M.E., Thornsberry, C., Evangelista, A.T., Yee, Y.C., Sahm, D.F.
2005. Stable antimicrobial susceptibility rates for clinical isolates of
Pseudomonas aeruginosa
from the 2001-2003 Tracking Resistance in the United States Today Surveillance studies.
Clin Infect Dis
, Vol.40, pp.S89 –S98.
Wu, J., Xiao, Q., Xu, J., Li, M.Y., Pana, J.Y., Yang, M. 2008. Natural Products from true mangrove flora: source, chemistry and bioactivities.
Nat. Prod. Report
, Vol.25, pp.955-981.
Fabricant, D.S Farnsworth, N.M. 2001. The value of plants used in traditional medicine for drug discovery.
Environ Health Perspect
, Vol.109, pp.69-75. Wayne, P.A. 2009.
Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 9th edition.
Clinical and Laboratory Standards Institute. Nascimento, G.F., Locatoli, J., Freitas, P.C., Silva, G.L. 2000. Antibacterial activity of
plant extracts and phytochemicals on antibiotic resistant bacteria.
Braz J Microbiol,
Vol.31, pp.247-256. Yili, A., Mutalipu, H., Aisa, A., Isaev, I. 2009. Betulinic acid and sterols from
Astragalus altaicus
.
J. Chemistry of Natural Compounds
, Vol.45, pp.4. Tenover, F.C. 2006. Mechanism of Antimicrobial Resistance in Bacteria.
The American Journal of Medicine
, Vol.1196A, pp.S3-S10. Garrett, R.H. Grisham, C.M. 2009.
Biochemistry 5ed
. Saunders College Publishing. Nelson, D.L. Cox, M.M. 2008.
Lehninger Principle of Biochemistry 5th ed
. W.H. Freeman Company.
Proceedings of MatricesFor IITTEP – ICoMaNSEd 2015
ISBN: 978-602-74204-0-3
Chemistry Page 106
THE MATTEUCINOL FLAVONOID ISOLATED FROM THE STEM OF THE FERN
CHINGIA SAKAYENSIS
ZEILLER HOLTT
Suyatno
1
, Nurul Hidajati
1
, Erika Widiarini
1
, Anandya Wahyuningtyas
1
1
Department of Chemistry, State University of Surabaya, Jl. Ketintang Surabaya, Indonesia 60231 suyatno_kimunesayahoo.com
Abstract A flavonoid compound, namely matteucinol 5,7-dihydroxy-
4’-methoxy-6,8-dimethyl flavanone had been isolated from the stem of the fern
Chingia sakayensis.
It was separated by chromatographic techniques, purified by recrystalization and obtained as pale yellow powder with melting point of 171-
172
o
C. Its molecular structure was elucidated on the basis of spectroscopic evidences, including UV, IR,
1
H-NMR,
13
C-NMR, 2D-NMR, and EIMS as well as by comparation with those reported data in literature.
Keywords: Fern,
Chingia sakayensis
, flavonoid, matteucinol
1. Introduction